Chagas DiseaseSarah Anderson

BIOL 402

http://www.cdc.gov/parasites/chagas/diagnosis.html http://www.cdc.gov/parasites/chagas/

gen_info/vectors/index.html

http://www.dndi.org/diseases/chagas/disease-background.html

Overview

http://www.treatchagas.org/cp_chagas_background.aspx http://www.dndi.org/diseases/chagas/global-view.htmlhttp://www.who.int/mediacentre/factsheets/fs340/en/index.html

T. cruzi

http://www.tulane.edu/~wiser/protozoology/notes/kinet.htmlTeixeira, A.R. et.a. “Pathogenesis of chagas’ disease: aparasite persistence and autoimmunity” Clin. Microbiol Rev. 2011 Jul. 24

Life Cycle: Transmission

http://www.cdc.gov/parasites/chagas/gen_info/vectors/index.html http://www.tulane.edu/~wiser/protozoology/notes/kinet.html#forms

Life Cycle: T. cruzi infects cells

Fernandes, M. C. et. al. “Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway.” J Exp Med. 2011 May 2. http://www.nature.com/nrmicro/journal/v9/n7/full/

nrmicro2597.html

Life Cycle: Morphological Forms

Epimastigote:

Trypomastigote:

Amastigote:

http://www.tulane.edu/~wiser/protozoology/notes/kinet.html#forms

Chagas Disease: Symptoms

• Acute Stage

• Chronic stage

http://www.cdc.gov/parasites/chagas/disease.html

http://www.dndi.org/diseases/chagas.html

http://www.ncbi.nlm.nih.gov/books/NBK62523/Teixeira, A.R. et.a. “Pathogenesis of chagas’ disease: aparasite persistence and autoimmunity” Clin. Microbiol Rev. 2011 Jul. 24

Chagas Disease: DiagnosisDiagnosis can be difficult

http://www.ncbi.nlm.nih.gov/books/NBK62523/

http://www.cdc.gov/parasites/chagas/diagnosis.html

Teixeira, A.R. et.a. “Pathogenesis of chagas’ disease: aparasite persistence and autoimmunity” Clin. Microbiol Rev. 2011 Jul. 24

Chagas Disease: Treatment

Nifurtimox:

http://thematthewsstory.com/2010/10/20/got-ahold-of-bayer/thumb/ http://papabolivia.blogspot.com/p/health-and-medicine.html

Benznidazole:

Wilkinson, S. R. et. al. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. PNAS. 2008 Apr. 1. 5022-5027

Teixeira, A.R. et.a. “Pathogenesis of chagas’ disease: aparasite persistence and autoimmunity” Clin. Microbiol Rev. 2011 Jul. 24

Chagas Disease: Prevention

http://www.cgdev.org/section/initiatives/_archive/millionssaved/studies/case_12

http://www.ncbi.nlm.nih.gov/books/NBK62523/#appendixes.app1.21.s7