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BASF Product Catalogue Actives 2017

BASF - IMPAG · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

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Page 1: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

B A S FProduct Catalogue Actives 2017

Page 2: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

Product

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Ant

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tive

ACTIWHITETM PW LS 9860 x x

ADVANCED MOIST COMPLEXTM NP R11016 x x x

AH CARETM L-65 x x

ANASENSYL® LS 9322 x

AQU‘ACTIVTM LS 9856 x x x

ARGANYLTM LS 9781 x x x x x

ARGANYLTM PW LS 9830 x x x x x

ARGASSENTIALTM BC09959 x x

ARGATENSYLTM PW BIO LS 9902 x x

ASEBIOLTM LS 9853 x

BETA HYDROXYDETM AC SD G00011 x x

BETAPURTM A00067 x x

BIOPHYTEXTM LS 9832 x x

COBIALIFTTM 18 BC 10014 x x x

COLLGUARDTM A00263 x x

COLLREPAIRTM DG A00331 x x x

DANSONYLTM LS 9715 x x x x

DELINERTM A00199 x x

DERMAGENISTTM PW BC 10004 x x

DERMAWHITETM WF BC09993 x

DERMICANTM PW LS 9838 x

DERMICANTM SPB LS 9837 x

DN-AGETM LS 9547 x x x

DN-AGETM PW LS 9827 x x x

D-STRIATM A00259 x x

DULCEMINTM PW BIO LS 9903 x x

ELESTABTM HP 100 x x x x

ELESTANTM LS 9913 x x x

ELESTANTM PW LS 9879 x x x

EPERULINETM PW LS 9627 x x x

EPIGENISTTM LS 10003 x

FRESHAXYLTM LS 9980 x x

GENEROLTM R x x x

2

P R O D U C T O V E R V I E W Application fields

Page 3: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

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Sens

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Skin

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Skin

Lig

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Ant

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Firm

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Pres

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tive

HIBISCINTM HP LS 9198 x x x x

HYALUFIXTTM GL A00102 x

HYALURONIC FILLING SPHERESTM C00498 x x

HYALUROSMOOTHTM LS 8998 x x x

HYALUROSMOOTHTM PW LS 8997 x x x

HYDRASENSYL® SPB LS 9938 x

IRWINOLTM LS 9890 x x x x

LACTOLANTM LS 5879 x x x

LARICYLTM LS 8865 x x x x

LINEFACTORTM C A00314 x x x x

LIPOFRUCTYLTM ARGAN LS 9779 x x

LIPOFRUCTYLTM CYPERUS LS 9892 x

LIPOFRUCTYLTM MO LS 9305 x x x x

LITCHIDERMTM LS 9704 x x x x x

LOX-AGETM A00327 x x

LYS'LASTINETM V A00077 x x x

LYS‘SUNTM BC10006 x x x

MARINE FILLING SPHERESTM C00468 x x x x x

MARIPONICSTM PSR R11009 x x

MAT-XSTM CLINICAL A00098 x x

MELHYDRANTM LS 9876 x x

MELLIDYNTM LS 9834 x x x x

MYOXINOLTM LS 9736 x

NEUROBIOXTM A00112 x x

OLIGOLINTM BC 10028 x x

OSMHYDRANTM LS 8453 x x

OSMOGELINETM R10979 x x x

OXYGENTM COMPLEX LS 9641 x x

PA REVIVISCENCETM LS 9562 x

PATCH2OTM A00297 x x

PERLAURATM A00316 x x

PHOTOTANTM LS 2261 E x

PHYTOKINETM A00287 x x x x

3

P R O D U C T O V E R V I E W Application fields

Page 4: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

Product

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calp

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ural

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Ski

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Sebu

m R

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in

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ll re

vita

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Skin

Lig

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PHYTOLIGHTTM BG A00043 x

PHYTOSOOTHETM LS 9766 x x x x

PILISOFTTM LS 9760 x

PROTEASYLTM PW PSE LS 8951 x x x

PROTEASYLTM TP POE LS 9818 x x x

PURICARETM POE LS 9727 x

PURISOFTTM POE LS 9726 x

PURISOFTTM PW PSE LS 9836 x

RADIANSKINTM PW LS 9918 x x

RELIPIDIUMTM A00265 x x

SANICAPYLTM BC 10030 x

SEBARYLTM FL 9088 x

SHADOWNYLTM R11026 x x

SKINASENSYLTM LS 9749 x

SKINASENSYLTM PW LS 9852 x

SLIM-EXCESSTM A00073 x x x

SPECI‘MENTM BC10001 x x x

SPHINGOCERYLTM VEG LS 9948 x x x x x

SQISANDRYLTM LS 9905 x

SVELTINETM ST BC10032 x x

SYMBIOCELLTM BC10015 x

SYMBIOCELLTM A00110 x

SYNIORAGETM PW LS 9847 x

TRICHOGENTM VEG UL LS 9922 x

TRICHOLASTYLTM LS 9912 x

ULTRA FILLING SPHERESTM x x

VEGESERYLTM HGP LS 9874 x x x x

VITACELL® PW LS 7979 x x

VIT-A-LIKETM PW LS 9898 x x

VIT-A-LIKETM SPB LS 9793 x x

VITAPLEXTM LS 9799 x x x

X-PRESSINTM C R11021 x x

4

P R O D U C T O V E R V I E W Application fields

Page 5: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

ACTIWHITETM PW LS 9860

Maltodextrin (and) Sucrose Dilaura-te (and) Sodium Cocoyl Glutamate (and) Pisum Sativum Extract

Inhibition of melanosome maturation, Inhibition of melanogenesis, Tyrosinase-inhibition

Whitening (1.7%, W6, W12), Anti-age spots efficacy (2%, D56), “Reduction of number, size and color intensitiy of dark spots” (2%, D56; Evaluation by a dermatologist), “More even and brighter skin complexion” (2%, D56; Panelist’s evaluation)

None 2% Hydrosoluble

ADVANCED MOIST COMPLEXTM NP R11016

Glycerin (and) Aqua (and) Sodium PCA (and) Urea (and) Trehalose (and) Hexylene Glycol (and) Polyquaternium-51 (and) Triacetin (and) Caprylyl Glycol (and) Sodium Hyaluronate

Water binding capacity (10%), More hydrating than HA (5%, 0.5h, 2h, 4h, 6h, 8h), Reinforcement of the cutaneous barrier (10%, 2h, 6h), Immediate and all day moisture (3%, 2 min, 4min, 6min, 8h), Longterm moisture (10%, D15)

None 3 - 10% Hydrosoluble

AH CARETM L-65 Lactic Acid (and) Aqua (and) Arginine

Increase of cell turnover (14.7%, D21), Reduction of acute irritation (Stinging) (14.7%, 2min, 4min, 6min, 8min), Reduction of cumulative irritation (14.7%, D1-14)

None 5 - 10% Hydrosoluble

ANASENSYL® LS 9322

Mannitol (and) Ammonium Glycyrrhizate (and) Caffeine (and) Zinc Gluconate (and) AesculusHippocastanum Seed Extract

Reduction of LDH, PGE2, IL-alpha release

Soothing and calming after capsaicin application (1%, 30min), Reduction of erythema after shaving (1%, D7, D14)

None 0.5 - 1.5% Hydrosoluble

AQU‘ACTIVTM LS 9856 Behenyl Alcohol (and) Glyceryl Oleate (and) Cocamide MIPA (and) Calcium Citrate

Increase of Involucrin, Transglutam-inase and Thight junctions protein levels, Increase of lipid neo-synthesis, Inhibits ceramidase activity

Skin moisturization (3%, D14), Increase of skin elasticity (3%, D14)

None 2 - 3% Liposoluble

ARGANYLTM LS 9781 Aqua (and) Glycerin (and) Argania Spinosa Extract

Anti-collagenase activity (in-tubo), Anti-collagenase activity (ex-vivo), Anti-MMP activity, Anti-free radical activity, Cell protec-tion against pollution stress (PM2.5 + PAH, B[a]P + UVA)

“Skin is more elastic, skin texture is smoother and skin is softer” (3%, D56; panelist’s evaluation), Anti-oxidative potential vs placebo and vs 1% tocopheryl acetate (3%, D15)

Phenoxy-ethanol

1 - 3% Hydrosoluble

ARGANYLTM PW LS 9830

Argania Spinosa Extract (and) Maltodextrin

Anti-collagenase activity (in-tubo), Anti-collagenase activity (ex-vivo), Anti-MMP activity, Anti-free radical activity, Cell protec-tion against pollution stress (PM2.5 + PAH, B[a]P + UVA)

“Skin is more elastic, skin texture is smoother and skin is softer” (0.21%, D56; panelist’s evaluation), Anti-oxidative potential vs placebo and vs 1% tocopheryl acetate (0.21%, D15)

None 0.07 - 0.21% Hydrosoluble

ARGASSENTIALTM BC09959

Dicaprylyl Ether (and) Sorbitol (and) Lauryl Glucoside (and) Poly-glyceryl-2 Dipolyhydroxystearate (and) Aqua (and) Argania Spinosa Fruit Extract (and) Glycerin

Increase type I collagen synthesis, Stimulation of pre-adipocyte differ-entiation, Increase of lipid storage in mature adipocytes

Face firming (2%, D56), Face plumping (2%, D56), Lips plumping (2%, D28

None 1 - 2% Hydrodis-persible & lipodispersible

ARGATENSYLTM PW BIO LS 9902

Argania Spinosa Kernel Extract (and) Sodium Cocoyl Glutamate

Immediate lifting / wrinkle smoothing (test on crow’s feet area (0.6%, 15Min, 60Min), Long term wrinkle smoothing in crow’s feet area (0.6%, D28)

None 0.15 - 0.6%; 1.25% for flash serums Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

5

P R O D U C T L I S T A – Z

Page 6: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

ASEBIOLTM LS 9853 Aqua (and) Pyridoxine HCl (and) Niacinamide (and) Glycerin (and) Panthenol (and) Hydrolyzed Yeast Protein (and) Threonine (and) Allantoin (and) Biotin

Anti-oily hair effect (5%, D28) Phenoxy-ethanol, Potassium Sorbate

3 - 5% Hydrosoluble

BETA HYDROXYDETM AC SD G00011

Acacia Senegal Gum (and) Salicylic Acid

Transcutaneous penetration (ex-vivo) Skin renewal (0.4%, 2%, D15), Pore size reduction (0.4%; 3%, D28), Reduction of number of pore (0.4%; 3%, D28), Shine reduction (0.4%; 3%, D28), General improvement of oily skin: “Refined pores, Complexion eveness, Brightness, blackheads, Inflammatory lesions” (0.4%;3%; D14, D30 Clinician evaluation), “Less oily skin, matified skin, less visible pores, removed blemishes, comfort” (0.4%; 3%; D14, D30 Panelist’s evaluation)

None 0.4 - 5% Hydrosoluble

BETAPURTM A00067 Aqua (and) Butylene Glycol (and) Peumus Boldus Leaf Extract (and) Pentylene Glycol (and) Xanthan Gum

Stimulation of the production of β-de-fensins, Inhibition of the production of inflammatory cytokines and IL8 and MIP3-α

Reduction of skin redness (2%, D28), Purification of the skin (2%, D28), “Purified complexion, refined skin texture, compexion eveness, pores less visible” (2%, D28; panelist’s evaluation), Decrease of inflammatory aspect and improvement of the skin’s overall appearance (4%, D28)

None 0.5 - 5% Hydrosoluble

BIOPHYTEXTM LS 9832 Aqua (and) Butylene Glycol (and) Panthenol (and) Escin (and) Glycerin (and) Ruscus Aculeatus Root Extract (and) Ammonium Glycyrrhizate (and) Centella Asiatica Leaf Extract (and) Hydrolyzed Yeast Protein (and) Calendula Officinalis Flower Extract

Anti-inflammatory (ex-vivo) Soothing (5%, D21), Anti-eye dark circle effect (3%, D28), Anti-couperose (3%, D14)

None 2 - 5% Hydrosoluble

COLLALIFTTM 18 BC10014

Glycerin (and) Aqua (and) Khaya Senegalensis Bark Extract (and) Maltodextrin

Stimulation of collagen XVIII synthesis in keratinocytes, Stimulation of collagen XVIII synthesis in adipocytes, Improvement of biomechanical properties (3D Mimeskin)

Improvement of skin’s surface homogeneity, Smoothing of wrinkles (crow’s feet area), Improve-ment of skin elasticity, (1%, D28, D56)

None 1% Hydrosoluble

COLLGUARDTM A00263 Water (and) Butylene Glycol (and) Davilla Rugosa Leaf Extract (and) Pentylene Glycol (and) Xanthan Gum

Inhibition of glycation, Boost of collagen synthesis, Radical scavenging activity, Inhibition of collagenase, Increase of collagen I deposition

None 1 - 3% Hydrosoluble

COLLREPAIRTM DG A00331

Aqua (and) Niacin (and) Hexylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum (and) Salvia Miltior-rhiza Leaf Extract

Extracellular deglycation activity (in-tubo), Intracellular deglycation activity, Intracellular cytoskeleton morphology, Cellular resilience im-provement, Breaking the viscous cycle of glycation propagation (in-tubo)

Decrease of AGEs (3%, D112), Skin tone improve-ment (3%, D112), Improvement of skin elasticity (5%, D28)

None 3 - 5% Hydrosoluble

DANSONYLTM LS 9715 Hydrolyzed Adansonia Digitata Extract

Moisture retention Tightening (10%, D21), Sensorial improvement (5%, 5min, 45min)

Phenoxy-ethanol

3 - 10% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

6

P R O D U C T L I S T A – Z

Page 7: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

DELINERTM A00199 Aqua (and) Butylene Glycol (and) Pentylene Glycol (and) Zea Mays Extract (and) Xanthan Gum

Activation of fibronection synthesis (ex-vivo), Activation of tissue repair (ex-vivo)

Wrinkle reduction (3%, D56), Redensification of the skin (3%, D120)

None 3% Hydrosoluble

DERMAWHITETM WF BC09993

Aqua (and) Tartaric Acid (and) Di-sodium EDTA (and) Glycerin (and) Butylene Glycol (and) Psidium Guajava Fruit Extract (and) Carica Papaya Fruit Extract (and) Saxifraga Sarmentosa Extract

Inhibition of melanin synthesis Skin lightening vs placebo on indian volenteers (2%, D84), Skin lightening vs kojic acid on indian volenteers (2%, D56) “Skin is fairer, lighter and looks brighter” (2%, vs placebo D56, vs kojic acid D14); Panelist’s evaluation), Lightening effect of a facial rinse off soap bar (1.5%, D14, D28), “Made my skin fairer”, “Helps to lighten my skin”, “Makes my skin tone even”, “Makes my skin look brighter” (1.5%, D28) (Panelist’s evaluation)

Sodium Sulfite, Sodium Metabisulfite

2% Hydrosoluble

DERMICANTM PW LS 9838

Mannitol (and) Acetyl Tetrapeptide-9

Stimulation fibroblast cell growth and structural proteins (gene expression), Stimulation of lumican synthesis (on aged fibroblasts and pseudo-dermis), Stimulation of collagen I (gene expres-sion and on fibroblasts)

Structuring by increasing dermis’s thickness, firming (0.9%, D112)

None 0.3 - 1% Water dispersible

DERMICANTM SPB LS 9837

Aqua (and) Glycerin (and) Acetyl Tetrapeptide-9

Stimulation fibroblast cell growth and structural proteins (gene expression), Stimulation of lumican synthesis (on aged fibroblasts and pseudo-dermis), Stimulation of collagen I (gene expres-sion and on fibroblasts)

Structuring by increasing dermis’s thickness, firming (0.9%, D112)

None 0.3 - 1% Hydrosoluble

DERMAGENISTTM PW BC10004

Maltodextrin (and) Origanum Majorana Leaf Extract

Reinforce fibroblast intracellular struc-tures and contractility, Re-activating cells’machinery through epigenetic regulation, Re-building of collagen network, Strengthening of cell-matrix interactions

Improvemnet of skin density and firmness (0.4%, D28, D56, D84)

None 0.40% Hydrosoluble

DN-AGETM LS 9547 Aqua (and) Glycerin (and) Cassia Alata Extract

Nuclear DNA protection from UV-B, mitochondrial DNA protection from UV-A, Support of DNA repair

Improvement of skin microrelief after UV irradiation (preventive application) (3%, Pre-treatment D6, treatment & irradiation D4, Microrelief alterations after D6)

Phenoxy-ethanol

1 - 3% Hydrosoluble

DN-AGETM PW LS 9827

Cassia Alata Extract (and) Maltodextrin

Nuclear DNA protection from UV-B, mitochondrial DNA protection from UV-A, Support of DNA repair

Improvement of skin microrelief after UV irradiation (preventive application) (0.25%, Pre-treatment D6, treatment & irradiation D4, Microrelief alterations after D6)

None 0.1 - 0.25% Hydrosoluble

D-STRIATM A00259 Butylene Glycol (and) Pentylene Glycol (and) Alcohol (and) Serenoa Serrulata Fruit Extract

Relaxing of myofibroblast, Elastin gene expression, Stimulation of collagen I

Improvement of stretch marks (3%, D84), “Skin is more supple, the stretch mark is smoother, appearance of stretch marks is reduced” (3%, D84, Panelist’s evaluation

None 1 - 3% Hydrosoluble

DULCEMINTM PW BIO LS 9903

Prunus Amygdalus Dulcis Protein Skin: Cell vitalization by ATP boosting,Hair: Film forming, Sensorial improvement

Cumulative moisturization (0.3%, D28), Wrinkle smoothing (0.3%, D28), Improvement of skin’s tonicity and tensor effect (0.3%, D28)

None 0.2 - 1% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

7

P R O D U C T L I S T A – Z

Page 8: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

ELESTABTM HP 100 Hexamidine Diisethionate Anti dandruff (0.1%, D28), Anti-disquamation (0.1%, D28), “Improvement in: state of hair, itching, dandruff and regresing” (0.1%, D28; Panelist’s evaluation)

None 0.01 - 0.1% Hydrosoluble

ELESTANTM LS 9913 Glycerin (and) Manilkara Multinervis Leaf Extract (and) Aqua

Anti-elastase activity on skin sections, Anti-glycation performance (in-tubo), Stimulation of tropoelastin gene expression, Stimulation of (tropo)elastin protein synthesis, Stimulation of fibulin-5 synthesis, Stimulation of emilin-1 synthesis, Type I collagen synthesis (ex-vivo), GAGs synthesis (ex-vivo), Elastin synthesis (ex-vivo)

Skin suppleness, skin tonicity (3%, D56; cutometer), Skin suppleness, skin tonicity (3%, D56; Dynaskin method), Anti-stretch mark (3%, D84)

None 2 - 3%

ELESTANTM PW LS 9879

Manilkara Multinervis Leaf Extract(and) Maltodextrin

Anti-elastase activity on skin sections, Anti-glycation performance (in-tubo), Stimulation of tropoelastin gene expression, Stimulation of (tropo)elastin protein synthesis, Stimulation of fibulin-5 synthesis, Stimulation of emilin-1 synthesis, Type I collagen synthesis (ex-vivo), GAGs synthesis (ex-vivo), Elastin synthesis (ex-vivo)

Skin suppleness, skin tonicity (0.5%, D56; cutom-eter), Skin suppleness, skin tonicity (0.5%, D56; Dynaskin method), Anti-stretch mark (0.5%, D84)

None 0.3 - 0.5% Hydrosoluble

EPERULINETM PW LS 9627

Dextrin (and) Eperua Falcata Extract Reduction UVB induced of cytokine expression, Inhibition of plasmin, Inhibition of release of pro-inflamma-tory neuropeptide CGRP by sensory neurons, Anti-oxidative effect, De-crease of IL-8 release in kerotinocytes exposed to PM2.5/UVA, Decrease of IL-8 release in kerotinocytes exposed to VOC (Formaldehyde)

Improvement of skin biomechanical properties and barrier function (1%, D28)

None 1% Hydrosoluble

EPIGENISTTM LS 10003

Maltodextrin (and) Voandzeia Subterranea Seed Extract

Boosts the neuritogenesis, Increase of epidermal thickness

Increases of epidermal thickness (0.5%, D56), Increase of skin luminocity and radiance (0.5%, D56), Decrease of roughness (0.5%, D56)

None 0.5% Hydrosoluble

FRESHAXYLTM LS9980

Glyceryl Laurate (and) Moringa Oleifera Seed Extract

Inhibition of the growth of dermal microflora

Reduction of odor caused by perspiration upto 24hrs after application (0.4%, 6h, 24h), “Effective long-term odor control” (0.4%, 6h, 24h; Panelist’s evaluation)

None 0.4% Liposoluble

GENEROLTM R Brassica Campestris (Rapeseed) Sterols

Anti-Neurodermitis/Anti-itching effect (Lit.), UV-Erythema (Lit.), Diaper Dermatitis (Lit.), Anti-pruritic, Anti-inflammatory effect (Lit.)

None 1 - 2% Liposoluble

potentially NaTrue Cosmos approved CHINA approved

8

Page 9: BASF - IMPAG  · PDF fileBASF Product Catalogue Actives 2017. Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Exfoliation Hair Care

P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

HIBISCINTM HP LS 9198

Aqua (and) Esculentus Seed Extract Moisturization (5%, D28), (immediate (5%, 15min, 30min, 60min)) Lifting (5%, D28), Tightening (5%, D28)

Phenoxy-ethanol

2 - 5% Hydrosoluble

HYALUFIXTM GL A00102

Aqua (and) Butylene Glycol (and) Alpina Galanga Extract (and) Pen-tylene Glycol (and) Xanthan Gum (and) Caprylic/Capric Triglyceride

Boosts the synthesis of HAS-2, Doubles the production of hyaluronic acid, Restores densitiy to the dermis

Reduction of nasogenian folds (3 %, D84), “Increas-ingly radiant skin, greater density, fewer wrinkles” (3%, D30; Panelist’s evaluation)

None 1 - 3% Hydrosoluble

HYALURONIC FILLING SPHERESTM C00309

Ethylhexyl Palmitate (and) Trihydroxystearin (and) Sodium Hyaluronate

Water binding properties, No unwant-ed pre-swelling in formulations

Skin penetration (tape stripping), Thickening of stratum corneum (5%), Anti-wrinkle (2%, 1h, 6h), “Reduced expression lines” (3%, 1h, 6h; Panelist’s evaluation)

None 0.5 - 3% Oil dispersible

HYALURO-SMOOTHTM LS 8998

Aqua (and) Cassia Angustifolia Extract

Immediate and long-term moistur-ization

Improvement of skin complexion (3%, 3min, 15min, 30min), “Improvement of skin’s suppleness, softness and moisturized sensation” (10%; Panelist’s evaluation)

Phenoxy-ethanol

2.5 - 5% Hydrosoluble

HYALURO-SMOOTHTM PW LS 8997

Cassia Angustifolia Extract Immediate and long-term moisturization

Improvement of skin complexion (0.075%, 3min, 15min, 30min), “Improvement of skin’s suppleness, softness and moisturized sensation” (0.25%, Omin, 45Min; Panelist’s evaluation)

None 0.05 - 0.1% Hydrosoluble

HYDRASENSYL® SPB LS 9938

Aqua (and) Glycerin (and) Butylene Glycol (and) Serenoa Serrulata Fruit Extract (and) Hydrolyzed Adansonia Digitata Extract

Hydrosoluble

IRWINOLTM LS 9890

Octyldodecanol (and) Irvingia Gabonensis (and) Hydrogenated Coco-Glycerides

Skin: Moisturizing activity compared to shea butter (ex-vivo), Sensorial properties compared to jojoba oil and shea butter Hair: Conditioning effect, improvement of hair sensorial properties

Skin: Repairing activity on damaged lips (3%, D7), Softening, smoothing and soothing (2%, 5min)

None Skin care: 1 - 3%Lip care:0.5 - 3%Hair care: 0.5 - 1% Liposoluble

LACTOLANTM LS 5879 Hydrolyzed Milk Protein ATP-boosting, vitalizing Hair: UV color and structure protection, improvement of combability, condition-ing, repairing, reduction of electrostatic charge, hydro retainingSkin: Immediate and long-term mois-turization (ex-vivo), Elasticity (ex-vivo)

Skin: Softness/tolerance on babies (7%, D21) Phenoxy-ethanol

1 - 10% Hydrosoluble

LARICYLTM LS 8865 Butylene Glycol (and) Fomes Officinalis Extract

Astringent, pore tightening, immediate and long-term moisturizing (ex-vivo)

Astringent and pore tightening (3%) Phenoxy-ethanol

2 - 5% Hydrosoluble and soluble in diluted ethanol

potentially NaTrue Cosmos approved CHINA approved

9

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P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

LINEFACTORTM C A00314

Aqua (and) Butylene Glycol (and) Pentylene Glycol (and) Hibiscus Abelmoschus Extract (and) Xanthan Gum

FGF-2 protection, Cell proliferation, Stimulation of collagen synthesis, Stimulation of total and sulphated GAGs synthesis, Stimulation of Aqua-porine-3 synthesis, Recovery of skin barrier function (ex-vivo), Stimulation of fillagrin expression (ex-vivo)

Wrinkle reduction (3%, D42), Improvement of skin texture and elasticity (3%, D42)

None 1 - 3% Hydrosoluble

LIPOFRUCTYLTM ARGAN LS 9779

Argania Spinosa Oil None 1 - 5% Liposoluble

LIPOFRUCTYLTM CYPERUS LS 9892

Cyperus Esculentus Oil Moisturizing activity on skin,Hair: Sensorial evaluation

None 1 - 3%Liposoluble

LIPOFRUCTYLTM MO LS 9305

Moringa Oleifera Seed Oil None 2 - 10% Liposoluble

LITCHIDERMTM LS 9704

Butylene Glycol (and) Litchi Chinen-sis Pericarp Extract

Anti-free radical (in-tubo), Anti-in-flammatory induced by UV-A and -B, Anti-MMP-1 induced by UV-A and -B (ex-vivo), Moisturizing

Anti-free radical (5%, 10nin), Improvement of skin complexion (5%, D28, D56)

None 2 - 5% Hydrosoluble

LOX-AGETM A00327 Aqua (and) Cichorium Intybus (Chicory) Leaf Extract (and) Hex-ylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum

Stimulation of the gene expressionof LOX, Increase of LOX protein syn-thesis, Increase of differentiation and cohesion of keratinocytes, Stimulation of Collagen-I synthesis

Reduces skin blemishes (2%, D28, D56), Reduces the appearance of pores (2%, D28, D56), Increases the skin elasticity (2%, D28, D56), Reduction of lines and fine lines (2%, D28, D56), Restoration of youthful skin appearance (2%, D56; Panalist’s evaluation)

None 2% Hydrosoluble

LYS‘LASTINETM V A00077

Aqua (and) Butylene Glycol (and) Peucedanum Graveolens Extract (and) Pentylene Glycol (and) Xanthan Gum

Stimulation of LOXL synthesis, Activity only after percutaneous absorption, Decrease of progerin accumulation (= reduction of replicative senescence), Stimulation of Khloto production (= Delay of metabolic senescence), Improvement of elasticity (reconstructed dermis)

Improvement of elasticity and stretchability (1%, D56), Anti-wrinkle (1%, D56), Restructuring of face contour (1%), ”Skin texture is improved, skin is more elastic, facial architecture is improved and satisfied” (1%; Panelist’s evaluation), Improvement of skin tonicity on the decolette (1%, D84)

None 1 - 2% Hydrosoluble

LYS‘SUNTM BC10006 Aqua (and) Pentylene Glycol (and) Hamamelis Virginiana Leaf Extract (and) Xanthan Gum (and) Caprylyl Glycol

Increase of LOX-L gene expression under UV radiation, Inhibition of elafin synthesis under UV-exposion (ex-vivo), Radical scavenging (in-tubo), Anti-MMP-12 and -MMP-2 (in-tubo)

Reduaction of wrinkles and skin roughness vs. Placebo (1%, D56), Increase of skin firmness vs. Placebo (1%, D84),

None 1% Hydrosoluble

MARINE FILLING SPHERESTM C00468

Pentaerythrityl Tetraisostearate (and) Silica Dimethyl Silylate (and) Butylene Glycol (and) Pentylene Glycol (and) Sodium Chondroitin Sulfate (and) Atelocollagen

Water binding properties Cutaneous penetration (1%, 1h, 5h), Anti-Wrinkle (1%, 1h), Longterm hydration (1%, D3), Lips plumping (3%, 1h)

None 0.5 - 4% Liposoluble

potentially NaTrue Cosmos approved CHINA approved

10

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P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

MARIPONICSTM PSR R11009

Aqua (and) Pentylene Glycol (and) Butylene Glycol (and) Algae Extract (and) Faex

Gene expression of Superoxid Dismutase 1, Gene expression of Cytochrome P450, Gene expression of Prostaglandin-endoperoxide synthase 2

“Skin feels clean, non-greasy but still moistured” (3%, D28, D56; Panelist’s evaluation), Reduction of wrinkles on forehead (3%, D56), Pore refining on forehead (3%, D56), Improvement of skin tone evenness (3%, D56)

None 1 - 3% Hydrosoluble

MAT-XSTM CLINICAL A00098

Water (and) Butylene Glycol (and) Pentylene Glycol (and) Sarcosine (and) Xanthan Gum

Inhibition of 5α-reductase type I, Decrease of squalane production (a component of sebum)

Decrease in skin shine and sebum secretion (2%, , D14, D28), Pore refining (2%, D14, D28), “Skin is less oily, skin complexion is more even, no quick re-greasing and pores are tightened” (2%, D28; Panelist’s evaluation)

None 0.5 - 3% Hydrosoluble

MELHYDRANTM LS 9876 Aqua (and) Butylene Glycol (and) Mel Extract (and) Glycerin (and) Urea (and) Sodium Lactate (and) Arginine HCI (and) Lysine HCI (and) Ornithine HCI

Aqua (and) Butylene Glycol (and) Mel Extract (and) Glycerin (and) Urea (and) Sodium Lactate (and) Arginine HCI (and) Lysine HCI (and) Ornithine HCI

Improvement of skin micro relief (5%, D28), Hydro-retention on hair (2%, 5%, D28)

None 1 - 5% Hydrosoluble

MELLIDYNTM LS 9834 Aqua (and) Propylene Glycol (and) Mel Extract (and) Glycerin (and) PEG-40 Hydrogenated Castor Oil (and) Royal Jelly (and) Mel (and) Propolis

Anti-inflammation, Immediate to long-term moisturization (ex-vivo)

None 3 - 5% Hydrosoluble

MYOXINOLTM LS 9736 Hydrolyzed Hibiscus Esculentus Extract (and) Dextrin

Inhibition of muscle cell contraction, Anti-oxidant

Anti-wrinkle (1%, D21) None 0.5 - 2% Hydrosoluble

NEUROBIOXTM A00112

Aqua (and) Butylene Glycol (and) Pentylene Glycol (and) Achillea Millefolium Extract (and) Xanthan Gum

Stimulation of the synthesis of POMC-related receptors, Stimulation of epidermal differentialtion (ex-vivo), Improvement of epidermal thickness (ex-vivo)

Acceleration of epidermal renewal (2%, D56), Wrinkle smoothing (2%, D56), Pore refining (2%, D56), Skin softening (2%), Improvement of the skin radiance vs placebo and glycolic acid (2%, D56), Brightening (2%, D56), Blurring effect: “The product improves my skin clarity”, “The product makes my complexion look renewed”, “The product smoothes my skin surface”, “The product refines the appear-ance of pores” (2%, D56; panelist’s evaluation)

None 1 - 5% Hydrosoluble

OLIGOLINTM BC 10028

Hydrolyzed Linseed Extract Increase of the expression of involucrin, filaggrin, loricrin, Synthesis of collagen IV, Fibroblast proliferation and migra-tion, Increase of collagen I, collagen III and lumican, Inhibition of heparanase and hyaluronidase activity (in-tubo), improvement of epidermal thickness (ex-vivo), Increase of the filaggrin expression (ex-vivo), Improvement of the level of collagen I and III (ex-vivo), Increase of the GAGs expression (ex-vivo)

Improvement of skin firmness (Dynaskin) and skin hydration (Corneometer) (1%, D28)

None 1% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

11

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P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

OSMHYDRANTM LS 8453

Mannitol (and) Arginine (and) Serine (and) Sucrose (and) PCA (and) Citrulline (and) Glycogen (and) Histidine HCl (and) Alanine (and) Threonine (and) Glutamic Acid (and) Lysine HCl

Hydro-retaining/ osmo-regulation (ex-vivo)

Improvement of skin microrelief and sensory properties of skin (2%, D21)

None 2 - 5% / Hydrosoluble

OSMOGELINETM R10979

Aqua (and) Algae Extract (and) Citric Acid

Reduction of UV-B-mediated TNF-α secretion, Prevention of cellular lipoperoxidation (in-tubo), Stimulation of involucrin synthesis, Protection of the dermal matrix, Stimulation of gene expression of the proteins coding for skin barrier function, Increase of ceramide synthesis (ex-vivo)

“Skin feels moistured, smooth and soft” (10%, D3, D7; Panelist’s evaluation)“Skin looks more radiant and luminous” (3%, D3; Panelist’s evaluation)

Phenoxy-ethanol

1 - 10% / Hydrosoluble

OXYGEN COMPLEXTM LS 9641

Mannitol (and) Faex Extract (and) Glycogen (and) Magnesium Ascorbyl Phosphate

Stimulation of protein synthesis, ATP-boosting, Control of lactic acid release, Stimulation of oxygen consumption, Control of ROS

None 1% / Hydrosoluble

PA REVIVI-SCENCETM LS 9562

Aqua (and) Glycerin (and) Treha-lose (and) Tamarindus Indica Seed Polysaccharide (and) Myrothamnus Flabellifolia Leaf Extract

Cell protection from UV-A and -B, DNA protection, Heat- and cold-shock protection, Osmotic shock protection, Immediate and long-term moisturization (ex-vivo)

Immediate (30min, 60min) and long term mois-turization (ex-vivo and in-vivo (5%, D7)), Softening and anti-drying (5%, 60Min)

Phenoxy-ethanol

3 - 5% / Hydrosoluble

PATCH2OTM A00297 Aqua (and) Glycerin (and) Trehalose (and) Urea (and) Serine (and) Pentylene Glycol (and) Glyceryl Polyacrylate (and) Algin (and) Caprylyl Glycol (and) Sodium Hyaluronate (and) Pullulan (and) Disodium Phosphate (and) Potassium Phosphate

Reduction of water evaporation, Immediate and long-term moisturization (ex-vivo), Recovery of cellular ATP level impaired by PAH loaded PM2.5 under UVA, Reduction of MDA release induced by B[a]P under UVA

Immediate and long-termin moisturization, Sus-tained hydration (3%, 30min, 48h), “Skin is more hydrated, soft, visibly elastic and visibly nourished” (3%, D21; Panelist’s evaluation), (2%, Immediate increase of scalp hydration (2%, 4h), Scalp mois-turizing effect (during and after treatement) (2%, D21, D24), “Reduces itchiness on my scalp”, “Allows my scalp skin to feel more relaxed” (cumulative and sustained effect) (2%, D21, D24) (Panelist’s evaluation)

None 1 - 3% / Hydrosoluble

PERLAURATM A00316 Aqua (and) Polygonum Bistorta Root Extract (and) Hexylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum

Increase of perlecan and dystroglycan protein expression in keratinocytes, Increase of perlecan and dystroglycan protein expression in endothelial cells, Stimulation of Claudin-5 expression in endothelial cells, contribution to compensate the decrease of perlecan and dystroglycan with aging (ex-vivo)

Improvment of skin radiance, evenness and smooth-ness and wrinkle (crow’s feet, length and surface) reduction (1%, D14, D28)

None 1 - 3% / Hydrosoluble

PHOTOTANTM LS 2261 E Sorbitol (and) Arginine HCI (and) Ornithine HCI (and) Tyrosine (and) Silica

Stimulation of melanin synthesis, Stimulation of tyrosinase activity

None 3 - 5% / Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

12

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P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

PHYTOKINETM A00287

Hydrolyzed Soy Protein (and) Butylene Glycol (and) Pentylene Glycol (and) 1,2-Hexanediol (and) Caprylyl Glycol

Increase of collagen neo-synthesis and deposition, Increase of GAGs neo-synthesis, Increase of elastin neo-synthesis, Improvement of colla-gen fibrillogenesis and organization of collagen fibers, Recovery of epidermal thickness, Activation of lipids synthesis (ex-vivo)

Synthesis of dermal collagen (2.5%, D28), Synthesis of dermal glycosaminoglycans (2.5%, D28)

None 1 - 4 % Hydrosoluble

PHYTOLIGHTTM BG A00043

Aqua (and) Butylene Glycol (and) Cucumis Sativus (Cucumber) Fruit Extract (and) Pyrus Malus (Apple) Fruit Extract (and) Camellia Sinensis Leaf Extract (and) Disodium EDTA (and) Scutellaria Baicalensis Extract

Anti-tyrosinase activity, Dose-effect on the tyrosinase activity of B16 cells

None 1 - 4% Hydrosoluble

PHYTOSOOTHETM LS 9766

Brassica Campestris (and) Cetearyl Alcohol

Anti-inflammation Hair: Improvement of the clinical symptoms on the scalp and hair beautifying effect (3%, D16) skin: Moisturizing and skin barrier strengthening effect with 1% GenerolTM 122 N PRL

None 1 - 3% Liposoluble

PILISOFTTM LS 9760 Aqua (and) Pentylene Glycol (and) Gymnema Sylvestre Extract

Anti-proliferation effect, Anti-hair growth on hair follicles in culture

Anti-hair growth (1%, D28) None 0.5 - 1% Hydrosoluble

PROTEASYLTM PW PSE LS 8951

Pisum Sativum Extract (and) Cyclodextrin

Plasmin inhibition, Stimulation of Col-lagen III-, elastin- and GAG-synthesis, Anti-elastase (ex-vivo), Moisturizing (ex-vivo), Immediate and long-term moisturization (ex-vivo)

Improvement of skin elasticity (0.14%, 15h, 24h), Improvement of skin firmness (0.23%, D42)

None 0.2 - 0.5% Hydrosoluble

PROTEASYLTM TP POE LS 9818

Aqua (and) Glycerin (and) Pisum Sativum Extract

Plasmin inhibition,Stimulation of collagen III-, elastin- and GAG-synthesis, Anti-elastase (ex-vivo), Moisturizing (ex-vivo), Immediate and long-term moisturization (ex-vivo)

Improvement of skin elasticity (3%,12h, 24h), Impro-vement of skin firmness (5%, D42)

Phenoxy-ethanol

3 - 5% Hydrosoluble

PURICARETM POE LS 9727

Aqua (and) Glycerin (and) Moringa Oleifera Seed Extract

Hair: Anti-pollution, Anti-odor, Condi-tioning and repairing, Photo protective activity, Hair strengthening, Anti-free radical activity, Anti-greasy hair effect

Phenoxy-ethanol

2 - 4% Hydrosoluble

PURISOFTTM POE LS 9726

Aqua (and) Glycerin (and) Moringa Oleifera Seed Extract

Cyto-protection against heavy metals, Protection against cigarette smoke (ex-vivo), Cell protection against pollution stress (PM2.5 + PAHs)

Purification, cleansing enhancement (1.5 %) Phenoxy-ethanol

1 - 3% Hydrosoluble

PURISOFTTM PW PSE LS 9836

Moringa Oleifera Seed Extract (and) Maltodextrin

Cyto-protection against heavy metals, protection against cigarette smoke (ex-vivo), Cell protection against pollution stress (PM2.5 + PAHs)

Purification, cleansing enhancement (0.03 %) None 0.02 - 0.06% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

13

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P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

RADIANSKINTM PW LS 9918

Hydroxyphenoxy Propionic Acid Melanogenesis inhibition on B16 me-lanocytes, Protection against damages caused by UV-B on keratinocytes

Anti-age spots on face (asian population) (1%, D14, D28, D56), Anti-age spots on hand (caucasian population) (1%, D14 ,D28, D56), Skin lightening on forearm (asian population) (1%, D14, D28, D56)

None 0.5 - 1% Hydrosoluble

RELIPIDIUMTM A00265

Hydrolyzed Yeast Protein (and) Butylene Glycol (and) Pentylene Glycol

Activation of lipids synthesis Visible relipiding effect (3%), “Skin is less dry” (3%; Panelist’s evaluation), Evaluation of skin barrier improvemnet through TEWL (1%, D14), Effect on skin microbiota and skin hydration (2%, D14)

None 1 - 3% Hydrosoluble

SANICAPYLTM BC 10030 Butylene Glycol (and) Sodium Lau-royl Lactylate (and) Sodium Caproyl Lactylate (and) Piper Nigrum Fruit Extract (and) Inga Alba Bark Extract

Anti-microbial activity, Anti-inflam-matory activity, Moisturizing

Reduction of dandruff and sebum (1%, D14, D28), Health of scalp and hair (1%, D14, D28)

None 0.3 - 1%

SEBARYLTM FL 9088 Aqua (and) Niacinamide (and) Faex Extract (and) Aesculus Hippocasta-num Seed Extract (and) Ammonium Glycyrrhizate (and) Panthenol (and) Propylene Glycol (and) Zinc Gluco-nate (and) Caffeine (and) Biotin

Inhiition of 5α-reductase Seboregulation (5%, D28), Anti-seborrhea activity on scalp (3%, D28)

Phenoxy-ethanol

3 - 5% Hydrosoluble and soluble in diluted ethanol

SHADOWNYLTM R11026

Aqua (and) Algae Extract (and) Hexylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum

Stimulation of heme oxygenase-1 gene expression, Increase of HO-1 protein, Stimulation of collagen-1 synthesis, Anti-oxidation, Inhibition of IL-8

Decrease of the dark color under the eyes (2%, D14), Decrease of the area of the dark circles under the eyes (2%, D14), Decrease of the crow’s feet wrinkles in length, surface and volume (2%, D7), “Eye area has smoother texture and is visibly refreshed” (2%, D7, D14; Panelist’s evaluation)

None 1 - 2% Hydrosoluble

SKINASENSYLTM LS 9749 Aqua (and) Glycerin (and) Coco-Glucoside (and) Acetyl Tetrapeptide-15

CGRP release from cultured sensory neurons, Mechanism of action

Soothing: Reduction of cutaneous over-sensitivity against capsaicin (3%, D4), Reduction of cutaneous thermal over-sensitivity (2%, 60min, 120min)

Sorbic Acid 1 - 3% Hydrosoluble

SKINASENSYLTM PW LS 9852

Mannitol (and) Sodium Citrate (and) Acetyl Tetrapeptide-15

CGRP release from cultured sensory neurons, Mechanism of action

Soothing: Reduction of cutaneous over-sensitivity against capsaicin (1%, D4), Reduction of cutaneous thermal over-sensitivity (0.67%, 60min, 120min)

None 0.3 - 1% Hydrosoluble

SLIM-EXCESSTM A00073

Aqua (and) Butylene Glycol (and) Pentylene Glycol (and) Sodium Chloride (and) Hydrolyzed Rhodo-phycea Extract (and) Xanthan Gum

Activation of the lipolysis, Inhibition of adipocytes proliferation, Inhibition of lipogenesis

Reduction of cellulite (3%, D14, D28), Slimming of the tights (3%, D28, D56), Boost of the activity of caffeine (3%), Face contour correction (2%, D28, D56, D84), Reduction of the double chin (2%, D28, D56, D84), Improvement of the skin elasticity (2%, D84), “Cellulite has diminished and figure is reshaped” (3%; panelist’s evaluation)

None 1 - 3% Hydrosoluble

SPECI‘MENTM BC10001

Glycerin (and) Aqua (and) Hydrolyzed Adansonia Digitata Extract

Versican mRNA expression of normal human dermal fibroblasts from aged male, Inhibition of MMP-12 enzymatic activity (in-tubo)

Skin tonicity recovery (Cutometry measurement on the cheekbones) (3%, D28, D56), Anti-wrinkle effect on nasogenian fold (3%, D56), Decrease of the eyebag volume & lower eyelid slackening (3%, D28, D56), “The wrinkles are softened”, “The skin is more radiant”, “The skin is toner”, “The product helps to feel my skin healthier”, The skin aspect is improved”, “The pores are less visible”, The fine lines are smoothed” (3%, D28, D56; panelist’s evaluation)

None 1 - 3% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

14

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P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

SPHINGOCERYLTM VEG LS 9948

Octyldodecanol (and) Hydrogenated Coco-Glycerides (and) Helianthus Annuus Seed Extract

Repair of cutaneous micro relief (5%, D21), Strengthening of corneocytar cohesion (5%, D21)

None Skin Care: 2 - 5%Hair Care: 1 - 3% Liposoluble

SQISANDRYLTM LS 9905

Schisandra Chinensis Fruit Extract Increase of COL17A1 MRNA expression, Increase of collagen XVII synthesis, Increase of LAD-1 mRNA expression, Increase of ladinin-1 synthesis

Improvement of the skin resilience, elasticity and firmness (0.3%, D56)

None 0.1 - 0.5% Liposoluble

SVELTINETM ST BC10032

Maltodextrin (and) Lythrum Salicar-ia Extract

Increase of fibroblast-populated collagen lattices (dermis tightening), Reduction of lipid storage, hypodermis and adipocytes thickness (hypodermis thinning)

Buttock push-up effect (0.25%, D14, D28, D56), Tigh shaping (0.25%, D14, D28, D56)

None 0.25% Hydrosoluble

SYMBIOCELLTM BC10015 Aqua (and) Butylene Glycol (and) Pentylene Glycol (and) Cestrum Latifolium Leaf Extract (and) Xanthan Gum

Regulation of dentritic cells activation Skin homogenity (2 %), Reduction of skin redness (2 %), „Skin is less sensitive to irritation, feels more comfortable, increasingly radiant, skin is better adapted to the environment“ (2 %; Panelist‘s evaluation)

None 1 - 2% Hydrosoluble

SYMBIOCELLTM A00110 Aqua (and) Butylene Glycol (and) Pentylene Glycol (and) Cestrum Latifolium Leaf Extract (and) Xanthan Gum

Regulation of dentritic cells activation Skin homogenity (2%), Reduction of skin redness (2%), “Skin is less sensitive to irritation, feels more comfortable, increasingly radiant, skin is better adapted to the environment” (2%; Panelist’s evaluation)

None 1 - 2%

SYNIORAGETM PW LS 9847

Mannitol (and) Acetyl Tetrapeptide-11

Overall gene expression profile of ke-ratinocytes, Repression of DDR1 gene, Stimulation of keratinocytes growth, Stimulation of syndecan-1 synthesis (test on keratinocytes), Stimulation of syndecan-1 synthesis (test on human reconstructed skin), Stimulation of the expression of collagen XVII gene

Increase of firmness and elasticity (1%, D28, D56) None 0.5 - 1.5% Hydrosoluble

TRICHOGENTM VEG UL LS 9922

Aqua (and) Arginine (and) Acetyl Tyrosine (and) PEG-12 Dimethicone (and) Calcium Pantothenate (and) Zinc Gluconate (and) Niacina-mide (and) Ornithine HCI (and) Polyquaternium-11 (and) Citrulline (and) Hydrolyzed Soy Protein (and) Glucosamine HCI (and) Arctium Majus Root Extract (and) Panax Ginseng Root Extract (and) Biotin

Stimulation of cell metabolism, Substantivity effect on hair tress, Conditioning and repairing on dry hair, Photo-protection on hair tress, Strengthening on hair

Anti-hair loss activity and improvement of aesthetic qualities of hair (10%, 8W, 16W), “Improvement of appearance and sensorial qualities scalp/hair, decrease of hair loss and increase in hair growth” (10%, 8W, 16W; Panelist’s evaluation)

Phenoxy-ethanol

5 - 10% Hydrosoluble

TRICHOLASTYLTM LS 9912

Glycerin (and) Aqua (and) Sorbitol (and) Pterocarpus Marsupium Bark Extract (and) Disodium Succinate (and) Glutamic Acid

Anti-glycation on collagen, Anti-free radical (in-tubo), Anti-inflammatory

Anti-hair loss preventive activity (10%, 6M) None 2 - 5% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved

15

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Distributed byIMPAG AG Räffelstrasse 128045 ZürichSwitzerlandTel.: +41 43 499 25 00Fax: +41 43 499 25 01E-Mail: [email protected]: www.impag.ch

IMPAG Group Country OfficesAustria/Vienna – www.impag.atFrance/Nancy – www.impag.frGermany/Offenbach – www.impag.dePoland/Warsaw – www.impag.plSwitzerland/Zurich – www.impag.ch

05/ 2017

P R O D U C T L I S T A – Z

Product INCI in-vitro / ex-vivo Preser-vatives

Use level Solubility

ULTRA FILLING SPHERESTM C00487

Ethylhexyl Palmitate (and) Trihydroxystearin (and) Sodium Hyaluronate (and) Amorphophallus Konjac Root Powder

Water absorbtion capacity, Thickening of stratum corneum (ex-vivo)

None 0.5 - 3% Liposolbule

VEGESERYLTM HGP LS 9874

Aqua (and) Glycine Soja Protein Nutritive, vitalizing and protective effect, Preventive cytoprotection against a surfactant

Anti-wrinkle (10%, D28), Improvement of cutane-ous elasticity, Silky and softening effect (10%, D42), Hydroretaining effect (10%, D42)

Sodium Benzoate, Potassium Sorbate

3 - 10% Hydrosoluble

VITACELL® PW LS 7979 Mannitol (and) Faex Extract Stimulation of cell vitality, Stimulation of cell metabolism on epidermal keratinocytes, Stimulation of O

2

consumption of epithelial cells, Stimulation of the epidermal ATP synthesis (ex-vivo)

Stimulation of metabolic activity (TcpO2) (2 %) None 1 - 2%

VIT-A-LIKETM PW LS 9898

Vigna Aconitifolia Extract (and) Maltodextrin

Stimulation of epidermal cellular renewal, Enhancement of type I collagen gene expression, Increase of collagen synthesis

Stimulation of epidermal cellular renewal (0.21%; 0.35%, D15), Anti-wrinkle (crow’s feet area) (0.35%, D56)

None 0.2 - 0.4% Hydrosoluble

VIT-A-LIKETM SPB LS 9793

Aqua (and) Vigna Aconitifolia Extract (and) Sodium Cocoyl Glutamate

Stimulation of epidermal cellular renewal, Enhancement of type I collagen gene expression, Increase of collagen synthesis

Stimulation of epidermal cellular renewal (3%;5%, D15), Anti-wrinkle (crow’s feet area) (5%, D56)

Phenoxy-ethanol

3 - 5% Hydrosoluble

VITAPLEXTM LS 9799 Mannitol (and) Chondrus Crispus Powder (and) Xanthan Gum (and) Laminaria Digitata Extract (and) Glycogen

Revitalizing activity on human kera-tinocytes Hair: Evaluation of sensory properties on human hair

Sensorial evaluation after a single application (2 %) None 2 - 4% Hydrosoluble

X-PRESSINTM C R11021

Aqua (and) Papain (and) Carbomer (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Algin

Effect of crosslinker on thermostability on X-Pressin C (in-tubo), Comparison of thermostability of X-Pressin C vs free proteases (in-tubo), Thermostability of X-Pressin C in formulations (in tubo)

Exfoliation activity (1%; 3%, D14), Increase of brightness with better skin tolerance (1%, D28), Reduction of skin imperfections (1%, D28), Skin softening and smoothing (1%, D21), “Skin is soft and smooth, gentle, has an even skin tone and refined” (1%, D21; Panelist’s evaluation)

None 1 - 3% Hydrosoluble

potentially NaTrue Cosmos approved CHINA approved