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    ANXIETY DISORDER

    Jeny Rose Quiblat, MD

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    ANXIETY

    Fearful emotion accompanied by certain physicalsymptoms

    perceived as a subjective feeling of heightenedtension and diffuse uneasiness

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    SUBCLASSESOF ANXIETY DISORDER

    Panic Disorder

    Phobic

    obsessive-compulsive

    Generalized anxiety disorder post-traumatic stress

    social phobia

    atypical anxiety

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    PANIC DISORDER

    recurrent episodes of intense

    apprehension

    Fear

    terror

    accompanied by at least four particular symptoms, all ofwhich reach a peak within 10 minutes.

    Attacks are followed by the fear of having additional

    episodes

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    PANIC DISORDER

    key distinguishing feature of panic disorder is theepisodic and recurrent nature of the panic attacks

    2 types Panic Disorder with Agoraphobia

    Panic Disorder without Agoraphobia

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    PANIC DISORDER

    onset of panic disorder is generally between theages of 17 and 30 years

    It is often precipitated by stressful life events.

    familial, with up to 40% of first-degree relatives alsobeing affected

    50% to 90% risk of having a major depressiveepisode at some point in their lifetime

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    CRITERIAFOR PANIC ATTACK

    A period of intense fear or discomfort in which 4symptoms developed abruptly and reached a peakperiod of 10 minutes.

    Dyspnea palpitations,

    chest pain choking or smothering

    Dizziness paresthesias, diaphoresis,

    trembling or shaking, chills or hot flashes,

    nausea or abdominal distress,

    fears of dying, going crazy or losing control during anattack

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    CRITERIAFOR PANIC ATTACK

    at least one of the attacks must be followed by 1month of persistent concern about having additionalattacks, worry about the implications of the attackor its consequences

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    THREE STAGESINTHE DEVELOPMENTOFPANIC DISORDER

    Stage 1 : Initial acute panic attack or cluster ofattack Described as the worst experience in their life, after one or a

    series of life events overwhelm their coping mechanisms

    Stage 2

    Panic attacks increase in frequency

    phobias develop

    anticipatory anxiety and avoidance behavior develop medical care seeking dramatically increases for

    somatic complaint

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    THREE STAGESINTHE DEVELOPMENTOFPANIC DISORDER

    Stage 3: Agoraphobia

    fear of the marketplace

    Fear of being in places or situation from which escape indifficult , embarrassing in the event of panic attack

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    PANIC DISORDER W/O AGORAPHOBIA

    The following two conditions are present:

    recurrent unexpected panic attacks;

    at least one of the attacks has been followed by amonth (or more) of persistent concern about having

    additional attacks, worry about the implications of the attacks or their

    consequences

    a significant change in behavior related to the attacks.

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    PANIC DISORDER W/O AGORAPHOBIA

    Agoraphobia is not present.

    The panic attacks are not a result of the direct

    effects of a substance or a general medical

    The anxiety is not better accounted for by anothermental disorder

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    PANIC DISORDER WITH AGORAPHOBIA

    The following two conditions are present:

    recurrent unexpected panic attacks;

    at least one of the attacks has been followed by amonth (or more) of persistent concern about having

    additional attacks, worry about the implications of the attacks or their

    consequences

    a significant change in behavior related to the attacks.

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    PANIC DISORDER WITH AGORAPHOBIA

    Agoraphobia is present.

    The panic attacks are not a result of the direct

    effects of a substance or a general medical

    The anxiety is not better accounted for by anothermental disorder

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    COMPONENTSOF PANIC DISORDER

    Cognitive

    Worry

    Sense of foreboding

    Sense of impending doom or dread

    Tendency to be inattentive, distractible

    Sense of unreality

    Rumination

    Loss of control

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    COMPONENTSOF PANIC DISORDER

    Affective

    Isolation

    Anxiety or nervousness

    Secondary depression

    Irritability

    Social

    Dependency

    Vocational limitations

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    COMPONENTSOF PANIC DISORDER

    Somatic

    Tachycardia

    Hyperventilation

    Diaphoresis

    Dizziness or syncope

    Flushing

    Muscle tension

    Tremulousness

    Restlessness

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    a phobic disorder is the persistent andirrational fear of a specific object, activity, orsituation that results in a compelling desire to

    avoid the dreaded object, activity, or situation.

    The fear is recognized by the individual asexcessive or unreasonable in proportion to theactual danger of the situation, object, or activity

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    Specific Phobia Social Phobia

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    A specific phobia involves a persistentirrational fear and compelling desire to avoidan object or a situation.

    Common among women

    Peak of onset :5-9 yrs for natural environment

    type and blood inj type Peak of onset :mid 20s for situational type

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    fears are related to most social situations

    (e.g., initiating conversations, dating,participating in small groups, attending

    parties). has its onset during the teenage years

    Onset can occur after a humiliating incident orsituation

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    GENERALIZED ANXIETY DISORDER

    Generalized anxiety disorder is excessive worry forat least 6 months.

    The person finds it difficult to control the worry.

    Panic disorder, major depression, alcohol abuse,and organic causes need to be ruled out.

    Prevalence is 6% in primary care, affecting twiceas many women as men.

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    GENERALIZED ANXIETY DISORDER

    The anxiety and worry are associated with at leastthree of the following six symptoms

    1. Restlessness or feeling keyed up or on edge

    2. Becoming easily fatigued3. Difficulty concentrating or the mind goingblank

    4. Irritability

    5. Muscle tension6. Sleep disturbance

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    GENERALIZED ANXIETY DISORDER

    The anxiety, worry, or physical symptoms causeclinically significant distress or impairment in social,occupational, or other important areas offunctioning.

    The disorder is not the result of the direct effects ofa substance or a general medical condition

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    POST TRAUMATIC STRESS DISORDER

    experienced or witnessed a severe catastrophicevent that involved actual or threatened death orserious injury to oneself or others.

    They frequently reexperience the event throughdreams or feelings that the event is recurring andmay have panic attacks during these flashbacks.

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    CRITERIAFOR POST TRAUMATIC STRESSDISORDER

    The person has been exposed to a traumatic eventin which both of the following conditions have beenmet

    The person has experienced, witnessed, or been

    confronted with an event or events that involve actual orthreatened death or serious injury or a threat to thephysical integrity of oneself or others.

    The person's response involved intense fear,helplessness, or horror

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    CRITERIAFOR POST TRAUMATIC STRESSDISORDER

    The traumatic event is persistently reexperienced inat least one of the following ways

    Recurrent recollections of the event, including images,thoughts, or perceptions.

    Recurrent distressing dreams of the event.

    Acting or feeling as though the traumatic event wererecurring

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    The traumatic event is persistently reexperienced in atleast one of the following ways

    Intense psychological distress at exposure to internal or

    external cues that symbolize or resemble an aspect ofthe traumatic event.

    Physiologic reactivity on exposure to internal or externalcues that symbolize or resemble an aspect of thetraumatic event.

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    CRITERIAFOR POST TRAUMATIC STRESSDISORDER

    Persistent avoidance of stimuli associated with thetrauma and numbing of general responsiveness(not present before the trauma at least 3 of thefollowing

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    Efforts to avoid thoughts, feelings, or conversations

    associated with the trauma Efforts to avoid activities, places, or people that arouse

    recollections of the trauma

    Inability to recall an important aspect of the trauma

    Markedly diminished interest or participation in significantactivities

    Feeling of detachment or estrangement from others

    Restricted range of affect

    Sense of a foreshortened future

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    CRITERIAFOR POST TRAUMATIC STRESSDISORDER

    Persistent symptoms of increased arousal (notpresent before the trauma), as indicated by at leasttwo of the following:

    Difficulty falling or staying asleep

    Irritability or outbursts of anger

    Difficulty concentrating

    Hypervigilance

    Exaggerated startle response

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    CRITERIAFOR POST TRAUMATIC STRESSDISORDER

    The duration of the disturbance is longer than 1month.

    The disturbance causes clinically significantdistress or impairment in social, occupational, or

    other important areas of functioning.

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    HISTORY The history is probably the single best diagnostic

    tool in the workup of an anxious patient, whetherthe anxiety is of an acute or chronic nature.

    The history taking process should be sufficientlyopen-ended and unhurried to elicit informationabout the patient's concerns and fears, current life

    situation, family and other support systems, andconcurrent medical problems.

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    PHYSICAL EXAMINATION

    The patient looks worried and acts tense.

    Increased motor activity is often evident,

    Facial muscles may show twitching or tics.

    Breathing is often rapid and superficial and, unsteady voice, strained facies, grinding of teeth,

    dilated pupils

    tremor of hands, flushing and excessive

    perspiration, and labile hypertension.

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    MANAGEMENT

    Prerequisites for the Physician

    Adequate Workup

    Treatment Based on Cause

    Development of a Therapeutic Plan his plan usually entails a series of office visits on a

    regular basis over time and may require specifictherapeutic interventions,

    provides the physician opportunity to reassess the

    effectiveness and progress of management p

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    Education

    Building Support Mechanisms

    Members of the extended family and friends arefrequently helpful in this respect

    It is often useful to involve other family members indevelopment of the therapeutic plan.

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    PANIC DISORDER

    Pharmacologic therapy, once effective, should befollowed by gradual reexposure to the situationsthat were being avoided.

    Start with a selective serotonin reuptake inhibitor(SSRI) or tricyclic antidepressant such asimipramine at a low dosage and then increase untilepisodes cease.

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    PANIC DISORDER

    first-line treatment of choice for panic disordershould be SSRIs.

    paroxetine, sertraline, fluoxetine, citalopram, andfluvoxamine

    Started at a low doasge Increased dosage by 5mg until panic attacks

    disappear

    Common S.E: Jitteriness, nausea headache

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    PHOBIC DISORDERS

    desensitization,

    the patient learns a relaxation technique and then, whilein a relaxed state, is exposed to a gradual hierarchy ofstimuli (through imagery or in vivo) that approaches the

    phobic object or situation For agoraphobia, evidence from two studies has

    shown that imipramine in combination withexposure enhances the effects of exposure

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    POST-TRAUMATIC STRESS DISORDER

    SSRIs are effective in civilians but not veterans,whereas imipramine and monoamine oxidaseinhibitors (MAOIs) are effective in veterans.

    Cognitive-behavioral therapy and eye movementdesensitization therapy have been shown to beeffective.

    The combination of antidepressant medication andpsychotherapy may be optimal therapy.