Data System Varian Galaxie ChromatographyData System

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Save time and money by centralizing data acquisition and management

Increase productivity with simplified user interfaces and universal instrumentcontrol for the LCs and GCs in your laboratory

Secure system and data integrity with software for 21 CFR Part 11 compliance

One Platform, One SolutionGalaxie Chromatography Data System from Varian

IEEE 488

RS232/RS422

Stand-Alone Galaxie Workstation

The Galaxie™ Chromatography Data System is an intuitive, easy-to-use software platform thatcontrols GC and LC instruments from multiple vendors. Galaxie’s unique architecture readily expandsfrom a single workstation to an enterprise-wide network controlling hundreds of instruments.

Today’s laboratories must remain competitive. Updating equipment often results in the proliferationof multi-vendor, multi-model instrumentation and software. To improve laboratory efficiency,networks are becoming the standard for centralizing data management. Galaxie is the universalsolution for controlling a wide range of instruments. Galaxie is scalable and includes all the softwaretools necessary for 21 CFR Part 11 compliance.

Galaxie’s single platform dramatically improves daily workflow with easy-to-use graphical interfacesfor acquisition, processing, interpretation, and reporting—all contained within a secure networkedenvironment.

For even greater productivity, network users can initiate sample sequences, control instruments,monitor acquisitions, and review results from any location on the network. Precious bench space isreleased as Galaxie’s compact Star 800 Module Interface Box (MIB) replaces multiple PC workstations.

Galaxie—a simple, secure, state-of-the-art chromatography data system from Varian.

Scalable Client/Server SolutionsGalaxie grows with you

Galaxie minimizes hardware costs associated with building a new network or growing anexisting one. Flexible client/server architecture easily accommodates the use of multipledomains and servers, optimizing efficiency for networks with constantly increasingprocessing requirements.

Uptime is maintained and network reconfiguration is unnecessary with Galaxie. Additionalservers can be added without reconfiguration and assigned user-specified processing tasksat any time.

Fewer workstations are needed as dedicated PCs for existing instruments are largelyeliminated. Instruments connect to the network via Star 800 Module Interface Boxes ordirectly through Ethernet. Galaxie’s Star 800 MIBs, with Ethernet connectivity, replacemultiple PCs and can reside anywhere on a network. Star 800’s support a range ofcommunication protocols for controlling a wide range of instrument models from multiplevendors.

Galaxie offers a unique combination of scalable hardware and software to meet the widestrange of requirements for instrument control and data management.

Star 800Star 800

Star 800

Galaxie Client/Server Network

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Begin with the basics• Easy LC and GC automation• Reliable peak integration and identification• All standard chromatography calculations• Numerous graphical data manipulation tools • User-defined report formats

Superior client/server solution• Control all LCs and GCs and view analyses from anywhere on the network• Centralize storage of methods, data, and results• Interface to LIMS• Replace PCs with compact, intelligent Star 800 Module Interface Boxes

Achieve regulatory compliance• Meet Installation Qualification (IQ) and Operational Qualification (OQ)

requirements • Automate Performance Verification checks • Control access to data and reports through user profiles• Track records with the audit trail function• Review, approve, and lock records using electronic signatures• Comply with GLP/cGMP and 21 CFR Part 11 regulations

Unrivaled instrument control• Control multiple vendors’ instruments through a common user interface• Easily link instruments with different communication protocols on an Ethernet network• Archive all LC and GC methods, data, and results in a single file format

Scalable SolutionsGalaxie Chromatography Data System from Varian

Extra power• Automatically compare complex chromatograms• Add further calculation power with customized Plug-In applications

Easy for the occasional user• Intuitive graphical methods building• Identical screens automate analysis and recalculations• User-customized screens show just the information needed• Reduced need for third-party software

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Link Galaxie to a wide range of LC and GC instrumentswith versatile, preconfigured Star 800 Module InterfaceBoxes.

With a range of configurations and capabilities, a singleStar 800 connects multiple instruments with differentcommunication protocols to Galaxie. Star 800 MIBssave bench space and reduce computer costs.

Ethernet connectivity provides the flexibility to placeboth instruments and workstations exactly whereneeded for the best productivity—at a remote samplinglocation, in the lab, or in your office.

Simultaneously control a variety of instruments withGalaxie to simplify operations and reduce errors.

Control More InstrumentsStar 800 MIB for Ethernet connectivity and security

Remote connections for multipleinstruments. Star 800 MIBs connectnew and old instruments to Galaxieusing multiple communicationprotocols.

two or four A/D channels

four or eight RS232 ports

one or two IEEE 488 controllers

four relays standard plus oneor two optional 32 channel I/Oboards

64 MB buffer memory foranalog signals

Digitize analog signals for improvedhigh speed transmission quality

Control instruments and transmitdigital signals, independent of thedistance from instrument to PC

Control instruments and transmitdigital signals, independent of thedistance from instrument to PC

Control valves for GC gas analysis orLC fraction collection

Add data security in the event of anetwork failure

Star 800 Module Interface Box

Galaxie with Star 800Star 800 Options

Locate workstations exactlywhere needed. Instrumentsconnect to adjacent Star 800MIBs with analog, RS232 andIEEE 488 cables. Star 800s arelinked via Ethernet to PCs.

Rapidly Build Rugged Methods

Instrument control and data handlingmethods are quickly generated with Galaxie’sintuitive graphical interface to deliverdependable results.

For more reliable peak identification, Galaxieprovides a choice of absolute retention times,relative retention times, or Kovats retentionindices. To correctly select from severalcandidates in the same time window, anadditional peak ID algorithm can be applied.

Building peak integration methods forcomplex chromatograms is simplified withon-screen editing and display of more than20 peak integration events.

Peak identification and measurement areassured with Galaxie.

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Galaxie specifically addresses ease-of-use as aproductivity issue. Simplified interfaces help users of alllevels quickly navigate through method building,automation, data review, and report generation.

User screens are individually configurablefor information-rich or very simple displays.Operators see as much or as littleinformation required to complete tasks.

For further productivity, Galaxie can displaymultiple active chromatograms while userssimultaneously work in word processing orspreadsheet applications.

Superior Ease-of-UseFrom method building to final reports

Simple or information-rich displays. Galaxie’s graphicalinterfaces let users see just the information they need in asingle screen.

Easy method building. Interactive on-screen graphics andpowerful algorithms deliver dependable peak identificationand area measurements.

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Easy calibration and custom calculations

Calibrate for Productivity

Galaxie provides a wide range of calculation types andcurve fitting algorithms (e.g., linear, quadratic, andcubic). Calibration functions are managed interactivelyon-screen. Curves are edited with immediaterecalculation of curve coefficients.

Calibration data are automatically archived,sorted by date or component, and are alwaysretrievable at the click of a mouse.

Galaxie lets you spend more time analyzingsamples and less time on calibration.

The Right Answer, Instantly

The chore of exporting data to an externalprogram for additional manipulation is ofteneliminated with Galaxie’s extendablecalculation capabilities.

Standard methods include the uniqueVariable Editor where users can createcustom calculations reducing the need forthird-party software. Preventing softwareproliferation in the laboratory saves time and training.

Vital calculations and reports are directlydelivered in a timely manner with Galaxie.

Manage calibration data with speed. Data is generated,edited, archived, and retrieved faster with Galaxie.

Handle custom calculations within one method. Galaxie’sVariable Editor makes it easy to include additional calculationsfor advanced data reduction and reporting.

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Automation as it Should Be

Day-to-day operation with Galaxie is easier with just afew familiar screens needed for frequently usedfunctions. Automation is accomplished with one screenfor data acquisition and post-run data manipulation.

Galaxie’s user-customizedSample Sequence andReprocessing List includes copy,paste, and autofill functions.Once an automation sequenceis launched, users can modifyits content or insert newsamples while maintainingboth the running acquisitionand sequence. The samefamiliar screen is used againfor bracketing calibration.

Galaxie provides simple, directbridges between users and thevolumes of data they need to generate.

Multi-Function Single ScreensProductivity made easy

Easy-to-use, familiar screens. Automateanalysis and batch reprocessing of datafrom a single list.

User-friendly data analysis. In the single-screen Galaxie Browser, users select and viewchromatograms, methods, and reports.

All Results on a Single Screen

For reviewing acquired data, Galaxie’s graphical userinterface helps control the information displayed on asingle screen. Confusion is avoided as each user viewsjust the right amount of information needed tocomplete a task.

The Galaxie Browser provides an intuitive way to viewone or many chromatograms, compare results, and referto methods with a minimum number of mouse clicks.

Clean screen configurations allow even occasional usersto work efficiently.

Simple Summaries

Galaxie’s Summary Report tool providesadvanced data handling such as statistics andcontrol charts for multiple chromatograms.By highlighting a series of chromatograms,tabular and graphical reports are easilygenerated.

The Summary Report tool frequently allowsusers to bypass the complexity of workingwith databases.

Galaxie—for simple, statistically soundmanagement of data quality.

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Answering Questions, Making DecisionsEasy-to-create, flexible reports

Easily track results and trends. Controlcharts monitor data quality by trackingsample trends or chromatographic variables.

Customized Reports in Seconds

Galaxie reports answer the questions asked bychromatographers every day. Reports contain onlyrelevant information and display the facts required torelease a product, monitor a process, or answer aspecific inquiry.

With Galaxie Report Editor, customized report formatsare quickly produced. Objects, including chromatograms,result tables, calibration curves, peak purity results, andUV spectral library searches can be inserted and resizedwith the mouse. Fonts and orientation can be changedjust as easily.

Just the facts with Report Editor. Quicklycustomize reports on-screen for routineand research results.

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Galaxie from Varian is the complete software packagefor integrating all of your LCs and GCs into a singlenetworked system. Our client/server solution meetstoday’s management challenge by providing:

• Data acquisition and remote instrument control fromany point on the network

• One user screen for all instrument control

• One user screen for all data handling and reporting

• Centralized administration of users, instruments, andmethods

• Comprehensive tracking of file additions, deletions,and changes

• Centralized storage of data and methods by projectfor access at any time by authorized users

• User profiles and access rights control

• Tools for GLP compliance, including 21 CFR Part 11

• Easy interfacing to LIMS

Galaxie helps reduce training overhead, improve dataquality, and provide data security for laboratories invirtually any industry or environment.

The Management ChallengeGalaxie’s superior client/server solution

Gain control and improveproductivity. Integrate all yourLCs and GCs into a singlenetwork system.

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Increase productivity. Use one screen to organize method and data files as well as control user access.

Improve Laboratory EfficiencyOrganize workflow and data with Galaxie

With Galaxie’s flexible Configuration Manager, allworkflow and data are readily organized according tolaboratory size and function. Managers andadministrators organize method and data files byproject, identify users, and control file access.

For example, a small research laboratory with a Galaxienetwork can set up user and project profiles to segmentdata for easy access and retrieval. All users may begiven rights to modify methods and manipulate data.

Alternatively, a large pharmaceutical QC laboratory witha Galaxie network can limit and track user access toprojects, methods, and data. Users complete assignedtasks with access only to the files and functions theyneed.

Set data security and organize workflow for maximumefficiency with Galaxie’s Configuration Manager.

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Galaxie’s extensive range of instrument control driversprovide a uniform look and feel for popular LCs and GCsto facilitate method building and operation. Instrumentsare controlled and monitored remotely from anylocation on the network.

Use instrument control to:

• Automatically run a set of samples with severalrelated methods, or run several sets of samples withone method

• Track changes in experimental LC and GC methods

• Re-create exact chromatographic conditions fromarchived records

Increase laboratory productivity and reduce costs byoptimizing computer locations, and controlling new andold instruments with the Galaxie Chromatography DataSystem.

Unrivaled Instrument Control Easily control multiple vendors’ LCs and GCs

Superior multi-vendor instrument control.Galaxie provides complete control over a wide rangeof instruments from a single software platform.

Varian GCs

Agilent GCs

Waters LCs

Varian LCs

Agilent LCs

PerkinElmer GCs

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Extending Control to PDAs

Galaxie can control Photodiode Array (PDA) detectors,including Varian ProStar 330, and HP/Agilent 1100,1050, and 1090. Detectors are controlled through acommon user interface and all acquired spectral dataare processed in an identical manner.

Isocontour and 3D views are available in real timeduring analytical runs, as well as in post-run dataprocessing. Powerful peak identification algorithms,including spectral library searches, areperformed automatically at the end of eachrun. Numerical and visual confirmation ofpeak purity further assures data quality.

Again, Galaxie increases productivity as users easily manipulate complex data from a variety of PDA instruments.

More instrument and post-run control with Galaxie

Extending Control to Post-Run Processing

Galaxie automatically interfaces to external computer systems for:

• Exporting file formats such as HTML, ASCII, AIA/ANDI (ASTME 1947-98), Microsoft® Word, and Microsoft® Excel

• Consolidating reports from a variety of instruments on a LIMS

• Launching post-run applications residing outside of Galaxie

Get answers quickly, in the formats you need, as Galaxie easilyintegrates with computer systems and applications you already use.

Assure peak identification and purity. Galaxie simplifies datainterpretation by processing spectral data from a range of PDAdetectors using the same algorithms and views.

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Regulatory ComplianceQualification, validation, and analytical performance

The road to compliance begins with the installation ofGalaxie. Together with IQ/OQ, Galaxie provides the toolsneeded to meet GLP/cGMP requirements and achieve 21CFR Part 11 compliance.

The optional Galaxie Validation Manager contains theIQ/OQ protocols and files required to validate systeminstallation. During installation, all IQ/OQ documentsand associated files copy automatically to a secure OQproject folder where test reports are archived for reviewand printing.

Additionally, Galaxie provides a variety of tools forsystem Performance Verification. System SuitabilityTests (e.g., resolution, asymmetry, baseline noise, andeven user-defined variables) may be applied to every run.

Varian products and services provide security and valueat every stage of the analytical process in a regulatedenvironment.

Automatically identify and flag outliers. Select and display warning messages on-screenor as hard copy reports with the Galaxie System Suitability Test.

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Regulatory ComplianceMeeting the stringent requirements of 21 CFR Part 11

Galaxie’s audit trail tools, electronic signature capability,and electronic record generation, help ensure that yourrecords are in compliance with 21 CFR Part 11requirements.

Compliance, data security, and productivity cometogether with Varian’s Galaxie Chromatography Data System.

Locate file changes instantly. View versions ofany file and highlight changes with the ‘showdifferences’ function on the Audit Trail screen.

Meet electronic record and signature require-ments. Data and records are secured and archivedas users approve and lock reports.

Electronic SignatureUser profiles defined in the Galaxie ConfigurationManager control the access users have to methods,data, and reports. Security is managed through user IDand password checks.

On any workstation screen, users can review, approve,and validate reports with an electronic signature.Operators and supervisors may sign a single report withvarious levels of authority.

Audit TrailA rigorous Audit Trail tool records and archives alloperations and file modifications with an automaticallyincremented version number. Details of various fileversions, e.g., chromatograms, methods, sequences, andcalibration curves, are viewed on-screen.

Electronic RecordsProcessed chromatograms and corresponding records can be locked within Galaxie when electronicallysigned by authorized users. Only the same authorized users can unlock these files. When final reports areissued, approved, and electronically signed, Galaxie automatically generates a PDF file which can be readwith Adobe™ Acrobat. All signature/locking operations are tracked in the audit trail.

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Problem-Solving Power Beyond the OrdinaryFully-integrated Galaxie Plug-In applications

MatchCompare Chromatogram ComparisonMatchCompare automates the comparison of complexchromatograms for samples including fragrances,flavors, paints, and peptide digests. Peak distortions,scaling, column aging, and retention time shifts fromchanging experimental conditions are automaticallyidentified and correlated. Area percent comparisons ofmatched peaks are checked against user-defined limitswith color-coded reports for easy pass/fail QC decisions.

Galaxie reduces method development time whileexpanding the problem-solving power of your existingLCs and GCs with plug-in application software solutions:MatchCompare, Simulated Distillation (SimDist), and GelPermeation Chromatography (GPC). Additionally, Varianwill consult with users to develop custom Plug-Inapplications.

Peak

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Dramatically save time with MatchCompare.Corresponding reference and sample peaks aregraphically linked for immediate comparison.

Plug-In Tool KitThe Plug-In software tool kit allows power users to develop customized calculation modules which fullyintegrate with Galaxie. Plug-Ins are developed using Delphi, Visual Basic™, or Visual C++. The integral,yet independent, nature of Galaxie Plug-In applications eliminates the requirement for time-consumingrevalidation of the entire Galaxie system.

Gel Permeation ChromatographyGalaxie GPC generates calibration curves for processingand reporting molecular weight results of samplesindividually or as a batch. Galaxie GPC softwaresupports Narrow, Broad, and Universal (Mark-Houwink)calibration modes.

Improve product quality. Automated simulateddistillation delivers fast, accurate standard testmethod results for refinery products.

Simulated DistillationGalaxie SimDist provides automated boiling pointdistributions of a full range of petroleum products forapplications that comply with ASTM, IP, DIN, and ISOstandard test methods. The SimDist package includesautomated calibration and validation procedures, and canbe performed using Varian, Agilent, or PerkinElmer GCs.

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Meeting Your Analytical NeedsVarian systems, services, and supplies

Varian’s 50-plus years of continuous innovation inanalytical instrumentation and consumables assures youthe best in high performance products and services. Varianis committed to providing innovative consumable productsbacked by expert technical support.

Advance your analytical capabilities today. Speak with aVarian representative to discuss your specific applicationneeds. Call today to request your free Varian catalog orShop Varian Online at www.varianinc.com.

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Varian ProStar HPLC. A complete rangeof systems to serve pharmaceutical,environmental, chemical, and otherresearch and QC/QA laboratories.

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