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HERMINE I. BRUNNER MD MSc MBA FAAP FACR
Last update: 10/24/2012
Business Address: Cincinnati Children’s Hospital Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229
Tel: 513-636-7982
Fax: 513-636-5990
Email: [email protected]
EDUCATION
Degrees, Diplomas, Licensures and Certifications
1981 - 1982 Master in Business Administration (MBA) Siemens Company Munich/ Berlin, Germany 1985 – 1990 M.D.; Ludwig Maximillians University Munich, Germany Subject: Medicine; Dissertation: HLA Class I Association in Juvenile Rheumatoid Arthritis Magna cum laude 1992 - 1993 ―Arzt im Praktikum‖ (Internship) Dr. von Haunersches Kinderspital Ludwig Maximillians University Munich, Germany 1994 - 1997 FAAP; Pediatric Residency Wyler's Children’s Hospital University of Chicago Chicago, U.S.A
1998 – 2001 Master in Clinical Epidemiology (MSc) University of Toronto Toronto, Canada
Thesis topic: The association between disease activity and disease damage in childhood-onset Systemic Lupus Erythematosus
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Specialty Training
1997 - 1999 Hospital for Sick Children University of Toronto Toronto, ON Subject: Pediatric Rheumatology 1999- 2000 Cincinnati Children's Hospital and Medical Center University of Cincinnati Cincinnati, OH Subject: Pediatric Rheumatology
Additional Training
1985 – 1990 Medical Balneotherapy Ludwig Maximillians University Munich, Germany 1991 Pediatric Ultrasound Certification Ludwig Maximillians University Munich, Germany 1992 Basic Acupuncture Training German Society of Acupuncture Munich, Germany 1990-1992 Basic Psychosomatic Medicine Training Aerztlicher Weiterbildungskreis Munich 2001 RASCH Measurement Training Institute of Measurement, University of Illinois Chicago, USA 2005 RASCH Measurement Training University of Melbourne Melbourne, Australia
EMPLOYMENT - APPOINTMENTS
1982 – 1985 Siemens Headquarter, Munich Market Research, Software Engineering, Teaching of MBA Courses 1991 – 1992 Doctors without Borders Angola, Cunene
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Hospital Appointments
1986 – 1993 Research Assistant - 2/16/2011Tissue & HLA Laboratory Ludwig Maximillians University Munich, Germany 2000 - 2001 Research associate Cincinnati Children's Hospital and Medical Center, Pediatric Rheumatology University of Cincinnati Cincinnati, OH 2001 - 2002 Instructor of Pediatrics Cincinnati Children's Hospital and Medical Center, Pediatric Rheumatology University of Cincinnati Cincinnati, OH 2002 - 2006 Assistant Professor of Pediatrics Cincinnati Children's Hospital and Medical Center, Pediatric Rheumatology University of Cincinnati Cincinnati, OH 2006 - 2011 Associate Professor of Pediatrics Cincinnati Children's Hospital and Medical Center, Pediatric Rheumatology University of Cincinnati Cincinnati, OH Since 2011 Professor of Pediatrics, Tenured Cincinnati Children's Hospital and Medical Center, Pediatric Rheumatology University of Cincinnati Cincinnati, OH
Hospital & University Committees
Since 2006 Faculty, CCHMC Health Services Matrix
Since 2007 Member, Rheumatology Core Center P30; IT Core Steering Committee
Since 2007 Head, Cincinnati Children’s Lupus Center
Since 2009 Member, Scientific Advisory Council of the Cincinnati Clinical & Translational
Research Center
2008 - 11 Disease-specific Innovation and Outcome Project – Lupus
2010 - 11 CCHMC Transition Taskforce for SLE
Since 2008 Building Interdisciplinary Research Careers in Women's Health (BIRCWH) mentoring committee
Since 2011 Co-leader High-impact Disease Program for JIA and Lupus
2012 Searchable Database Committee for CCTST
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Cross Appointments
2000 – 2008 Institute for the Study of Health University of Cincinnati Cincinnati, OH 2002 – Division of Clinical Epidemiology & Biostatistics Cincinnati Children's Hospital and Medical Center University of Cincinnati Cincinnati, OH 2010 The Anderson Center
BOARD CERTIFICATION:
Pediatrics 1997
Pediatric Rheumatology 2003, 2012
MEDICAL/SCIENTIFIC ORGANIZATIONS-COMMITTEES/AFFILIATIONS
American Academy of Pediatrics
Since 1997 Diplomat
Society of Clinical Decision Making
Since 2001 Member, abstract review committee
Lupus Foundation of America
Since 2007 Medical-Scientific Advisory Council
Since 2006 Grant reviews
Arthritis Foundation of America
Since 2001 Member, presentations, volunteer
Childhood Arthritis Rheumatology and Research Alliance
Since 2002 Member, Transitional Research and SLE Subcommittee
Lead, NPSLE Working Group
April 2010 Consensus Conference Leader for SLE development of standard of care protocols
August 2010 Steering Committee Member as Large Center Representative
International Myositis Disease Activity and Damage Collaborative Study Group
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Since 2003 Member
Pediatric Rheumatology Collaborative Study Group
2004 - 2006 Adjunct Senior Scientist
2006 – now Scientific Director
American College of Rheumatology
2006, 2010, 2011 Abstract Selection Committee
Since 2007 - 2010 ACR Publication Committee
Since 2007 ACR Criteria Subcommittee; Committee of Research
2012 ACR Blue Ribbon Taskforce
Lupus Research Institute
Since 2010 Pediatric National Program Development Committee
Other National and International Committees
2006 NIAMS Roundtable Discussion, Washington, DC
2010 European Medicine Agency Rheumatology Expert Group Meeting, London, UK
2011 PHARMACHILD Steering Committee
2010 CARRANet and CARRA Core Steering Committee
2012 Editorial board of Revista Paulista de Pediatria
HONORS AND AWARDS RECEIVED
1987 – 1991 Friedrich Ebert Stiftung, Fully scholarship for Medical School Training
1988 National student representative of Friedrich Ebert Foundation
1988-90 Students’ representative of Council of Medicine, Ludwig Maximillians University, Munich
1991 DAAD/DED (German Academic Exchange Service)
1992 Instidade de Lingua Portuguesa
1993 DAAD/DED (German Academic Exchange Service)
JOURNAL PEER REVIEW
Annals of Rheumatic Diseases
Journal Clinical Drug Investigation
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Journal of Rheumatology
Scandinavian Journal of Rheumatology
Arthritis & Rheumatism
Arthritis Care and Research
Pediatrics
Annals of Rheumatic Diseases
Brain
Pediatric Rheumatology Online Journal
Lupus
Clinical and Experimental Rheumatology
Rheumatology
Medical Decision Making
Journal of Clinical Epidemiology
Journal of Pediatrics
Lancet
GRANT REVIEWER
Since 2002 NIAMS and NIAID Special Emphasis Panels; Ad hoc member
Since 2005 CARRA (Childhood Arthritis Rheumatology and Research Alliance) Protocol Scientific Review Committee
2006, 2007, 2010,2011 T32 Trainings Grants
2007 Proctor Award Review
2006, 2007, 2008, 2009, 2010 Lupus Foundation
2009, 2010 American College of Rheumatology
Since 2009 National Institutes of Health BIRCHW Award (grant HD051953)
2011 PSI Foundation, Canada
EDITOR & EDITORIAL BOARD
2006 – 2012 Arthritis Care and Research
2006 - 2010 Lupus Now Advisory Board (LNAB)
Since 2010 Pediatric Editor, Arthritis Care & Research
OTHER PROFESSIONAL ACTIVITIES
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Since 2002 CCHMC Rheumatology Improvement Committee
Since 2004 Assistant Director MCRC Methodology Core
2006, 2007 University of Cincinnati; Medical student physical examination course
Since 2007 Pediatric Rheumatology Collaborative Study Group, Scientific Director
Since 2007 Head and Scientific Director – CCHMC Lupus Center
Since 2009 Scientific Advisory Board, University of Cincinnati Clinical Translational Research
Center (CCTST)
Since 2007 Scientific Oversight Committee, Pediatric Fellowship Research
Since 2007 Pediatric Residency Mentorship Program (Role: mentor)
2009 Search Committee for Pediatric Rheumatology Director
2010 & 2011 CARRA Lupus Nephritis Consensus Conference Facilitator
EDUCATION
Since 2002 Monthly fellowship clinic supervision, quarterly formal teaching presentation
Since 2008 Building Interdisciplinary Research Careers in Women's Health (BIRCWH) mentor
Since 2011 ACR/ CARRA Mentorship Initiative AMIGO, Leadership Committee
Since 2008 CCTST PS2 Research Mentor for Nursing and Allied Health Professionals
PUBLICATIONS
Peer-reviewed publications
1. J.P. Haas, H.I. Brunner, A. Andreas et al.: A model for the role of HLA-DQ molecules in the pathogenesis of juvenile chronic arthritis. Rheumatology International 1991191-197.
2. H.I. Brunner, J.P. Haas, A. Andreas et al: Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor negative juvenile chronic arthritis. Rheumatology International 1993;13: 83-88.
3. H.I. Brunner, B.M. Feldman, C. Bombardier, E.D. Silverman: The SLEDAI, SLAM and BILAG are sensitive to change in clinical disease activity in childhood-onset Systemic Lupus Erythematosus (SLE). Arthritis & Rheumatism 1999; 7: 1354-60.
4. H.I. Brunner, M Freedman, E.D. Silverman: Close Relationship Between Thrombotic Thrombocytopenic Purpura And Systemic Lupus Erythematosus In Childhood. Arthritis & Rheumatism 1999; 42: 2346-55.
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5. H I. Brunner, K.N. Kim, S.H. Ballinger, S.L. Bowyer, T.A. Griffin, G.C. Higgins, R. Mier, M.H. Passo, R. Rennebohm, K. Schikler, D.J. Lovell: Medication choices in juvenile rheumatoid arthritis Journal of Clinical Rheumatology 2001; 7: 295-300.
6. F.W. Miller, L. G Rider, for the International Myositis Outcome Assessment Collaborative Study
Group (member: H.I. Brunner): Proposed preliminary core set measures for disease outcome assessment in adult and juvenile idiopathic inflammatory myopathies. Rheumatology 2001; 40: 1262-1273.
7. M.P. Scola, S.D. Thompson, H.I. Brunner M.K. Tsoras, D. Witte D. et al. (Type 1 inducing cytokines (IL-12, IL-15, IL-18) and IFN-gamma :IL-4 ratios in juvenile rheumatoid arthritis synovial tissue. J Rheumatology 2002. 29: 369-78.
8. H.I. Brunner, E.D. Silverman, T. To, C. Bombardier, B.M. Feldman: Risk factors for damage in childhood-onset SLE (cSLE): cumulative disease activity over time and medication use predict disease damage. Arthritis and Rheumatism 2002; 45: 436-44.
9. H.I. Brunner, W.S. Chan, J. Ginsberg, B.M. Feldman: Long-term anticoagulation is preferable for patients with antiphospholipid antibodies syndrome (APLAS): results of a decision analysis. J Rheumatology 2002; 29:490-501.
10. H.I. Brunner, D. J. Lovell, B. K. Finck, E.H. Giannini: Preliminary definitions of disease flare in juvenile rheumatoid arthritis (JRA). Journal of Rheumatology 2002; 29:1058-64.
11. S. Thornton, D. Sowders, B. Aronow, D.P. Witte, H.I. Brunner, E.H. Giannini and R. Hirsch. 2002. DNA microarray analysis reveals novel gene expression profiles in collagen induced arthritis. Clinical Immunology 2002; 155-168.
12. S.,Bernstein, H. I. Brunner, R. Summerbell, U. Allen, P. Babyn, and S. E. Richardson. 2002. Blastomycosis acquired by three children in Toronto. Can J Infect Dis 13:259-263.
13. H.I. Brunner, B. Wright, B.M. Feldman, M.B. Urowitz, D.D. Gladman: Preliminary item weightings for Systemic Lupus International Collaboration Clinics/ American College of Rheumatology Damage Index (SLICC) for adults with systemic lupus erythematosus (SLE). J Rheumatology 2003; 30:292–7.
14. H.I. Brunner, E.D. Silverman, C. Bombardier, B.M. Feldman: The ECLAM may be more suitable than the SLEDAI to measure clinical important changes in disease activity in children with Systemic Lupus Erythematosus (cSLE). Arthritis & Rheumatism 2003; 49: 335–341.
15. H.I. Brunner, D. Maker, B. Grundland, N.L. Young, V. Blanchette, A-M. Stain, B.M. Feldman: Preference-based measurement of health related quality of life (HRQL) in children with chronic musculoskeletal disorders (MSKD): Utilities by standard gamble do not correlate with preferences measured by other techniques. Medical Decision Making 2003; 23: 314-322.
16. H.I. Brunner, O. Jones, D.J. Lovell, A.M. Tomasi, M.S. Klein-Gitelman: Lupus headaches (LHA) and their impact on disease activity measured by the SLEDAI and the prediction of damage (SDI) in juvenile systemic lupus erythematosus (jSLE). Lupus 2003; 12: 600-606.
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17. D.A. De Albuquerque, V. Saxena, D. E. Adams, G. P. Boivin, H. I. Brunner, D. P. Witte, R. R. Singh. An ACE inhibitor reduces Th2 cytokines and TGFb-1 and -2 isoforms in murine lupus nephritis. Kidney International. 2004; 65: 846-859.
18. H.I. Brunner, N. Ruperto. Outcome Measures for Childhood-onset Systemic Lupus Erythematosus (cSLE). Pediatric Rheumatology Online Journal; 2004 (2): May/June.
19. L. G. Rider, E. H. Giannini, H. I. Brunner, N. Ruperto, L. J.-Newton, A. M. Reed, P. A. Lachenbruch, F. W. Miller , for the International Myositis Assessment and Clinical Studies Group (IMACS). International Consensus Outcome Measures for Patients with Idiopathic Inflammatory Myopathies. Preliminary Definitions of Improvement for Adult and Juvenile Myositis. Arthritis & Rheumatism 2004; 50: 2281-90.
20. H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Baldwin, M. Trombley, et al: Health of children with chronic musculoskeletal diseases: relationship of different measures and the quality of parent-proxy reporting. Arthritis & Rheumatism 2004; 51: 763-773.
21. A C Barron, T-L Lee, J Taylor, T Moore, M H Passo, T B Graham, T A Griffin, A A Grom, D J Lovell,
and H I Brunner. Feasibility and Construct Validity of the Willingness-To-Pay (WTP) Technique for Measuring Health Care Preferences of Children with Juvenile Idiopathic Arthritis (JIA). Arthritis &
Rheumatism 2004; 51: 899-908.
22. H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Baldwin, M. Trombley, et al: Minimal clinically important differences of the childhood health assessment questionnaire (CHAQ). J Rheumatol; 2005; 32: 150-162.
23. G.D. Myer, H.I. Brunner, P.G. Melson, et al. Improved neuromuscular function and biomechanics with specialized neuromuscular training in a patient with quiescent JIA :a case report. Phys Ther. 2005; 85:791-802.
24. B. Carey; M. DeLay; J E. Strasser; C. Chalk; K. Dudley-McClain; G. N. Milligan; H.I. Brunner; S. Thornton, R. Hirsch. A Soluble Divalent Class I MHC/IgG Fusion Protein Activates CD8+T Cells in vivo. Clin Immunol, 2005;116: 65-76
25. H I Brunner, A C Barron, L Johnson, T B Graham, M H Passo, T Jackson, and D J Lovell. Gastrointestinal (GI) symptoms and their association with health related quality of life of children with juvenile rheumatoid arthritis (JRA) – validation of a GI symptom questionnaire. J Clin Rheumatol 2005; 194- 204
26. C.V. Oddis, L. G. Rider, A. M. Reed, N. Ruperto, H. I. Brunner, B. Koneru, B. M. Feldman, E. H. Giannini, F. W. Miller for the International Myositis Assessment and Clinical Studies Group (IMACS). Arthritis Rheum 2005; 2607-15.
27. N. Fall, K.E. Bove, K. Stirnger, D.J. Lovell, H.I. Brunner et al.:. Lack of angiogenic response in muscle tissues form patients with juvenile dermatomyositis is associated with high expression of angiostatic ELR-negative CXC-chemokines: Possible link to vasculopathy. Arthritis Rheum 2005; 3175-80.
28. H.I. Brunner, A. Bishnoi, A. C. Barron, L. J. Houk, A. Ware, Y et al. Long-term outcomes and ovarian function in childhood-onset Systemic lupus erythematosus (cSLE). Lupus 2006; 15: 198-206.
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29. H.I. Brunner, T M Sherrard, M S Klein-Gitelman. Cost of Treatment of Childhood-Onset Systemic Lupus Erythematosus; Arthritis Rheum 2006; 55: 184-188.
30. H. I. Brunner, J Taylor, M.T. Britto, M S Corcoran, S. L. Kramer et al. Differences in disease outcomes between Medicaid and privately insured children: possible health disparities in juvenile rheumatoid arthritis (JRA). Arthritis Rheum 2006; 55378-84
31. M Chaudari, M Moroldo, S. K. Thompson, P. Hillard, B Huang, H.I. Brunner, D.N. Glass: Decreased reproductive fitness in childhood autoimmune arthropathy families. Rheumatology 2006;45:1282-7.
32. H I. Brunner, M Mueller, C Rutherford, M H Passo, et al. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker of Nephritis in Childhood-onset Systemic Lupus Erythematosus. Arthritis Rheum 2006; 54: 2577-2584.
33. E. Sommers, H.I. Brunner. L. Nabors. Pain, Fatigue, Family Functioning, and Attitude Toward Illness in Children with Juvenile Rheumatic Diseases". J. Dev Phys Disabil 2007;18: 64- 71.
34. Bleesing J, Prada E, Siegel DM, Villanueva J, Olson J, Ilowite N, Brunner HI, Griffin T, Graham TB, Sherry DD, Passo MH, Filipovich A, and Grom AA. The Diagnostic Significance of soluble CD163 and soluble IL2Ra chains in Macrophage Activation Syndrome and Untreated New Onset Systemic Juvenile Idiopathic Arthritis. Arthritis Rheum 2007; 729-735.
35. L Nabors, E Jobst, J Weisman, B. Precht, P Chiu, H.I. Brunner. School support and Functioning for Children with Juvenile Rheumatic Diseases. J. Dev Phys Disabil 2007; 19:81-89.
36. S. Koneru, M. Shishov, A. Ware, Y. Farhey, A. B. Mongey, J. L. Houk, H.I. Brunner. Effectively Measuring Adherence to Medications For Systemic Lupus Erythematosus In A Clinical Setting. Arthritis Rheum 2007, 57: 1000-1006.
37. C.A Silva, H. I. Brunner. Gonadal Functioning With Pediatric Lupus, Lupus 2007, 16:593-99.
38. J Mikdashi* (Co-Chair), JM Esdaile (Co-Chair), GS Alarcón (Co-Chair), L Crofford, BJ Fessler, L
Schanberg, H Brunner, V Gall, JR Kalden, MD Lockshin, MH Liang, N Roberts Jr and M Schneider; for the Ad Hoc Committee on Lupus Response Criteria: Cognition Sub-committee: Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials. Lupus (2007) 16, 418–425.
39. HI Brunner, NM Ruth, A German, S Nelson, MH Passo, T Roebuck-Spencer, J Ying, D Ris: Initial validation of the pediatric automated neuropsychological assessment metrics for childhood-onset systemic lupus erythematosus. Arthritis Rheum 2007, 57: 1174-1182. PMID: 17907235
40. M. Suzuki, K.Wiers, S Nelson, C Rutherford, P Devarjan, H I Brunner: Identification of urinary proteomic signature for nephritis in children. Pediatr Nephrol. 2007; 22:2047-2057.
41. M. DiFrancesco, S. Holland, D. Ris C. Adler, M. DeBello, M. Altaye, H.I. Brunner. Functional magnetic resonance imaging of cognitive function in childhood-onset systemic lupus erythematosus: a pilot study. Arthritis Rheum. 2007;56:4151-63.
42. M. Suzuki, K. M. Wiers, M. Klein-Gitelman, K. A. Haines, J….., J. Ying, P. Devarajan, H.I. Brunner. Neutrophil Gelatinase Associated Lipocalin as a Biomarker of Disease Activity In Pediatric Lupus Nephritis; Pediatr Nephrol. 2008; 23(3):403-12
43. H.I. Brunner, D. D. Gladman, D. Ibañez, M. D. Urowitz, E. D. Silverman: Difference in disease features between childhood-onset and adult systemic lupus erythematosus (SLE). Arthritis Rheum 2008; 58: 556–562.
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44. S. Koneru, L Kochrala, G. C. Higgins, A. Ware, M. H. Passo, Y. D. Farhey, A-B Mongey, T.B.
Graham, J.L. Houk, H. I. Brunner. Adherence to medications in systemic lupus erythematosus. J Clin Rheumatol; 2008: 14(4):195-201.
45. M. Suzuki, K. Wiers, E.B. Brooks, K.D. Greis, K. Haines, M.S. Klein-Gitelman, J. Olson, K. Onel,
K.M. O'Neil, E.D. Silverman, L. Tucker, J. Ying, P. Devarajan, H. I. Brunner. Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis. Ped Research 2009 ;65(5):530-6
46. H.I. Brunner, M.S. Klein-Gitelman, J. Ying, L.B. Tucker, E. D. Silverman. Corticosteroid use in childhood-onset systemic lupus erythematosus – practice patterns at four pediatric rheumatology centers, Clin Exp Rheumatol 2009; 27: 155-162.
47. S Collins, DP Schauer, A Gupta, H Brunner, AB Storrow, MH Eckman. Cost-Effectiveness Analysis of Emergency Department Decision Making in Non-High Risk Heart Failure Patients. Amer J Emerg Medicine; 2009; 27:293-302.
48. L. E. Schanberg, C. Sandborg, H.X. Barnhart, … H.I. Brunner, L. Jung, J. B. Soep, A. Reed. Understanding Premature Atherosclerosis in Pediatric SLE: Risk Factors of Increased Carotid Intima Medial Thickness (CIMT) in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort. Arthritis Rheum 2009, 60; 1496-1507
49. H. I. Brunner, G. C. Higgins, K. Wiers, S.K. Lapidus, J.C. Olson, K. Onel, M. Punaro, J. Ying, M. S. Klein-Gitelman, M. Seid. Health-related Quality of Life (HRQoL) and its Relationship to Patient Disease Course in Childhood-onset Systemic Lupus Erythematosus (cSLE). J Rheumatology 2009; 36:1536–45.
50. C. H. Hinze, M. Suzuki, M. Klein-Gitelman, M. H. Passo, J. Olson, N. G. Singer, …, L. Tucker, J.
Ying, P. Devarajan, H. I. Brunner. Neutrophil Gelatinase-associated Lipocalin (NGAL) Predicts the Course of Global and Renal Childhood-Onset Systemic Lupus Erythematosus (SLE) Disease Activity. Arthritis Rheum 2009; 60:2772-2781. PMID: 19714584
51. L. Kocharla, J.L. Taylor, T. Weiler, T.V. Ting, M. Luggen, H. I. Brunner. Monitoring of methotrexate toxicity in juvenile idiopathic arthritis. J Rheumatology 2009; J Rheumatology 2009; 36(12):2813-2818.
52. K.R. Ford, G.D. Myer, P.G. Melson, S.C. Darnell, H. I. Brunner, T.E. Hewett. Land-Jump Performance in Patients with Juvenile Idiopathic Arthritis (JIA): A Comparison to Matched Controls," International Journal of Rheumatology, 2009:478526; Epub 2010 Jan 27.
53. H.I. Brunner, G.C. Higgins, K. Wiers, S.K. Lapidus, J.C. Olson, K. Onel, M. Punaro, J. Ying, M.S. Klein-Gitelman, E.H. Giannini. Validation of the Provisional Criteria for the Evaluation of Response to Therapy in Childhood-onset Systemic Lupus Erythematosus (cSLE). Arthritis Care Res. 2010; 62 (3): 335-344.
54. H.I. Brunner, M.S. Klein-Gitelman, G.C. Higgins, S.K. Lapidus, D. Levy, A. Eberhard, N. Singer, J.C. Olson, K. Onel, M. Punaro, L. Schanberg, E. Von Scheven, J. Ying, E.H. Giannini. Towards the Development of Criteria for Global Flares in Juvenile Systemic Lupus Erythematosus. Arthritis Care Res. 2010; 62: 811–820
55. G.S. Ross, F. Zelko, M. Klein-Gitelman, D. M. Levy, E. Muscal, L.E. Schanberg, K. Anthony, H. I.
Brunner for the Childhood Arthritis & Rheumatology Research Alliance (CARRA) Ad-Hoc Neurocognitive Lupus Committee. A proposed framework to standardize the neurocognitive assessment of pediatric patients. Arthritis Care Res. 2010; 62: 1029-33.
56. A.C. Sagcal-Gironella, T, Fukuda, K Wiers, Cox, S Nelson, B Dina, CMT Sherwin, M.S. Klein-
Gitelman, A.A. Vinks, H.I. Brunner. Pharmacokinetics and pharmacodynamics of
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Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relationship to response to therapy of childhood-onset systemic lupus erythematosus. Semin Arthritis Rheum. 2011 Feb;40(4):307-13.
57. H.I. Brunner, G.C. Higgins, K. Wiers, S.K. Lapidus, J.C. Olson, K. Onel, M. Punaro, J. Ying, M.S. Klein-Gitelman, E.H. Giannini. Minimal clinically important difference in disease activity measures for childhood-onset systemic lupus erythematosus. Arthritis Care Res. 2010; 62: 950-959.
58. SP Ardoin, LE Schanberg, C Sandborg, E Yow, HX Barnhart, KL Mieszkalski, NT Ilowite, E von Scheven, A Eberhard, DM Levy, Y Kimura, E Silverman, SL Bowyer, L Punaro, NG Singer, DD
Sherry, D McCurdy, M Klein-Gitelman, C Wallace, R Silver, L Wagner-Weiner, GC Higgins, HI
Brunner, LK Jung, L Imundo, JB Soep, AM Reed, APPLE for the and Investigators. Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort; Lupus 2010:1315-1325.
59. M. Antonchak, M. Saoudian, A Khan, H. Brunner, M. Luggen. Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus: a Controlled Study. J Rheumatol 2011; J Rheumatol 2011;38 1020-1025
60. H.I. Brunner, R. Mina, C. Pilkington, M.W. Beresford, A. Reiff, D.M. Levy, L.B. Tucker, B. A. Eberhard, A. Ravelli, L. Schanberg, C. Saad-Magalhaes, G.C. Higgins, K. Onel, N.G. Singer, E. von Scheven, L. Itert, M. S. Klein-Gitelman, M. Punaro, J. Ying, and E. H. Giannini. Preliminary Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. Arthritis Care & Research 2011 2011; 63: 1213-1223; doi : 10.1002/acr.20507.
61. A.C. Sagcal-Gironella, CMT Sherwin, T, Fukuda, Cox, S Nelson, B Dina, M.S. Klein-Gitelman, H.I.
Brunner, A.A. Vinks. Pharmacokinetics of prednisolone in childhood-onset systemic lupus erythematosus (cSLE). Clin Ther. 2011;33:1524–1536.
62. L. E. Schanberg, C. Sandborg, H. X. Barnhart,S. P. Ardoin, E. Yow, G. W. Evans, K. L. Mieszkalski, N. T. Ilowite, A. Eberhard, L. F. ImundoY. Kimura, E. von Scheven, Silverman, S. L. Bowyer, L. Punaro, N. G. Singer, D. D. Sherry, D. McCurdy, M. Klein-Gitelman, C. Wallace, R.
Silver, L. Wagner-Weiner, G. C. Higgins, H. I. Brunner, M.S., L. Jung, J. B. Soep, A. Reed, J. Provenzale, for the APPLE investigators. Use of Atorvastatin in Systemic Lupus Erythematosus (SLE) in Children and Adolescents. Arthritis & Rheum 2011; DOI: 10.1002/art.30645.
63. T. V. Ting, D. Kudalkar, S. Nelson, S. Cortina, J. Pendl, S. Budhani, J. Neveille, J. Huggins, D. Drotar, and H. I. Brunner. Usefulness of cellular text messaging for improving adherence among adolescents and young adults with systemic lupus erythematosus. J Rheumatol. 2012 Jan;39 (1):174-9. Epub 2011 Nov 15.
64. R. Mina, P. Melson; S. Powell, M Rao, C Hinze, M Passo, T. Graham, and H.I. Brunner. Effectiveness of dexamethasone iontophoresis for temporomandibular joint involvement in juvenile idiopathic arthritis. Arthritis Care & Research 2011 Nov (63): 1511–1516.
65. Fukuda, PhD, H. I. Brunner, A. C. Sagcal-Gironella, A. A. Vinks. Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Ther Drug Monit. 2011 Oct; 33(5):658-62.
66. L. E. Romick-Rosendale, H. I. Brunner, M. R. Bennett, R. Mina, M. Petri, A. Kiani, D. Witte, P. Devarajan, and M. A. Kennedy. Identification of urinary biomarkers to distinguish proliferative and membranous lupus nephritis and focal segmental glomerulosclerosis by NMR-based metabonomics analysis. Arthritis Research & Therapy 2011, 13:R199 (7 December 2011).
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67. R. Mina, E. von Scheven, A.B. Eberhard, M. Punaro, S. Ardoin, M. Klein-Gitelman, R. Suhas, E.
Muscal, H. Joyce, D. Levy, M. Nandini, L. Wagner-Weiner, C. Wallace, N. Ilowite, and H.I.
Brunner for the Disease Specific Systemic Lupus Erythematosus Committee of the Childhood Arthritis & Rheumatology Research Alliance. Consensus treatment plans for induction therapy of newly-diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558.
68. C.M.T. Sherwin, A.C.P. Sagcal-Gironella,T. Fukuda, H.I. Brunner & A.A. Vinks. Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.Br J Clin Pharmacol 2012;73: 727-740.
69. C.A. Wallace, E.H. Giannini, S.J. Spalding, P.J. Hashkes, K.M. O'Neil, A.S. Zeft, I.S. Szer, S.
Ringold, H.I. Brunner, L.E. Schanberg, R.P. Sundel, D. Milojevic, M.G. Punaro, P. Chira, B.S. Gottlieb, G.C. Higgins, N.T. Ilowite, Y. Kimura, S. Hamilton, A. Johnson, B. Huang and D.J. Lovell, for the Childhood Arthritis Rheumatology Research Alliance (CARRA). Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2012 64(6):2012-21. doi: 10.1002/art.34343.
70. R Mina, M.S. Klein-Gitelman, A. Ravelli, M. W. Beresford, T. Avcin, G. Espada, B. A. Eberhard, L. E. Schanberg, K. M. O’Neil, C.A. Silva, G. C. Higgins, K. Onel, N. G. Singer, L. Imundo, E. von
Scheven, S. Nelson, M. Punaro, E. H. Giannini, and H. I. Brunner. Inactive Disease and Remission in Childhood-onset Systemic Lupus Erythematosus. Arthritis Care & Rheum 2012 2012, pp 683–693; DOI: 10.1002/acr.21612
71. H. I. Brunner, M.R. Bennett, R. Mina, M. Suzuki, M. Petri, A. N. Kiani, J. Pendl, D. Witte, J. Ying, B. H. Rovin and P. Devarajan. Non-Invasive Renal Protein Biomarkers Are Associated With Histological Features Of Lupus Nephritis. Arthritis Rheum. 2012 64: 2687–2697; doi: 10.1002/art.34426
72. F. Zelko, D. Beebe, A. Baker, S.M. Nelson, A. Ali, A. Cedeno, B. Dina, M.S. Klein-Gitelman,
J.Ying, H.I. Brunner. Academic outcomes in childhood-onset systemic lupus erythematosus. Arthritis Care & Research 2012; 64: 1167–1174; DOI 10.1002/acr.21681.
73. Silva CA, Avcin T, Brunner HI.T axonomy for systemic lupus erythematosus with onset before adulthood. Arthritis Care Res (Hoboken). 2012 Jun 21. doi: 10.1002/acr.21757.
74. AG Uribe, AM Huber, SK, KM O’neil, DM Wahezi, L Abramson, K Baszis, SM Benseler, SL Bowyer, S Campillo, P Chira, AO. Hersh, GC Higgins, A Eberhard, K Ede, LF Imundo, L Jung, DJ Kingsbury, M Klein-Gitelman, EF Lawson, SC Li, DJ Lovell, T Mason, D Mccurdy, E Muscal, L Nassi, E Rabinovich, A Reiff, M Rosenkranz, KN Schikler, NG Singer, S Spalding, AM Stevens, &
DA Cabral, (Hermine Brunner – contributor). For The Archive Investigators Network. Increased Sensitivity of the European Medicines Agency Algorithm for Classification of Childhood Granulomatosis with Polyangiitis. First Release May 15 2012; J Rheumatol 2012;39:1687–97; doi:10.3899/jrheum.111352).
75. HI Brunner, MS Klein-Gitelman, F Zelko, EC Thomas, J Hummel, SM Nelson, J Huggins, ML Curran, T Roebuck-Spencer, DW Beebe, J Ying. Validation of the pediatric automated neuropsychological assessment metrics in childhood-onset systemic lupus erythematosus. Arthritis Care & Research 2012; 64: in press.
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76. F De Benedetti, HI Brunner, N Ruperto, A Kenwright, S Wright, I Calvo, R Cuttica, A Ravelli, R Schneider, P Woo, C Wouters, R Xavier, L Zemel, E Baildam, R Burgos-Vargas, P Dolezalova, S Maris Garay, J Garcia Consuegra, R Joos, A Grom, N Wulffraat, Z Zuber, F Zulian, D Lovell, A Martini for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)Tocilizumab in Systemic Juvenile Idiopathic Arthritis: A Randomized Trial. NEJM, in press.
77. N Ruperto, HI Brunner, P Quartier, T Constantin, N Wulffraat, Gerd Horneff, R Brik, L McCann, O Kasapcopur, L Rutkowska-Sak, R Schneider, Y Berkun, I Calvo, M Erguven, L Goffin, MHofer, Tilmann Kallinich, S Knupp, Y Uziel, S Viola, KNistala, C Wouters, R Cimaz, MA Ferrandiz, B Flato, M Luz Gamir, I Kone-Paut, A Grom, B Magnusson, S Ozen, FSztajnbok, A Martini, DLovell. for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG). Canakinumab in systemic juvenile idiopathic arthritis with active systemic features. NEJM, in press.
Manuscripts in Development.
1. R Mina, MS Klein-Gitelman, S Nelson, BA Eberhard, G Higgins, NG Singer, K Onel, L Tucker, K
O’ Neil, M Punaro, E Giannini, A Martini, N Ruperto, D Lovell, and H I Brunner. Validation of the Systemic Lupus Erythematosus Responder Index for Use in Juvenile Systemic Lupus Erythematosus. Arthritis Care & Rheum 2012; accepted with revisions
2. D W Moser, J Brown, E Haddix MB Burns, AC Sagcal-Gironella, TA Griffin, HI Brunner, E Morgan-DeWitt. Improving Tuberculosis Screening in Rheumatology Patients Receiving Biologic Response Modifiers. Submitted to Pediatrics May, 2012.
3. M DiFrancesco, D Gitelman, AC Sagcal-Gironella, F Zelko, DW Beebe, MS Klein-Gitelman, J
Ying, HI Brunner. Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus.
4. D Gitelman, MS Klein-Gitelman, J Ying, AC Sagcal-Gironella, F Zelko, DW Beebe, Mark
DiFrancesco, HI Brunner. Brain Morphometric Changes Associated with Childhood-Onset Systemic Lupus Erythematosus and Neurocognitive Deficit.
Non-peer reviewed publications / invited papers
1. D.J. Lovell, M.H. Passo, E.H. Giannini, H.I. Brunner: Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years [letter].Journal of Rheumatology 2001: 28:220.
2. H I. Brunner: Medication choices in juvenile rheumatoid arthritis. Orthopedics Today; 2002.
3. H.I. Brunner: Quality of Life with Musculoskeletal Disorders assessed. Parents are good proxies in reporting children’s physical function a Quality of Life. International Medical News Group; Pediatric News; 2002.
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4. H I. Brunner: Lupus Headaches in Children with Systemic Lupus Erythematosus. Lupus News Summer 2002.
5. Brunner HI Feldman BM: Intensity and Duration Of Oral Anticoagulation In Antiphospholipid
Antibody Associated Thrombosis - Reply. Journal of Rheumatol 2002: 29:2468.
6. H. I. Brunner, Silverman ED. Reply letter for Thrombotic thrombocytopenic purpura in a patient with Behcet’s disease. Arthritis Rheum 2004
7. J. L. Huggins, H.I. Brunner. Targeting B Lymphocytes in the Treatment of Childhood Systemic Lupus Erythematosus. [Editorial]. J. Peds 2006; 571-572.
8. L. A. Nabors, E. Iobst, J. Weisman, B. Precht, P. Chiu, and H. Brunner: School Support and Functioning for Children with Juvenile Rheumatic Diseases, Journal of Developmental and Physical Disabilities 2006; in press.
9. H.I. Brunner, L. Das, M.H. Passo, Sri Koneru, Reply letter for Adherence to medications in systemic lupus erythematosus. Arthritis Rheum 2007, 57: 1000-1006.
10. H.I. Brunner, M. Klein-Gitelman. Lupus in the Child’s Mind. The Rheumatologist, March 2009.
Reviews & Editorials
1. H.I. Brunner, E.D. Giannini: Evidence-based medicine in Pediatric Rheumatology. Review. Clinical and Experimental Rheumatology 2000; 18: 407-414.
2. H.I. Brunner, E.D. Giannini: Health-related Quality of Life in Children with Arthritis. Curr Opin Rheumatol 2003; 15:602–612.
3. C.A Silva, H. I. Brunner. Gonadal Functioning With Pediatric Lupus, Lupus 2007, 16:593-99.
4. Hinze C, H.I. Brunner. Pediatric Rheumatology – Its own Specialty. Nature in Clinical Rheumatology, 2008; 4:279
5. H.I. Brunner. More May Not Be Better — But Is Less Enough? Rheumatol January 2009 36:7-8.
6. M.S. Klein-Gitelman, H.I. Brunner. The impact and implications of neuropsychiatric systemic lupus erythematosus in adolescents. Current Rheumatology Reports 2009; 11: 212-217.
7. L. Das, H.I. Brunner. Biomarkers for Renal Disease in Childhood; Current Rheumatology Reports 2009; 11: 218-225.
8. Ravelli, H.I. Brunner. Outcome Measure Development in Pediatric Rheumatology. Best Practice and Research Clinical Rheumatology. 2009 Oct;23(5):609-24
9. Rina Mina, H I. Brunner. Clinical manifestations of childhood-onset systemic lupus erythematosus. Rheum Dis Clin N Am: 36 (2010) 53–80.
10. C. Sherwin, C; Y. Fukuda, J. Goebel, S. Cox, H.I. Brunner, A.A. Vinks. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ
transplantation and autoimmune disease. Clinical Pharmacokinetics 2011;50(1):1-24
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11. N. Ruperto, E. H. Giannini, A. Pistorio, H.I. Brunner, A. Martini, D. J Lovell. Is it time to move to active comparator trials in juvenile idiopathic arthritis Arthritis & Rheumatism 2010 Nov; 62(11):3131-9.
12. Sherwin CMT, Fukuda, T, Brunner, HI, Goebel, J, and Vinks, AA. The Evolution of Population Pharmacokinetic Models to Describe the Enterohepatic Recycling of Mycophenolic Acid in Solid Organ Transplantation and Autoimmune Disease. As per the endocrinology note DI is suspected but I had no way to know that this is now confirmed; British Journal of Clinical Pharmacology 2011. Jan 1;50(1):1-24. doi: 10.2165/11536640
13. H. I. Brunner, J. Huggins, M. Klein-Gitelman. Childhood-onset SLE - Towards A Comprehensive Management Plan. Nature Review Rheumatology 2011 Apr;7(4):225-33
14. Clovis A Silva, Tadej Avcin, and Hermine I Brunner. Taxonomy for Systemic Lupus Erythematosus with Onset before Adulthood. Arthritis Care and Research; in press.
Books / Chapters
1. H.I. Brunner: RFLP-Untersuchungen des DRB-Genortes sowie HLA-Klasse I und DRB-Assoziationen bei der seronegativen juvenilen chronischen Arthritis. University Press Ludwig Maximillians Universität, München, 1992.
2. H.I. Brunner. Investigation of the relationship between disease activity and disease damage in childhood-onset systemic lupus erythematosus. University of Toronto Press, 2001.
3. H.I. Brunner, E.D. Giannini. Therapy of Juvenile Arthritis. Koopman Textbook of Rheumatology. Saunders Publ.2004; 15
th edition Chapter 62, p1301-18.
4. Meller J, Adamczak R, Scola MP, Barnes M, Thompson SD, Passo MH, Brunner HI, Glass DN, Grom AA. Machine learning analysis of expression profiles in synovial tissue cytokines helps identify patients with systemic onset juvenile rheumatoid arthritis. 2006; a volume in the series Advances in Computational and Systems Biology, eds. J. Meller and W. Nowak, Peter Lang.
5. Rina Mina, H I. Brunner. Differences of adult and childhood-onset systemic lupus erythematosus. Clinical Manifestations of Childhood-onset SLE. 2010 Pediatric Rheumatology; Chapter 36, Systemic Lupus Erythematosus; 4t edition; Editors: R. Lahita and B. Hahn.
6. H.I. Brunner, E.D. Giannini. Design, Measurement and Clinical Investigations. Pediatric Rheumatology Cassidy Textbook; Editors: R Petty, R Laxer; 2010 ISBN-13: 978-1416002468
Radio Interviews:
1. Radio Oncogua, Angola; Information on new hospital in Cunene, Angola.
2. FM 1250, ―The Buzz‖; Health Show on Pediatric Systemic Lupus Erythematosus July 2003.
Invited Visits to Other Hospitals/Universities/Etc.
1. Outcome measures in pediatric systemic lupus erythematosus. Canadian Center for Lupus Outcome Studies, Toronto, Canada, December 2000.
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2. Outcome Measures in Pediatric SLE. Concurrent Session. AAP Winter-symposium 2003, Snowmass, CO.
3. Lupus in Action (NIH): Pediatric Rheumatology Studies. NIH, Bethesda. September 2003. Bethesda.
4. How do you know what is best for your pediatric patient with rheumatoid arthritis. Rheumatology Grand Rounds, University of Pittsburgh. October 2003.
5. Minimizing treatment side effects in children with SLE. 7th International Congress on SLE and
Related Diseases. May 2004.
6. Renal Biomarker of systemic lupus erythematosus. American College of Rheumatology Pediatric Winter Symposium March, 2008.
7. Health-related Quality of Life in Pediatric Rheumatic Diseases Brazilian Pediatric Congress, Maneio September 2008.
8. Reproductive Fitness and Renal Biomarkers in Pediatric Lupus Erythematosus. Brazilian Pediatric Congress, Maneio September 2008
9. Long-term Care of Children with Lupus. Pediatric Rheumatology Winter Symposium, Garmisch-Partenkirchen, Germany January 2009.
10. Novel Approaches to Neuroimaging in SLE. Pediatric Rheumatology Winter Symposium, Garmisch-Partenkirchen, Germany January 2009.
11. Biomarker Research in Pediatric SLE. Ohio State University, Immunology Grand Rounds, Columbus, Ohio, February 2009
12. Biomarker Research in Pediatric SLE. Children’s Memorial Hospital / Northwestern University, Illinois, February 2009.
13. Assessment and Therapy of lupus nephritis. Rheumatology Grand Rounds, Boston Children’s Hospital, May 2009.
14. Clinimetry on JSLE. 3rd Pediatric Rheumatology Congress, Colombia, Bogota, August 2009.
15. Difficult Cases of Juvenile Lupus Nephritis. 3rd Pediatric Rheumatology Congress, Colombia,
Bogota, August 2009.
16. Optimizing benefits and minimizing risk of treatment for JSLE. 3rd Pediatric Rheumatology
Congress, Colombia, Bogota, August 2009.
17. Transitions clinics. Rationale and methodology. as part of a symposium of pediatric rheumatologist for adult rheumatologists. 3
rd Pediatric Rheumatology Congress, Colombia, Bogota, August 2009.
18. Are children just little adults? The Management of Women with Chronic Immune Disorders. Chicago, September 2009.
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19. Clinical Symposium: Reproductive Issues with Adolescent SLE. American College of Rheumatology, Philadelphia; October 2009.
20. Pädriatrische Neuroimmunologie, Auotimmunität – das ZNS im Fokus: ZNS Lupus in Kinders und Jugendlichen; Germany, Halle, February 2010.
21. Biomarkers for Global and Renal Disease Activity in Juvenile Systemic Lupus Erythematosus (jSLE). Meet the Professor Session, 9
th International Congress on Systemic Lupus Erythematosus,
Vancouver, June 2010.
22. 14th Asian Pacific League Against Rheumatism. Differences between pediatric and adult onset systemic lupus erythematosus; Hong Kong July 2010.
23. 14th Asian Pacific League Against Rheumatism - Update on the management of childhood-onset systemic lupus erythematosus; Hong Kong July 2010.
24. 14th Asian Pacific League Against Rheumatism - Novel lupus nephritis biomarkers; Hong Kong July 2010.
25. 17th Pediatric Rheumatology European Congress, Valencia, Spain. – Juvenile Lupus Quality
Indicator; September 2010.
26. Ninth National Conference on Pediatric Rheumatology, Lucknow, Uttar Pradesh, India - Neuropsychiatric Lupus – Assessment, Treatment & Outcome; September 2011
27. Ninth National Conference on Pediatric Rheumatology, Lucknow, Uttar Pradesh, India - Newer biomarkers in SLE; September 2011
28. 18th Pediatric Rheumatology European Congress, Bruges, Belgium – Juvenile Lupus Quality
Indicator; September 2011.
29. 18th Pediatric Rheumatology European Congress, Bruges, Belgium – Measures of Activity &
Outcome in Pediatric Lupus.
30. Pediatric Grand Rounds, University of California in Los Angeles, Lupus Nephritis – Update of diagnosis, biomarkers and therapy; July 2012
31. Lupus In Children – What’s New; 2nd
Advanced Rheumatology Review Course, Abu Dhabi, United Arabic Emirates, October 2012.
Peer Reviewed Papers Read at Scientific Meetings
32. H.I. Brunner, Andreas, E.Keller, J.P.Haas et al. Significance of HLA-class I and DRB associations In JCA, 4th European Histocompatibility Conference, Paris 1990.
33. H.I. Brunner, M. Freedman, E.D. Silverman: Long-term anticoagulation is preferable for patients with antiphospholipid antibody syndrome. American College of Rheumatology Meeting, Boston 1999.
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34. H.I. Brunner, E.D. Silverman, T. To, C. Bombardier, B.M. Feldman. Accumulated disease activity and other risk factors of damage in childhood-onset systemic lupus erythematosus (cSLE). European Pediatric Rheumatology Meeting, Geneva 2000.
35. H.I. Brunner, E.D. Silverman, T. To, C. Bombardier, B.M. Feldman Accumulated disease activity and other risk factors of damage in childhood-onset systemic lupus Erythematosus (cSLE). American College of Rheumatology Meeting, Philadelphia 2000.
36. H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Housh, M Trombley, et al: The PedsQL, arthritis module can be used as a core response variable (CRV) in children with juvenile rheumatoid arthritis (JRA). American College of Rheumatology Meeting, San Francisco 2001.
37. H I Brunner, D Ibanez, D D Gladman, M D Urowitz, E D Silverman The same or different? Comparison of an inception cohort of childhood-onset versus adult systemic lupus erythematosus. AAP Winter Symposium 2003, Snowmass, CO.
38. T. Jackson, S. Foley, H.I. Brunner et al.: Measurement Properties of the Childhood Health Assessment Questionnaire (CHAQ) in the Evaluation of Physical Functioning in Children with Juvenile Rheumatoid Arthritis (JRA). American College of Rheumatology 2003; Orlando,FL.
39. H. I Brunner, A. C Barron, T B Graham, M H Passo, A L Johnson, J Lenihan, J Tsevat, D J Lovell, U R Kotagal. Effects of Treatment on Costs & Health-related Quality of Life (HRQL) of Children with Polyarticular Course Juvenile Rheumatoid Arthritis (JRA). American College of Rheumatology 2004; San Antonio, TX.
40. Mi Suzuki, K Wiers, K Haines, M Klein-Gitelman, J Olson, K O'Neil, K Onel, M Passo, N Singer, L
Tucker, S Nelson, P Devarajan, H. I. Brunner. New Biological Markers for Systemic Lupus Erythematosus (SLE) Renal Disease American College of Rheumatology 2007; Boston MA; S234.
41. H I Brunner, Ti M Sherrard, M S Klein-Gitelman. Cost of Treatment of Childhood-Onset Systemic Lupus Erythematosus (cSLE). 6th European Lupus Meeting, London, March 2005.
42. Svetlana Lvovich, Shannen Nelson, Natasha Ruth, Mark DiFrancesco, Scott Holland, Cal Adler,
Melissa DelBello, April German, Douglas Ris, Hermine I. Brunner: Functional Magnetic Resonance Imaging (fMRI) – Usefulness for the Diagnosis of Cognitive Impairment (CI) in Childhood-onset SLE (cSLE). American College of Rheumatology 2006; Washington, DC.
43. M Mueller, C Rutherford, M H Passo, A A Grom, J Mishra, P Devarajan H I. Brunner. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker of Nephritis in Childhood-onset Systemic Lupus Erythematosus. PAS Annual Meeting San Francisco 2006.
44. Michiko Suzuki, Kristina Wiers, Kathleen Haines, Marissa Klein-Gitelman, Judyann Olson, Kathleen O'Neil, Kathleen Onel, Murray Passo, Nora Singer, Lori Tucker, Shannen Nelson, Prasad
Devarajan, Hermine I. Brunner. Neutrophil Gelatinase Associated Lipocalin (NGAL) In Urine Predict the Course of Nephritis in Pediatric Systemic lupus erythematosus (pSLE). American Society of Nephrology; Philadelphia; 2008; SA−PO2937.
45. Claas H. Hinze, Michiko Suzuki, Marisa Klein-Gitelman, Murray Passo, Judyann Olson, Nora G. Singer, Kathleen A. Haines, Karen Onel, Kathleen O’Neil, Earl D. Silverman, Lori Tucker, Jun Ying,
Prasad Devarajan, Hermine I. Brunner. Neutrophil Gelatinase Associated Lipocalin (NGAL) In Urine Predicts the Course of Nephritis in Pediatric Systemic Lupus Erythematosus (pSLE). American College of Rheumatology 2008; San Francisco, CA; #1924.
46. Lena Das, Michiko Suzuki, P. Devarajan, Brad H. Rovin, Jun Ying and Hermine Brunner. Candidate Urinary Biomarkers May Predict Histological Features On Lupus Nephritis (LN) Biopsy . American College of Rheumatology 2008; Philadelphia, PA; #2005.
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47. Tsuyoshi Fukuda, A. Carmela Sagcal-Gironella, Kristina Wiers, Shareen Cox, Shannen Nelson,
Marisa Klein-Gitelman, Alexander A. Vinks and Hermine Brunner. Pharmacokinetics, pharmacodynamics and pharmacogenetics of mycophenolate mofetil in childhood systemic lupus erythematosus(cSLE 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) March, 2010; Atlanta. GA at the Atlanta Marriott Marqius, Atlanta, Georgia. # O1-A-3 .
48. Carmela Sagcal-Gironella, Tsuyoshi Fukuda, Kristina A. Wiers, Shareen Cox, Shannen Nelson,
Marisa Klein-Gitelman, Alexander A. Vinks and H. I Brunner. Variability of mycophenolic 1. acid (MPA) pharmacokinetics (PK) in childhood‐ onset systemic lupus erythematosus (cSLE) may be partly explained by UGT genotype. 9th International Congress on Systemic Lupus Erythematosus, Vancouver, June 2010.
49. F De Benedetti, H Brunner, N Ruperto, S Wright, A Kenwright, R Cuttica, P Woo, R Schneider, D Lovell, A Martini. Efficacy and Safety of Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis (sJIA): 12-week Data from the Phase 3 TENDER Trial, EULAR Meeting, Rome June 2010.
50. Rina Mina, Anne Eberhard , Emily von Scheven, Gloria Higgins , Sivia Lapidus, Jamie Eaton, Laura Schanberg, Karen Onel, Marilynn Punaro, Judyann Olson, Jun Ying, Marisa Klein-Gitelman,
and Hermine Brunner Defining Flares in Juvenile Systemic Lupus Erythematosus. 9th
International Congress on Systemic Lupus Erythematosus, Vancouver, June 2010.
51. Carmela Sagcal-Gironella, Tsuyoshi Fukuda, Kristina A. Wiers, Shareen Cox, Shannen Nelson,
Marisa Klein-Gitelman, Alexander A. Vinks and Hermine Brunner Variability of mycophenolic acid (MPA) Pharmacokinetics (PK) in childhood onset systemic lupus erythematosus (cSLE) may be partly explained by UGT genotype. 9th International Congress on Systemic Lupus Erythematosus, Vancouver, June 2010.
52. Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Inmaculada Calvo, Ruben Cuttica, Clara Malattia, Rayfel Schneider, Patricia Woo, Carine H. Wouters, Ricardo Xavier, Lawrence S. Zemel, Stephen Wright, Andrew Kenwright, Alberto Martini, Daniel J. Lovell. Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis: Efficacy Data from the Placebo-Controlled 12-Week Part of the Phase 3 TENDER Trial. 17
th Pediatric Rheumatology European Society Meeting, 2010, Atlanta;
O14.
53. Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Inmaculada Calvo, Ruben Cuttica, Clara Malattia, Rayfel Schneider, Patricia Woo, Carine H. Wouters, Ricardo Xavier, Lawrence S. Zemel, Stephen Wright, Andrew Kenwright, Alberto Martini, Daniel J. Lovell. Tocilizumab is Efficacious in Patients with Systemic Juvenile Idiopathic Arthritis (sJIA) Across Basline Disease Characteristics and Prio/ Baseline Treatments; 17
th Pediatric Rheumatology European Society Meeting, 2010,
Valencia, Spain; O13.
54. Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Inmaculada Calvo, Ruben Cuttica, Clara Malattia, Rayfel Schneider, Patricia Woo, Carine H. Wouters, Ricardo Xavier, Lawrence S. Zemel, Stephen Wright, Andrew Kenwright, Alberto Martini, Daniel J. Lovell. Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis: Efficacy Data from the Placebo-Controlled 12-Week Part of the Phase 3 TENDER Trial. 17
th Pediatric Rheumatology European Society Meeting, 2010,
Valencia, Spain
55. Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Inmaculada Calvo, Ruben Cuttica, Clara Malattia, Rayfel Schneider, Patricia Woo, Carine H. Wouters, Ricardo Xavier, Lawrence S. Zemel, Stephen Wright, Andrew Kenwright, Alberto Martini, Daniel J. Lovell. Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis: Efficacy Data from the Placebo-Controlled 12-Week Part of the Phase 3 TENDER Trial. American College of Rheumatology Annual Meeting, 2010, Atlanta.
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56. Rina Mina, Michael Bennett, Joseph M Ahearn, Joshua Pendl, Jamie Eaton, Nicole Wilson, Prasad
Devarajan, Hermine Brunner. Biomarkers for Global and Renal Disease Activity in Juvenile Systemic Lupus Erythematosus (jSLE). American College of Rheumatology Annual Meeting, 2010, Atlanta.
57. F. de Benedetti, H. Brunner, N. Ruperto, I. Calvo, R. Cuttica,C. Malattia, R. Schneider, P.Woo, C.Wouters, R. Xavier, L. Zemel, S. Wright, A. Kenwright, D. Lovell, A. Martini. Efficacy and safety of tocilizumab (TCZ) in patients. (PTS) with systemic juvenile idiopathic arthritis (SJIA): tender 52-week data Abstract N° OP0006; EULAR 2011, London.
58. Rina Mina, Laura E. Schanberg, Marisa Klein-Gitelman, B. Anne Eberhard, Gloria Higgins, Karen Onel, Nora G. Singer, Kathleen M. O'Neil, Deborah M. Levy, Shannen L. Nelson, Wajeeha Yousaf, Rubén J. Cuttica, Lori B. Tucker, BC Childrens Hospital, Michael W. Beresford, Graciela Espada,
Angelo Ravelli, Alberto Martini, Edward H. Giannini, and Hermine Brunner, Defining Clinical Remission and Inactive Disease in Juvenile Systemic Lupus Erythematosus. American College of Rheumatology; Chicago, IL, USA; #2454
59. Marisa Klein-Gitelman, Adlin Cedeno, Aimee Baker, Frank Zelko, Dean Beebe, Blair Dina, Anna
Carmela P. Sagcal-Gironella, Darren Gitelman, Hermine Brunner, Mark Difrancesco and Brian Zappia Distinct Functional Activation and Connectivity Patterns for a Visuo-Constructional Task in Childhood-Onset Systemic Lupus Erythematosus and Matched Controls American College of Rheumatology ; Chicago, IL, USA; #2456
60. Hermine Brunner, Nicolino Ruperto, Gerd Horneff, Pierre Quartier, Tamás Constantin, Yackov Berkun, Tilmann Kallinich, Riva Brik, Manuel A. Ferrandiz, Karine Lheritier, Ralph Preiss, Lillian Tseng, Daniel J. Lovell, Alberto Martini, Paediatric Rheumatology International Trials Organisation and Pediatric Rheumatology Collaborative Study Group [PRCSG]. Phase III Study Results on the Efficacy and Safety of Canakinumab, a Long-Acting, Fully Human Anti-Interleukin-β Antibody, in Systemic Juvenile Idiopathic Arthritis with Active Systemic Features. American College of Rheumatology; Chicago, IL, USA; #2622
61. Rina Mina, Hermine Brunner, B. Anne Eberhard, Marilynn G. Punaro, Stacy P. Ardoin, Marisa Klein-Gitelman, Lakshmi N. Moorthy, Suhas M. Radhakrishna, Mindy S. Lo, Matthew C. Hollander, Eyal Muscal, Joyce J. Hsu, Linda Wagner-Weiner, Deborah M. Levy, Carol Wallace, Norman T. Ilowite, and Emily von Scheven. Developing Consensus Treatment Plans for Proliferative Nephritis in Juvenile Systemic Lupus Erythematosus: Maintenance Therapy. American College of Rheumatology; Chicago, IL, USA; # 2624
62. Fabrizio De Benedetti, Hermine Brunner, Roger Allen, Diane Brown, Jeffrey Chaitow, Manuela Pardeo, Graciela Espada, Berit Flatø, Gerd Horneff, Clare Devlin, Andrew Kenwright, Rayfel Schneider, Patricia Woo, Alberto Martini, Daniel Lovell and Nicola Ruperto, Ospedale Pediatrico Bambino Gesù, Rome, Italy, Pediatric Rheumatology Collaborative Study Group [PRCSG]. Tocilizumab Is Efficacious in Patients with Systemic Juvenile Idiopathic Arthritis Across Baseline Demographic and Disease Characteristics and Prior/Baseline Treatments: -Week Data From a Phase Clinical Trial American College of Rheumatology ; Chicago, IL, USA; #2621
63. Marisa Klein-Gitelman, Adlin Cedeno, Aimee Baker, Frank Zelko, Dean Beebe, Blair Dina, Anna
Carmela P. Sagcal-Gironella, Darren Gitelman, Hermine Brunner, Mark Difrancesco and Travis Beck. Brain Morphometric Changes Associated with Childhood-Onset Systemic Lupus Erythematosus and Neurocognitive Deficit American College of Rheumatology; Chicago, IL, USA; #751
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Other Lectures or Papers Given
1. Validation of Pediatric Outcome Measures. Institute for Health Research and Health Services; Cincinnati, OH. September 2001.
2. Cost-effectiveness and Outcome of JRA patients on MTX and Enbrel. Institute of Health Policy and Health Services Research, University of Cincinnati. February 2004.
3. Systemic Lupus Erythematosus and Antinuclear antibodies. Scioto Medical Association. March 2006
4. My child is limping. Arthritis Foundation of Ohio Valley. March 2006.
5. Renal Biomarker for SLE. Alliance for Lupus Research Science Meeting, May 2006.
6. Decision Model for Enbrel use in Juvenile Arthritis. University of Cincinnati, Grand Rounds, 24th
May 2006:
7. Renal Biomarker for SLE. Alliance for Lupus Research Science Meeting, May 2007.
8. Neuropsychiatric Lupus University of Cincinnati, Immunology Grand Rounds, March 2008.
9. Pediatric & Young Adult Lupus Care - Renal Biomarker Research at CCHMC. University of Cincinnati, Nephrology Grand Rounds, February 2009.
10. Childhood SLE – Keynote for Annual Lupus Symposium, Lupus Foundation, Richmond Virginia; October 2009
11. Lupus Nephritis Biomarkers. University of Cincinnati, Immunology Grand Rounds, February 2010
12. Tocilizumab therapy in JIA. University of Cincinnati, Immunology Grand Rounds, February 2011
Poster Presentations, Scientific Exhibits
64. E.D. Albert, S. Scholz, J.P. Haas, H.I. Brunner et al: HLA-Class II Haplotypes determined by RFLP typing in JCA. 7th International Congress of Immunology, Berlin 1989.
65. Andreas, E.Keller, J.P.Haas ,H. Brunner et al: RFLP Typing for HLA Class II Five point haplotypes:DRA, DRB, DQA1, DQB1, DQA2. 7th International Congress of Immunology, Berlin 1989.
66. E.D. Albert, J.P. Haas, H.I. Brunner: The Role of HLA Associations in the Pathogenesis of JCA. 1st International Congress for Pediatric Rheumatology, Prague 1989.
67. J.P. Haas, H.I. Brunner et al: RFLP determined HLA class II Haplotypes in JCA. 4th European Histocompatibility Conference, Paris 1990.
68. H. Brunner, A. Andreas, E. Keller, J.P. Haas, E.D. Albert: HLA - Assoziationen bei der juvenilen chronischen Arthritis’, 6. Süddeutsche Rheumatologische Tagung, Garmisch-Patenkirchen (Germany) 1993.
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69. H.I. Brunner, B. Feldman, C. Bombardier, E.D. Silverman: The SLEDAI, SLAM, and BILAG are Sensitive Measures to Evaluate Clinical Chance in Childhood Onset Systemic Lupus Erythematosus. 6th International Pediatric Rheumatology Symposium, Parkcity (USA), 1998.
70. H.I. Brunner, B. Feldman, C. Bombardier, E.D. Silverman: The SLEDAI, SLAM, and BILAG are Sensitive Measures to Evaluate Clinical Chance in Childhood Onset Systemic Lupus Erythematosus. 5th International Conference on Systemic Lupus Erythematosus, Cancun (Mexico) 1998.
71. H.I. Brunner, B. Feldman, C. Bombardier, E.D. Silverman: The SLEDAI, SLAM, and BILAG are Sensitive Measures to Evaluate Clinical Chance in Childhood Onset Systemic Lupus Erythematosus. American College of Rheumatology Conference, San Diego (USA), 1998.
72. H.I. Brunner, E.D. Silverman, J. Ginsberg, B.M. Feldman: Long-Term Anticoagulation Is Preferable In Patients With Antiphospholipid Antibody Syndrome After The First Thrombotic Event. European League of Rheumatology Conference Glasgow (UK) 1999.
73. H.I. Brunner, M. Freedman, E.D. Silverman: Thrombotic Thrombocytopenic Purpura are closely related in childhood. European League of Rheumatology Conference Glasgow (UK) 1999.
74. H.I. Brunner, D. Maher, B. Grundland, N.L. Young, V. Blanchette, A-M. Stain, B.M. Feldman: Can We Measure Utilities/ Health Related Quality Of Life (HRQL) In Children With Musculoskeletal Disorders (MSKD)? American College of Rheumatology Meeting, Boston 1999.
75. H. I. Brunner, J. Taylor, A. Grom, E. Schorry, M.H. Passo: Case Report Of A Patient With CATCH 22 Sequence: Hematologic And Bony Abnormalities. The Chronic Arthritis Responds To Etanercept. European Pediatric Rheumatology Meeting, Geneva (CH) 2000.
76. E. K. Schorrey, H.M. Scaal, M.H. Passo, H.I. Brunner. Autoimmune disorders in Velo-Cardio-Facial Syndrome. Symposium of in Velo-Cardio-Facial Syndrome, Philadelphia, 2000.
77. H.I. Brunner, E.D. Silverman, C. Bombardier, B.M. Feldman: The ECLAM May Be More Responsive Than The SLEDAI And Can Be Used To Predict Damage In Childhood-Onset Systemic Lupus Erythematosus (cSLE). European Pediatric Rheumatology Meeting, Geneva (CH) 2000.
78. H.I. Brunner, E.D. Silverman, T. To, C. Bombardier, B.M. Feldman: Accumulated Disease Activity And Other Risk Factors of Damage In Childhood-Onset Systemic Lupus Erythematosus (cSLE). European Pediatric Rheumatology Meeting, Geneva 2000.
79. H.I. Brunner, E.D. Silverman, T. To, C. Bombardier, B.M. Feldman: Accumulated disease activity and other risk factors of damage in childhood-onset systemic lupus Erythematosus (cSLE). American College of Rheumatology Meeting, Philadelphia 2000.
80. H.I. Brunner, D.J. Lovell, E.D. Giannini: Preliminary Criteria For Defining Disease Flare In Patients With Juvenile Rheumatoid Arthritis (JRA). European Pediatric Rheumatology Meeting, Geneva (CH) 2000.
81. H.I. Brunner, E.D. Silverman, C. Bombardier, B.M. Feldman: The ECLAM May Be More Responsive Than The SLEDAI And Can Be Used To Predict Damage In Childhood-Onset Systemic Lupus Erythematosus (cSLE). American College of Rheumatology Meeting, Philadelphia 2000.
82. H.I. Brunner, A.I. Tomasi, T.M. Sherrard, J. Taylor, M.H. Passo, T.B. Graham and D.J. Lovell: Effectiveness and safety of etanercept for the treatment of juvenile rheumatoid arthritis (JRA) in clinical practice. American College of Rheumatology Meeting, San Francisco 2001.
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83. H.I. Brunner, O. Jones, D.J. Lovell, A.M. Tomasi, M.S. Klein-Gitelman: Lupus headaches (LHA) and their impact on disease activity measured by the SLEDAI and the prediction of damage (SLICC) in juvenile systemic lupus erythematosus (jSLE). American College of Rheumatology Meeting, San Francisco 2001.
84. H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Housh, M Trombley, et al: What is the minimal clinically important difference in worsening of the childhood health assessment questionnaire (MCIDCHAQ)? American College of Rheumatology Meeting, San Francisco 2001.
85. H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Housh, M Trombley, et al: Are parents good proxy reporter for children with chronic musculoskeletal disorders (MSKD)? American College of Rheumatology Meeting, San Francisco 2001.
86. H.I. Brunner, B. Wright, B.M. Feldman, M.B. Urowitz, D.D. Gladman: Preliminary item weightings for Systemic Lupus International Collaboration Clinics/ American College of Rheumatology Damage Index (SLICC) for adults with systemic lupus erythematosus (SLE). American College of Rheumatology Meeting, San Francisco 2001.
87. G. Fan, H.I. Brunner, R.R. Singh: Genetic vaccination using VH-derived CTL epitopes ablates autoantibody-secreting B cells and ameliorates. American College of Rheumatology Meeting, San Francisco 2001.
88. H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Housh, M Trombley, et al: The PedsQL, arthritis module can be used as a core response variable (CRV) in children with juvenile rheumatoid arthritis (JRA). American College of Rheumatology Meeting, San Francisco 2001.
89. E.H. Giannini EH, C. Wallace, H.I. Brunner for the CARRA Network. Barriers to Participation in Clinical Research Within the US Pediatric Rheumatology Community. American College of Rheumatology Meeting New Orleans, 2002.
90. Tsz-Leung Lee, Janalee L Taylor, Terry M Moore, Paula G Melson, Daniel J Lovell, Murray H
Passo, Thomas B Graham, H.I. Brunner. Initial Validation of the Willingness To Pay (WTP) Technique for Measuring Health Care Preferences In Juvenile Rheumatoid Arthritis (JRA). American College of Rheumatology Meeting New Orleans, 2002.
91. H.I. Brunner, A. Barron, Janalee L Taylor, Terry M Moore, Paula G Melson, Daniel J Lovell, Murray H Passo, Thomas B Graham. Initial Validation of the Willingness To Pay (WTP) Technique for Measuring Health Care Preferences In Juvenile Rheumatoid Arthritis (JRA). AAP Winter Symposium 2003, Snowmass.
92. H I Brunner, MD MSc, M V Paterno, PTMS ATC, P G Melson, PTMS, K R Ford, MSc, T E Hewett, MD PhD, D J Lovell, MD MPH and G D Myer, MSc. Pilot study: improvement of joint use of a patient with quiescent juvenile idiopathic arthritis after focused athletic training based on biodynamic testing. AAP Winter Symposium 2003, Snowmass.
93. E H Giannini, C A Wallace, H I Brunner, for the Childhood Arthritis & Rheumatology Research Alliance. Barriers to participation in clinical research within the use pediatric rheumatology community. AAP Winter Symposium 2003, Snowmass. (http://www.pedrheumonlinejournal.org/August/Pediatric%20Rheumatology/180.htm)
94. H I Brunner, A C Barron, T M Moore, M H Passo, D J Lovell. Gastrointestinal symptoms and health-related quality of life in juvenile idiopathic arthritis. ISPOR 2003, Arlington, Virginia. Winter Symposium 2003, Snowmass.
95. H I Brunner, A C Barron, T M Moore, M H Passo, D J Lovell. Gastrointestinal symptoms and health-related quality of life in juvenile idiopathic arthritis. ISPOR 2003, Arlington, Virginia.
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96. LG Rider, E Giannini, H Brunner, N Ruperto, A Reed, P Lachenbruch, F Miller, for the IMACS Group. Preliminary definitions of improvement for adult and juvenile myositis. Ann Rheum Dis. 2003; 62 (suppl).: 32
97. H I Brunner, A C Barron, T M Moore, M H Passo, D J Lovell. Gastrointestinal symptoms and health-related quality of life in juvenile idiopathic arthritis. American College of Rheumatology 2003;Orlando,FL.
98. H I Brunner, D Ibanez, D D Gladman, M D Urowitz, E D Silverman The same or different? Comparison of an inception cohort of childhood-onset versus adult systemic lupus erythematosus. American College of Rheumatology 2003; Orlando,FL.
99. Saijla Manne, H.I. Brunner, Anne-Barbara Mongey: Are there Clinical Risk Factors for Osteoporosis in Older Men? American College of Rheumatology 2003; Orlando,FL.
100. Chet Otis, LG Rider, E Giannini, H Brunner, N Ruperto, A Reed, P Lachenbruch, F Miller: Development of Consensus Criteria on the Conduct of Clinical Trials in Adult and Juvenile Idiopathic Inflammatory Myopathy (IIM); American College of Rheumatology 2003; Orlando,FL.
101. L. Rider, E. Giannini, H. Brunner, N. Ruperto, A. Reed, L. James-Newton, T. Sanghvi, M. Cronin, I. Garcia-de la Torre, D. Isenberg, L. Kagen, T. Levine, I. Lundberg, C. Oddis, S. Rutkove, K. Sivakumar, Y. Song, I. Targoff, J. Vencovsky, R. Wortmann, S. Ytterberg, P. Lachenbruch, F. Miller, for the International Myositis Assessment and Clinical Studies (IMACS) Group. Preliminary Definitions of Improvement for Adult Myositis. American College of Rheumatology 2003; Orlando,FL.
102. L. Rider, E. Giannini, H. Brunner, N. Ruperto, A. Reed, L. James-Newton, T. Sanghvi, B. Feldman, R. Finkel, A. Huber, C. Lindsley, D. Lovell, P. Malleson, L. Pachman, M. Passo, C. Pilkington, R. Rennebohm, B. Russman, D. Sherry, R. Sundel, P. Lachenbruch, F. Miller, for the International Myositis Assessment and Clinical Studies (IMACS) Group. Preliminary Definitions of Improvement for Juvenile Myositis; American College of Rheumatology 2003; Orlando,FL.
103. Hermine I Brunner, Marisa S Klein-Gitelman, Anne L Johnson, Olcay Y Jones, Earl D Silverman. Frequency of disease flare in childhood-onset systemic lupus erythematosus (SLE). 7
th
International SLE & Related Disease Congress. Lupus 2004: 13 (suppl).
104. Amita Bishnoi, Andrea C Barron, T Brent Graham, Murray H Passo, Frederick Strife, Anne-
Barbara Mongey, Lawrence J Houk, Hermine I Brunner. Long-term outcomes of childhood-onset systemic lupus erythematosus (cSLE). 7
th International SLE & Related Disease Congress. Lupus
2004: 13 (suppl).
105. Sri Koneru, Anne-Barbara Mongey, Yolanda Farhey, Evelyn V Hess, Douglas Lienesch, Avis
Ware, Lawrence J Houk, Hermine I Brunner. The unmeasured lupus outcome - compliance with medication. 7
th International SLE & Related Disease Congress. Lupus 2004: 13 (suppl).
106. Hermine I Brunner, Paula G Melson, Kevin R Ford, Shannon C Darnell, Greg D Myer, Julie V Ranz, Timothy E Hewett. Improved Assessment of Physical Function in Children with Juvenile Idiopathic Arthritis (JIA) using Biomechanical Testing (BMeT). American College of Rheumatology 2004; San Antonio. TX.
107. Sri Koneru, Anne-Barbara Mongey, Yolanda Farhey, Evelyn V Hess, Douglas Lienesch, Avis
Ware, Lawrence J Houk, Hermine I Brunner. The Unmeasured Lupus Outcome - Compliance with Medications. American College of Rheumatology 2004; San Antonio. TX.
108. Janalee Taylor Hermine I Brunner, T Brent Graham, Melinda S Corcoran, Sandy L Kramer, Paula G Melson, Uma R Kotagal, Maria L Britto and Murray H Passo. Health Disparity in Juvenile
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Rheumatoid Arthritis (JRA): Impact of Socioeconomic Status (SES) on Patient Outcomes. American College of Rheumatology 2004; San Antonio. TX.
109. Amita Bishnoi, Andrea C Barron, T Brent Graham, Murray H Passo, Lawrence J Houk, Anne-
Barbara Mongey, Frederick Strife, Hermine I Brunner. Long-Term Outcomes Of Childhood-Onset Systemic Lupus Erythematosus (cSLE). American College of Rheumatology 2004; San Antonio. TX.
110. Paula G Melson, Hermine I Brunner, Kevin R Ford, Shannon C Darnell, Greg D Myer, Julie V Ranz, Timothy E Hewett. Improved Assessment of Physical Function in Children with Juvenile Idiopathic Arthritis (JIA) using Biomechanical Testing (BMeT). American College of Rheumatology 2004; San Antonio. TX.
111. Hermine I Brunner, Tina M Sherrard, Marisa S Klein-Gitelman. Cost of Treatment of Childhood-Onset Systemic Lupus Erythematosus (cSLE). American College of Rheumatology 2004; San Antonio. TX.
112. M. Passo, Janalee Taylor, Hermine I Brunner, Melinda S Corcoran, Maria L Britto, Uma R Kotagal. Poverty Is Associated with Worse Outcomes in Juvenile Rheumatoid Arthritis (JRA) Despite Similar Use of Advanced Therapies. PAS Annual Meeting, Washington, DC, May 2005
113. M. Passo, Janalee Taylor, Hermine I Brunner, Melinda S Corcoran, Maria L Britto, Uma R Kotagal. Poverty Is Associated with Worse Outcomes in Juvenile Rheumatoid Arthritis (JRA) Despite Similar Use of Advanced Therapies. PAS Annual Meeting, Washington, DC, May 2005
114. Paula G Melson, Hermine I Brunner, Kevin R Ford, Shannon C Darnell, Greg D Myer, Julie V Ranz, Timothy E Hewett. The Use of Three Dimensional Motion Analysis (MA) to Improve Objective Measurement of Lower Extremity Joint Function and Detect Clinical Changes in Children with Juvenile Idiopathic Arthritis (JIA). American College of Rheumatology 2005; San Diego. CA.
115. Hermine I. Brunner, T.Brent Graham, Cynthia Rutherford, Anne Johnson, Murray H. Passo, Daniel J. Lovell, and Uma R. Kotagal. Change in the Outcomes of Polyarticular-Course Juvenile Rheumatoid Arthritis (JRA) during the Last Decade. American College of Rheumatology 2005; San Diego, CA.
116. Hermine I. Brunner, Marisa S. Klein-Gitelman, Thomas A. Griffin, Alexei Grom, Shannen Nelson, Murray H. Passo, Tina M. Sherrard, Lori Tucker, David Cabral. Diane Hebert, Elizabeth Harvey, T. Brent Graham, Earl D. Silverman. Current Use of Prednisone in Childhood-onset Systemic Lupus Erythematosus (cSLE). American College of Rheumatology 2005; San Diego, CA.
117. Paula G. Melson, Hermine I. Brunner, Kevin R. Ford, Greg D. Myer, Shannon C. Darnell, Julie V. Ranz, Timothy E. Hewitt. The use of three dimensional motion analysis (MA) to improve objective measurement of lower extremity biomechanics and detect clinical changes in these measures with juvenile idiopathic arthritis (JIA). American College of Rheumatology 2005; San Diego, CA.
118. Michael Shishov, Kelly A. Rouster-Stevens, Gloria C. Higgins, Robert M. Rennebohm, Dorothy
W. Wortmann, Rita Jerath, Ekhlas Alhumoud, Hermine I. Brunner, Richard J. Mier. Pediatric Onset Mixed Connective Tissue Disease (p-MCTD) in North America. American College of Rheumatology 2005; San Diego, CA.
119. Richard Mier, Hermine Brunner, Alan Rosenberg, Carol Wallace Diagnostic Predictors of Poor Outcome of Uveitis associated with Juvenile Idiopathic Arthritis (JIA). American College of Rheumatology 2005; San Diego, CA.
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120. Janalee Taylor, Paula Melson, T. Brent Graham, Hermine Brunner, Daniel Lovell, Terry Moore, Melinda Corcoran, Sandy Kramer, Maria Britto, Uma Kotagal, Murray Passo Integration of Quality Improvement in Pediatric Rheumatology Academic Subspecialty: Balancing the Missions. American College of Rheumatology 2005; San Diego, CA.
121. Ndate Fall, Kevin E. Bove, Keith Stringer, Daniel J. Lovell, Hermine I. Brunner, Jennifer Weiss, Gloria C. Higgins, Susanne L. Bowyer, T. Brent Graham, Sherry Thornton, Alexei A. Grom. High Expression of Angiostatic ELR-Negative CXC-Chemokines: Possible Link to Vasculopathy in Juvenile Dermatomyositis. American College of Rheumatology 2005; San Diego, CA.
122. M Mueller, C Rutherford, M H Passo, A A Grom, J Mishra, P Devarajan H I. Brunner. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker of Nephritis in Childhood-onset Systemic Lupus Erythematosus. PAS Annual Meeting San Francisco 2006
123. Brandie Heald, Hermine Brunner, Marta B. Moroldo, Anne Lovell, David N. Glass. Mothers of kids with juvenile rheumatoid arthritis: Assessment of Reproductive Fitness Questionnaire. National Society of Genetic Counselors (NSGC). Atlanta, GA. J of Genetic Counseling 2006 (12).
124. Nathasha Ruth, April German, T. Brent Graham, Murray Passo, Douglas Ris, Hermine I.
Brunner: Diagnosis Of Childhood-Onset Lupus Neurocognitive Impairment in a Clinical Setting: Usefulness of Computer Based Testing and Self-Report. American College of Rheumatology 2006; Washington, DC.
125. Laura Nabors, Thomas Griffin, Hermine Brunner. Cognitive Behavioral Therapy for Managing Pain in Juvenile Idiopathic Arthritis. Kansas Conference of Clinical Child and Adolescent Psychology 2006.
126. Svetlana Lvovich, Shannen Nelson, Natasha Ruth, Mark DiFrancesco, Scott Holland, Cal Adler,
Melissa DelBello, April German, Douglas Ris, Hermine I. Brunner: Functional Magnetic Resonance Imaging (fMRI) – Usefulness for the Diagnosis of Cognitive Impairment (CI) in Childhood-onset SLE (cSLE). American College of Rheumatology 2006; Washington, DC.
127. Michiko Suzuki, G Ross, H Brunner, P Devarajan: Identification of signature urinary biomarker patterns in lupus nephritis sub-types. ASN's 39th Annual Renal Week. San Diego 2006.
128. Maria Thomas-John, Hermine I. Brunner, Nelson Watts, Anne-Barbara Mongey: How Important is Determining Bone Mineral Density (BMD) in Evaluating the Risk for Fracture in Older Males? American College of Rheumatology 2006; Washington, DC.
129. Michiko Suzuki, Kristina Wiers, Kathleen Haines, Marissa Klein-Gitelman, Judyann Olson, Kathleen O'Neil, Kathleen Onel, Murray Passo, Nora Singer, Lori Tucker, Shannen Nelson,
Prasad Devarajan, Hermine I. Brunner. New Biological Markers for Systemic Lupus Erythematosus (SLE) Renal Disease American College of Rheumatology 2007; Boston MA; S234.
130. Michiko Suzuki, Kristina Wiers, Kathleen Haines, Marissa Klein-Gitelman, Judyann Olson, Kathleen O'Neil, Kathleen Onel, Murray Passo, Nora Singer, Lori Tucker, Shannen Nelson,
Prasad Devarajan, Hermine I. Brunner. Neutrophil Gelatinase Associated Lipocalin (NGAL) in Plasma and Urine Change with Disease Activity in Pediatric Lupus (pSLE). American College of Rheumatology 2007; Boston MA; S235.
131. Kristina Wiers, Marisa S. Klein-Gitelman, Gloria C. Higgins, Shannen Nelson, T. Brent Graham, Jamie Meyers-Eaton, Sivia K. Lapidus, Jay Nocton, Karen Onel, Judyann C. Olson, Marilynn
Punaro, Hermine I. Brunner. Health-Related Quality of Life (HRQoL) and Its Relationship to Patient Disease Course in Pediatric Systemic Lupus Erythematosus (pSLE) American College of Rheumatology 2007; Boston MA; S236.
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132. L. E. Schanberg, C. Sandborg, S. P. Ardoin, K. L. Mieszkalski, E. Yow, N. T. Ilowite, A. Eberhard, D. M. Levy, Y. Kimura, E. von Scheven, E. Silverman, S. L. Bowyer, L. Punaro, N. G. Singer, D.
Sherry, D. McCurdy, M. Klein-Gitelman, C. Wallace, R. Silver, L. Wagner-Weiner, G. Higgins, H.
I. Brunner, L. Jung, J Soep A Reed, H. Barnhart. Predictors of Increased Carotid Intima Medial Thickness (CIMT) in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) American College of Rheumatology 2007; Boston MA ; L8/524 .
133. Deborah M. Levy, Tresa M. Roebuck-Spencer, Cynthia Aranow, Hermine I. Brunner. The Pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) in Childhood-Onset Systemic Lupus Erythematosus (cSLE) - No Significant Practice Effect in First Three Trials American College of Rheumatology 2007; Boston MA; S883.
134. Hermine I. Brunner, Gloria C. Higgins, Jun Ying, Kristina Wiers, T Brent Graham, Sivia K. Lapidus, Jay Nocton, Karen Onel, Marilynn Punaro, Judyann Olson, Marisa Klein-Gitelman. Sensitivity & Specificity of Adult Lupus Flare Measures When Used in Pediatric Systemic Lupus Erythematosus. American College of Rheumatology 2007; Boston MA S885.
135. Daniel McLinden, Paula Melson, , Shannon Darnell, Sandy Kramer, Hermine I. Brunner. Revision of the Childhood Health Assessment Questionnaire (CHAQ) for the Improved Evaluation of Physical Functioning (PF) with Juvenile Idiopathic Arthritis (JIA) American College of Rheumatology 2007; Boston MA; S912.
136. Lakshmi P. Kocharla, Janalee Taylor, Murray H. Passo, Brent T. Graham, Lukasz Itert, Tracy Weiler, Hermine Brunner. Monitoring Of Methotrexate Toxicity In Pediatric Population. Keystone ACR 2008
137. Frank Zelko, Marisa S. Klein-Gitelman, Deborah Levy, Laura Schanberg, Kelly Anthony, Hermine
I. Brunner, Gail Ross. Standardizing the Neuropsychological Evaluation of Children with Systemic Lupus Erythematosus. Keystone ACR 2008; #136.
138. Kristina Wiers, Marisa S. Klein-Gitelman, Gloria C. Higgins, Shannen Nelson, T. Brent Graham, Jamie Meyers-Eaton, Sivia K. Lapidus, Jay Nocton, Karen Onel, Judyann C. Olson, Marilynn
Punaro, Hermine I. Brunner. Neutrophil Gelatinase Associated Lipocalin (NGAL) in Plasma and Urine Change with Disease Activity in Pediatric Lupus (pSLE). Keystone ACR 2008; #120.
139. Kristina Wiers, Marisa S. Klein-Gitelman, Gloria C. Higgins, Shannen Nelson, T. Brent Graham, Jamie Meyers-Eaton, Sivia K. Lapidus, Jay Nocton, Karen Onel, Judyann C. Olson, Marilynn
Punaro, Hermine I. Brunner. Health-Related Quality of Life (HRQoL) and Its Relationship to Patient Disease Course in Pediatric Systemic Lupus Erythematosus (pSLE) Keystone ACR 2008; #121.
140. Laura E. Schanberg, Christy Sandborg, Stacy P. Ardoin, Kelly L. Mieszkalski, Eric Yow, Norman T. Ilowite, Anne Eberhard, Deborah M. Levy, Yukiko Kimura, Emily von Scheven, Earl Silverman, Suzanne L. Bowyer, Lynn Punaro, Nora G. Singer, David Sherry, Deborah McCurdy, Marissa
Klein-Gitelman, Carol Wallace, Richard Silver, Linda Wagner-Weiner, Gloria Higgins, Hermine I.
Brunner, Lawrence Jung, Jennifer Soep Ann Reed, Huiman Barnhart. Childhood Arthritis and Rheumatology Research Alliance, (CARRA), CA. Predictors of Increased Carotid Intima Medial Thickness (CIMT) in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort. Keystone ACR 2008; #129
141. Laura E. Schanberg, Christy Sandborg, Stacy P. Ardoin, Kelly L. Mieszkalski, Eric Yow, Norman T. Ilowite, Anne Eberhard, Deborah M. Levy, Yukiko Kimura, Emily von Scheven, Earl Silverman, Suzanne L. Bowyer, Lynn Punaro, Nora G. Singer, David Sherry, Deborah McCurdy, Marissa
Klein-Gitelman, Carol Wallace, Richard Silver, Linda Wagner-Weiner, Gloria Higgins, Hermine I.
Brunner, Lawrence Jung, Jennifer Soep Ann Reed, Huiman Barnhart. Childhood Arthritis and
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Rheumatology Research Alliance, (CARRA), CA. Associations Between Race/Ethnicity and Clinical SLE Features in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort. Keystone ACR 2008; #130.
142. Hermine Brunner, Frank Zelko, Deborah Levy, Laura Schanberg, Kelly Anthony, Gail Ross, Marisa S. Klein-Gitelman,. Standardizing the Neuropsychological Evaluation of Children with Systemic Lupus Erythematosus. 7
th European Lupus Congress, Amsterdam. Lupus 2008; 17.
#32; p 467.
143. Kathleen M. O'Neil, Lauren M. Kickingbird, Hermine I. Brunner, Marilynn Punaro, Suzanne C. Li, Barry L. Myones, Andrew S.Zeft. Clinical Features of Pre Pubertal Onset Systemic Lupus Erythematosus in Girls. American College of Rheumatology 2008; San Francisco, CA, #232.
144. A Carmela Sagcal, Sivia K. Lapidus, Gloria C. Higgins, Jun Ying, T Brent Graham, Karen Onel,
Marilynn Punaro, Judyann Olson, Marisa Klein-Gitelman, Hermine I. Brunner. Minimal Clinically Important Difference (MCID) of SLE Disease Activity Measures When Used In Juvenile Systemic Lupus Erythematosus (jSLE). American College of Rheumatology 2008; San Francisco, CA. #225.
145. Shannen Nelson, Kristina Wiers, Blair Dina, Jamie Meyers-Eaton, Shirley Henry, Sivia K.
Lapidus, Marsha Malloy, Catherine A McGraw, Becky Pupluva, Gloria Higgins, Hermine
Brunner. Relationship of Organ Involvement Determinant of Health-related Quality of Life (HRQoL) in Juvenile Systemic Lupus Erythematosus (jSLE). American College of Rheumatology 2008; San Francisco, CA; #1907/629.
146. Eyal Muscal, Frank Zelko, Deborah Levy, Laura Schanberg, Kelly Anthony, Linda Wagner-
Weiner, Gail Ross, Marisa Klein-Gitelman, Hermine Brunner. Impairment in Children with Systemic Lupus Erythematosus: Assessing Diagnostic Practices, and Research Needs in the CARRA Network. American College of Rheumatology 2008; San Francisco, CA. #224.
147. Stacy Ardoin, Laura Schanberg, Huiman Barnhart, Eric Yow, Kelly Mieszkalski, Emily von Scheven, Norm Ilowite, Anne Eberhard, Deborah Levy, Yukiko Kimura, Earl Silverman, Suzanne Bowyer, Marilyn Punaro, Nora Singer, David Sherry, Richard Silver, Deborah McCurdy, Marisa
Klein-Gitelman, Carol Wallace, Linda Wagner-Weiner, Gloria Higgins, Hermine Brunner, Lawrence Jung, Jennifer Soep, Ann Reed, Christy Sandborg. Clinical Laboratory Markers of Cardiovascular Risk in a Pediatric SLE Cohort. American College of Rheumatology 2008; San Francisco, CA. #230.
148. Lakshmi P. Kocharla, Janalee Taylor, Tracy Weiler, Michael Luggen, Hermine Brunner. Methotrexate (MTX) Toxicity Surveillance in Juvenile Idiopathic Arthritis (JIA). American College of Rheumatology 2008; San Francisco, CA; # F24/478.
149. A. Carmela Sagcal-Gironella, Kristina M. Wiers, Marisa S. Klein-Gitelman, Shannen Nelson, Blair Dina, Shareen Cox, Barbara Logan, Sanne de Ridder, Tsuyoshi Fukuda, Alexander A. Vinks,
Hermine I. Brunner. Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mycophenolic Acid (MPA) and Their Relation to Response to Therapy of Childhood Systemic Lupus Erythematosus (cSLE). American College of Rheumatology 2008; San Francisco, CA; # F41/495.
150. Mahnaz Saoudian, Amber Khan, Hermine Brunner, Michael Luggen. - Prevalence and Burden of Cognitive Dysfunction in a Community-Based Cohort of Patients with SLE. American College of Rheumatology 2008; San Francisco, CA; # F44/498.
151. Lena Das, Michiko Suzuki, P. Devarajan, Brad H. Rovin, Jun Ying and Hermine Brunner. Candidate Urinary Biomarkers May Predict Histological Features On Lupus Nephritis (LN) Biopsy. American College of Rheumatology 2009; Philadelphia, PA; #2005.
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152. Rina Mina, B. Anne Eberhard, Emily von Scheven, Gloria C. Higgins, Sivia Lapidus, Jamie Eaton, Laura E. Schanberg, Karen Onel, Marilynn G. Punaro, Judyann C. Olson, Jun Ying1, Marisa
Klein-Gitelman and Hermine Brunner. Defining and Measuring Global Flares of Juvenile Systemic Lupus Erythematosus (JSLE). American College of Rheumatology 2009; Philadelphia, PA; #1531.
153. Carmela Sagcal-Gironella, Tsuyoshi Fukuda, Kristina Wiers, Shareen Cox, Shannen Nelson,
Marisa Klein-Gitelman, Alexander A. Vinks and Hermine Brunner. Variability of Mycophenolic Acid (MPA) Pharmacokinetics (PK) in Childhood-Onset Systemic Lupus Erythematosus (cSLE) May Be Partly Explained by UGT Genotype. American College of Rheumatology 2009; Philadelphia, PA; # 1525.
154. Carmela Sagcal-Gironella, Marisa Klein-Gitelman, Aimee Baker, April German, Eric Anderson, Tresa Roebuck-Spencer, Dean Beebe, Frank Zelko, Darren Gitelman, Scott Holland, Mark
DiFrancesco and Hermine Brunner. Preliminary Findings of Functional Magnetic Resonance Imaging (fMRI) Assessments of Visuoconstructional Ability in Childhood-Onset Systemic Lupus Erythematosus (cSLE) Patients and Best-Friend Controls. American College of Rheumatology 2009; Philadelphia, PA; #1534.
155. Lena Das, Michiko Suzuki, Michael Bennett, Kathleen A. Haines, Marisa Klein-Gitelman, Judyann C. Olson, Karen Onel, Kathleen O`Neil, ED. Silverman, Nora G. Singer, Lori B. Tucker, Michael
Wyder, Kenneth Greis, Prasad Devarajan and Hermine Brunner. Urinary Biomarkers May Differentiate Between Children with ISN/RPS Class IV Versus Class V of Lupus Nephritis (LN)Class V Nephritis in Pediatric SLE: Treatment and Long-Term Outcome. American College of Rheumatology 2009; Philadelphia, PA; #1527.
156. Tracy V. Ting, Deepa P. Kudalkar, Shannen Nelson, Jamie Eaton, Jennifer Rammel, Jennifer L.
Huggins, Dennis Drotar and Hermine Brunner. Use of Cellular Text Messaging to Improve Visit Adherence in Adolescents with Childhood-Onset Systemic Lupus Erythematosus (cSLE). American College of Rheumatology 2009; Philadelphia, PA; #1536.
157. Deepa P. Kudalkar, Tracy V. Ting, Shannen Nelson, Jennifer L. Huggins, Avis E. Ware, Jamie
Eaton, Jennifer Rammel, Shweta Srivastava, Dennis Drotar and Hermine Brunner. Monitoring Adherence to Hydroxychloroquine (HCQ) in Childhood-Onset Systemic Lupus Erythematosus (cSLE) and Possible Impact of Successful Self-Management in Improving Medication Adherence. American College of Rheumatology 2009; Philadelphia, PA; #316.
158. Marc A. Antonchak, Mahnaz Saoudian, Amber Khan, Tara Adhikari, Hermine Brunner and Michael E. Luggen, Cognitive Dysfunction in Patients with SLE: A Controlled Study. American College of Rheumatology 2009; Philadelphia, PA; #1573.
159. Marc A. Antonchak, Mahnaz Saoudian, Amber Khan, Tara Adhikari, Hermine Brunner and Michael E. Luggen1, Cognitive Dysfunction in Patients with SLE: A Prospective Study. American College of Rheumatology 2009; Philadelphia, PA; #1576.
160. Tsuyoshi Fukuda, A. Carmela Sagcal-Gironella, Kristina Wiers, Shareen Cox, Shannen Nelson,
Marisa Klein-Gitelman, Alexander A. Vinks and Hermine Brunner. Pharmacokinetics(pk)-pharmacodynamics (PD) and pharmacogenetics (PG) of mycophenolate mofetil in childhood systemic lupus erythematosus (cSLE 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) March, 2010; Atlanta. GA at the Atlanta Marriott Marqius, Atlanta, Georgia. # O1-A-3
161. Tsuyoshi Fukuda, A. Carmela Sagcal-Gironella, Kristina Wiers, Shareen Cox, Shannen Nelson,
Marisa Klein-Gitelman, Alexander A. Vinks and Hermine Brunner. Pharmacokinetic monitoring of mycophenolate mofetil may predict response to therapy in childhood systemic lupus
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erythematosus (cSLE); 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) March, 2010; Atlanta. GA at the Atlanta Marriott Marqius, Atlanta, Georgia. # O1-A-3
162. Carmela Sagcal-Gironella, Tsuyoshi Fukuda, Kristina A. Wiers, Shareen Cox, Shannen Nelson, Marisa Klein-Gitelman, Alexander A. Vinks and Hermine Variability of mycophenolic acid (MPA) pharmacokinetics (PK) in childhood‐onset systemic lupus erythematosus (cSLE) may be partly explained by UGT genotype. 9
th International Congress on Systemic Lupus Erythematosus,
Vancouver, June 2010.
163. Yee Ling Wu, Emeli Lundström, Chau-Ching Liu, Yan Yang, Bi Zhou, Karla N. Jones, Haikady N.
Nagaraja, Gloria C. Higgins, Charles Spencer, Hermine Brunner, Dan J. Birmingham, Brad H. Rovin, Betty P. Tsao, Joseph M. Ahearn, Lee A. Hebert, Leonid Padyukov, C. Yung Yu,Low copy-number of complement CA, the presence of HLA-DR3, and the presence of HLA-DR2 are independent and additive risk factors for human systemic lupus erythematosus (SLE). 9
th
International Congress on Systemic Lupus Erythematosus, Vancouver, June 2010.
164. Rina Mina, Anne Eberhard , Emily von Scheven, Gloria Higgins , Sivia Lapidus, Jamie Eaton, Laura Schanberg, Karen Onel, Marilynn Punaro, Judyann Olson , Jun Ying, Marisa Klein-
Gitelman, and Hermine Brunner Defining Flares in Juvenile SLE. 9th International Congress on
Systemic Lupus Erythematosus, Vancouver, June 2010.
165. Lena Das, Michiko Suzuki, Michael Bennett, Kathleen A. Haines, Marisa Klein-Gitelman, Judyann C. Olson, Karen Onel, Kathleen O`Neil, ED. Silverman, Nora G. Singer, Lori B. Tucker, Michael
Wyder, Kenneth Greis, Prasad Devarajan and Hermine Brunner. Urinary Biomarkers May Differentiate Between Children with ISN/RPS Class IV Versus Class V of Lupus Nephritis (LN) Class V Nephritis in Pediatric SLE: Treatment and Long-Term Outcome. 9
th International
Congress on Systemic Lupus Erythematosus, Vancouver, June 2010.
166. F De Benedetti, H Brunner, N Ruperto,S Wright, A Kenwright, R Cuttica, P Woo, R Schneider, D Lovell, and A Martini for the Pediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) Efficacy and Safety of Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis (sJIA): 12-week Data from the Phase 3 TENDER Trial. EULAR Meeting, Rome June 2010.
167. Amy Zhang, Peter. N. Morcos, Fabrizio De Benedetti, Hermine Brunner, Nicolino Ruperto ,Felicity Schaefer, Stephanie Roseti, Andy Kenwright, Alberto Martini, and Daniel Lovell for the Pediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG). Pharmacokinetics (PK) and Pharmacodynamics (PD) of Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis (SJIA): 12-Week Data from the Phase 3 TENDER Trial. EULAR Meeting, Rome June 2010.
168. Rina Mina, Michael Beresford, B. Anne Eberhard, Edward H Giannini, Deborah M Levy, Clarissa Pilkington, Marilynn G Punaro, Angelo Ravelli, Andreas O Reiff, Claudia Saad-Magalhaes, Laura E Schanberg, , Lori B Tucker, Marisa S Klein-Gitelman, Shannen L Nelson, , Jamie Eaton, Jun
Ying, Hermine I. Brunner. Preliminary Criteria for Global Disease Flares in Juvenile Systemic Lupus Erythematosus (jSLE). 17
th Pediatric Rheumatology European Society Meeting, Valencia,
Spain.
169. Rina Mina, MD, Paula G Melson, Stephanie Powell, Claas H Hinze, Joshua Pendl, Thomas B
Graham, Hermine I. Brunner. Effectiveness of Dexamethasone Iontophoresis in Temporomandibular Joint (TMJ)-Arthritis in Juvenile Idiopathic Arthritis (JIA). 17
th Pediatric
Rheumatology European Society Meeting, Valencia, Spain.
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170. Rina Mina, Laura E Schanberg, B. Anne Eberhard, Marisa S Klein-Gitelman, Gloria C Higgins, Karen Onel, Nora G Singer, Kathleen M O'Neil, Lori B Tucker, Lisa F Imundo, Emily Von Scheven, Shannen L Nelson, Frank Dressler, Ruben Cuttica, Claudia Saad Magalhães, Angelo
Ravelli, Alberto Martini, Hermine I Brunner. Preliminary Criteria for Remission for Juvenile Systemic Lupus Erythematosus. 17
th Pediatric Rheumatology European Society Meeting,
Valencia, Spain.
171. Rina Mina, MD, Paula G Melson, Stephanie Powell, Claas H Hinze, Joshua Pendl, Thomas B
Graham, Hermine I. Brunner. Effectiveness of Dexamethasone Iontophoresis in Temporomandibular Joint (TMJ)-Arthritis in Juvenile Idiopathic Arthritis (JIA). American College of Rheumatology Annual Meeting, 2010, Atlanta.
172. Kathleen M O'Neil, Lauren M Kickingbird, Andrew S Zeft, Hermine Brunner, Marilynn G Punaro, Barry L Myones, Suzanne C Li, Tracey Wright. Pre-Pubertal Onset Systemic Lupus Erythematosus in Girls: Clinical and Serologic Manifestations Differ from Post-Pubertal Onset SLE. American College of Rheumatology Annual Meeting, 2010, Atlanta.
173. Laura E Schanberg, Christy I Sandborg, Huiman X. Barnhart, Stacy P. Ardoin, Eric Yow, Gregory W. Evans5, Kelly L. Mieszkalski, Normal T. Ilowite, Anne Eberhard, Lisa F Imundo, Yukiko Kimura, Emily Von Scheven, Earl Silverman, Suzanne L. Bowyer, Lynn Punaro, Nora G. Singer, David D. Sherry, Deborah McCurdy, Marisa Klein-Gittelman, Carol A. Wallace, Richard Silver,
Linda Wagner-Weiner, Gloria C. Higgins, Hermine I. Brunner, Lawrence Jung, Jennifer B. Soep, Ann Reed, Charles Tegler, APPLE Investigators. Does Atorvastatin Reduce Progression of Carotid Intimal Medial Thickening (CIMT) in Childhood SLE? Results from the Atherosclerosis Prevention in Pediatric Lupus (APPLE) Trial: A Multicenter, Randomized, Double-Blind Placebo-Controlled Study. American College of Rheumatology Annual Meeting, 2010, Atlanta.
174. David W Moser, Elaine Haddix, Mary Beth Burns, James Brown, Anna Carmela P Sagcal-
Gironella, Thomas A Griffin, Hermine Brunner, Esi M Morgan DeWitt. The Use of Electronic Health Record To Improve Tuberculosis Screening in Pediatric Rheumatology Patients Receiving Biologic Response Modifiers. American College of Rheumatology Annual Meeting, 2010, Atlanta.
175. Hermine Brunner, Michael Bennett, Lindsey Romick-Rosendale, Michiko Suzuki, Shannen L Nelson, Joshua Pendl, Adnan Kiani, Lena Das, Michelle Petri, Kenneth Greis, Pavel Shiyanov, Michael Kennedy, Prasad Devarajan. Urinary Biomarkers To Distinguish Class IV vs Class V Lupus Nephritis. American College of Rheumatology Annual Meeting, 2010, Atlanta.
176. Rina Mina, Hermine Brunner, B. Anne Eberhard, Marilynn G Punaro, Stacy P Ardoin, Marisa S Klein-Gitelman, Joyce J Hsu, Lakshmi N Moorthy, Linda Wagner-Weiner, Eyal Muscal, Suhas M Radhakrishna, Jenny Palter, Laura Schanberg, Carol A Wallace, Norman T Ilowite, Emily Von Scheven, for the CARRA Lupus Disease-specific Group . Towards the Development of Standardized Treatment Protocols for Proliferative Nephritis in Juvenile Systemic Lupus Erythematosus (jSLE). American College of Rheumatology Annual Meeting, 2010, Atlanta.
177. Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Inmaculada Calvo, Ruben Cuttica, Clara Malattia, Rayfel Schneider, Patricia Woo, Carine H. Wouters, Ricardo Xavier, Lawrence S. Zemel, Stephen Wright, Andrew Kenwright, Alberto Martini, Daniel J. Lovell. Tocilizumab in Patients with Systemic Juvenile Idiopathic Arthritis: Efficacy Data from the Placebo-Controlled 12-Week Part of the Phase 3 TENDER Trial. American College of Rheumatology Annual Meeting, 2010, Atlanta.
178. Rina Mina, Michael Beresford, B. Anne Eberhard, Edward H Giannini, Deborah M Levy, Clarissa Pilkington, Marilynn G Punaro, Angelo Ravelli, Andreas O Reiff, Claudia Saad-Magalhaes, Laura E Schanberg, , Lori B Tucker, Marisa S Klein-Gitelman, Shannen L Nelson, , Jamie Eaton, Jun
33
Ying, Hermine I. Brunner. Preliminary Criteria for Global Disease Flares in Juvenile Systemic Lupus Erythematosus (jSLE). American College of Rheumatology Annual Meeting, 2010, Atlanta.
179. Rina Mina, Michael Bennett, Joseph M Ahearn, Joshua Pendl, Jamie Eaton, Nicole Wilson,
Prasad Devarajan, Hermine Brunner. Biomarkers for Global and Renal Disease Activity in Juvenile Systemic Lupus Erythematosus (jSLE). American College of Rheumatology Annual Meeting, 2010, Atlanta.
180. Blair Dina, Aimee Baker, Anna Carmela Sagcal-Gironella, Marisa Klein-Gitelman, Frank Zelko,
Dean Beebe, Darren Gitelman, Mark DiFrancesco, Hermine Brunner. Preliminary Findings of Functional Magnetic Resonance Imaging (fMRI) Assessments of Specific Cognitive Domains in Childhood-Onset Systemic Lupus Erythematosus (cSLE) Patients and Best-Friend Controls. American College of Rheumatology Annual Meeting, 2010, Atlanta.
181. Rina Mina, Laura E Schanberg, B. Anne Eberhard, Marisa S Klein-Gitelman, Gloria C Higgins, Karen Onel, Nora G Singer, Kathleen M O'Neil, Lori B Tucker, Lisa F Imundo, Emily Von Scheven, Shannen L Nelson, Frank Dressler, Ruben Cuttica, Claudia Saad Magalhães, Angelo
Ravelli, Alberto Martini, Hermine I Brunner. Preliminary Criteria for Remission for Juvenile Systemic Lupus Erythematosus. American College of Rheumatology Annual Meeting, 2010, Atlanta.
182. Lining Qi; Hermine Brunner; Michael Bennett; Prasad Devarajan; Shannen Nelson; Prasad Devarajan; John Schlager; Pavel Shiyanov. ee quantiLabel-free Method of Proteomic Profiling to Detect Novel Proteins for Systemic Lupus Erythematosus (SLE) Kidney Damage during Disease Flaring. American Sociate for Mass Spectrometry, 2011, Denver.
183. Chaitow J, De Benedetti F, Brunner H, Ruperto N, Allen RC, Murray KJ, Schneider R, Woo P, Wright S, Kenwright A, Martini A, Lovell DJ. Tocilizumab in patients with systemic juvenile idiopathic arthritis: efficacy data from the placebo-controlled 12-week part of the phase III TENDER trial. Australian Rheumatology Congress; May 2011, Brisbane, Queensland, Australia.
184. Xiaoping Zhang, Peter N. Morcos, Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Felicity Schaefer, Stephanie Roseti, Andrew Kenwright, Alberto Martini, Daniel Lovell Pharmacokinetics and Pharmacodynamics of Tocilizumab in Systemic Juvenile Idiopathic Arthritis; ASCPT2011 Annual Meeting , Dallas, Tx March 2011.
185. Xiaoping Zhang, Peter N. Morcos, Fabrizio De Benedetti, Hermine Brunner, Nicola Ruperto, Felicity Schaefer, Stephanie Roseti, Andrew Kenwright, Alberto Martini, Daniel Lovell Pharmacokinetics and Pharmacodynamics of Tocilizumab in Systemic Juvenile Idiopathic Arthritis; EULAR Meeting, London, June 2011.
186. F De Benedetti, H Brunner, N Ruperto, I Calvo, R Cuttica, C Malattia, R Schneider, P Woo, C Wouters, R Xavier, L Zemel, S Wright, A Kenwright , D Lovell, A Martini . Efficacy and Safety of Tocilizumab (TCZ) in Patients with Systemic Juvenile Idiopathic Arthritis (sJIA): TENDER 52-Week Data. EULAR Meeting, London, June 2011.
187. J. Pendl, S. Nelson, C. Reed, W. Yousaf, S. Budhani, A. Baker, E. Morgan Dewitt, J Taylor, D.J.
Lovell, M. Henrickson, J.L. Huggins, H.I. Brunner. Adherence to Quality Indicators for Patients with systemic lupus erythematosus at the Cincinnati Children’s Hospital Medical Center. #33; Pediatric Rheumatology symposium, Miami, June 2011.
188. A. Hersh, M.B. Son, H Brunner, B.A. Eberhard, E. von Scheven, and the CARRANet Investigators. Use of immunosuppressive medications and prevalence of disability among
34
patients with pediatric systemic lupus erythematosus: initial analysis of the CARRANet Registry. #44; Pediatric Rheumatology symposium, Miami, June 2011.
189. D.J. Lovell, S.P Spalding, K. Onel, B.S. Gottlieb, H.I. Brunner, Y. Kimura, P.W. Morris, J.Olson, A. Johnsons, E.H. Giannini. Understanding the biology and use of anti-TNF agents in JIA – interim results; #80; Pediatric Rheumatology symposium, Miami, June 2011.
190. R. Mina, M Rao, S. Powell, J. Pendl, P.G. Melson, H.I. Brunner. Predictors for the effectiveness of dexamethasone treatment of TMJ-involvement with JIA. #83; Pediatric Rheumatology symposium, Miami, June 2011.
191. C.A.Wallace, E.H. Giannini, S.J Spalding, P.J. Hashkes, K.O’Neil, A.S. Zeft, I. Szer, S.Ringold,
H.I. Brunner, L. E Schanberg, R.P. Sundel, D. Milojevic, M. Punaro, Y. Kimura, B. huang, D.J. Lovell. The effects of early aggressive therapy in JIA: Results of the TREAT study. #91; Pediatric Rheumatology symposium, Miami, June 2011.
192. F..De Benedetti, H.I.Brunner, N Ruperto, C Malattia, R. Schneider, P. Woo, D. Eleftheriou, E Baildam, R Burgos-Vargas…D.J. Lovell. Efficacy and Safety of Tocilizumab in patients with systemic juvenile idiopathic arthritis. #93; Pediatric Rheumatology symposium, Miami, June 2011.
193. C. Sandborg, L. Schanberg, H. Barnhart, N Ilowite, A Eberhard, L Imunod, Y Kimura, E von
Scheven, E Silverman, S Bowyer, L Punaro, N Singer, D Sherry,,,,H. Brunner, L Jung, J Soep, A Reed. Does atorvastatin reduce caritoid atherosclerosis in pediatric SLE? Results and secondary analyses from the Atherosclerosis Prevention in Pediatric Lupus erythematosus (APPLE) trial. #98; Pediatric Rheumatology symposium, Miami, June 2011
194. Joshua D. Pendl, Matthew C. Hollander, Shannen L. Nelson, Xolti Morgan, Nicolino Ruperto, Michael W. Beresford, Marisa Klein-Gitelman, Marilynn G. Punaro, Anne M. Stevens, Tadej Avcin, Graciela Espada, Tsz-Leung Lee, Yu-Lung Lau, Jennifer L. Huggins, Esi Morgan Dewitt
and Hermine Brunner. Achieving Consensus on Quality Indicators for Pediatric Systemic Lupus Erythematosus. American College of Rheumatology 2011; Chicago, IL, USA; #612.
195. Carol Wallace, Edward H. Giannini, Steven J. Spalding, Philip Hashkes, Kathleen M. O'Neil,
Andrew S. Zeft, Ilona S. Szer, Sarah Ringold, Hermine Brunner, Laura E. Schanberg, Robert P. Sundel, Diana Milojevic, Marilynn G. Punaro, Peter Chira, Beth S. Gottlieb, Gloria Higgins, Norman T. Ilowite, Yukiko Kimura, Anne Johnson, Stephanie Hamilton, Bin Huang and Daniel J. Lovell. Trial of Early Aggressive Therapy in Polyarticular Juvenile Idiopathic Arthritis; American College of Rheumatology 2011; Chicago, IL, USA; #721.
196. Marisa Klein-Gitelman, Adlin Cedeno, Aimee Baker, Frank Zelko, Dean Beebe, Blair Dina, Anna
Carmela P. Sagcal-Gironella, Darren Gitelman, Hermine Brunner, Mark Difrancesco and Travis Beck. Brain Morphometric Changes Associated with Childhood-Onset Systemic Lupus Erythematosus and Neurocognitive Deficit American College of Rheumatology 2011; Chicago, IL, USA; #751
197. David W. Moser, Tracy V. Ting, Janalee Taylor, Daniel J. Lovell, Hermine Brunner, Jennifer L. Huggins and Esi M. Morgan DeWitt. Generating Run Charts for Quality Improvement Using the Electronic Health Record. American College of Rheumatology 2011 ; Chicago, IL, USA; #754
198. Janalee Taylor, Elaine F. Haddix, Kim Badinghaus, Mary Beth Burns, Terry M. Moore, Julie V. Ranz, Amy Anneken, Pam Fiorini, Eva Spiegel, Esi Morgan DeWitt, Michael Henrickson,
Hermine Brunner and Jennifer L. Huggins, Participation in Hospital Influenza Collaborative. American College of Rheumatology 2011 ; Chicago, IL, USA; #1578
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199. Hermine Brunner, Aimee Baker, Adlin Cedeno, Jennifer L. Huggins, Anna Carmela P. Sagcal-Gironella, Jun Ying, Marisa Klein-Gitelman and Tresa Roebuck-Spencer
. The Pediatric
Automated Neuropsychological Assessment Metrics Has Reproducibility and Criterion Validity in Childhood-Onset Lupus American College of Rheumatology 2011 ; Chicago, IL, USA; #2008
200. Adlin Cedeno, Aimee Baker, Marisa Klein-Gitelman, Anna Carmela P. Sagcal-Gironella, April
German, Cynthia Scharf, Jun Ying, Hermine Brunner, Dean Beebe and Frank Zelko. Behavior, Executive and Perceived Neuropsychological Functioning with Childhood-Onset Systemic Lupus Erythematosus – Results of a Best-Friend Controlled Study . American College of Rheumatology 2011; Chicago, IL, USA; #2011
201. Rina Mina, Marisa Klein-Gitelman, Shannen L. Nelson, B. Anne Eberhard, Gloria C. Higgins, Nora G. Singer, Deborah M. Levy, Karen Onel, Judyann C. Olson, Joshua D. Pendl, Aimee Baker, Lisa F. Imundo, Lori B. Tucker, Laura E. Schanberg, Marilynn G. Punaro, Kathleen M.
O'Neil, Nicolino Ruperto, Daniel J. Lovell and Hermine Brunner. Performance of the Systemic Lupus Erythematosus Responder Index in Juvenile Systemic Lupus Erythematosus American College of Rheumatology 2011 ; Chicago, IL, USA; #2014
202. Stacy P. Ardoin, Laura E. Schanberg, Christy I. Sandborg, Huiman Barnhart, Eric Yow, Greg Evans, Kelly Mieszkalski, Norman T. Ilowite, Emily von Scheven, B. Anne Eberhard, Lisa F. Imundo, Deborah M. Levy, Yuki Kimura, Earl D. Silverman, Suzanne L. Bowyer, Marilynn G. Punaro, Nora G. Singer, David D. Sherry, Deborah K. McCurdy, Marisa Klein-Gitelman, Carol A.
Wallace, Richard M. Silver, Linda Wagner-Weiner, Gloria Higgins, Hermine Brunner, Lawrence K. Jung, Jennifer B. Soep, Ann M. Reed, Susan D. Thompson and for the APPLE investigators
.A
Secondary Analysis of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Study Shows That Atorvastatin Therapy Reduces Progression of Carotid Intima Medial Thickening in Pubertal SLE Patients with Higher C Reactive ProteinAmerican College of Rheumatology ; Chicago, IL, USA; # 2015
203. Shannen L. Nelson, Rina Mina, Lindsey Romick-Rosendale, Hermine Brunner, Michael Bennett, Joshua D. Pendl, Michelle Petri, Adnan Kiani, Prasad Devarajan and Michael Kennedy. Use of Urinary Metabolites to Distinguish Proliferative From Membranous Lupus Nephritis. American College of Rheumatology; Chicago, IL, USA; #2047
204. Stacy P. Ardoin, Thomas Povsic, Laura E. Schanberg, Christy I. Sandborg, Huiman Barnhart, Eric Yow, Greg Evans, Kelly L. Mieszkalski, Norman T. Ilowite, Emily von Scheven, B. Anne Eberhard, Lisa F. Imundo, Yuki Kimura, Earl D. Silverman, Suzanne L. Bowyer, Marilynn G. Punaro, Nora G. Singer, David D. Sherry, Deborah K. McCurdy, Marisa Klein-Gitelman, Carol
Wallace, Richard M. Silver, Linda Wagner-Weiner, Gloria C. Higgins, Hermine Brunner, Lawrence K. Jung, Jennifer B. Soep, Ann M. Reed, Susan D. Thompson and APPLE Investigators
. CD146+ Endothelial Progenitor Cell Number Increases Following Months of
Atorvastatin Therapy in Children and Adolescents with SLE: The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort. American College of Rheumatology; Chicago, IL, USA; # 2047
205. Mary Beth F. Son, Aimee O. Hersh, Hermine Brunner, B. Anne Eberhard and, Emily von Scheven and CARRAnet Investigators.Socioeconomic Status Is Associated with Disability in Pediatric Systemic Lupus Erythematosus American College of Rheumatology ; Chicago, IL, USA; #2294
206. Rina Mina, Laura E. Schanberg, Marisa Klein-Gitelman, B. Anne Eberhard, Gloria Higgins, Karen Onel, Nora G. Singer, Kathleen M. O'Neil, Deborah M. Levy, Shannen L. Nelson, Wajeeha Yousaf, Rubén J. Cuttica, Lori B. Tucker, BC Childrens Hospital, Michael W. Beresford, Graciela
Espada, Angelo Ravelli, Alberto Martini, Edward H. Giannini, and Hermine Brunner, Defining
36
Clinical Remission and Inactive Disease in Juvenile Systemic Lupus Erythematosus. American College of Rheumatology; Chicago, IL, USA; #2454
207. Marisa Klein-Gitelman, Adlin Cedeno, Aimee Baker, Frank Zelko, Dean Beebe, Blair Dina, Anna
Carmela P. Sagcal-Gironella, Darren Gitelman, Hermine Brunner, Mark Difrancesco and Brian Zappia Distinct Functional Activation and Connectivity Patterns for a Visuo-Constructional Task in Childhood-Onset Systemic Lupus Erythematosus and Matched Controls American College of Rheumatology ; Chicago, IL, USA; #2456
208. Hermine Brunner, Nicolino Ruperto, Gerd Horneff, Pierre Quartier, Tamás Constantin, Yackov Berkun, Tilmann Kallinich, Riva Brik, Manuel A. Ferrandiz, Karine Lheritier, Ralph Preiss, Lillian Tseng, Daniel J. Lovell, Alberto Martini, Paediatric Rheumatology International Trials Organisation and Pediatric Rheumatology Collaborative Study Group [PRCSG]. Phase III Study Results on the Efficacy and Safety of Canakinumab, a Long-Acting, Fully Human Anti-Interleukin-β Antibody, in Systemic Juvenile Idiopathic Arthritis with Active Systemic Features. American College of Rheumatology; Chicago, IL, USA; #2622
209. Rina Mina, Hermine Brunner, B. Anne Eberhard, Marilynn G. Punaro, Stacy P. Ardoin, Marisa Klein-Gitelman, Lakshmi N. Moorthy, Suhas M. Radhakrishna, Mindy S. Lo, Matthew C. Hollander, Eyal Muscal, Joyce J. Hsu, Linda Wagner-Weiner, Deborah M. Levy, Carol Wallace, Norman T. Ilowite, and Emily von Scheven. Developing Consensus Treatment Plans for Proliferative Nephritis in Juvenile Systemic Lupus Erythematosus: Maintenance Therapy. American College of Rheumatology; Chicago, IL, USA; # 2624
210. Fabrizio De Benedetti, Hermine Brunner, Roger Allen, Diane Brown, Jeffrey Chaitow, Manuela Pardeo, Graciela Espada, Berit Flatø, Gerd Horneff, Clare Devlin, Andrew Kenwright, Rayfel Schneider, Patricia Woo, Alberto Martini, Daniel Lovell and Nicola Ruperto, Ospedale Pediatrico Bambino Gesù, Rome, Italy, Pediatric Rheumatology Collaborative Study Group [PRCSG]. Tocilizumab Is Efficacious in Patients with Systemic Juvenile Idiopathic Arthritis Across Baseline Demographic and Disease Characteristics and Prior/Baseline Treatments: -Week Data From a Phase Clinical Trial American College of Rheumatology ; Chicago, IL, USA; #2621.
211. N. Ruperto, H. Brunner, P. Quartier, T. Constantin, N. Wulffraat, G. Horneff1, R. Brik1, L. McCann1, O. Kasapcopur, L. Rutkowska-Sak, R. Schneider, Y. Berkun, I. Calvo, M. Erguven, L. Goffin, M. Hofer, T. Kallinich, S. Knupp, Y. Uziel, S. Viola, K. Nistala, C. Wouters, R. Cimaz, M. Ferrandiz, B. Flato, M. Luz Gamir, I. Kone-Paut, A. Grom, B. Magnusson, S. Ozen, F. Sztajnbok, K. Lheritier, D. Kim, K. Abrams, A. Martini, D. Lovell, and for PRINTO/PRCSG. Efficacy And Safety Of Canakinumab, Fully Human Anti-Interleukin-1beta Antibody, In Systemic Juvenile Idiopathic Arthritis. European League against Rheumatism, Berlin 2012; # [AB1182]
212. F. De Benedetti, H. Brunner, N. Ruperto, A. Kenwright4, C. Devlin4, I. Calvo, R. Cuttica, A. Ravelli, R. Schneider, D. Eleftheriou, C. Wouters, R. Xavier, L. Zemel, E. Baildam, R. Burgos-Vargas, P. Dolezalova, S.M. Garay, R. Joos, A. Grom, N. Wulffraat, Z. Zuber, F. Zulian, D. Lovell, A. Martini
Efficacy And Safety Of Tocilizumab (Tcz) In Patients With Systemic Juvenile Idiopathic Arthritis (SJIA): 2-Year Data From Tender, A Phase 3 Clinical Trial. ; European League against Rheumatism, Berlin 2012; FRI0328
PATENTS
Devarajan P and Brunner HI: ―Method for the Early Detection of SLE Nephritis‖ Submitted 2007-0609, US and WO publications.
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RESEARCH AND INVESTIGATION
Senior Investigator's name appears in BOLD and total direct grant funds in brackets
Research Funding - Peer Reviewed
Completed
1. P60 AR47784; Giannini ($750,000) 09/01/01 - 06/30/06
NIH/NIAMS: Methodology Core
―Multidisciplinary Clinical Research Center in Cincinnati‖ (Glass)
The major goal of the core is to support research projects with statistical support and study design questions.
2. Lupus Foundation; Brunner ($100,000) 09/01/02 - 08/01/04
―Long-term Outcomes and Gonadal Function in Childhood Systemic Lupus Erythematosus‖
3. R03 PAR AR049860; Brunner ($100,000) 05/08/03 – 04/30/06
―Guidelines for Steroids in Children with Lupus‖
The major goal of this project is to develop preliminary data on the practice patterns of pediatric rheumatologist for lupus therapy in children.
4. Arthritis Foundation; Kotagal ($450,000) 07/01/02 - 02/30/07
Role: Co-PI
―Outcomes & Cost-effectiveness Evaluation of Etanercept in JRA‖
The major goal of this project is to assess the outcomes and quality of life of children with JRA treated with methotrexate standard therapy and/or etanercept and to assess the cost-effectiveness of these treatments.
5. U01-AR5868; Brunner ($450,000) 09/30/04- 9/29/09
―Meaningful Outcomes of Pediatric Lupus Clinical Trials‖
The major goal of the project is to develop surrogate markers for pediatric SLE clinical trials in collaboration various pediatric rheumatology research groups.
6. CCHMC Translational Research Initiative; Brunner ($40,000) 07/01/06 – 6/30/07
―Biomarkers for Pediatric Lupus Nephritis ‖
The major goal of the project is to discover novel lupus nephritis biomarkers and test the usefulness of NGAL for assessing the course of lupus nephritis.
7. CCHMC Translational Research Initiative; Brunner ($100,000) 07/01/07 – 6/30/08
―Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid‖
The major goal of the project is to pharmacokinetic, pharmacodynamic and pharmacogenetic markers of MMF response in SLE.
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8. Alliance for Lupus Research; Brunner ($500,000) 01/01/06- 12/30/09
―Towards Biomarkers for Lupus Renal Disease‖
The major goal of the project is to identify and validate biomarkers for SLE using proteomics and to establish the predictive properties of neutrophil gelatinase associated lipocalin (NGAL) to serve as renal biomarker of SLE.
9. CCHMC Health-Services Matrix; Brunner ($120,000) 07/01/08 – 06/30/10
―Improving Adherence To Medical Interventions In Childhood-Onset Lupus‖
The major goal of the project is to use interventions at the level of the health delivery system for improving visit and medication adherence in children, adolescent and young adults with SLE.
10. Lupus Foundation of America; Ahearn ($200,000) 09/01/08 - 08/30/10
Role: Co-Investigator
―Biomarkers for Diagnosis, Monitoring and Prognosis in Pediatric SLE‖
The major goal of the project is to identify and validate biomarkers for SLE to serve as renal and global biomarker of SLE.
11. CCHMC Translational Research Initiative; Devarajan ($100,000) 07/01/00 – 06/30/10
Role: Co-PI
―Biomarkers for Pediatric Lupus Nephritis ‖
The major goal of the project is to test novel lupus nephritis biomarkers and compare them to novel complement biomarkers.
12. FD-R-002369; Brunner ($750,000) 09/30/03 – 09/29/11
Food & Drug Administration
―Triptorelin for Ovary Protection in Childhood Lupus‖
The major goal of the project is to provide pivotal information on the use of triptorelin in cSLE which will allow for the subsequent initiation of a definitive clinical trial of triptorelin in this population, permitting Watson Inc. to request orphan-drug designation of triptorelin for ovarian protection in cSLE.
13. U01 AR06-006; Brunner ($450,000) 01/01/07 – 09/30/11
―Efficacy Measures for Pediatric Lupus Trials‖
The major goal of this project is develop criteria of remission and flare as well as a National CARRA Lupus Registry.
14. CCHMC Translational Research Initiative ; Devarajan ($100,000) 07/01/10-06/30/11
―Comparative Biomarkers of Lupus‖
Role: Co-Investigator
The major goal of the project is to test novel lupus nephritis biomarkers and compare them to novel complement biomarkers.
15. ABBOTT: Adalimumab 2- 4 year old Study
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The major goal of this project is to assess the pharmacokinetic properties of adalimumab in young children with polyarticular JIA
Current
1. P035278 Department of Defense; Devarajan ($1.0 Mio) 07/01/07 – 06/30/12
Role: Co-PI
―Early Biomarkers for Lupus Nephritis ―
The major goal of the project is to identify and validate biomarkers for SLE using proteomics
2. P60 AR47784 (Glass); Project Brunner ($650,000) 04/01/08 - 03/03/13
NIH/NIAMS: Project:‖ Improved Diagnostics & Advanced Magnetic Resonance Imaging For Pediatric NPSLE. ―Multidisciplinary Clinical Research Center in Cincinnati‖ (Lovell)
The major goal of the project is to develop clinically useful screening tools for NPSLE and explore the value of functional imaging techniques for NPLSE.
3. U01 DK085673-01; Rovin ($1.5 mio) 01/01/10 – 12/30/15
Role: Co-investigator
―Forecasters of Future and Progressive CKD in Patients with Microvascular Glomerular Injury‖
The major goal of the project is to develop and validate biomarkers of chronic kidney disease.
4. NIAMS – U01; Brunner ($650,000) 08/08/10 - 07/30/13
―Towards measures of lupus nephritis activity and damage‖
The major role of this project is to validate a set of lupus nephritis biomarkers with the intent to achieve commercialization.
5. CDC and the Myositis Association; Brunner ($100,000) 09/01/10-09/01/11
―Myositis Registry ―
The major goal of this project is: to investigate social & biological determinants of health in children & adolescents with jSLE in the US;
6. CCTST Pilot; Bennett ($100,000) 07/01/11-06/30/12
Role: Co-investigator
―Biomarkers to distinguish classes of Lupus Nephritis ―
The major goal of this project is: to delineate biomarkers for ISN/PRS Class V
Role: Co PI
7. Lupus Foundation of America; Brunner ($100,000) 10/01/11-09/3012
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―Validation of PROMIS Modules for Use in Pediatric Lupus‖
The major goal of this study is to investigate the construct validity of the Pediatric PROMIS Modules in pSLE and to establish the discriminant validity of the Pediatric PROMIS Modules in pSLE.
8. Lupus Foundation of America; von Scheven ($100,000) 10/01/11-09/3012
―Standardized Treatment Plans for Proliferative Lupus Nephritis in Children‖
To understand the variation of the quality of care of children & adolescents with jSLE in the US. To establish the comparative effectiveness of current treatment approaches for proliferative LN in jSLE.
Role: Co-PI
9. CCTST Pilot; Brunner ($100,000) 07/01/12-06/30/13
―MicroRNA as Biomarkers of Lupus Nephritis ―
The major goal of this project is to explore the potential of urinary miRNA to serve as biomarker of lupus nephritis activity and chronicity.
10. P50 Pediatric Nephrology Center of Excellence; 09/01/12-08/30/17
($500,000 annually; Brunner Project PI)
―Critical Biomarkers in Pediatric Lupus Nephritis‖
The major goal of this project is to discover and validate biomarkers of response to therapy of lupus nephritis and discover mechanisms underlying histological kidney changes with lupus nephritis
Current – Industry
7. ROCHE - Coordinating Center/ PRCSG ($450,000) 09/01/08 – 09/01/2011
―Randomized placebo controlled clinical trial of tocilizumab in Systemic JIA/ TENDER STUDY‖
Role: Project Manager
The major goal of this study is to assess the safety and efficacy of tocilizumab (ACTEMRA) in systemic JIA.
8. ROCHE - Coordinating Center/ PRCSG ($375,000) 09/01/09 – 09/01/2012
―Randomized placebo controlled clinical trial of tocilizumab in polyarticular JIA/ CHERISH STUDY‖
Role: Project Manager
The major goal of this study is to assess the safety and efficacy of tocilizumab (ACREMRA) in polyarticular JIA.
9. NOVARTIS – Coordinating Center / PRCSG ($670,000) 02/01/10 – 09/01/2013
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―CANAKINUMAB in Systemic JIA - Studies 2301, 2305 and 2305E‖
Role: Project Manager
The major goal of this study is to assess the safety and efficacy of tocilizumab (ACTEMRA) in systemic JIA.
10. CENTOCOR/JANSEN – Coordinating Center/ PRCSG ($160,000)
―CNTO148JIA3001: Randomized withdrawal study with long-term extension of the safety and efficacy of golimumab (SIMPONI) in polyarticular JIA (GO-KIDS Study‖
Role: Project Manager
The major goal of this study is to assess the safety and efficacy of golimumab (SIMPONI) in polyarticular JIA.
11. Bristol-Myer Squipp – Coordinating Center/ PRCSG ($5.6 Mio) 11/01/10 – 10/30/20
―Phase IV Registry of abatacept‖
Role: Medical Director
The major goal of this study is to assess the safety of the CTLA4 antagonist abatacept in children with JIA.
Site Investigator for the following Studies
1. NIH (Wallace)
―Early Aggressive Treatment of Polyarticular JIA:
The major goal of this RCT is to test the frequency of inducing remission of JIA with methotrexate, etanercept.
2. NIH (Stevens)
―Familial autoimmunity‖
The major goal of this project is to assess the effects and importance of microchimerism on the development of rheumatic autoimmune diseases.
3. NIAMS (O’Neil)
―Puberty in Pediatric SLE‖.
The major goal of this project is to assess the effects of puberty on autoantibody development in girls with SLE.
4. ABBOTT: Adalimumab Registry
The major goal of this project is to assess the long-term safety of adalimumab in polyarticular JIA.
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5. PFIZER: SINCERE Registry
The major goal of this project is to assess the long-term safety of celecoxib in children with JIA.
6. UCB - Phase III Trial Protocol RA0043 Since 4/2012
“A Multicenter, Open-Label Study To Assess The Pharmacokinetics, Safety, And Efficacy Of Certolizumab Pegol In Children And Adolescents With Moderately To Severely Active Polyarticular-Course Juvenile Idiopathic Arthritis‖
The major goal is to test the safety and efficacy certolizumab (CIMZIA) in polyarticular course JIA
7. Eli-Lilly – Phase III Trial Since 6/2012
―A Phase 3 multicenter randomized double-blind placebo controlled study to evaluate the efficacy and safety of LY2127399 in patients with lupus―
The major goal is to test the safety and efficacy of LY2127399 in adults with SLE
8. GSK – Phase II Trial Since 9/2012
―A Phase 2, Multicenter, Randomized Withdrawal Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Belimumab, a Fully Human Monoclonal Anti-BLyS Antibody, in Pediatric Patients with Systemic Lupus Erythematosus (SLE)‖ The major goal is to test the safety and efficacy of belimumab (Benlysta) in children with SLE
Steering Committee Member
1. ROCHE: TENDER Study
The major goal of this project is to assess the long-term safety and efficacy of tocilizumab in children with systemic JIA.
2. ROCHE: CHERRISH Study
The major goal of this project is to assess the long-term safety and efficacy of tocilizumab in children with systemic JIA.
3. NOVARTIS: Canakinumab
The major goal of this project is to assess the safety and efficacy of Canakinumab children with systemic JIA.
4. CENTOCOR: Golimumab
The major goal of this project is to assess the long-term safety and efficacy of golimumab in children with systemic JIA.
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5. PHASE IV REGISTRY OF ABATACEPT (ORENCIA) IN JIA
The major goal of this project is to assess the long-term safety of abatacept in children with JIA.
6. CARRA Rx & NET (NIAMS, Wallace)
The major goal of these studies is to develop a national pediatric rheumatology registry and to develop standard of care protocols for pediatric lupus, dermatomyositis, JIA and scleroderma.
7. UCB - Phase III Trial Protocol RA0043
The major goal is to test the safety and efficacy certolizumab (CIMZIA) in polyarticular course JIA
8. GSK – Phase II Trial ProtocolBEL114055
The major goal is to test the safety and efficacy of belimumab (Benlysta) in children with SLE
Director Study Coordinating Center
1. ROCHE: TENDER Study
The major goal of this project is to assess the long-term safety and efficacy of tocilizumab in children with systemic JIA.
2. ROCHE: CHERRISH Study
The major goal of this project is to assess the long-term safety and efficacy of tocilizumab in children with systemic JIA.
3. NOVARTIS: Canakinumab
The major goal of this project is to assess the safety and efficacy of Canakinumab children with systemic JIA.
4. CENTOCOR: Golimumab
The major goal of this project is to assess the long-term safety and efficacy of golimumab in children with systemic JIA.
5. PHASE IV REGISTRY OF ABATACEPT (ORENCIA) IN JIA
The major goal of this project is to assess the long-term safety of abatacept in children with JIA.
Pending
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1. CDC- Brunner ($2.5 Mio)
―National Juvenile Lupus Registry– Natural History, Therapy & Social Determinants‖
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PREGRADUATE EDUCATION – RESEARCH TRAINING & MENTORING
Melissa Kunkel, 2006, Medical Student
Project: Adherence of pediatric rheumatology patients to physical therapy
Present status: Pediatric resident at University of Utah
Michelle Mueller, 2007, Medical Student
Project: Neutrophil Gelatinase Associated Lipocalin in Lupus Nephritis
Present status: Internal Medicine resident at University of Dayton
Denarius Frazier, 2011 Chemical Engineering Student
Project: Neutrophil Gelatinase Associated Lipocalin in Lupus Nephritis – Response to Therapy
Present status: Student at Morehouse University, Atlanta, GA
Ravi Nunna, 2012, Medical Student
Project: Isolation of Exosomes and testing of microRNA in patients with lupus nephritis
Present status: Student at University of Cincinnati College of Medicine, OH
Michael Flannery, 2012, Movement Science
Project: Quality of Life in Pediatric Lupus – PROMIS Itembank Validation
Present status: Student at University of Cincinnati College of Medicine, OH
GRADUATE EDUCTION – CAREER DEVELOPMENT
I am faculty mentor for pediatric rheumatology residents at CCHMC
Dr. Pae-Yu Lu; 2007 - 2009
Present status: Pediatric Rheumatology Fellowship
Cincinnati Children’s Hospital Medical Center, OH
Dr. Hailey Wasserman; since 2009
Present status: Pediatric Residency
Cincinnati Children’s Hospital Medical Center, OH
Dr. Lori Singleton; since 2010
Present status: Pediatric Residency
Cincinnati Children’s Hospital Medical Center, OH
Dr. Anna Peters; since 2011
Present status: Pediatric Residency
Cincinnati Children’s Hospital Medical Center, OH
46
GRADUATE EDUCATION - RESEARCH TRAINING
I am the primary supervisor for the following graduate students (part-time research under my supervision)
Brandie Heald; 2004-2006; MSc Genetics
Project: Development and validation of a reproductive fitness questionnaire
Present status: Assistant Professor of Pediatrics
Cleveland Clinics, Cleveland, OH
PROSTGRADUATE EDUCATION – RESEARCH TRAINING
I am the primary supervisor for the following post-doctoral fellows (part-time research under my supervision)
Dr. Amita Bishnoi, 2003 – 2005, Adult Rheumatology Fellow
Project: Long-term outcomes of pediatric SLE
Present status: Practicing rheumatologist
Dr. Sri Koneru, 2003 – 2005, Adult Rheumatology Fellow
Project: Adherence to medication in adults with SLE
Present status: Practicing rheumatologist
Dr. Tasha Ruth, 2003 – 2006, Pediatric Rheumatology Fellow,
Supported by: NIH Loan Repayment Program; T32 Trainings Grant
Project: Cognitive functioning and quality of life in children with SLE
Present status: Assistant Professor of Pediatrics
University of South Carolina, Charlotte, SC
Dr. Michael Shishov, 2003 – 2006; Pediatric Rheumatology Fellow,
Supported by: NIH Loan Repayment Program, T32 Trainings Grant;
Project: Predictors of Adherence in SLE
Award: ACR Pediatric Research Award 2005
Present status: Assistant Professor of Pediatrics, Phoenix; University of Arizona, Az
Dr. Amber Khan, 2007, Internal Medicine Resident
Project: Criteria for Improvement in Pediatric SLE
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Present status: Rheumatology fellow, University of Cincinnati
Dr. Svetlana Lvovich, 2004 – 2007, Pediatric Rheumatology Fellow
Supported by: T32 Trainings Grant
Project: Functional Magnetic Resonance Imaging in children with SLE
Present status: Assistant Professor of Pediatrics
Drexel University, Philadelphia, PA
Dr. Kristina Wiers 2005- 2008; Pediatric Rheumatology Fellow; NIH Loan Repayment Program
Supported by: NIH Loan Repayment Program, T32 Trainings Grant
Project: Pharmacokinetics of mycophenolate mofetil
Present status: Assistant Professor of Pediatric University of South Florida, Miami, FL
Dr. Lakshmia, Kocharla, 2006 – 2008, Adult Rheumatology Fellow
Project: Side effects and surveillance of methotrexate in children with juvenile idiopathic arthritis
Present status: Practicing rheumatologist, Michigan
Dr. Deepa Kudalkar, 2008-2009, Adult Rheumatology Fellow
Project: Targeted Interventions to improve adherence to medications in children with SLE
Present status: Practicing rheumatologist, Cincinnati
Dr. Claas Hinze, 2008- 2009, Pediatric Rheumatology Fellow; 2008 Earl J. Brewer Research Award
Project: Prospective validity of neutrophil gelatinase associated lipocalin for lupus nephritis
Award: ACR Pediatric Research Award 2008
Present status: Assistant Professor of Rheumatology University of Munich, Germany
Dr. Carmela Sagcal; 2008-2010; Pediatric Rheumatology Fellow
Project: Pharmacodynamics and genomics of mycophenolate mofetil
Award: ACR Travel Award
Present status: Assistant Professor of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia
Dr. Lena Das, 2008-2010; Pediatric Rheumatology Fellow
Project: Biomarkers of lupus nephritis
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Award: ACR Earl Brewer Award of Pediatric Rheumatology Excellence; 2009
Present status: Practicing rheumatologist, Singapore
Dr. Rina Mina, 2009 – 2010, Pediatric Rheumatology Fellow
Supported by: T32 Trainings Grant
Project: Development of Flare Criteria for Children with SLE
Award: ACR Travel Award, FDA Travel Award, EULAR Travel Award
Present status: Adult/Pediatric Rheumatology fellow
Dr. Jennifer Neveille, 2010, Internal Medicine Resident
Project: Targeted Intervention to Improve Adherence in Lupus
Present status: Internal Medicine Resident
Dr. Yousefa Washea, 2010, Internal Medicine Resident
Project: Targeted Immunosuppression with Mycophenolate Mofetil
Present status: Internal Medicine Resident
Dr. Shaaista Budhani, 2010, Medical School Graduate, Kenya
Project: Quality Improvement in juvenile SLE
Present Status: Pediatric Residency, Rush Medical Center, Chicago, IL
Dr. Matthew Hollander, 2010 – 2014, Pediatric Rheumatology Fellow
Project: Quality Indicators for Children with SLE
Present status: Pediatric Rheumatology fellow in Seattle
Dr. Xolti Morgan, 2010 – 2013, Adult Rheumatology Fellow
Project: Quality Indicators for Children with SLE
Present status: Adult Rheumatology fellow, Cincinnati
Dr. Arshia Ali, 2012, Internal Medicine Resident
Project: Validation of the Pediatric Automated Assessment Metrics in childhood-onset lupus
Present status: Internal Medicine Resident
49
Dr. HaiMei Lu, 2012, Visiting Professor, Shanghai
Project: Validation of the Pediatric Automated Assessment Metrics in childhood-onset lupus
Present status: Professor of Pediatrics
Dr. Lisa Ravinder, Internal Medicine Resident
Project: Impact of e-capture on the validity of quality of life and review of system measurement
in pediatrics
Present status: Internal Medicine Resident