Can we break the beta cell barrier in T1DM (Juvenile insulin dependent DM) ?

Preliminary observations

The amazing response to DAMM therapy (Dynamic Acupuncture Mediated

Metaphysical) being researched at TAG VHS DRC, VHS Hospital, Chennai has

thrown up a highly exciting therapy that increases the basal C-peptide values in

insulinopenic Juvenile diabetic subjects resulting in corresponding reduction in

their insulin requirements. (www.tagvhsdrc.com)

The most recent case of great interest is that of an young 14 year old boy with

type I Diabetes, from Karnataka, who has obtained remission of his Diabetes is

given below. He has obtained remission following DAMM therapy intervention

and is under close observation to know its long-term sustainability (at the time

of writing , he is doing well without insulin from 11/10/2014).

Our research centre was inaugurated in 2011 with this very dream of finding a

lasting solution for the IDDM children who have been subjected to multiple

insulin shots daily - ever since the discovery of insulin (92 years ago), to sustain

life and growth and live normally. The present step forward looks almost like a

Giant leap in the history of Juvenile type I diabetes research - nearly a century

after the discovery of insulin, and a Harbinger of hope to these hapless diabetic

children. Much more research plus huge funding is urgently required to carry

forward this noble (Potentially NOBEL?) effort!!!

Case history of Master T 14 years.

Referred by Endrocrinologist from Columbia Asia Referral Hospital –

Yeshwanthpur, Karnataka state, India.

He was diagnosed as T1DM 3 weeks ago and admitted with a blood sugar of 554

mg/dl and full blown Diabetic Keto Acidosis at Columbia Asia Hospital, Bangalore and

treated, recovered fully. After treatment he was sent to us for further care and

management.

1st visit and admission to TAG VHS Diabetes Research Centre

(21/07/2014 to 25/07/2014)

He came to our centre on 21/07/2014 for complete workup and assessment of his

diabetic status. At that time he was on Inj. H. Mixtard 18 U pre breakfast and 12 U pre

dinner, asymptomatic, blood sugars fairly under control. Weight : 28.3 kgs; Height :

140 cms.

Routine baseline investigations revealed –

Low Hb: 9.4 gms/dl,

Peripheral smear Study - Microcytic Hypochromic Anaemia.

FOB: Negative.

Fasting C-Peptide level : 0.27 ng/ml.

After informed consent he was enrolled in the DAMM therapy research by (Mr. Rajan

Iyer) to improve his C-Peptide levels.

He was given advice on diet & life style measures such as exposure to sunlight for 15

mins, pranayama for 15 mins & walking for 45 mins.

Taught self insulin administration and self blood glucose monitoring.

He was discharged on 25/07/2014 with the final treatment regime of 20 units of Inj.

H.Mixtard 30/70 pre breakfast and 10 units pre dinner.

He has completed 5 sittings of DAMM therapy at discharge.

2nd visit and admission to TAG VHS Diabetes Research Centre

(02/09/2014 to 06/09/2014)

He came for the 2nd session of Dynamic Acupuncture Mediated Metaphysical

(DAMM) therapy on 02/09/2014. He was feeling very well and asymptomatic.

On admission, Weight: 30.5 kgs, BP: 70/50 mmHg, PR: 86/min, Afebrile.

Hb: 12.2 gms%, Fasting C-Peptide (03/09/2014) – 0.10 ng/mL, CBG: 90 mg/dl at

6am, continuing same insulin as advised (Inj. H.Mixtard 30/70 20 units pre breakfast

& 10 units pre dinner).

He was discharged on 06/09/2014 with the following insulin dosage (Inj. H.Mixtard

30/70 20 units pre breakfast & 8 units pre dinner).

During this visit, he has completed 6 sittings.

3rd visit and admission to TAG VHS Diabetes Research Centre

(07/10/2014 to 09/10/2014)

He came for the 3rd session of Dynamic Acupuncture Mediated Metaphysical (DAMM)

therapy by Mr. Rajan Iyer. He continues to feel well and asymptomatic.

On admission, Weight: 30.1 kgs, Height: 142 cms, BP: 100/60 mmHg, PR:

80/min, afebrile. He was continuing on Inj. H.Mixtard 30/70 20 units pre breakfast &

8 units pre dinner.

Routine blood tests done on 07/10/2014 were all normal.

Repeat Fasting C-Peptide level done on 07/10/14 – 0.35 ng/mL (previous reading on

03/09/14 – 0.10 ng/mL).

At discharge, Weight: 32.1 kgs, Height: 142 cms, BP: 110/70 mmHg, PR:

76/min, afebrile, he is feeling energetic and cheerful, having good appetite.

He was discharged on 09/10/2014, CBG at 6 pm was 114 mg/dl, advised to have the

following insulin dosage (Inj. H.Mixtard 30/70 16 units pre breakfast & 4-6 units pre

dinner).

Telephonic followup.

On 10/10/2014 at 6 am CBG was 106 mg/dl and taken insulin 15 units pre breakfast.

At the same day evening, he experienced hypo’s and the CBG pre dinner (6 pm) 57

mg/dl. No insulin before dinner.

On 11/10/2014 again his 6 am CBG was low 88 mg/dl. No insulin for the whole day.

On 12/10/2014 , his CBG at 6 am was 112 mg/dl.

On 13/10/2014, his FBS – 110 mg/dl and PPBS: 135 mg/dl (Lab values). Advised no

insulin till further advice.

Once a week to do FBS, PPBS (at Lab) and pre dinner CBG.

From 11/10/2014 to 06/11/2014 he did not require any insulin and his blood sugars

were within normal range (home monitoring) and he was asymptomatic.

4th visit on admission to TAG VHS DRC (06/11/14 – 08/11/14)

DateSymptoms

CBG Value (or) Blood sugars

Fasting C-Peptide level

Weight & Height

Insulin requirement

06/11/14(on admission)

Free of symptoms

FBS -191mg/dl, PPBS – 449 mg/dl.

06/11/14 - 0.76

07/10/14 – 0.35

03/09/14 – 0.10

22/07/14 – 0.27

30.3 kgs & 142 cms

Nil

08/11/14(at discharge)

Free of symptoms

Fasting CBG -160 mg/dl

30.4 kgs, 142 cms

Insulin restarted(Inj. H.Mixtard30/70 10 U pre breakfast & 6 U pre dinner)

Telephonic conversion between 09/11/2014 to 12/11/2014

Date CBG valueWeight &

HeightInsulin requirement

09/11/14 191 mg/dl at 6 am 252 mg/dl at 6 pm

30.3 kgs & 142 cms

Inj. H.Mixtard 30/70 12 U pre breakfast

10/11/14 105 mg/dl at 6 am222 mg/dl at 6 pm

Inj. H.Mixtard 30/70 12 U pre breakfast & 6 U pre dinner

11/11/14 160 mg/dl at 6 am Inj. H.Mixtard 30/70 12 U pre breakfast

12/11/14 107 mg/dl Inj. H.Mixtard 30/70 12 U pre breakfast

Telephonic conversion between 13/11/2014 to 17/11/2014

Date CBG value Weight & Height Insulin requirement

13/11/14 109 mg/dl at 6 am 232 mg/dl at 6 pm

32 kgs Inj. H.Mixtard 30/70 12 U pre breakfast, 6 U pre dinner

14/11/14 116 mg/dl at 6 am219 mg/dl at 6 pm

Same

15/11/14 88 mg/dl at 6 am160 mg/dl at 6pm

Inj. H.Mixtard 30/70 12 U pre breakfast, 5 U pre dinner

16/11/14 86 mg/dl at 6 am109 mg/dl at 6pm

Inj. H.Mixtard 30/70 10 U pre breakfast, 4 U pre dinner

17/11/14 75 mg/dl at 6am Inj. H.Mixtard 30/70 8 U pre breakfast

Telephonic followup.

24/11/2014:

Fasting blood sugar (Lab.) : 130 mg/dl,

2 hours post lunch blood sugar: 170 mg/dl.

Weight: 32 kgs.

Insulin dosage - Inj. H.Mixtard 30/70 - 10 U pre breakfast, 4 U pre dinner.

(28.4 kgs)

(30.4 kgs)

(32.1 kgs)

(30.4 kgs)

(32 kgs)

26

27

28

29

30

31

32

33

25/07/2014 06/09/2014 09/10/2014 08/11/2014 13/11/2014

0.27

0.10

0.35

0.76

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

22/07/2014 03/09/2014 07/10/2014 06/11/2014

30 u

28 u

20 u

15 u

0 u

14 u

0

5

10

15

20

25

30

35

20/07/2014 06/09/2014 09/10/2014 10/10/2014 13/10/2014 24/11/2014 24/12/2014

Remarks:

The case of Master T. with Type I Diabetes is perhaps the first of its kind to

achieve a True Remission for a period of 3 weeks following the use of the novel

Dynamic Acupuncture Mediated Metaphysical (DAMM) therapy at our Centre.

Even after the flare-up his blood sugars, he is progressing with very good

Glycaemic control with approximately 50% of the original dose of insulin. He is

reporting to our centre on weekly basis.

Note:

Please watch this space for regular updates on this case every month.

In the past 9 months, we have taken up 10 cases (Type I DM, MODY, Genetic

syndrome with DM) where the Fasting Serum C-Peptide levels (Basal Insulin

level) were negligibly low. DAMM therapy was administered to them and all of

them have registered increasing values.

This would mean that there is some Betacell activity in the body !

This is truly an unheard of “Effect” in the field of Diabetology – in Juvenile insulin

– dependent Diabetes Mellitus (JIDDM) or Type I DM).

Case study of Master D. given below.

Master D admitted to TAG VHS DRC on 27/05/2013 with high blood sugars and with

the classical osmotic symptoms of weight-loss nearly 5 Kgs over 3 months and

polyphagia, polydipsia, polyuria.

He complained of on & off abdominal pain since 3 months

Thoroughly investigated in Mumbai revealing elevated blood sugars.

On admission, he was in a state of ketosis (CBG: 528 mg/dl, Urine sugar: 3+, Urine

ketone: Large) but there was no evidence of acidosis. (He was not

breathless, electrolytes especially bicarbonate was normal 25 meq/l).

From Day 1 of admission, he was started on a new modality of treatment Dynamic

Acupuncture Mediated Metaphysical (DAMM) Therapy by (Dr.) Rajan Iyer, to improve

his Betacell activity - he took 6 sittings.

The fasting C-Peptide when he came here was 0.888 mU/L done on 28/05/2013 and

other investigations were normal.

On the 3rd day, he was started only on combo insulin (Inj. Novomix 30/70) twice a day.

The dose was adjusted taking into consideration his blood sugar values, eating habits

etc.

The final prescription at the time of discharge was Inj. Novomix 22U pre breakfast &

14U pre dinner.

His low backache got better and he started gaining weight at 0.4 Kgs every day.

A detailed discussion on his diet was held with his parents.

Training was imparted to him and his parents in the self – administration of injection

and home monitoring of blood glucose. At the time of discharge he was free from

complaints, cheerful, energetic, & urine acetone negative.

Post- admission –

First OP session (13 – 15 Aug. 2013) Review after 3 months

Repeat fasting C-Peptide value was 2.35 mU/L.

During this visit, he took 2 sittings of DAMM Therapy.

Second OP session (30/12/2013 - 03/01/2014):

5 sittings of DAMM Therapy continuously.

Post therapy C-Peptide value showed 2.46 mU/L.

Insulin dosage was reduced to Inj. Novomix 18U pre breakfast, 8U pre dinner and Tab.

Glipizide XL 5 mg twice a day before food was added.

When he went back home, he started experiencing frequent hypos. Hence morning

dose was reduced to 14U and night dose to 6U.

Even with this his hypos continued. His night dose was thus completely stopped.

Presently - morning dose of insulin and Tab. Glipizide 5 mg twice a day.

In February 2014, his weight: 48 kgs (previous: 44.7 kgs) C-peptide value was 2.24

(previous: 2.46), FBS: 115 mg/dl, PPBS: 211 mg/dl, HbA1c: 8.1%,

Symptom- free with only one dose of insulin along with OHA.

Followup of this case is erratic due to the child’s studies and lack of

motivation of the parents; Further reports on this child will be put up on a

monthly basis in this space.

16 u 15 u

32 u

36 u

26 u

10 u

26 u

24 u

30 u

0

5

10

15

20

25

30

35

40

29/05/2013 30/05/2013 31/05/2013 01/06/2013 30/12/2013 03/01/2014 03/02/2014 30/05/2014 15/08/2014 18/12/2014

Insulin Requirement

For more details on the use of Dynamic Acupuncture Mediated Metaphysical (DAMM)

therapy in Type I Diabetes please contact our Centre.

Address:-TAG VHS Diabetes Research CentreT.T.T.I. Post, Chennai – 600 113.

Phone No. 044-2254 1921 / 1922.

E-Mail ID: info@tagvhsdrc.com / cvk@diabetopaedia.com

Name of the contact person – Mrs. Ramalakshmi & Mrs. Subhashini

Thank You All