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BIO 345 001 - PATHOPHYSIOLOGY SPRING, 2020

Tuesday/Thursday 8:45–10:00 AM

Luther Bonney 510, Portland Campus

Credit Hours: 3

Tracy Anne Filler, VMD MS

Best form of Contact is Email: Tracy.Filler@Maine.edu

You may also leave a message for me at the Biology Department (207-780-4260)

Office hours: Available upon Request.

I am willing to meet with students in the lounge of Luther Bonney or if we need a

more private setting the adjunct office connected to the Department of Biology’s

Main Office, USM Science Building 107.

Mandatory Text and Materials:

Essentials of Pathophysiology, Concepts of

Altered States, 4th edition

By: Carol Porth; ISBN 9781451190809

Access to BLACKBOARD is required for this class.

Please check your USM email account for Blackboard announcements

regularly. I will be updating this site during the semester. Use your

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USM email account for all correspondences. It is the student’s

responsibility to keep informed of ALL changes and assignments via

email, announcements, and Blackboard posts.

Course Description: Pathophysiology is the study of the genetic

physiological, biochemical and anatomical pathways of non-infectious

diseases. This web-based class will consist of lecture sessions and

assignments on blackboard.

Prerequisites: Bio 109 or Bio 113 or Bio 223. These are the pre-

requisites as established by the university. This is an upper level

science course it is recommended that you have completed two

semesters of Anatomy & Physiology.

Course Objectives & Learning Outcomes: Pathophysiology is the

study of how normal body function is altered by disease. Most of the

people in this class have had a recent (or not so recent) course in

Anatomy & Physiology. This should provide an excellent background in

the basic form and function of the normal body.

In this course we will explore normal function in greater detail and go

on to discuss abnormalities in function caused by disease. We will begin

by discussing some general concepts of pathophysiology and will then

focus on genetic diseases, cancer, immune disturbances, cardiovascular

disease, respiratory disease, GI disease, renal disease, hepatobiliary

disease, and endocrine disease (including diabetes). By the end of this course you should be able to:

1) Expand your understanding of normal body function, and to use this understating as the basis for gaining an appreciation of the physiological basis for some important diseases.

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2) Provide a basic understanding of how the body reacts to disease and compensates for some important diseases, and

3) Explore the physiological basis for the treatment of some important diseases.

4) Be able to communicate said concepts and terminology of pathophysiology and disease utilizing terminology of a clinical professional.

Student Responsibilities:

Attend ALL lectures.

Take careful notes during lecture.

Keep up with all assignments, Blackboard postings and readings.

Stay current with your readings from the text book.

Participate actively in lectures.

Ask questions to help clarify any assignments or material that is

confusing and unclear.

Turn in all assignments on time. Late assignments will be

penalized. Do not get behind on you assignments.

Turn in college level work that is respectful. No slang

terminology, profanity or abbreviations are accepted.

Contact the professor if you have any questions. Do not be afraid

to ask for help.

Be respectful to your professor and all of your fellow classmates.

Review the USM honor code. It is imperative to uphold the

integrity and decorum of an USM student.

And finally-have fun!!! Yes this can be an intense course but I

assure you if you plan on pursuing a career in science or medicine

this class is imperative to your future. You are here to learn and I

will be the guide.

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Course Outline of Topics

Here is a list of the chapters we will complete this semester.

CHAPTER TOPIC

1 Introduction and Terminology

2 Cells Respond to Stress

4 Cell Proliferation & Tissue Repair

6 Genetic and Congenital Diseases

7 Neoplasia

8 Fluid, Electrolyte & Acid-Base Balances

15 Normal Immunity

16 Disorders of Immunity

18 Disorders of Blood Flow and Pressures

19 Disorders of Cardiac Function

20 Disorders of Heart Failure and Shock

23 Disorders of Gas Exchange and Ventilation

26 Kidney Disease

29 Disorders of GI Function

30 Hepatobiliary Disease

32 Endocrine Disorders

33 Diabetes Mellitus

Technology: You are permitted to bring laptops and tablets to class.

However I ask that all cell phones be turned off and placed away. Cell

phones are a distraction, if you need to take a call please step out into

the hall during lecture.

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Below is how your performance will be assessed in our class.

ASSIGNMENT % of GRADE

DESCRIPTION

Homework Assignments per

Chapter

100 points total

Questions to review material discussed in class

will be available for a certain period of time on

Blackboard.

Examinations- Three exams during the semester. The final exam will be

administered during final exam period

300 points (each exam 100 points)

Exams are utilized to measure your

understanding of the assigned material from both lab and lecture. There will be an exam

every five weeks.

Case Discussions 100 points Group Project

Student groups lead discussion about a chosen topic that ties in with the lecture schedule for the

week.

TOTAL POINTS AVAILABLE

500 points

Grading Scale & Description of Assignments

A 93-100 B 83-86 C 73-76 D 60-66

A- 90-92 B- 80-82 C- 70-72 F < 60

B+ 87-89 C+ 77-79 D+ 67-69

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Attendance Policy: Attendance will not be recorded but is expected

during the semester. Attendance is especially important when case

discussion are scheduled. The path to success begins with good

attendance.

How to Contact the Professor: The best way to contact me is by

USM email. I will respond to your questions within 24 hours during the

week and within 36-48 hours during the weekend. Please include your

name and the course code in the subject line. Please be professional

and clear with your questions.

Please note that I am only campus Tuesdays and Thursdays for class. I

am unavailable on Wednesdays, Fridays and Saturdays during the

semester due to my other employment.

Inclement Weather Policy: Class will be closed if USM closes or

delays due to inclement weather. If we miss class time due to

inclement weather I will contact the entire class via email with the

updated schedule and plan. If we miss an exam day, we will hold the

exam on the next regularly scheduled class day. If we miss the final,

plan to take the exam on the Tuesday following finals week.

End-of-Course Evaluation: USM is now using an Electronic Course

Evaluation (ECE) system and this course is included in the project.

During the last week of classes, students will receive an email notice

that asks you to complete your course evaluation online. This email will

include a direct link to the course evaluation, and you will log-in by

using your Mainestreet ID and password.

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Your ratings on the evaluation would be very useful to your instructor if

you answer thoughtfully and honestly. The responses you give are

confidential and will be collected by the Office of Academic

Assessment. After the final grades are posted, your instructor will

receive a summary report of the student responses. All student

feedback is valued and is being used for course and program

improvement purposes. Thanks, in advance, for your participation.

USM Course Policies

Accommodations: If you need course adaptations or accommodations

because of a disability, please Contact the Disabilities Services Center,

242 Luther Bonney Hall, Portland campus. You can call them at 780-

4706 to arrange an appointment with the Coordinator of DSC. This is in

accordance with the ADA.

Title IX statement: The University of Southern Maine is committed to

making our campuses safer places for students. Because of this

commitment, and our federal obligations, faculty and other employees

are considered mandated reporters when it comes to experiences of

interpersonal violence (sexual assault, sexual harassment, dating or

domestic violence, and stalking). Disclosures of interpersonal violence

must be passed along to the University’s Deputy Title IX Coordinator

who can help provide support and academic remedies for students who

have been impacted.

More information can be found by contacting Sarah E. Holmes at

sarah.e.holmes1@maine.edu or 207-780-5767online at

http://usm.maine.edu/campus-safety-project. If students want to

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speak with someone confidentially, the following resources are

available on and off campus:

University Counseling Services (207-780-4050)

24 Hour Sexual Assault Hotline (1-800-871-7741)

24 Hour Domestic Violence Hotline (1-866-834-4357)

Add-Drop & Withdrawal: USM establishes the policy for grading

when a student drops a course. A student may receive a grade of “W” if

s/he withdraws before 60% of the course is completed. Withdrawals

do not affect your GPA. They do affect your course completion rate.

Failure to attend or ceasing to attend class does not constitute

withdrawal from the course. If you fail to come to class after the after

the withdrawal period, the grade is “F.” It is important that students

understand that this is a University policy. I cannot give grades of “W”

to students who leave a class after the set date no matter how much I

may wish to. There is no refund associated with withdrawal.

I do, of course, understand that circumstances beyond the control of a

student (for example, health or family emergencies) may arise late in

the semester and that these circumstances may make it impossible for

a student to complete a course. If you are passing this course and an

emergency arises that makes it impossible for you to finish, please

contact me to discuss a grade of “Incomplete.” I will consider requests

for an incomplete when:

1) A legitimate emergency exists.

2) The student is passing at the time of the request.

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3) The student has a realistic plan to complete the course work by the

end of the following semester.

4.) The student has talked to the head of the department and their

advisor to confirm the acceptance of an ‘Incomplete”.

Plagiarism and other forms of Cheating

Academic honesty is of the utmost importance in all classes because it

maintains the integrity of the entire educational process. Everyone

associated with USM is expected to adhere to the principles of

academic integrity central to the function of the University. Breech of

these policies represents a serious offense. Plagiarism, cheating, and

falsification of information are violations of academic integrity that will

not be tolerated in this class. Adherence to ethical academic standards

is obligatory.

Cheating is a serious offense, whether it consists of taking credit for

work done by another person or doing work for which another person

will receive credit. Taking and using the ideas or writings of another

person without clearly and fully crediting the source is plagiarism and

violates the academic code as well as the Student Code of Conduct.

Please check the USM Office of Community Standards website for

official definitions of these practices. Evidence of a violation of the

academic integrity policy will normally result in disciplinary action. A

copy of this policy may be obtained from the office of Community

Standards and Mediation by calling 207-780-5245 or online at

USM.maine.edu.

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You can also get a copy of the policy through the Office of Student

Judicial Affairs. If you are in doubt concerning the requirements, please

consult me before you complete any assignment so that we can discuss

what is not acceptable.

If it is suspected that a student in any course in which s/he is enrolled

has knowingly committed a violation the instructor has the authority to

review the alleged misconduct and determine the grade that the

student should receive for the assignment and the course. The

instructor may assign a failing grade for the assignment or course and

may require the student to complete additional work for the course.

The instructor may also consult with the department chair faculty

member and/or the College’s chief academic officer prior to making

such decisions.

This is a web-enhanced course. Many of the assignments and

examinations are on-line and completed outside the classroom. It is of

vital importance that all students adhere to USM’s honor code. This

means that no one is permitted to have assistance for any exam or to

have another person take the exam in their place. If for any reason

during the semester the instructor feels that this policy is being

violated I reserve the right to stop on-line assignments and begin in-

class, closed book homework.

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PATHOPHYSIOLOGY BIO 345 SPRING, 2020

SCHEDULE OF LECTURES & ASSIGNMENTS

DATE CHAPTER ASSIGNMENTS 1/21 Syllabus Review and

Terminology Welcome to our class

1/23 Chapter 2 Cells Response to Stress

& Chapter 4 Cell Proliferation &

Tissue Repair

1/28

Chapter 6 Genetic & Congenital

Diseases

1/30

Chapter 6 Genetic & Congenital

Diseases

Homework due

Syllabus, Chapter 2 & 4 2/4 Chapter 7

Neoplasia Case Discussion-

Genetics/Congenital

2/6 Chapter 7 Neoplasia

Homework due Chapter 6

2/11 Chapter 8 Fluid, Electrolyte & Acid-Base Balances

Case Discussion

Neoplasia

2/13 Chapter 8

Fluid, Electrolyte & Acid-Base Balances

Homework due

Chapter 7

2/18 Test #1 Intro, Ch. 2, 4, 6, 7, & 8

Homework due Chapter 8

2/20 Chapter 15 Normal Immunity

2/25 Chapter 16 Disorders of Immunity

2/27 Chapter 16 Disorders of Immunity

Case Discussion Autoimmune Disease

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DATE CHAPTER ASSIGNMENTS

3/3

Chapter 18 Disorders of Blood Flow

& Pressure

Homework due Chapter 15 & 16

3/5

Chapter 18 Disorders of Blood Flow

& Pressure

Case Discussion Blood Pressure

3/10

Chapter 19 Disorders of Cardiac

Function

Homework due

Chapter 18

3/12 Chapter 19

Disorders of Cardiac Function

Case Discussion Cardiac Disease

3/16-3/20

SPRING BREAK Happy & Safe SPRING BREAK

3/24

Chapter 20 Disorders of Heart

Failure & Shock

Homework due

Chapter 19

3/26 Chapter 20

Disorders of Heart Failure & Shock

Case Discussion

Congestive Heart Failure

3/31 Chapter 23

Disorders of Gas Exchange & Ventilation

Homework due

Chapter 20

4/2 Chapter 23

Disorders of Gas Exchange & Ventilation

Case Discussion

Pulmonary Disease 4/7 Test #2

15, 16, 18, 19, 20 & 23 Homework due

Chapter 23 4/9 Chapter 26

Kidney Diseases

4/14 Chapter 29 Disorders of GI Function

Homework Chapter 26 Case Discussion Kidney Disease

4/16 Chapter 30 Hepatobiliary Diseases

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DATE CHAPTER ASSIGNMENTS

4/21 Chapter 32 Endocrine Disorders

Homework due Chapter 29 & 30

4/23 Chapter 32 Endocrine Disorders

Case Discussion GI/Liver Disease

4/28 Chapter 33 Diabetes Mellitus

Homework due Chapter 32

4/30 Chapter 33 Diabetes Mellitus

Case Discussion Endocrine Disease

5/5 No Class

Homework due Chapter 33

5/7 Final Exam 8:00 AM – 10:00 AM

Test #3 Ch. 26, 29, 30, 32, 33

Please note that this schedule is TENTATIVE. It may change based on weather,

illness, and the pace of our class. After all this is Maine in winter. I am asking all of you to

be flexible with adaptions during the semester. For instance if there are numerous snow

days we may need to bump the presentations to May 5th.

Make sure that you are comfortable with blackboard. I will be posting

assignments such as the quizzes, lecture slides and discussions on this site. I will also

have announcements here and via email concerns class schedules during the semesters.

IT IS THE RESPONSIBILITY OF THE STUDENT TO KEEP ABREAST OF ALL ASSIGMENTS AND

CHANGES IN THE SCHEDULE.

Here is to an exciting semester in Pathophysiology.