Biomanufacturingin North Carolina

Biomanufacturing in N.C.

What is biotechnology?

A collection of technologies that use living cells and/or biological molecules to solve problems and make useful products.

Biomanufacturing in N.C.

The making of these products is called biomanufacturing or bioprocessing.

Biomanufacturing in N.C.A Growing Industry in N.C.

16 biomanufacturing companies

More than 30 other companies engaged in related manufacturing of pharmaceuticals, diagnostics and medical devices

Together, they employ more than 20,000 people.

Biomanufacturing in N.C.

Types of products made in N.C. include:

Vaccines for humans and animals Biopharmaceuticals Amino acids Industrial enzymes Therapeutics isolated from blood Custom DNA sequences

Biogen Idec Produces biopharmaceuticals to treat cancer,

multiple sclerosis and inflammatory diseases. Its large-scale manufacturing in

Research Triangle Parkis one of the largest cell culture facilities

in the world.

AjinomotoIs a world leader in the

production of amino acids, the building blocks of

proteins. Like many bioprocessing facilities, the

Raleigh plant operates at full capacity

24 hours a day, 365 days a year.

Is a world leader in production of recombinant protein

biopharmaceuticals. Its state-of-the-art facilities are located in Research

Triangle Park.

Diosynth RTP

AlphaVax Is developing a new

vaccine technology with broad applications against infectious

disease, cancer and biodefense threats. Its manufacturing plant is

located in Lenoir.

Novozymes North AmericaIs located on 1,600 acres

in Franklinton. It is the largest multi-purpose

enzyme manufacturing plant in the United States

and employs approximately

350 people. Novozymes is the biotech-based world leader in industrial enzymes and microorganisms.

EmbrexIs an international ag biotech company that

developed the first in ovo (in the egg) injection

system. It eliminates the need for manual

vaccination of newly hatched broiler chicks.

The manufacturing plant is located in

Laurinburg.

Wyeth Vaccines

Operates one of the world’s largest

vaccine facilities in Sanford. The vaccines that

eliminated small pox and polio in the

U.S. came from Wyeth laboratories.

Greer LabsIs a leading supplier

of allergy testing and treatment materials. Its

manufacturing facility is located in

Lenoir.

KBI BioPharmaIs a contract

biomanufacturer in Durham. The

company produces a

variety of bio-pharmaceuticals

for other companies.

MWG Biotech

Offers products and services for gene

research. The company

produces custom DNA sequences.

The facility is located in

High Point.

Argos TherapeuticsIs developing therapeutic vaccines in Durham, which are given to treat (instead of prevent) diseases such as cancer and HIV/AIDS.

BiolexProduces hard-to-make therapeutic

proteins by growing them in the aquatic

plant Lemna (duckweed).

The biomanufacturing plant is in Pittsboro.

Isolates a variety of therapeutic proteins from human blood and plasma in its

Clayton, N.C., facility.The diseases these proteins treat

include:● Hemophilia

● Clotting disorders● Shock ● Burns

● Immune disorders● Hepatitis ● Tetanus

● Rabies exposure.

Talecris Biotherapeutics

Archer Daniels Midland

Is one of the largest agricultural processors in the world. The plant, in Southport, N.C., produces citric acid.

Corn Products International

Produces high-

fructose corn syrup and starch

in Winston-Salem.

Merck & Co.Broke ground on a new

biomanufacturing facility in 2004. When

completed in 2008, the Durham facility

will produce vaccines for chicken pox and

measles-mumps-rubella (MMR).