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憂鬱 神經科部 核心課程編號:B17

B17 憂鬱 [相容模式]

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Microsoft PowerPoint - B17 []1. 2. 3. 4. 5.
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-- (HPA) HPA cortisol CRF
2 serotonin norepinephrine
serotonin (synaptic cleft) (serotonin transporter)
3



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60 — CBT
·Martin Seligman ( )
3
-· Albert Bandura
4 —

5
—·Abraham Maslow
1


5-SSRIs NRIs Dopamine NE
3


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2 20~50 25~50%
2 2010 1990 1990 2010 37.5%
Global Burden of Disease study years lived with disabilityYLD PLoS Med, 2013. 10(11): p. e1001547.
3
2003 2005 18 1.2%20
15%
Psychol Med, 2012.42(6): p. 1227-37.
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DSM-5
2013 5 DSM-5
The Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders, DSM-5
Major Depressive Disorder Persistent Depressive Disorder
Dysthymia Adjustment Disorders Premenstrual Dysphoric Disorder BipolarAffectiveDisorder
DSM-5 (I) (1)(2)
(1)
(1)(2)(3) (4)(5) (6)
DSM-5 (II)
DSM-5 (I)


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: :
2 : (ECT): 50

MAOI) 3. (selective serotonin reuptake
inhibitors, SSRI) 4. (serotonin and
norepinephrine reuptake inhibitors, SNRI) 5. NaSSA(noradrenergic and specific serotonergic
antidepressants)
4 : :

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