1999 anthracene derivatives

anthracene derivativesQ 1080

18 - 09110-Hydrocinnamoyl- and 10-Cinnamoyl-1,8-dihydroxy-9(10H)-anthracenones as Inhibitors of Leukotriene B4 Biosynthesis andHaCaT Cell Growth. — Synthesis and biological evaluation of anthra-cenones bearing 10-hydrocinnamoyl and 10-cinnamoyl substituents are reported.Many compounds (III) are potent inhibitors of the growth of HaCaT cells withIC50 values in the submicromolar range. — (MUELLER, KLAUS; REINDL,HANS; GAWLIK, INGO; Eur. J. Med. Chem. 33 (1998) 12, 969-973; Inst.Pharm. Chem., Westfael. Wilhelms-Univ., D-48149 Muenster, Germany; EN)

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