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Cerebral hemorrhageCerebral hemorrhage
Etiology and pathogenesis Etiology and pathogenesis
Hypertension and arteriosclerosisAtherosclerosis, bleeding tendency
(hemophilia, leukemia, aplastic anemia, thrombocytopenia), congenital angiomatous malformation, arteritis, tumor
lenticulostriate arteries vertical to MCAMicroaneurysms → rupture
Pathology Pathology
Site: basal ganglia (70%), brain lobe, brain stem, cerebellum
Lateral hemorrhage: the bleeding is confined lateral to the internal capsule (lenticular nucleus, external capsule)
Medial hemorrhage: thalamus hematoma →edema →herniation hematoma →stroke capsule
Clinical featureClinical feature
Age: 50-70Male > femaleOccur at physical exertion or excitementSudden onset of focal signsUsually accompanied by headache and
vomiting May have consciousness disturbance
1. Putamen hemorrhagecontralateral hemiplegia, hemianesthesia,
and hemianopiaEyes are frequently deviated toward the
side of the affected hemisphereAphasia if dominant hemisphere is affected
Clinical featureClinical feature
2. Thalamus hemorrhage contralateral hemiplegia, hemianesthesia,
and hemianopiaDeep sensation disturbanceOcular signsDisturbance of consciousness
Clinical featureClinical feature
3. Pontine hemorrhageMild: crossed paralysisSevere (>5ml) coma pinpoint pupils hyperpyrexia tetraplegia die in 48 hours
Clinical featureClinical feature
4. Cerebellar hemorrhageOccipital headache, intense vertigo and
repeated vomiting, ataxia, nystagmusSevere cerebellar hemorrhage : coma,
compression of brain stem, tonsillar herniation
Clinical featureClinical feature
5. Lobar hemorrhageSeen in AVM, Moyamoya disease, Headache, vomiting, neck stiffnessSeizureFocal signs
Clinical featureClinical feature
Investigation Investigation
1. CT First choice High density blood Mass effect and edema High density →
isodensity → low density
2. MRIBrain stem hemorrhage<24h, not distinguishable with thrombosis3. DSAYoung and with normal blood pressure4. CSFBloodyDone only when the CT is not available and
without increased ICP
Investigation Investigation
Diagnosis Diagnosis
Age >50, with hypertensionSudden onset of headache, vomiting, focal
signOccur at physical exertion or excitementCT: high density blood
Differential diagnosisDifferential diagnosis
Coma: poisoning, hypoglycemia, hepatic or diabetic coma
Focal signs: cerebral infarction, brain tumor, subdural hematoma, SAH
Treatment Treatment
1.Keep rest, monitoring, air way, good nursing
2. Keep electrolytes and fluid balance.
3. Reduce ICP: 20% Mannitol 125-250ml, 3 to 4 times per
dayFurosemide, albumin, dexamathasone
4. Control hypertension: <180/105mmHg in acute stage, ACEI, beta-blocker
5. Prevent complications:Infection:antibioticsgastric hemorrhage: Cimetidine, LosecVenous thrombosis: heparin
Treatment Treatment
6. Surgical therapy: Putamen, lobar: >40-50 ml, deterioratingCerebellum: >15ml, diameter>3cmThalamus: obstructive hydrocephalus
→ventricular drainage
7. Rehabilitation
Treatment Treatment
Subarachnoid hemorrhageSubarachnoid hemorrhageSAHSAH
SAH SAH
Cranial bone → dura mater → arachnoid → pia mater → brain lobe
Primary spontaneous SAH
Traumatic SAHSecondary to cerebral
hemorrhage
Etiology Etiology
1. Intracranial saccular aneurysm 2. AVM (arteriovenous malformation) 3. Hypertension and atherosclerosis4. Moyamoya disease5. Mycotic aneurysm, tumor, polyarteritis
nodasa, bleeding disease
Pathology Pathology
Anterior cerebral and anterior communicating
Internal carotid Middle cerebralBasilar
Clinical featureClinical feature
1. Age of onset: Saccular aneurysm: adult 30-60 AVM: juvenile Hypertension: more than 60
2. Prodromal symptoms Warning leaks: headache, vomiting Cranial nerve paralysis: oculomotor
3. Acute SAHSudden onset of severe headache: “explode,
burst, the worst of my life”VomitingAssociated with physical exertion, excitementTransient loss of consciousness or comaPain of neck, back, legMental symptoms: apathy, lethargy, delirium
Clinical featureClinical feature
3. Acute SAHSigns of meningeal irritation: neck stiffness,
positive Kernig’s signFundus examination: papilloedema,
sub-hyaloid hemorrhageCranial nerve palsy
Clinical featureClinical feature
4. Delayed neurologic deficitsRerupture: in first 4 weeks, again has severe
headache, vomiting, unconsciousness, with poor outcome. Due to fibrinolysis
Cerebrovascular spasm: 4-15 days after initial SAH, → cerebral infarction →disturbance of consciousness and focal signs
Hydrocephalus: 2-3 weeks after SAH, → gait difficulty, incontinence, dementia
Clinical featureClinical feature
InvestigationInvestigation
1. CTSubarachnoid clot in
75% of cases
2. CSFUniformly blood-stainedXanthochromia: 12 hours to 2-3 weeks ICP ↑
3. DSA: etiologic diagnosis, important to surgery
4. MRA, CTA
InvestigationInvestigation
Diagnosis Diagnosis
Sudden onset of severe headache, vomitingNeck stiffness, positive Kernig’s signUniformly blood stained CSFCT shows subarachnoid clot
Differential diagnosisDifferential diagnosis
Cerebral hemorrhageMeningitisTumorPsychosis
TreatmentTreatment
1. General management Absolute bed rest for 4-6 weeksPrevent constipation, excitementSedatives and analgesics
2. Reduce ICPMannitol, Furosemide, albumin
3. Prevent reruptureAntifibrinolytic drugs: EACA for 3 weeks
4. Prevent cerebrovascular spasmNimodipine, flunarizine
5. Lumbar puncture to replace CSF
6. Surgery: within 24-72 hours
TreatmentTreatment