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Chemicals of emerging concern

Åke Bergman

Director of SWETOX*

Professor at Stockholm University, Stockholm, Sweden

Guest professor at Tongji University, Shanghai, China

*Swetox is a academic centre incl. 11 Swedish universities and working on all aspectson chemicals, health & environment; The Swetox hub is based at Karolinska Institutet

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2

What is emerging?

- A chemical pollutant

- An environmental issue

- Societal concern

A chemical pollutant may be:

Established

Emerging

Novel

PotentialAn environmental issue of

emerging concern may be:

Area/region dependent

Discipline dependent

Regulatory dependent

Emerging Societal concern

Scientific driven

Public opinion

Organisation driven, e.g EPI (SAICM)

Åke Bergman, SwetoxCopenhagen Chemicals Summit 2016

3

Types of emerging chemicals

3

PBT Chemicals i.e. Legacy POPs or commonly only

PB chemicals with limited tox. and ecotox. data, that

are bioaccumulative due to their:

Lipophilicity or Proteinophilicity


4

POPs in Mothers’ milk

2 0 25 5 5 6 8

12 14 15

3236

46 4853

94

110113

140

0

20

40

60

80

100

120

140

160

Articles per substance group


5

Emerging pattern of PCBs:highly chlorinated biphenyls

Zhou et al., Chemosphere 150 (2016) 491-498Åke Bergman, SwetoxCopenhagen Chemicals Summit 2016

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Concentration range in wildlife:

<LOQ – up to 340 μg/g fat

Significant chlorinated paraffin contamination in wildlife sampled close to the mouth of Yangtze river

Zhou et al., Science of the Total Environment 554–555 (2016) 320–328

7

Unexpected findings of CPs coming from hand mixers

7

1615141312111098765

10 000000

8 000000

6 000000

4 000000

2 000000

Min.

µV

1615141312111098765

6 000000

5 000000

4 000000

3 000000

2 000000

1 000000

Min.

Hand mixer #55µV

Strid et al., Reports to KemI and NFA, Oct., 2014

CPs

CPs Hand mixer #10


8

The unknowns

Indicated but structurally not confirmed – Emerging, indeed

Reason: Lack of authentic reference standards

Zhou et al., STOTEN 554-555 (2016) 320-328

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Persistent and Proteinophilic

PFOA

BP2

Transthyretin

Zhang, J. et al. ES&T, In pressÅke Bergman, SwetoxCopenhagen Chemicals Summit 2016

10

10

0

10000

20000

30000

40000

50000

60000

PFOS PFOA

SJ

ER

AC

CAW

0

50000

100000

150000

200000

250000

300000

350000

400000

PFOS PFOA

SJ

ER

AC

CAW

ÅB

KAO

Ed

Stine

Suzann

Exposed Children

PFOS and PFOA in humans (pg/ml plasma)

Data from Safe Planet (UN), Bergman and Jakobsson et al., Pers commun


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http://www.aces.su.se/misse/

0

10

20

30

40

50

60

70

ng

/g d

ust

Median PFAS levels in household dust

Childs bedroom Adult bedroom Living room


Bergman et al. from the Misse project

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Types of emerging chemicals

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PBT Chemicals i.e. Legacy POPs or commonly only

PB chemicals with limited tox. and ecotox. data, that

are bioaccumulative due to their:

Lipophilicity or Proteinophilicity

Semi-persistent Chemicals, defined as compounds

with high persitency (abiotically stable chemicals)

that are rapidly metabolised in vivo, are frequent

contaminants of our ambient and outdoor

environments


13


Emerging semi-persistent Chemicals

For example:

Halogenated and Non-halogenated phenols

Phosporus containing additives

Per- and polyfluorinated chemicasl


14

BisphenolsBPA


15

Fluorinated phosphate esters as contaminants

15

0

10

20

30

40

50

60

70

ng

/g d

ust

Median PFAS levels in household dust

Childs bedroom Adult bedroom Living roomÅke Bergman, SwetoxCopenhagen Chemicals Summit 2016 Bergman et al. from the Misse project

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Chemical profile in Swedish household dust

1

10

100

1000

10000

100000

DEH

P

DP

HP

DIN

CH

TCIP

P

TDC

IPP

TBO

EP

BD

E-4

7

BD

E-9

9

BD

E-2

09

BB

-20

9

DB

DP

E

2,4

,6-T

BP

6O

H-B

DE4

7

CB

15

3

DD

E

PC

P

PFO

A

PFO

S

6:2

PA

P

6:2

diP

AP

pm

ol/

g d

ust

Average from all rooms, 17 families


Bergman et al. from the Misse project

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1038 Potential EDCs*

Industrial byproducts

Heavy metalls

Surface protectors

Plastics

Plasticizers

PharmaceuticalsFungicides

POPs

Flame Retardants

Herbicides

Personal Care

products/Cosmetics

Pesticides

* TEDX List of Potential Endocrine Disruptors, accessed Sept. 28, 2016http://www.endocrinedisruption.org/endocrine-disruption/tedx-list-of-potential-endocrine-disruptors/chemicalsearch?action=search&sall=1

http://www.endocrinedisruption.org/endocrine-disruption/tedx-list-of-potential-endocrine-disruptors/chemicalsearch?action=search&sall=1

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Urgent needs

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Declaration of chemicals in materials and goods

Advanced monitoring of chemicals and effects

Priorterization of tox. and ecotox. testing and assessment

Highly developed substitution strategies

Safety assessments prior to manufacturing


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Thank you!

AcknowledgementsFor financial support from previous

funders of my research, and present:

• The EU for EDC-MixRisk

• Formas for EDC-2020

• Formas Misse project

• VR for Chemstrres and

• Swetox

Documents

Chemicals of emerging concern - cw-presentations.com · Heavy metalls Surface protectors Plastics Plasticizers Fungicides Pharmaceuticals POPs Flame Retardants Herbicides Personal