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Chapter 22 (Part 2)
Protein Synthesis
Ribosomes
Prokaryotic Ribosome Structure
Eukaryotic Ribosome Structure
Ribosome Assembly
• Assembly is coupled w/ transcription and pre-rRNA processing
Ribosome Structure
Identification of Initiator Codon in Prokaryotes
Prokaryotic Translational Initiation
Eukaryotic Initiation of Translation
Recycling of EF-
Tu
Peptide Bond formation
N
NN
N
NH2
O
OHO
HH
HH
O
5' tRNA
N
CH
C
H
O
N
NN
N
NH2
O
OHO
HH
HH
O
5' tRNA
NH3+
CH
C
H
O
H
H
H
BASE
H+
P-Site A-Site
N
NN
N
NH2
O
OHO
HH
HH
O
5' tRNA
N
CH
C
H
O
N
NN
N
NH2
O
OHOH
HH
HH
O
5' tRNA
NH3+
CH
C
H
O
HH
P-Site A-Site
Formation of Peptide Bond
More on elongation
Regulation of Gene Expression
AAAAAA5’CAPmRNA
RNA Processing
RNA Degradation
Protein DegradationPost-translational modification
Activeenzyme
Regulation of Globin gene
translation by heme
