B O S - Home - NNC Med Consulting...B O S iological rganisation ystem Presenting the Product Range of NNCMED - Consulting / Germany BOS-S-86/3000, BOS -S-86/800 and BOS -M NNC-MED

B O S iological rganisation ystem

Presenting the Product Range of NNC-MED Consulting / Germany BOS-S-86/3000, BOS-S-86/800 and BOS-M

S y s t e m l i n e

25.11.2016 Strictly Confidential 1


NNC-MED Group History NNC-MED Consulting, based near Hamburg/Germany, was founded in late 2003 .The founder picked up a business idea for the health care product, which was on the market since a couple of years but was not yet implemented successfully. Due to the increasing demand for blood storage products they expected new business of providing a safe, organized and cost effective solution for the storage of biological material. In close cooperation with German hospitals they developed the BOS-S/040 storage system, the first device in a family of products improving the services of transfusion medicine centers of hospitals.

Uwe Nehrmann

Mission The objective of NNC is to develop, manufacture, and market systems and components which enable users to freeze biological material up to minus 150° Celsius, store it at a constant temperature, and manage its input/output/warehousing, using state-of-the-art technology which controls the product from its origin to final usage. Vision The vision of the company is to help all organizations, which need `deep freezing´ storage capacity for their products to

reduce the overall expense improve product quality improve the handling and logistics ensure reliable documentation


The Role of NNC-MED Consulting NNC Group develops new, future-oriented Cryo-technology

in Cooling and Storage of biological Materials, in particular Blood and Blood products.

Analysis of current Problems to develop new Solutions Reduction of Costs through Reorganization and Optimization of

Equipment Minimizing operational Risks through development of optimized

Systems Development and Production of new Medical Technology for all

Applications


Five important facts > one philosophy

BOS–System Line NNC-MED Consulting

Germany

Efficiency

Transparency Flexibility

Patient Security Quality Assurance


Areas of Competency of NNC

The efficient use of liquid N₂ for Cooling

IT-supported Storage and Management of stored Products


More facts Competency of NNC

Energy

Maintenance

Handling

Installation Space

Cost Situation

NNC Consulting Systems

Current Systems

Up to 50%

Up to 50%

Up to 50%

Up to 30%

0 50 100


LN2-196°C

ExternalTank-

system

Cascading usage of liquid nitrogen (LN2)Developed by NNC-MED Consulting

- 160°C - 86°C - 40°C + 4°C

Need of LN2100%

erythrocytes,sperm,

stem cells,tissue

LN2 pipe

Air c

ondi

tion

?

Isolation

Heat

exc

hang

er

Exhaust pipe for N2Basic principles:- N2 provides the basic temperature - LN2 will be refilled to adjust the temperature to the required level

Need of LN2app. 80%

(erythrocytes), tissue

Need of LN2app. 60%

FFP

Need of LN2app. 25%

erythrocytes

Isolation Isolation Isolation

Part of N2cooling

app. 20%

Part of N2cooling

app. 40%

Part of N2cooling

app. 75%

The Cascading System of NNC

Strictly Confidential 8

The Double Wall System of NNC More than 24 ours to loose the temperature

25.11.2016

End of test 09:05:2011, 10:11 am


Quality Jump: better temperature stability

Abb. 1 : Temperature inside a Plasma-store system with compressor technology

Abb. 2 : Temperature inside a Plasma-store system from NNC, running with LN2

Diff. tem

perature D

iff. temperature


The BOS-M IT Management System


The BOS-Systems applied to Blood


The Components of the BOS Systems BOS-S ( Storage ) • Temperature and Size adjustable according to stored Material • Clear localization of Substances • Maximum Utilization of Capacity • Automatic Recording • Network Capable

BOS-F (Freeze ) • Suitable for wide range of biological Materials • Most modern Compressor Technology drives high performance Freezing • Can be driven with N2 • Automatic Recording • Network Capable

BOS-M ( Management )

IT- supported Management, Controlling and Logistics Information

BOS-T (Transport ) • High Performance Thermal Insulation • Low Energy Consumption • Transport safety through high Quality Materials

Further Options • Automatic Recording • Network Capable


Design and Optimized Ergonomics


Precision Technology: Optimal Performance


BOS-S-86/3000 production


BOS-S-86/3000 production


The “Little Brother“ BOS-S-86/800 The “Little Brother“ is now available! • The BOS-S-86/800 is a Storage System for smaller

installations, for organizations that have smaller storage needs or limited available space.

• Approx. 800 Slots for 450ml Bags filled to 300ml. Capacity for other products must be calculated.

• The System has a capacity of >1,000l.

• The Temperature range is from +10 to -86°C.

• A further option is the Blast Freezer for 6-8 Plasma bags, -30°C in 30 minutes.

NNC-MED Consulting


Better Performance at lower Costs The BOS-System was conceived from the start to provide better performance at lower cost

• The BOS-System is designed to produce better quality products, as the result of precise

and consistent temperature control. • After 2½ years evaluation in practice, the Dept. Of Hemostasis and Transfusion

Medicine of the Heinrich Heine University Medical Centre, Düsseldorf compared the product quality of BOS-stored biological products with that from conventional refrigerator technology.

• Using Hemostasis profiling, including coagulation factor activities including FVIII:C, the

stability of the stored products after freezing and thawing was found to be significantly superior from the BOS-System

• This is the result of the precise maintenance of set temperature of the cooled products,

even under conditions of frequent accessing, loading and removal of products.


Better Performance at lower Costs The BOS-System was conceived from the start to provide better performance at lower cost From the design of the individual storage units, the high-tech Equipment specifications, precise temperature control, integrated organization, low space requirement, and very long Life Cycle Planning, all components of the specification are integrated to provide the lowest-cost Solution. Additionally, on top of all these Benefits it is possible that existing systems can be purchased by NSC, to allow the installation of an integrated unified Installation. For details of financing possibilities, contact your NNC Sales Partner.

• Space-Saving: ca. 4m² for 2.592 Storage Compartments / ca. 3.000l Storage Volume • Safer: Automatic Surveillance • Faster Service: Remote Maintenance and Service • Long Service Life and maximum Reliability. More than 20years designed-in life expectancy • Silent: No Compressors - no noise • No Air Conditioning Costs: No warmth generated by compressors • Highly professional Logistics Performance: Perfect Organization • Continuous Product Overview: Permanent Inventory as Standard • Capable of Integration in other Systems: Network Capable • Precise Temperature Management: from +10 to -86°C continuously • Perfect for all biological products and dimensions: Flexible internal compartmentalization


The BOS-System needs less space

Access Area

2.100 mm

3.00

0 m

m

2.00

0 m

m

Ca. 3.000l Capacity

4,2 m² Area 6,3 m²

Incl. Access Area

BOS-S-86/3000

Access Area

6.000 mm

2.00

0 m

m

1.00

0 m

m

Ca. 3.000l Capacity 6 m² Area

12 m² Incl. Access Area

500l Refrigerator

Access Area

1.300 mm

2.10

0 m

m

1.10

0 m

m Ca. 1.000l

Capacity 1,4 m² Area

2,7 m² Incl. Access Area

BOS-S-86/800

476 L p.m²

370 L p.m²

250 L p.m²


Lower running cost for the BOS-System • Maintenance, Life Span, Primary, Secondary Energy Running Costs are very low: • ca. $2000 Maintenance Costs p.a. (much lower than for 5-6 Refrigerators p.a.) • ca. 20-30 years specified Life Span (much longer than the life expectancy for Refrigerators/Cool Rooms) • 40-50l LN₂ per day at -40°C (much less than with 5-6 Refrigerators and associated Air Conditioning Units)

BOS-S-86/3000 = 50 L LN₂ per day x Price/l At 20 Cent = $15 per day At 40 Cent = $25 per day At 60 Cent = $40 per day

Refrigerator = kw/h Rating x No. Of Fridges x kw/h Price + kw/h x No. Of a/c Units x kw/h Price = Energy Costs At 20 Cent = 5 kw/h x 20 hrs. Running Time = 100kw/h + a/c, 50 kw/h = 150 kw/h At 20 Cent = $40 per day At 30 Cent = $70 per day At 40 Cent = $100 per day

The running costs are much lower than those of Fridges, and that over a much longer working life span


Problems with the old Fridge Technology The problems of the old technology have been well-known for decades: Fridge, Chest, Cold-room. For as long as these products exist, they have had the same problems: • High Energy Costs, since the generated heat has to be led away

• No Organization, since there is no integrated IT-Management

• Short Life Expectancy, 6-8 years

• High Space Requirement, since there are many small systems, each with its own cooling generation

• No System Concept is possible, since this is not integral to the installation • Electricity as Cooling Provider= Small Compressors Low Performance Large Compressors High Space Requirement and extreme Heat Generation The BOS-System solves these Problems through Game-Changing Design and Superior Engineering

For more Problem/ Solution

Analysis, see Attachments


The Advantages of the BOS-System

• Perfect Temperature Control, less Space Requirement, Organization and Documentation - and all that with lower costs It‘s not a fridge, or a Chest, or a Room, yet it‘s all of these. The BOS-System combines Design and Technology to bring the Performance of all of these. The BOS-S-86/3000 • Maintains temperature exactly ( through circular heat exchangers with high efficiency) • Maintains temperature up to 3 times longer in the event of massive power failure (extremely efficient insulation) • Has sufficient Energy to cool products quickly, which are introduced too warm • Is organized. The System always knows and shows, what current status is. (BOS-M) • Needs less space for the storage of the same quantity of Product • Documents all movements independently and securely. (Secured Databank) • Always knows who currently has access and is doing what (Access and Security Management) • Warns of Errors/ Irregularities independently (GLT Connection)

Game-Changing Technology that is changing the world of medical cooling forever


The BOS-System is an integrated System

The BOS-System integrates all components, to make a System Solution The overall Management is performed by the BOS-M Management system. This System pulls together all relevant Systems (including non-related, external ones), and shows their status. Stock situation can be shown, movements, system reports can be seen and generated. All Products of the BOS Line are optimal partners for the BOS –M Software. Other products can be included, at a (calculable) cost. BOS is one System. The individual components for Storage, Freezing and Transport are optimized Leaders in their relevant technical fields. The BOS-System is an intelligent, Highly Integrated System, steered and controlled by an Intuitive Management System


The BOS-System is extremely flexible

• Flexibility has a name: BOS • Blood Plasma bags, various sizes, with/without packaging • Tubes • Storage „plates“, modules, trays • Metal, Glass, Plastic

What would you like to store, and above all, find again?

RFID Takes

http://www.bloodbag.net/index.php?categoryid=1&m17_sectionid=1&m17_imageid=29

http://www.bloodbag.net/index.php?categoryid=1&m17_sectionid=1&m17_imageid=21


The Thermo Cassettes are extremely flexible Thermo cassettes for Blood pouches and Functional Packs • Hospitals • Blood Banks • Blood Donation Organizations, private, public

Thermo cassettes for specific functional boxes, sample boxes • Hospitals • Blood Banks • Blood Donation Organizations, private, public • Pharmaceutical • Forensic

Thermo cassettes for retain samples and sample tubes • Pharmaceutical • Forensic • Research • DANN, Gene Storage • Tissue, Sample storage


An Example of a BOS LN2 - System

Liquid N2 Tanks

Client Level

Internet

Building communications system

Sample Management

BOS–S Level

Sample Management/ System Operation

Remote Maintenance/ Archiving

System surveillance/ Coordination


An Example of a BOS LN2 -Installation

BOS-S 800

BOS-S 800

BOS-S 800

BOS-S 800

BOS-S 800

BOS-S 800

BOS-S 800

BOS-S 800

BOS-S 800








System Improvements For all our products, systems, concepts we offer to do the full Paperwork. We work together with independent organizations to do that in high quality.


System News The New project, BOS S -150 automatic The Partners are - NNC Hamburg, / Germany - TEDI, Technische Dienste - Cryotherm, Siegtal / Germany - Fraunhofer Institute Lübeck / Germany - University of Lübeck - And more small partners

- Germen Government / Founding

- We are looking for a clinical partner

Plan-System Askion Sysmex Liconics Brooks Produkt BOS-S 150/A HS-200 Smart freezer z.B.

STC12K5 ULT z.B.

BioStore II Temperaturbereich Stufenlos in der Steuerung +4°C … -150 °C -130 °C -130 °C 0°C … -80 °C 0°C … -80 °C

Automatisiertes System Ja Ja Ja Ja Ja Standalone Unit Ja Ja Ja Ja Ja Keine baulichen Maßnahmen erforderlich Ja Ja Ja Ja Ja

Cherry picking – andere Proben verbleiben bei Tieftemperatur Ja Ja Ja Ja Ja

Vereisung der Vials wird vermieden Ja Ja Ja Ja

Separater und tiefkalter/klimatisierter Ein- und Auslagerungsbereich

Ja Ja Nein Nein Nein

Kühlkette wird eingehalten Ja Ja Nein Nein Nein

Kühlung ist unabh. von Stromversorgung = LN2 Ja Ja Ja Nein Nein (optional)

Modularer Aufbau Ja Nein Nein Ja Ja Lagertemperatur über Gefrierpunkt möglich Ja Nein Nein Nein Nein

Horizontal angeordnete Tiefkältelagerung Ja

Unterschiedlich temperierte Teilbereiche / Temperaturmodule möglich

Ja Nein Nein Nein Nein

Kühlkette wird eingehalten Ja Ja Nein Nein Nein Integriertes flexibles Probenhandling Ja

Einbau in Standardcontainer Ja Nein Nein Nein Nein Variabler Temperaturbereich Ja Nein Nein Ja Ja

Deckt weiten Temperaturbereich ab Ja Nein Nein Ja Ja

Kein Probenkontakt mit LN/LN2 (Gas, Aerosol, Flüssig) Ja Nein ? Ja ?

Gefahr von Kreuzkontaminationen unterbunden

Ja Nein ? Ja ?

Wärmetauscher Ja Nein Nein Nein Nein

Geschlossene Kaskadenkühlung -150°C System kühlt -86°C Syst. Und weiterführende Installation

Ja Nein Nein Nein Nein

Energie-Recycling durch Kompatibilität mit Haustechnik Ja Nein Nein Nein Nein

Kaltwassererzeugung durch Abkälte am System Ja Nein Nein Nein Nein

Unabh. von Probenformat Ja Nein Nein Nein Nein

Altproben können kombiniert gelagert werden Ja Nein Nein Nein Nein

Massenlagerung möglich Ja Nein Nein Nein Nein

Mobile Lagerung möglich (Container) Ja Nein Nein Nein Nein

Ext. Raumerweiterung möglich (Container) Ja Nein Nein Nein Nein


The BOS-System solves other Refrigeration Problems Further Problems of old Refrigerator Technology: All Compressor-supported Storage Systems in the world have a Compressor or Compressor Complex dimensioned to the Storage Volume. This produces Cooling inwards, and Warmth externally The remaining Warmth is generally deposited in the area of the Installation (An exception is water-cooled systems, which necessitate a further installation). The design is generally structured so that the internal storage is adequately cooled when the external temperature up to 30°C. So what happens when the external temperature is higher, or fresh products are introduced and have to be brought down to storage temperature, or during normal introduction or removal a fridge door stands open for a time, and cold air is replaced? Here, cooling within the legal limits is not possible, since the cooling capacity is insufficient. When a system requires 24 hours to get to temperature, this is not acceptable. Possible Solutions: • Deliver new Products to be stored at a lower temperature ( normally not possible) • Introduce fresh products in smaller quantities (requires more capacities) • Ensure fridge doors are not left open for too long (Conflicts with the necessity to search for products, as the storage is not organized) • Reduce the temperature of the external environment further (high energy costs for air conditioning) These are all Inadequate Solutions The BOS-System solves all of these problems through focused Design and Engineering The LN₂ - cooled BOS-Systems are conceived, so that adequate cooling capacity is always available. The BOS-System releases no warmth to the immediate environment – rather it cools. With the BOS-System, all legal requirements can be met. Perfect Temperature Control leads to higher Product Quality, and highest Product Safety.


The BOS-System solves other Refrigeration Problems

NNC-MED Group you find: Westerort 12, in 25879 Süderstapel / Germany Tel. 0049 – (0)4883 – 859-40-87 Uhlenstroot 3, in 25797 Wöhrden / Germany Tel. 0049 – (0) 4839 – 865-99-82 [email protected] www.nnc-med-consulting.com

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