Chem Quiz 4 and 5

8/13/2019 Chem Quiz 4 and 5

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Quiz 4 LIVER FUNCTION TEST WITH AST AND ALT

___________________1. What specific enzyme is required in the conjugation of bilirubin?

___________________2. Type of hepatic jaundice that shows increased total bilirubin, decrease

conjugated bilirubin and increased unconjugated bilirubin

___________________3. An acute illness characterized by non-inflammatory encephalopathy, and fatty

degeneration of the liver with a clinical presentation of profuse vomiting accompanied

by varying degrees of neurologic impairment suck as fluctuating personality changes and

deterioration in consciousness.

___________________4. The aspartate aminotransferase is responsible for catalysing aspartate to

______________.

___________________5. The alanine aminotransferase is responsible for catalysing alanine to

______________.

___________________6. Using the malloy-evelyn procedure the most commonly used accelerator to

solubilise unconjugated bilirubin is__________________

___________________7. The addition of __________which is an accelerator in the jendrassik groff for

total bilirubin and conjugated bilirubin. The addition of this accelerator will solubilise

the water-insoluble fraction of bilirubin and will yield a total bilirubin value.

__________________8. Amount of urobilinogen excreted in feces per day.

__________________9. Type of jaundice that shows, increased total bilirubin, increased conjugated

bilirubin and increased unconjugated bilirubin.

10-11.Give 2 types of hepatic jaundice with increased total bilirubin, increased conjugated bolorubin

while unconjugated bilirubin is not affected:

__________________________________ and _____________________________

_________________12. The term referred to CONJUGATED bilirubin bound to albumin

_________________13. Used to describe yellow discoloration of the skin , eyes, mucus membrane, due

to bilirubin retention.

_________________14. Form of bilirubin which is insoluble in water and cannot be removed from the

body until it is conjugated by the liver.

________________15. Form of bilirubin which is a polar water soluble compound that is found in

plasma in the free state.


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Quiz 4 ANSWER SHEET

__URIDYL DIPHOSPHATE GLUCURONYL TRANSFERASE__1. What specific enzyme is required in the

conjugation of bilirubin?

_CRIGLER-NAJJAR SYNDROME_2. Type of hepatic jaundice that shows increased total bilirubin, decrease

conjugated bilirubin and increased unconjugated bilirubin

__REYE SYNDROME_3. An acute illness characterized by non-inflammatory encephalopathy, and fatty

degeneration of the liver with a clinical presentation of profuse vomiting accompanied

by varying degrees of neurologic impairment suck as fluctuating personality changes and

deterioration in consciousness.

__OXALOACETATE___4. The aspartate aminotransferase is responsible for catalysing aspartate to

______________.

__PYRUVATE__5. The alanine aminotransferase is responsible for catalysing alanine to ______________.

__METHANOL___6. Using the malloy-evelyn procedure the most commonly used accelerator to

solubilise unconjugated bilirubin is__________________

__CAFFEINE BENZOATE__7. The addition of __________which is an accelerator in the jendrassik groff

for total bilirubin and conjugated bilirubin. The addition of this accelerator will solubilise

the water-insoluble fraction of bilirubin and will yield a total bilirubin value.

_50-250 mg__8. Amount of urobilinogen excreted in feces per day.

__POST HEPATIC JAUNDICE__9. Type of jaundice that shows, increased total bilirubin, increased

conjugated bilirubin and increased unconjugated bilirubin.

10-11.Give 2 types of hepatic jaundice with increased total bilirubin, increased conjugated bolorubin

while unconjugated bilirubin is not affected:

___DUBIN-JOHNSON___ and ___ROTOR SYNDROME____

__DELTA BILIRUBIN__12. The term referred to CONJUGATED bilirubin bound to albumin

__JAUNDICE___13. Used to describe yellow discoloration of the skin , eyes, mucus membrane, due to

bilirubin retention.

_INDIRECT/UNCONJUGATED BILIRUBIN___14. Form of bilirubin which is insoluble in water and cannot

be removed from the body until it is conjugated by the liver.

__CONJUGATED OR DIRECT BILIRUBIN__15. Form of bilirubin which is a polar water soluble compound

that is found in plasma in the free state.


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QUIZ 5 ENZYMOLOGY EXCEPT AST AND ALT

1-5. Give 5 anatomical parts which ALP activity is highest

1._____________________

2._____________________

3._____________________

4._____________________

5._____________________

__________________6. In primary bone disease ALP is elevated. Give the enzyme which is usually

normal or slightly elevated in primary bone disease.

__________________7. Give the enzyme mainly affected due to chronic alcohol intake.

__________________8. Enzyme that is found elevated in pregnancy due to its release from the placenta.

__________________9. Enzyme that is useful in the diagnosis of drug-induced haemolytic anemia

_________________10. Enzyme useful in the diagnosis of prostatic carcinoma

_________________11. Enzyme useful in the diagnosis of myocardial infarction and skeletal muscle

disorder.

_________________12. Give the LDH isoenzyme which is localized in the heart and red blood cells. It is

elevatedin cases of megaloblastic anemia, acute renal infarction, and hemolyzedsamples.

13-14. Give 2 enzymes that are useful in diagnosis of acute pancreatitis

13_________________________

14_________________________

________________15. A chronic bone disorder that produces the highest elevations of ALP activity. It is

also known as osteitis deformans.


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QUIZ 5 answer sheet

1-5. Give 5 anatomical parts which ALP activity is highest

1.__LIVER_

2.__BONE__

3.__INTESTINES___

4.__KIDNEY____

5.__PLACENTA_____

__5-NUCLEOTIDASE___6. In primary bone disease ALP is elevated. Give the enzyme which is usually

normal or slightly elevated in primary bone disease. P528

_GAMMA GLUTAMYL TRANSFERASE__7. Give the enzyme mainly affected due to chronic alcohol intake.

_ALKALINE PHOSPHATASE___8. Enzyme that is found elevated in pregnancy due to its release from the

placenta.

_ GLUCOSE 6 PHOSPHATE DEHYDRGENASE_9. Enzyme that is useful in the diagnosis of drug-induced

haemolytic anemia

_ACID PHOSPHATASE_10. Enzyme useful in the diagnosis of prostatic carcinoma

_CREATINE KINASE_11. Enzyme useful in the diagnosis of myocardial infarction and skeletal muscle

disorder.

__LDH-2 (HHHM)_12. Give the LDH isoenzyme which is localized in the heart and red blood cells. It is

elevated in cases of megaloblastic anemia, acute renal infarction, and hemolyzed

samples.

13-14. Give 2 enzymes that are useful in diagnosis of acute pancreatitis

13-14_AMYLASE, LIPASE, TRYPSIN___

PAGETS DISEASE15. A chronic bone disorder that produces the highest elevations of ALP activity. It is

also known as osteitis deformans.

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Chem Quiz 4 and 5