Authors Lin Chang, MD Jennifer Christie, MD Rosemarie Fisher, MD
Rebekah Gross, MD Amy Foxx-Orenstein, MD Asma Khapra, MD Caroline
Loeser, MD Suwebatu T. Odunsi, MD Lin Chang, MD Jennifer Christie,
MD Rosemarie Fisher, MD Rebekah Gross, MD Amy Foxx-Orenstein, MD
Asma Khapra, MD Caroline Loeser, MD Suwebatu T. Odunsi, MD Ann
Ouyang, MBBS S. Devi Rampertab, MD Robin Rutherford, MD Pratima
Sharma, MD, MS Grace L. Su, MD Trinh Truong, MD Jacqueline Wolf, MD
Rebecca Van Dyke, MD Ann Ouyang, MBBS S. Devi Rampertab, MD Robin
Rutherford, MD Pratima Sharma, MD, MS Grace L. Su, MD Trinh Truong,
MD Jacqueline Wolf, MD Rebecca Van Dyke, MD Senior Author Suzanne
Rose, MD, MSEd Professor of Medical Education and Medicine Mount
Sinai School of Medicine GASTROSLIDES Project Director Jean-Pierre
Raufman Professor of Medicine University of Maryland School of
Medicine GASTROSLIDES Project Director Jean-Pierre Raufman
Professor of Medicine University of Maryland School of Medicine
GASTROSLIDES Art Director Jerry Schoendorf, MAMS Duke University
Medical Center GASTROSLIDES Art Director Jerry Schoendorf, MAMS
Duke University Medical Center Digestive Health and Disease in W
men Slide 2 Pathophysiology of GERD Castell Do et al. Aliment
Pharmacol Ther 2004; 20 (Suppl 9):14 Lower esophageal sphincter
(LES) Decreased salivation Impaired esophageal acid clearance
Impaired tissue resistance Decreasing resting tone of LES Delayed
gastric emptying Transient LES relaxation Duodenum GERD / Dyspepsia
II-4 Slide 3 Anorectal angle Descent of pelvic floor Straining to
defecate Symphysis pubis Symphysis pubis Anorectal angle Coccyx
External anal sphincter Puborectalis Rectum At rest Pelvic Floor
Musculature Constipation IV-9 Slide 4 Chapron C et al. Human
Reproduction 2006: 21:1839 Deeply Infiltrating Endometriosis of the
Digestive Tract: Anatomical Distribution Omentum1.7% Omentum1.7%
Cecum andileocecal junction4.1% Cecum andileocecal junction4.1%
Appendix6.4% Appendix6.4% Small bowel4.7% Small bowel4.7% Sigmoid
colon17.4% Sigmoid colon17.4% Rectosigmoidjunction and rectum65.7%
Rectosigmoidjunction and rectum65.7% V-54 Slide 5 Effects of
Estrogens/Pregnancy on Transporters Involved in Cholesterol
Excretion Cholesterol Sinusoid to bile duct Liver Gall bladder
Common bile duct Hepatocyte NTCP OATPs Bilirubin Bile Acids Na +
ABC C2 ABC B11 ABC G5/G8 ABC B4 Phosphatidylcholine (PC) Pregnancy
and Liver Disease Geier A, et al. BBA 2007; 1773:283 VII-79 Slide 6
Mitochondrial -Oxidation and Oxidative Phosphorylation Outer
membrane Inner membrane CO 2 O2O2 O2O2 oxidation Citric acid cycle
Acetyl Co-A Fatty acids NADH e - ATP H2OH2O H2OH2O H+H+ H+H+ H+H+
H+H+ H+H+ H+H+ H+H+ H+H+ ADP+P i VIII-61 Mitochondrial -Oxidation
and Oxidative Phosphorylation Slide 7 Barriers to Successful
Colonoscopy in Women Completion Rates Women88-96% Men94.3-99.8%
Anatomical differences Low BMI Previous pelvic surgery Hysterectomy
Diverticulosis in women Completion Rates Women88-96% Men94.3-99.8%
Anatomical differences Low BMI Previous pelvic surgery Hysterectomy
Diverticulosis in women Church JM. American Journal of
Gastroenterology 1994; 89(4):556 Anderson JC et al.
Gastrointestinal Endoscopy 2001; 54(5):558 Church JM. American
Journal of Gastroenterology 1994; 89(4):556 Anderson JC et al.
Gastrointestinal Endoscopy 2001; 54(5):558 Special Issues - Colon
Cancer IX-12 Slide 8 Nutrition X-3 Diet vitamin D 3 and D 2 Vitamin
D 3 7-dehydroxycholesterol Vitamin D 3 7-dehydroxycholesterol UVB
Vitamin D 3 + VDBP or albumin Enterocyte Chylomicron + vitamin D
Enterocyte Chylomicron + vitamin D 25-hydroxylase 25-OHD 1
hydroxylase 1,25-(OH) 2 vitamin D Active form of vitamin D
1,25-(OH) 2 vitamin D Active form of vitamin D Terminal ileum
Reabsorption of bile salts and conjugated vitamin D metabolites
Bile salts and conjugated vitamin D Skin Small intestine Vitamin D
Absorption
