A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology

Bordbar, Feist, Usaite-Black, Woodcock, Palsson, FamiliBMC Systems Biology 2011

Obese vs. Diabetic ObeseGene expression samples from gastric bypass patients in fasting

state.

Objective: AM triacylGlycerol + MM protein HM glucose

Unique reactions:Gene expression: 27 obese, 40 diabeticMulti-tissue model: 29 obese, 94 diabeticExpression FP: 39 of 67

Differences mainly in AM

Obese vs. Diabetic ObeseDiabetic AM:

[deminished insulin response] carnitine shuttle and FA oxidation Elevated free FA, lactate HM gluconeogenesis hyperglycemia

Diabetic catalase is inactive causes oxidative damage to tissues

Diabetic cysteine deoxygenase is inactive (breaks down excess cysteine to pyruvate and taurine)