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Cancer as an Evolving and Systemic Disease Memorial Sloan Kettering Cancer Center

New York, NY

March 12-15, 2016

Conference Program

Saturday, March 12 

5:00 p.m. Welcome reception

Zuckerman Building Lobby

417 E. 68th

 Street, NY, NY 10065

7:00 p.m. Close of the day

Sunday, March 13

Keynotes, Scientific and Poster SessionsRockefeller Research Laboratories

430 E. 67th

 Street, NY, NY 10065

8:00 a.m. Registration and breakfast

9:00 a.m. Opening Remarks

Scott Lowe, Memorial Sloan Kettering Cancer Center

Keynote  Chair: Scott Lowe

9:15 a.m. Mechanistic insights into multi-step tumorigenesis and its

(evolutionary) adaptations Douglas Hanahan, ISREC, Swiss Institute for Experimental Cancer

Research

Session I  Cancer Origins and Evolution

Chair: Alexia-Ileana Zaromytidou, Nature Cell Biology

10:15 a.m. Epigenetic stochasticity in cancer evolution 

Andrew Feinberg, Johns Hopkins University School of Medicine

10:45 a.m. Single cell mapping of developmental trajectories in health and

disease 

Dana Pe’er, Columbia University

11:15 a.m. Coffee break

11:45 a.m. Inhibition and degradation of bromodomain proteins 

Jay Bradner, Novartis Institutes for Biomedical Research

12:15 p.m. The dynamic interplay between extrinsic and intrinsic force regulates

cancer progression 

Valerie Weaver, University of California, San Francisco

12:45 p.m. Short talk

Connecting cancer to aging: An evolutionary approach using in silico

and in vivo modeling James DeGregori, University of Colorado School of Medicine

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  1:00 p.m. Midday break

1:45 p.m. Meet the Editors

Session II The Tumor Niche: Local and Systemic Effects

Chair: Johanna Joyce, Memorial Sloan Kettering Cancer Center

2:30 p.m. CYP3A5 mediates basal and acquired therapy resistance in different

subtypes of pancreatic ductal adenocarcinoma 

Andreas Trumpp, DKFZ, Germany Cancer Research Center

3:00 p.m. Intravital imaging of therapy failure 

Erik Sahai, The Francis Crick Institute 

3:30 p.m. Deconstruction and in silico reconstruction of the evolving tumour

microenvironment of ovarian cancer  

Frances Balkwill, Queen Mary, University of London

4:00 p.m. Coffee break

4:30 p.m. The biology and function of exosomes in pancreatic cancer

Raghu Kalluri, The University of Texas MD Anderson Cancer Center

5:00 p.m. Local and systemic effects of senescent cells 

Judith Campisi, Buck Institute California

5:30 p.m. Short talk

BRD4 connects super enhancer remodeling to senescence immune

surveillance

Ana Banito, Memorial Sloan Kettering Cancer Center

5:45 p.m. Poster Session A and Reception

7:45 p.m. Close of day

Monday, March 14

8:00 a.m.  Registration and breakfast 

Session III  Cancer Metabolism: Cancer-cell-intrinsic and -systemic effects

Chair: Victoria Aranda, Nature 

9:00 a.m. Exploring how cancer cell metabolism influences the stromal

environment  

Craig Thompson, Memorial Sloan Kettering Cancer Center

9:30 a.m. Oncogenes strike a balance between cellular growth and

homeostasis

Celeste Simon, University of Pennsylvania

10:00 a.m. PI3K and cancer metabolism

Lewis Cantley, Weill Medical College of Cornell University

10:30 a.m. Coffee break

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  11:00 a.m. Microbial metabolites and development of colorectal cancer  

Christian Jobin, University of Florida School of Medicine

11:30 a.m. Cachexia, wasting and the browning of adipose tissues: Role of

PTHRP 

Bruce Spiegelman, Dana-Farber Cancer Institute

12:00 p.m.  An oncogenic metabolic switch mediates resistance to NOTCH1

inhibition in T-ALL

Daniel Herranz, Columbia University

12:15 p.m. Midday Break

Keynote Chair: Scott Lowe, Memorial Sloan Kettering Cancer Center

1:45 p.m. The mutations that drive tumor evolution 

Bert Vogelstein, Ludwig Center at Johns Hopkins University

Session IV  The metastatic cascade and systemic effects

Chair: Ross Levine, Memorial Sloan Kettering Cancer Center

2:45 p.m. Tumor exosomes dictate pre-metastatic niches 

David Lyden, Weill Medical College of Cornell University

3:15 p.m.  Maladapted vascular niche initiates tumor invasion and metastasis 

Shahin Rafii, Weill Medical College of Cornell University

3:45 p.m. Coffee break

4:15 p.m. Metastasis through the prism of CTCS

Shyamala Maheswaran, Massachusetts General Hospital Cancer

Center, Harvard University

4:45 p.m. Metastatic colonization of vital organs 

Joan Massagué, Memorial Sloan Kettering Cancer Center

5:15 p.m. Oxidative stress inhibits distant metastasis by human melanoma cells

Sean Morrison, University of Texas Southwestern Medical Center 

5:45 p.m. Short talk

Quantitative clonal dynamics define mechanisms for CLL evolution in

response to combination chemotherapy

Dan Landau, Weill Cornell Medical College and the New York

Genome Center

6:00 p.m. Poster Session B and Reception

8:00 p.m. Close of the day

Tuesday, March 15

8:00 a.m.  Registration and breakfast 

Memorial  Alan Hall and Chris Marshall Memorial Lecture

Chair: Joan Massagué, Memorial Sloan Kettering Cancer Center

9:00 a.m. TKS adaptors, invadopodia and tumor progression 

Sara Courtneidge, Oregon Health & Science University

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Session V Therapeutic prospects

Chair: Sarah Seton-Rogers, Nature Reviews Cancer  

9:50 a.m. PD-1 blockade in cancer: Immunotherapy meets precision medicine

Suzanne Topalian, Kimmel Cancer Center at Johns Hopkins University

10:20 a.m. Inflammation and cancer: Reprogramming the immunemicroenvironment as an anti-cancer therapeutic strategy  

Lisa Coussens, Knight Cancer Institute of the Oregon Health &

Science University

10:50 a.m. Coffee break

11:20 a.m.  Ag-221 offers a survival advantage in a primary human IDH2 mutant

 AML xenograft model  

Katharine Yen, Agios Pharmaceuticals

11:50 a.m. Targeting actionable genomic alterations and tumor evolution

Jose Baselga, Memorial Sloan Kettering Cancer Center12:20 p.m. Cancer Diversity and Evolution

Charles Swanton, The Francis Crick Institute

12:50 p.m. Closing Remarks

1:20 p.m. Close of conference