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CH 9 – Cellular Respiration . Cellular Respiration → breaking down food (chemical energy) to get ATP. mitochondria. Powerhouse of the cell! The organelle responsible for cellular respiration The Krebs Cycle and ETC take place here ATP is produced here! It is a double membrane - PowerPoint PPT Presentation
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Cellular Respiration → breaking down food (chemical energy) to get ATP
CH 9 – Cellular Respiration
MITOCHONDRIA
Intermembrane Space
• Powerhouse of the cell!• The organelle responsible for cellular respiration
• The Krebs Cycle and ETC take place here ATP is produced here!
• It is a double membrane with the inner membrane highly folded (to increase the surface area and make the mitochondria more efficient).
CELLULAR RESPIRATION – BACKGROUND INFO
Equation – C6H12O6 + 6O2 → 6CO2 + 6 H2O +
36 or 38 ATP-When food is broken down, energy is released gradually and stored in ATP.
-Respiration is done by BOTH plants and animals
GENERAL OVERVIEW – CELLULAR RESPIRATIONGlycolysis:• In the cytosol• Anaerobic• Turns glucose to 2 pyruvate net gain of 2 ATP and 2 NADH
Krebs:• In the mitochondrial matrix • Makes little ATP, NADH, and FADH2 (electron taxis) • Passes e- to ETC
ETC → uses chemiosmosis to make LOTS of ATP
GLYCOLYSISMain Goal of Glycolysis is to turn glucose into two pyruvate: - Series of 10 steps - Produces a net gain of 2 ATP and 2 NADH (e- carriers) - From here it can go to the Krebs cycle (aerobic respiration) or to Fermentation (anaerobic) - Glycolysis is anaerobic - Occurs in the cytosol
Overall: Glucose → 2 Pyruvate; net gain 2 ATP and 2 NADH
INTERMEDIATE STEP
Pyruvate (made in the cytosol via glycolysis) diffuses into the mitochondria. As it diffuses is, it loses a carbon (goes from 3C to 2C) when it produces one molecule of CO2. This new 2C molecule is acetyl CoA. Acetyl CoA is what goes into the Krebs cycle.
KREBS/ CITRIC ACID CYCLEMain Function of the Krebs → to make electron carriers (NADH and FADH2) to send to the ETC Series of 8 steps; Occurs in the mitochondrial matrixSo…1 glucose produces:
2 ATP6 NADH2 FADH2
(remember: 1 glucose = 2 pyruvates)Acetyl CoA (2C) enters the Krebs and combines with another molecule (4C) to form citric acid (hence citric acid cycle)
Electron Carriers
Krebs →Makes 1 ATP, 3 NADH, and 1 FADH2 per turnYou do NOT need to memorize this!
ELECTRON TRANSPORT CHAIN (ETC)Occurs on the inner membrane of the mitochondria; Energy from NADH and FADH2 power ATP synthesisThe ETC is a series of proteins throughout the membrane; the electrons lose energy every time they get passed down the chainOXYGEN IS THE FINAL ELECTRON ACCEPTOR!!! → oxygen combines with the electrons and H+ to make WATER
Main Goal of the ETC → it’s a stepwise free energy drop from food to oxygen; it creates a proton gradient that powers chemiosmosis to create ATP via ATP Synthase
The ETC uses energy from the electrons and pumps the protons OUT of the matrix into the intermembrane space; it then diffuses back in via ATP synthase.
-NADH and FADH2 drop off e- to the ETC-As the e- get passed down the chain, they lose energy; that energy is used to pump H+ OUT of the matrix into the intermembrane space-This creates a concentration gradient-The protons then diffuse back INTO the matrix via the ATP synthase (chemiosmosis); this creates ATP -Makes a TON of ATP!!!
Final e- acceptor after they go down the ETC is OXYGEN (from the atmosphere) …it combines with e- and H+ to make WATER
CELLULAR RESPIRATION OVERVIEW
ATP Summary →Glycolysis – 2Krebs – 2ETC – 32/34
CELLULAR RESPIRATION VS. FERMENTATION
Oxygen Present → Aerobic Respiration (efficient!)
Oxygen NOT Present → Fermentation (not efficient)Respiration = 66%
efficientFermentation = 3.5% efficient
FERMENTATION If there is no oxygen present
(anaerobic) the pyruvate (from glycolysis) goes to fermentation
The main goal of fermentation is to make NAD+ to put back into glycolysis; it makes NO ATP on its own (it just keeps glycolysis going so that it can make 2 ATP at a time)
Occurs in cytosol 2 types of fermentation: alcohol
and lactic acid
- Pyruvate is turned into ethanol- CO2 is released (bubbles!)- Done by yeast for brewing
3C Pyruvate → 2C Ethanol
Remember: Goal is to produce NAD+ to send back to glycolysis so it can keep going and produce more ATP
Alcoholic Fermentation
LACTIC ACID FERMENTATION
- Pyruvate is turned into Lactate (or lactic acid)- Lactate is eventually
carried away by the blood to the liver where it gets converted back into pyruvate
- Example: Muscle Cells!!
- The lactic acid is what makes your muscles sore after lifting or intensive exercise- No CO2 is released3C Pyruvate → 3C
Lactate
Remember: Goal is to produce NAD+ to send back to glycolysis so it can keep going and produce more ATP
LACTIC ACID VS. ALCOHOL
FERMENTATION Both start with pyruvate from glycolysis
Alcohol makes ethanol and gives off CO2
Lactic acid makes Lactic acid and does NOT give off CO2
Both create NAD+ to be sent back to glycolysis
Neither make any ATP on their own
FERMENTATION - OVERVIEW Obligate Aerobes → needs oxygen; can do respiration only
Obligate Anaerobes → can’t have oxygen; fermentation only
Facultative Anaerobes → can live with or without oxygen; prefer oxygen b/c more efficient
Respiration is 19 times more efficient than fermentation (38 ATP vs. 2 ATP)