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Bart De Moor
Chairman ‘IOF’ council
ESAT-SCDKatholieke Universiteit Leuven
A: Kasteelpark Arenberg 10, B-3001 Leuven BelgiumT: +32(0)475 2 8 7052W: www.esat.kuleuven.be E: [email protected]
Stimulating innovation and tech transfer
You don’t need eyes to seeYou need vision
Content
1. Trends
2. Some numbers
3. Universities and tech transfer
Trends…
New challenges in international context
- Globalising world
- Fast urbanisation
- Aging population
- Energy shortage
- Sustainibility issues
- Pandemia’s
- ‘on-line all the time’
- Exponentially fast technological evolutions
0
1 109
2 109
3 109
4 109
5 109
6 109
1975 1980 1985 1990 1995 2000 2005 2010
Year
BookkeepingAudio
Video
3D games
LUI
Opera
tions/
seco
nd
‘Understand’ ?
Moore
Car
lson
Exponential evolutions
BIOIBart De Moor, Yves Moreau, Kathleen Marchal
transcriptome proteome metabolome interactomegenome
‘high throughput ‘data
Fast evolution in bio-technology
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• Human genome project– Initial draft: June 2000– Final draft: April 2003– 13 year project– $300 million value
with 2002 technology• Personal genome
– June 1, 2007– Genome of James Watson, co-
discoverer of DNA double helix, is sequenced
• $1.000.000• Two months
• €1000-genome– Expected 2012-2020
1,00E-07
1,00E-061,00E-05
1,00E-04
1,00E-03
1,00E-021,00E-01
1,00E+00
1,00E+01
1,00E+021,00E+03
1,00E+04
1,00E+051,00E+06
1,00E+07
1,00E+08
1,00E+091,00E+10
1,00E+11
1990 1995 2000 2002 2005 2007 2010 2015
Cost per base pair
Genome cost
Year Cost per base pair Genome cost
1990 10 3E+10
1995 1 3.000.000.000
2000 0.2 600.000.000
2002 0.09 270.000.000
2005 0.03 90.000.000
2007 0.000333333 1.000.000
2010 3.33333E-06 10000
2015 0.0000001 300
Making Sense of the 1000$ Genome
Technological trends: transdisciplinary integration
Materials, energy, IT Ubiquitouscomputing
Ambient intelligence
Embedded intelligenceSmart pills
Neuron on chip
Rehabilitation engineeringMonitoring Sensors: EEG, glucose,blood, DNA, … Add-ons: vision, hearing, implants, …
Cellular
POTS
WLAN
wire
less
wire
less
Information
Culture
Social
EnvironmentLife
Materials
Energy
Content
1. Trends
2. Some numbers
3. Universities and tech transfer
Lisbon: R&D investments in % GRP
0,69
0,56
0,57
0,77
0,80
1,03
0,81
0,40
0,75
0,68
0,86
0,89
0,00 0,20 0,40 0,60 0,80 1,00 1,20
EU25
BE
FL
DE
DK
FI
FR
IE
NL
UK
US
J P
1,26
1,33
1,52
1,75
1,84
2,45
1,34
0,77
1,01
1,30
1,91
2,65
0,00 0,50 1,00 1,50 2,00 2,50 3,00
EU25
BE
FL
DE
DK
FI
FR
IE
NL
UK
US
J P
Public investment in R&D in % GRP
1% 2%
Companies investment in R&D in % GRP
600
800
1.000
1.200
1.400
1.600
1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
jaar
miljo
en e
uro If in 2014: 1 % GRP to public R&D
Then needed +230 mio euro/year from 2010 !
Evolution public R&D in % GRP 1995-2008
Human research potential
5,4
7,9
6,3
8,6
16,2
6,8
5,0
5,1
5,5
9,0
10,1
0,0 2,0 4,0 6,0 8,0 10,0 12,0 14,0 16,0 18,0
EU25
BE
DE
DK
FI
FR
IE
NL
UK
US
J P
12,2
11,0
8,4
12,5
22,2
24,2
7,3
21,0
10,9
13,2
0,0 5,0 10,0 15,0 20,0 25,0 30,0
EU25
BE
DE
DK
FR
IE
NL
UK
US
J P
21,3
29,0
24,0
31,9
33,2
23,2
26,3
27,5
29,2
38,4
37,4
0,0 5,0 10,0 15,0 20,0 25,0 30,0 35,0 40,0 45,0
EU25
BE
DE
DK
FI
FR
IE
NL
UK
US
J P
# researchers / 1000 employees (2003) Higher education share / 100 adults (25-64) (2003)
STEM masters / 1000 20-29 year (2003)
Entrepreneurship
7,6
14,0
6,7
15,6
11,0
8,2
1,7
14,7
7,4
11,2
12,7
0,0 2,0 4,0 6,0 8,0 10,0 12,0 14,0 16,0 18,0
EU25
BE
DE
DK
FI
FR
IE
NL
UK
US
J P
0,025
0,028
0,021
0,063
0,065
0,029
0,023
0,027
0,038
0,071
0,000 0,010 0,020 0,030 0,040 0,050 0,060 0,070 0,080
EU25
BE
DE
DK
FI
FR
IE
NL
UK
US
Broadband penetration (# bb-lines / 100 citizen)(2003)
‘Early stage’ venture capital (% GNP) (2003)
22,3
35,1
70,3
47,6
94,5
36,1
11,9
53,8
30,0
53,6
92,6
0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0 80,0 90,0 100,0
EU25
BE
DE
DK
FI
FR
IE
NL
UK
US
J P
17,8
7,4
14,7
13,4
20,6
20,4
29,9
18,8
21,0
26,9
22,7
0,0 5,0 10,0 15,0 20,0 25,0 30,0 35,0
EU25
BE
DE
DK
FI
FR
IE
NL
UK
US
J P
Patents per mio citizens (2000) High-tech share in export (2003)
Entrepreneurship
European paradox: Research excellent, Tech transfer insufficient !
0,0
2,0
4,0
6,0
8,0
10,0
12,0
14,0
2001 2002 2004 2005
VL
BE
DU
FR
NL
UK
USA
Total Entrepreneurial Activity (GEM)
Michael Porter’s three phase model
Step I
Factor driven economy
-Basic institutions-Physical infrastructure-Macroeconomic stability-Health and basic education
Step II
Efficiency driven economy
-Higher education-Efficient production -Labor market flexibel-Financial markets
operational-Health and basic education-Technology curiosity-International openess
Step III
Innovation driven economy
-Entrepreneurial-Global-(Open) innovation
China / India …. Western Europe
What to do ?
-Invest in ‘spear heads’ for innovation- ICT and health (e-health system for every citizen)- Translational biomedical research (integrate nano-bio-clinical-pharma)- Materials- Environment (smart grids) - Transport, Mobility, Logistics
- Increase DIMersity in talent (Diversity, Internationalization, Mobility) - Increase investments in higher education - Increase interaction between universities and future employers- Increase inter-, cross- and multidisciplinarity - STEM SELLS !
Content
1. Trends
2. Some numbers
3. Universities and tech transfer
Type of research (basic to applied)
Siz
e o
f p
roje
ct
(sm
all t
o larg
e)
FWO
FP7
IOF
KennisplatformenHefboomprojecten
Mandaten
Innovation-project EU
IDEASPEOPLE COOPERATION
SMEs CIP
OT
IDO
GOA IWT – O&O
IWT - OZM
IWT - SBO
IWT – SBOvoortraject (m. f.)
UniversityK.U.Leuven
Flemish Government
University CollegesAssociation
INDUSTRY
Reachability (easy to difficult)
Siz
e o
f org
an
isati
on
(sm
all t
o larg
e)
EUCommission
Reach-ability (easy to difficult)
Siz
e o
f org
an
isati
on
(sm
all t
o larg
e)
IWT
DOC & LRD
Cluster organisations
EURepresentatives
Researchers
EWI
Basic
Research
Strategic
ValorisationPatentsLicenses
BOF
IOF FP6/7
SME
Direct ContractResearch
KULResearch
group
spinoffNV
FFF BA/VC
founders employees
Fase 1
Fase 2Forms of tech transfer
Activity Area 1:(Applied) Research for
Companies
Activity Area 2:Technology Transfer
via Patents & Licensing
Activity Area 3:Generation of Spin-Off
Companies
cross-fertilisationnetwork
Industrial liason office: KUL-LRD
De accurate, adequate en efficiënte begeleiding en ondersteuning van de decentrale werking van de onderzoeksgemeenschap aan de K.U.Leuven en haar Associatie bij de commerciële exploitatie en de financiële rendabilisering van hun eigen vermogen opgebouwd door hun onderzoeksactiviteiten.
LRD Mission Statement
Three modes of operation; ‘Business development’
Push mode: - Start from potential in research groups- Researcher = source, inspiration, inventor - Contracts, licenses, consortia, spin-offs - LRD = support, negociator, ‘consiglieri’ - Numerous cases
Pull mode: - Reveal external opportunities to research groups - (Government initiated) consortia, incubators, science parks- LRD = takes initiatives, organization, coordination, architect - Examples: bio-incubator (VIB), science parks Arenberg, Tienen,…
ELAt, IMI-platform,….
Create mode: - Create synergy via tech transfer (‘valorisation’) platforms- Tech transfer platforms, new research initiatives, acquiring/providing funding- Examples: CD3, NERF (KUL-VIB-IMEC), Gemma Frisius, MRC, IBBT departments
27
development of business plan
protection and exploitation of intellectual property
finding investors
negotiation & legal support
finding infrastructure
management of growth of the spin-off company
stimulating networking & clustering
• Creation:– October 1997, cfr. Flemish decree 1995
• Partnership:– K.U. Leuven R&D – KBC - Investco – Fortis - VIV
• Complementarity:– Incubator K.U. Leuven R&D, detection + b-plan– Equity – financial expertise KBC – Fortis
Gemma-Frisius I & II: Seed Money
IOF Industrial Research Fund A bridge between university and industry
Project types:- leverage platforms- knowledge building platforms
People:- industrial research fellows - evaluated every 5 years
Gewicht ’04 in %
Doctoraten 25
Public/cit. 25
IWT-projecten* 10
EU-kaderprogramma 10
Octrooien 10
Spin-offs 10
Wetenschappelijk personeel
10
IOF Parameters
Tech transfer environment: ‘Yes, we can !’ Research climate @ university
- Major funding sources: IAP, GOA, CoE, Methusalem- IWT, IOF, EU, ERC,… - Research centers…
LRD- TTO- Spinoff tradition- Gemma Frisius - Entrepreneurial: University wide master course: ‘Initiatie tot ondernemen’
Leuven High-Tech Valley - Local networks: L.inc, DSP Valley, L-SEC, … - Interregional: ELAT,…
Flanders - Science policy: Budget growing since 1995 - Strategic Research Institutes: IMEC (nano), VIB (biotech), IBBT (broadband), VITO- Competence poles: FMTC (Mechatronics), Flanders Drive, Flanders-Bio,…- role of IWT: spinoff kick-off projects (up to 65 % funding) - government seed-money/VC incentives
Belgium - ‘defiscalisation’-measures for R&D in companies 30
