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Rooom4300Auditors Bldg
August 6 1984
Ms Francesca Nelson Nutrition Officer USAIDKingstonAgency for International DevelopmentWashington D C 20523
Dear Francesca
Enclosed is a copy of the Final Report on Iron Fortification of Corn Meal andWheat Flour inJamaica We hope itwill he a significant factor contributingto activites that result inan iron fortification program inJamaica
Were the suggestions regarding the questionnaire for the corn meal consumptionsurvey helpful We believe the survey is sorely needed and should be carriedout as soon as possible Did you say you do have the funding to have it done I saw the cable Sam Kahn sent regarding your reqsted actions I believe hisco ments on funding are good Our USDARSSA can provide the technicalassistance for (1)fortification technology (2)product testing (3)nutritioneducation and (4)quality assurance activities to help ensure the developmentof a good iron fortification program I believe the monitoring should becovered by someone else Sams suggestion on this is good Im not sure myselfhow much the monitoring activity can be modified
I hope Seprod Ltd has grasped the idea from our conversations and the reportthat itwould be very helpful if not necessary to have some testing done on cornmeal with ferrous sulfate added to it
I have talked with the US supplier of the premix that Jamaica Flour Mills Ltduses inthe bread flour They are doing their homework about ferrous sulfateand I understand even preparing some of their blend with ferrous sulfate fortesting Also I heard that Jamaica Flour Mills Ltd has contacted thesupplier and asked that the next shipment of premix be formulated with ferrous sulfate In it
Do you have a graceful way of finding out from the company such as fromCyrilVassel if this is correct Also he might provide some information on theirthoughts or actions concerning the iron source for the fortification of thecounter-flour when they start production later
Any and all of these activities indicate agood start toward a valuable nroiet and subsequently a successful fortification program
Iwould greatly welcome hearing from you periodically ontheprogresstoward aniron fortification program
Fred F Barrett PhD Food Technologist Nutrition amp Agribusiness Group
cc N Luykx STN SKahn STN
Enclosure AS
IRON-FORTIFICATION OF CORNMEAL ANDIWHEAT FLOUR
IN JAMAICA
REPORT
Dr IJimes took UniVersity Of Kansas Medical -Cenlter
and
Dr Fred Barrett US Department of Agriculture
This report prepared in cooperationwith
Office of Population Health Nutrition USAIDKingston
Office of Nutrition AIDWashington
Office of International Cooperation amp Development US-Department of Agriculture
International Center to Control Nutritional Anemia(ICCNA)Yi Universityof Kansas Medical Center
CONTENTS
I BACKGROUND-
II FOOD FORTIFICATION
III IRON FORTIFICATION PROGRAM- JAMAICA
A Wheat Flour
B Corn Meal
C- Monitoring
D Quality Assurance
E Nutrition Education
F Safety of Fortification
IV ADDITIONAL INFORMATION NEEDED
A Corn Meal Consumption Data
B Response to Added Iron
C Quality of Corn Meal withAddedIron-
D Quality of Counter-Flour with Added Iron
E Addition of Ferrous Sulfate toBakery Flour
V RECOMMENDATIONS AND SUGGESTIONS
APPENDICES
A Estimated Budget
B People Contacted
C Workshop Outline
I BACKGROUND
Discussions between UASIDJamaica the Ministry of Health-GOJ and the Caribbean
Food and NutritiDn Institute (CFNI) about how to combat anemia inJamaica by proshy
viding more iron to target-groups as well as the general population resulted in
the decision to obtain technical assistanceregarding the fortificationof foods
and for helping to develop a program for the iron fortification of cereal foods
in Jamaica
The authors visited Jamaica to provide that assistance by carrying outa feasishy
bility study andoutlininga program for (1) the iron fortification of corn
meal (2)the addition of iron and B-vitamins to counter-flour and (3)changing
the iron source used in the present enrichiment of bread flour to one with
improved bioavail ability properties
The current conditionsfrom which this feasibility studyand program suggestions
were developed~are
1 All bread (wheat) -flour is produced in Jamaica -Itcontains addedironof a
type which isnot readily absorbed by the body It also contains added B-shy
vitamins This flour isused inthe commercial production of all-typesof
bakery foods It isnot used inthe homebythe general population
2 Counter-flour (all-purpose or family flour) iswheat flour whichis
imported Itdoes not contain any added iron or other nutrients This
flour isconsumed by the majority of the population through every-day -use
3 All corn meal is produced inthe country Itis the principalweaningfood
for infants Also it isused as a breakfast food by therest of the family
Cornmeal is recognized as a staple food of the people inthe lower socio-I
economic group The standard market corn meal has no iron or vitamins added
to it
2
This report is the result of that visit
One purposeof the visit was to discussthe advisability of fortifying cornmeal with iron in Jamaica The justification for consideringthis -intervention strashy
tegy to combat iron deficiency stemsfrom the high prevalence of anemia that
has been observed repeatedly instudies conducted in-this countryduring theshy
past two decades A detailed monograph together with a reviewof availableshy
survey information and a discussion of a variety of strategies to combat iron
deficiency was published in 1982by CFNI This report indicates that vi rtuai ly
all surveys of anemia during the past 15 years in infants childrenand
pregnant or lactating women have shown prevalence of anemia varying from 35 to
80 based on current WHO criteria The survey published by McGregor (1974)
which was conducted in 300 infants during the late 1960s is particularly rele
vant to the issue of cornmeal fortification As defined by a hemoglobin conshy
centration-below 11 gdl 76 of infants were anemic at 8 months of age this
prevalence was even higher at 18 months Presumptive evidence was obtained
during this survey that this anemia lresulted from iron deficiency althoughno
specific laboratory measurementswere performed
More recent studies give little or no indication that the prevalence of anemia
is declini An island-wide survey inmore than400 lactatingwomen conducted
by Simmons indicated a Prevalence of anemia of 49based on a hemoglobin level
below12 gdl and aprevalence of 26 using a criteria of 11 gdl During the
first morning ofthis visit reference was made to an ongoingpediatric study in
whichdata on the hemdglobin bullleVels ininfants less than one year of age are
available as a byproduct of the study Based on a hematocrit below 33 which
is roughly equivalent-to WHO criteria of anemia in infants 6- months of age
9
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
Any and all of these activities indicate agood start toward a valuable nroiet and subsequently a successful fortification program
Iwould greatly welcome hearing from you periodically ontheprogresstoward aniron fortification program
Fred F Barrett PhD Food Technologist Nutrition amp Agribusiness Group
cc N Luykx STN SKahn STN
Enclosure AS
IRON-FORTIFICATION OF CORNMEAL ANDIWHEAT FLOUR
IN JAMAICA
REPORT
Dr IJimes took UniVersity Of Kansas Medical -Cenlter
and
Dr Fred Barrett US Department of Agriculture
This report prepared in cooperationwith
Office of Population Health Nutrition USAIDKingston
Office of Nutrition AIDWashington
Office of International Cooperation amp Development US-Department of Agriculture
International Center to Control Nutritional Anemia(ICCNA)Yi Universityof Kansas Medical Center
CONTENTS
I BACKGROUND-
II FOOD FORTIFICATION
III IRON FORTIFICATION PROGRAM- JAMAICA
A Wheat Flour
B Corn Meal
C- Monitoring
D Quality Assurance
E Nutrition Education
F Safety of Fortification
IV ADDITIONAL INFORMATION NEEDED
A Corn Meal Consumption Data
B Response to Added Iron
C Quality of Corn Meal withAddedIron-
D Quality of Counter-Flour with Added Iron
E Addition of Ferrous Sulfate toBakery Flour
V RECOMMENDATIONS AND SUGGESTIONS
APPENDICES
A Estimated Budget
B People Contacted
C Workshop Outline
I BACKGROUND
Discussions between UASIDJamaica the Ministry of Health-GOJ and the Caribbean
Food and NutritiDn Institute (CFNI) about how to combat anemia inJamaica by proshy
viding more iron to target-groups as well as the general population resulted in
the decision to obtain technical assistanceregarding the fortificationof foods
and for helping to develop a program for the iron fortification of cereal foods
in Jamaica
The authors visited Jamaica to provide that assistance by carrying outa feasishy
bility study andoutlininga program for (1) the iron fortification of corn
meal (2)the addition of iron and B-vitamins to counter-flour and (3)changing
the iron source used in the present enrichiment of bread flour to one with
improved bioavail ability properties
The current conditionsfrom which this feasibility studyand program suggestions
were developed~are
1 All bread (wheat) -flour is produced in Jamaica -Itcontains addedironof a
type which isnot readily absorbed by the body It also contains added B-shy
vitamins This flour isused inthe commercial production of all-typesof
bakery foods It isnot used inthe homebythe general population
2 Counter-flour (all-purpose or family flour) iswheat flour whichis
imported Itdoes not contain any added iron or other nutrients This
flour isconsumed by the majority of the population through every-day -use
3 All corn meal is produced inthe country Itis the principalweaningfood
for infants Also it isused as a breakfast food by therest of the family
Cornmeal is recognized as a staple food of the people inthe lower socio-I
economic group The standard market corn meal has no iron or vitamins added
to it
2
This report is the result of that visit
One purposeof the visit was to discussthe advisability of fortifying cornmeal with iron in Jamaica The justification for consideringthis -intervention strashy
tegy to combat iron deficiency stemsfrom the high prevalence of anemia that
has been observed repeatedly instudies conducted in-this countryduring theshy
past two decades A detailed monograph together with a reviewof availableshy
survey information and a discussion of a variety of strategies to combat iron
deficiency was published in 1982by CFNI This report indicates that vi rtuai ly
all surveys of anemia during the past 15 years in infants childrenand
pregnant or lactating women have shown prevalence of anemia varying from 35 to
80 based on current WHO criteria The survey published by McGregor (1974)
which was conducted in 300 infants during the late 1960s is particularly rele
vant to the issue of cornmeal fortification As defined by a hemoglobin conshy
centration-below 11 gdl 76 of infants were anemic at 8 months of age this
prevalence was even higher at 18 months Presumptive evidence was obtained
during this survey that this anemia lresulted from iron deficiency althoughno
specific laboratory measurementswere performed
More recent studies give little or no indication that the prevalence of anemia
is declini An island-wide survey inmore than400 lactatingwomen conducted
by Simmons indicated a Prevalence of anemia of 49based on a hemoglobin level
below12 gdl and aprevalence of 26 using a criteria of 11 gdl During the
first morning ofthis visit reference was made to an ongoingpediatric study in
whichdata on the hemdglobin bullleVels ininfants less than one year of age are
available as a byproduct of the study Based on a hematocrit below 33 which
is roughly equivalent-to WHO criteria of anemia in infants 6- months of age
9
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
IRON-FORTIFICATION OF CORNMEAL ANDIWHEAT FLOUR
IN JAMAICA
REPORT
Dr IJimes took UniVersity Of Kansas Medical -Cenlter
and
Dr Fred Barrett US Department of Agriculture
This report prepared in cooperationwith
Office of Population Health Nutrition USAIDKingston
Office of Nutrition AIDWashington
Office of International Cooperation amp Development US-Department of Agriculture
International Center to Control Nutritional Anemia(ICCNA)Yi Universityof Kansas Medical Center
CONTENTS
I BACKGROUND-
II FOOD FORTIFICATION
III IRON FORTIFICATION PROGRAM- JAMAICA
A Wheat Flour
B Corn Meal
C- Monitoring
D Quality Assurance
E Nutrition Education
F Safety of Fortification
IV ADDITIONAL INFORMATION NEEDED
A Corn Meal Consumption Data
B Response to Added Iron
C Quality of Corn Meal withAddedIron-
D Quality of Counter-Flour with Added Iron
E Addition of Ferrous Sulfate toBakery Flour
V RECOMMENDATIONS AND SUGGESTIONS
APPENDICES
A Estimated Budget
B People Contacted
C Workshop Outline
I BACKGROUND
Discussions between UASIDJamaica the Ministry of Health-GOJ and the Caribbean
Food and NutritiDn Institute (CFNI) about how to combat anemia inJamaica by proshy
viding more iron to target-groups as well as the general population resulted in
the decision to obtain technical assistanceregarding the fortificationof foods
and for helping to develop a program for the iron fortification of cereal foods
in Jamaica
The authors visited Jamaica to provide that assistance by carrying outa feasishy
bility study andoutlininga program for (1) the iron fortification of corn
meal (2)the addition of iron and B-vitamins to counter-flour and (3)changing
the iron source used in the present enrichiment of bread flour to one with
improved bioavail ability properties
The current conditionsfrom which this feasibility studyand program suggestions
were developed~are
1 All bread (wheat) -flour is produced in Jamaica -Itcontains addedironof a
type which isnot readily absorbed by the body It also contains added B-shy
vitamins This flour isused inthe commercial production of all-typesof
bakery foods It isnot used inthe homebythe general population
2 Counter-flour (all-purpose or family flour) iswheat flour whichis
imported Itdoes not contain any added iron or other nutrients This
flour isconsumed by the majority of the population through every-day -use
3 All corn meal is produced inthe country Itis the principalweaningfood
for infants Also it isused as a breakfast food by therest of the family
Cornmeal is recognized as a staple food of the people inthe lower socio-I
economic group The standard market corn meal has no iron or vitamins added
to it
2
This report is the result of that visit
One purposeof the visit was to discussthe advisability of fortifying cornmeal with iron in Jamaica The justification for consideringthis -intervention strashy
tegy to combat iron deficiency stemsfrom the high prevalence of anemia that
has been observed repeatedly instudies conducted in-this countryduring theshy
past two decades A detailed monograph together with a reviewof availableshy
survey information and a discussion of a variety of strategies to combat iron
deficiency was published in 1982by CFNI This report indicates that vi rtuai ly
all surveys of anemia during the past 15 years in infants childrenand
pregnant or lactating women have shown prevalence of anemia varying from 35 to
80 based on current WHO criteria The survey published by McGregor (1974)
which was conducted in 300 infants during the late 1960s is particularly rele
vant to the issue of cornmeal fortification As defined by a hemoglobin conshy
centration-below 11 gdl 76 of infants were anemic at 8 months of age this
prevalence was even higher at 18 months Presumptive evidence was obtained
during this survey that this anemia lresulted from iron deficiency althoughno
specific laboratory measurementswere performed
More recent studies give little or no indication that the prevalence of anemia
is declini An island-wide survey inmore than400 lactatingwomen conducted
by Simmons indicated a Prevalence of anemia of 49based on a hemoglobin level
below12 gdl and aprevalence of 26 using a criteria of 11 gdl During the
first morning ofthis visit reference was made to an ongoingpediatric study in
whichdata on the hemdglobin bullleVels ininfants less than one year of age are
available as a byproduct of the study Based on a hematocrit below 33 which
is roughly equivalent-to WHO criteria of anemia in infants 6- months of age
9
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
CONTENTS
I BACKGROUND-
II FOOD FORTIFICATION
III IRON FORTIFICATION PROGRAM- JAMAICA
A Wheat Flour
B Corn Meal
C- Monitoring
D Quality Assurance
E Nutrition Education
F Safety of Fortification
IV ADDITIONAL INFORMATION NEEDED
A Corn Meal Consumption Data
B Response to Added Iron
C Quality of Corn Meal withAddedIron-
D Quality of Counter-Flour with Added Iron
E Addition of Ferrous Sulfate toBakery Flour
V RECOMMENDATIONS AND SUGGESTIONS
APPENDICES
A Estimated Budget
B People Contacted
C Workshop Outline
I BACKGROUND
Discussions between UASIDJamaica the Ministry of Health-GOJ and the Caribbean
Food and NutritiDn Institute (CFNI) about how to combat anemia inJamaica by proshy
viding more iron to target-groups as well as the general population resulted in
the decision to obtain technical assistanceregarding the fortificationof foods
and for helping to develop a program for the iron fortification of cereal foods
in Jamaica
The authors visited Jamaica to provide that assistance by carrying outa feasishy
bility study andoutlininga program for (1) the iron fortification of corn
meal (2)the addition of iron and B-vitamins to counter-flour and (3)changing
the iron source used in the present enrichiment of bread flour to one with
improved bioavail ability properties
The current conditionsfrom which this feasibility studyand program suggestions
were developed~are
1 All bread (wheat) -flour is produced in Jamaica -Itcontains addedironof a
type which isnot readily absorbed by the body It also contains added B-shy
vitamins This flour isused inthe commercial production of all-typesof
bakery foods It isnot used inthe homebythe general population
2 Counter-flour (all-purpose or family flour) iswheat flour whichis
imported Itdoes not contain any added iron or other nutrients This
flour isconsumed by the majority of the population through every-day -use
3 All corn meal is produced inthe country Itis the principalweaningfood
for infants Also it isused as a breakfast food by therest of the family
Cornmeal is recognized as a staple food of the people inthe lower socio-I
economic group The standard market corn meal has no iron or vitamins added
to it
2
This report is the result of that visit
One purposeof the visit was to discussthe advisability of fortifying cornmeal with iron in Jamaica The justification for consideringthis -intervention strashy
tegy to combat iron deficiency stemsfrom the high prevalence of anemia that
has been observed repeatedly instudies conducted in-this countryduring theshy
past two decades A detailed monograph together with a reviewof availableshy
survey information and a discussion of a variety of strategies to combat iron
deficiency was published in 1982by CFNI This report indicates that vi rtuai ly
all surveys of anemia during the past 15 years in infants childrenand
pregnant or lactating women have shown prevalence of anemia varying from 35 to
80 based on current WHO criteria The survey published by McGregor (1974)
which was conducted in 300 infants during the late 1960s is particularly rele
vant to the issue of cornmeal fortification As defined by a hemoglobin conshy
centration-below 11 gdl 76 of infants were anemic at 8 months of age this
prevalence was even higher at 18 months Presumptive evidence was obtained
during this survey that this anemia lresulted from iron deficiency althoughno
specific laboratory measurementswere performed
More recent studies give little or no indication that the prevalence of anemia
is declini An island-wide survey inmore than400 lactatingwomen conducted
by Simmons indicated a Prevalence of anemia of 49based on a hemoglobin level
below12 gdl and aprevalence of 26 using a criteria of 11 gdl During the
first morning ofthis visit reference was made to an ongoingpediatric study in
whichdata on the hemdglobin bullleVels ininfants less than one year of age are
available as a byproduct of the study Based on a hematocrit below 33 which
is roughly equivalent-to WHO criteria of anemia in infants 6- months of age
9
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
I BACKGROUND
Discussions between UASIDJamaica the Ministry of Health-GOJ and the Caribbean
Food and NutritiDn Institute (CFNI) about how to combat anemia inJamaica by proshy
viding more iron to target-groups as well as the general population resulted in
the decision to obtain technical assistanceregarding the fortificationof foods
and for helping to develop a program for the iron fortification of cereal foods
in Jamaica
The authors visited Jamaica to provide that assistance by carrying outa feasishy
bility study andoutlininga program for (1) the iron fortification of corn
meal (2)the addition of iron and B-vitamins to counter-flour and (3)changing
the iron source used in the present enrichiment of bread flour to one with
improved bioavail ability properties
The current conditionsfrom which this feasibility studyand program suggestions
were developed~are
1 All bread (wheat) -flour is produced in Jamaica -Itcontains addedironof a
type which isnot readily absorbed by the body It also contains added B-shy
vitamins This flour isused inthe commercial production of all-typesof
bakery foods It isnot used inthe homebythe general population
2 Counter-flour (all-purpose or family flour) iswheat flour whichis
imported Itdoes not contain any added iron or other nutrients This
flour isconsumed by the majority of the population through every-day -use
3 All corn meal is produced inthe country Itis the principalweaningfood
for infants Also it isused as a breakfast food by therest of the family
Cornmeal is recognized as a staple food of the people inthe lower socio-I
economic group The standard market corn meal has no iron or vitamins added
to it
2
This report is the result of that visit
One purposeof the visit was to discussthe advisability of fortifying cornmeal with iron in Jamaica The justification for consideringthis -intervention strashy
tegy to combat iron deficiency stemsfrom the high prevalence of anemia that
has been observed repeatedly instudies conducted in-this countryduring theshy
past two decades A detailed monograph together with a reviewof availableshy
survey information and a discussion of a variety of strategies to combat iron
deficiency was published in 1982by CFNI This report indicates that vi rtuai ly
all surveys of anemia during the past 15 years in infants childrenand
pregnant or lactating women have shown prevalence of anemia varying from 35 to
80 based on current WHO criteria The survey published by McGregor (1974)
which was conducted in 300 infants during the late 1960s is particularly rele
vant to the issue of cornmeal fortification As defined by a hemoglobin conshy
centration-below 11 gdl 76 of infants were anemic at 8 months of age this
prevalence was even higher at 18 months Presumptive evidence was obtained
during this survey that this anemia lresulted from iron deficiency althoughno
specific laboratory measurementswere performed
More recent studies give little or no indication that the prevalence of anemia
is declini An island-wide survey inmore than400 lactatingwomen conducted
by Simmons indicated a Prevalence of anemia of 49based on a hemoglobin level
below12 gdl and aprevalence of 26 using a criteria of 11 gdl During the
first morning ofthis visit reference was made to an ongoingpediatric study in
whichdata on the hemdglobin bullleVels ininfants less than one year of age are
available as a byproduct of the study Based on a hematocrit below 33 which
is roughly equivalent-to WHO criteria of anemia in infants 6- months of age
9
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
2
This report is the result of that visit
One purposeof the visit was to discussthe advisability of fortifying cornmeal with iron in Jamaica The justification for consideringthis -intervention strashy
tegy to combat iron deficiency stemsfrom the high prevalence of anemia that
has been observed repeatedly instudies conducted in-this countryduring theshy
past two decades A detailed monograph together with a reviewof availableshy
survey information and a discussion of a variety of strategies to combat iron
deficiency was published in 1982by CFNI This report indicates that vi rtuai ly
all surveys of anemia during the past 15 years in infants childrenand
pregnant or lactating women have shown prevalence of anemia varying from 35 to
80 based on current WHO criteria The survey published by McGregor (1974)
which was conducted in 300 infants during the late 1960s is particularly rele
vant to the issue of cornmeal fortification As defined by a hemoglobin conshy
centration-below 11 gdl 76 of infants were anemic at 8 months of age this
prevalence was even higher at 18 months Presumptive evidence was obtained
during this survey that this anemia lresulted from iron deficiency althoughno
specific laboratory measurementswere performed
More recent studies give little or no indication that the prevalence of anemia
is declini An island-wide survey inmore than400 lactatingwomen conducted
by Simmons indicated a Prevalence of anemia of 49based on a hemoglobin level
below12 gdl and aprevalence of 26 using a criteria of 11 gdl During the
first morning ofthis visit reference was made to an ongoingpediatric study in
whichdata on the hemdglobin bullleVels ininfants less than one year of age are
available as a byproduct of the study Based on a hematocrit below 33 which
is roughly equivalent-to WHO criteria of anemia in infants 6- months of age
9
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
3
the prevalence of anemia ranges from 29 to 47 Unfortunately few ifany of
these surveys have included laboratory measurements that would define iron defishy
ciency as the cause of anemia Similarly no therapeutic trialshave beenco-shy
ducted to demonstrate a hemoglobin response to iron therapy Nevertheless
there islittle reason to doubt that the prevalence of anemia in Jamaicacon-
tinues 1to be high in all susceptible segments of the population and hat iron
deficiency isthe major ifnot only cause of this anemia
One of the major points of discussion during this visit was whether WHO criteria
of anemia based on hemoglobin levels should be applied inthe Jamaican populashy
tion One possible justificationfor employing less stringent criteria is that
on-going genetic studies at the MRC sickle-cell unit at the University of West
Indies have demonstrated a high prevalence of ok-thalassemia intheJamaican
population Brief discussions wereheld with personnel at the sickle-cell unit
at UWI Genetic mapping studies currently being conducted at Oxford insamples collected inJamaica have indicated a prevalence for homozygous ok-thalassemia of
4in ostensibly normal Jamaican childrenwith a frequency of roughly 30 for
heterozygous 4-thalassemia Homozygous -thalassemiais knownto be associated
with a spectrum of hematologic abnormalities comparable to heterozygous Bshy
thalassemia-including mild anemia and microcytosis but no overt tissue iron
loading One can therefore tentatively surmise that q-thalassemia by itself
could not account for the high prevalence of anemia observed inJamaica since
there would bea maximum error due to homozygous-thalassemia of 4 These
considerations do not fully resolve the-question of whether WHO standards of anemia should be applied-to thispopulation Hemoglobinlevels inAmerican
blacks are 05 to 1 gdl lower than inwhites and this is presumably not
accounted for by thalassemia Perhaps themajor implicationofg-thalassemia in
Jamaica isthat neitherhypochromianor microcytosis can be used to assist in
the detection of iron deficient erythropoiesis It shouldbe added thathematoshylogists inthe country agree that sickle cell anemia (SShemoglobin)does not
2)
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
4
occur with sufficientfrequency to affect the prevalence of anemia since it
occurs in less tha 1 of the population
II FOOD FORTIFICATION
The fortificationof foods - the addition of selected-nutrients tofoodsin
order toimprovetheir nutritive value - is acommonly used strategy for
improving or maintaining the nutritional status of a population by increasing the
daily intake ofspecific nutrients The technology foradding nutrients to
foods iswell developed and has been used-in many countries for many years Primary examples are the addition of iodine to salt vitamin A to fats and
sugar and vitamin C to juices The most widely used food fortification techshy
nology is for the addition of B-vitamins and iron to cereal foods such as flour
bread meals and pastaL Thefortification of wheat flour with vitamins and iron presently is being used inmore than20 developed and developing countries
Also in at least a dozen countries that do not produce their own flour the
imported flour is required to be fortified with vitamins and mineral s The forshy
tification of foods has been shown to be asimple effective and relatively shy
inexpensive way of introducing nutrients such as bioavailable iron into the
daily diet
The technology for the fortifilcatilon of acereal food such as wheat flour or
cornmeal with iron involves three major components 1 the installI ation andshy
operation of the equipment for adding the nutrient 2 the selectioInof the form
ofnutrient to be used and 3 a decision on the amount of nutrient-to be added to the food inorder to affect a desired daily intake
The crieteria for the selection of a foodas the vehicle forithe added nutrients
usually includes the considerations thatit be consumed (1)by essentiallyall
of the people including the target groups (2)in reasonable amounts (3)ona4
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
5
fairlyregular basis and (4)by those in the lower economic levels the ones
most in need of the nutrients Since cereal foods are the primary staple food
for so manyof the worlds population especially indevelOping countries they
are the most frequentlyselected vehicles forfortification
In thecaseof JAaica wheatflour and corn meal are -the staple foods of the
population thus are thelogical choices as vehicles for an iron fortification
program- Food forti fication technology already is being used inJamaica for
the enrichment ofwheat (bread) flourandspecial Porn meal withvitamins and
iron Thus nothing further need be written aboutfortification in general
Instead thisreport will focus attention on the task ofincreasing the level of iron
in the Jamaican diet by having ironadded to the counter-flourand standard corn
meal produced in-country The form of iron used to fortify these foods must be
-more availableand utilizablebythebody while at the same time-not produce an
adverse effect on the quality of the foods
III IRON FORTIFICATION PROGRAM AMAICA
inA Wheat Flour - As part of anIiron fortification program for cereal f ods
Jamaica speci fi cat i ons shoul d be established and plans developed with
Jamaica Flour Mills Ltd to ensure-that the form ofiron added to all Wheat
flour produced inthe countrybe ferrous sulfate ifat all possible
Thewheat flour component-of a fort ification program Can be vi ewed both as
1 a radeof the nutritional value the changein iron form used in a
food already part of an intervention and 2as a new nutrition intervention
involving the fortification of counter-flourwith ferrous sulfate and
B-vitamins This intervention will make iron fortified flIou available to
peoplewhqohave not had access tofortified flour
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
About 45of the flour used in the country is produced inthe Jamaica Flour
Mills Ltd mill inKingston The typeofflour currently produced is used in This flour is notcommerci-al bakeriesto produce breads of all types
available for home use or general consumption Theflour isfortified with
B-vitamins and iron by use of a specially preparedpremixwhichis addedto
the flour using typical food fortification technology This premix contain
enzymes and Oxidation materials inaddition to the vitamins and iron Theso
ingredients are not usually included in standard premixes The form of iroi used in the premix is hydrogn-reduced eemental iron This form of lron i
commonly used to add iron to foods It isa stable form of iron but when
compared to more soluble iron forms such asferrous sulfateits bioavai labi
lity ranks lower-onthescale
It needs to be determined in the case of Jamaica Flour Mills Ltd if the
iron source intheir special premix can be successfully changed to-ferrous
sulfate In-addition to the presence of the other ingredients inthis
premix another factor that warrants attention is that the premix is held
in inventory a relatively long period of time at the mill before it is used
Either or both of these factors could present problems in the reformulation
of the premix to include ferrous sulfate These specific concernsapply
only to thefortification of the bread flour since these other ingredients
will nIot be addedto counter-flour
Although precisecosts are not available at this time preliminary
calculations suggest a sHlight increase incost for premix containing-ferrous
sulfate over one with reduced iron However when related to the use rate
of the premix the difference is about US $000006perpound One would
expect the producer of the flour to absorb that increase -inthe cost as
part of his effort for Improving the nutritional Value of the floIur
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
7
Tie remaining 55 of the flour used in Jamaica iscounter-flour which
is imported This flour traditionally is used by Ithe majority of the popushy
lation for general home use Available information indicates that this
flour seldom has been fortified withany nutrients including iron sothat
the general population which consumes counter-flour has not been recipients
of anyadded iron intheir daily dietthrough the use of counter flour
Production of counter-flour by Jamaica Flour Mills Ltd isscheduled to
start later this year Plans are to fortify itwith B-vitaMins and iron
The iron source to be added to that flourisunder discussion Ferrous
sulfate isbeing considered asthe iron source ofchoice A premixi for
this use will be much less complicated ingredient-wise-than-that used for
the bread flour It is expected that this premix also will undergo a
long holding time inthe-mill before use but no problems are anticipated
with the use of ferroussulfate Standard premixes containing B-vitamins
and iron as ferrous sulfate (which is the standard for comparison) are
available from producerst of premixes The cost to fortify wheat flour wi th
B-vitamins and iron (ferrousi sulfate) to ci rrent US standards is abo ut US
$00004 per pound The iron levelf for this fortification would be 20 mg
per pound of flour
n review the iron source- contained in the-premixes used to fortify the
heat flour produced in the country should be ferrous sulfate The required
ron IeveI in all wheat- flours shoulld be 20 mg per pound regardlessof iron
1
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
8
source used Although itlooks feasible to do so effort is underway to
determine thatIt can successfully be done under the production and
marketing methods currently in use without resulting in adeterioration in
product qual ity or Inasignificant increase inthe cost Of theeproducts
Be Corn Meal - All cornmeal marketed in-Jamalca is produced in-coutry The
manufacturer isSeprod Ltd Theyproduce three types of c rnmeal One
type Miracle is degerminated meal which is fortified with vitamins and iron using typical fortification technology Its price is high compared to other
corn meals The iron source usedAcis iron Thelevelof0hydrogen-reduced
the iron and B-vitamins added are at typical levels forifortified corn meal
in other countries
A second type of cornmeal is called IMarigold It is considered a wh61e
kernel meal but ithas a lower fat content as the resultof a small -amount
of the germ being removed during production
The thirdtype of corn meal iscalled Daffodil It is a whole kernel
meal whichI is typically consumed by the majority-of the people It is used
as weaning food for infants porridge for all ftmily members and as an
ingredient along with wheat flour in the preparation of dumplings
Neither of these whole kernel corn-meals-are fortified with iron or
B-vitamin s
Theyearly consumption of Daffodl i1sapproximately20000 tons Figures
are not avai Iable as to how much of this used for children other familly
members and as pet food Such information is needed so that meaningful
levels of iron can be used in corn meal as partof anutrition intervention
program to decrease iron deficiency anemia
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
9
Corn meal is algical vehicle for carrying additional iron in a nutrition
intervention program because itisthe principal food for children up
to 24 months who represent a ajr target group vulnerabe to1ron defi
ciencyanemia It is reported that there isasmall onsumption of corn
meal bypregnant alctating women In this case a program for the iron
fortification of corn meal would not beconsidered asaninterventionfor
alleviating anemia in-that group
A program for theiron fortification of corn meal would involve the addishy
tion of iron such as ferrous sulfate to the corn meal inthe mill at the
time of production The iron would be blended intoa premix for ease and
accuracy of addition to the meal The level of added iron should be 40 mg
per pound This would provide 10 mg ofiron per day per child basedon
present information that a typical daily feeding Is 4 Oz ofcorn meal
made-up in2 oz portions twice a day in a pint of water This level of
iron equals or slightly exceeds the Jamaica RDA for this age group (7
mgday) This level represents less than half the Jamaican RDA for females
of child-bearing age and for those which are pregnant and lactating-Their
daily iron requirements must be met from other sources
The Daffodil and Marigold brand corn meals would haveonly ironadded to them
Discussions held with nutritionists and public health personnel during this
visit emphasized the point that regular corn meal does not need to be)bull
enriched with B-vitamins or other nutrients Only ironis of concern at
this time for this target group
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
10
SeprodLtd currently isequipped and has the expertise for the addition of
iron as a premix-tocorn meal by virtue of their experience withenrichin
theMarigold degerminated corn meal
Food fortification programs often involve-the addition of theselected
nutrient to all of a food vehicle produced inthe country However
because of the need for more specific information on the general consumption
of corn meal by all family members a program-of iron fortification ofcorn
meal would best be implemented in stages This would allow for the collecshy
tion of sufficient information on the consumptionof corn meal in the family
across the country (see section on Additional Information Needed) The
first stage of a program would involve the controlled shipment of iron forshy
tified corn meal to specific parishes in one area of Jamaica and regular
corn meal continued innormal distribution to the rest of the country Iron
status datawould be-collected from a randomly sampled population of
children 18-24 months of age both inthe test area receiving fortified meal
and in the control area receiving non-fortified meal These data would
indicate the present iron nutritional status of that target group This
first stage would continue for 18 months at which tiie a follow-up study
would be carried out on another randomly selected group of children two
years of age in both areas The results of this testing would be to
demonstrate the measure of benefit derivedfv= fortified corn meal -andproshy
vide data onwhich to base any necessary changesin the-level of added riron
The cost for adding 40 mg ofironper pound lof corn meal is about-US $0000168
To add 40 mg of iron perpound for the 2O000 tons of corn meal (Daffodil)
used per year would cost approximatelyUS $79400 The manufacturer has
exp ressed agreement to cover this Cost and not have itbe reflected inany
increase in the cost of the corn meal due to the added nutrient Since
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
SeprodiLtdalready-is-equipped and has experience in using fortification
technology it will be a simpletransitionto fortifytheDaffodil icorn meal during its production
C Monitoring
The importance of establishing the efficacy of an iron fortification program
cannot-be over emphasized It is seldom possible to measure the impact of a
fortification program once itlis implemented and this is particularlytrue
with respect to ironfortification Incontrast to fortification with nutrishy
ents such as niacin thiamine or riboflavin where the objective is to preshy
vent -the occurrenceof isolated deficiencies it is feasible to alterbody
iron stores of-an entire population through dietary manipulation
The customary approach to monitoring efficacy is to conduct a pilot study
but there are several drawbacks to this Duringa preliminary trial the
supply of a fortified food s usually ensured whereas -this is not necessarily
the case when implemented ona national scale Another importantlimition
of a preliminary iron trial is that because of the inhibitingeffect of the
diet on iron absorption changes in iron status in a populationproduced by
ironfortification occur ery slowly often only after several years IotPil
studies therefore delay the implementation of a fortification program and
are very costly because of the long duration ofthe trial
ne Way to circumvent the high cost of pilot s s to impementiron
fortification in a country in stages In the case of fortified cornmeal for
example one could supply the product to a certain geographic region
Because the major target of this program is 6-24 month old linfants baseline
iron status measurements would be performed immediately prior to introducing
the iron fortified cornmeal Approximately 300 infants 18-24 monthsof age
should be surveyed intwo widely separate geographic regions of the country
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
One regionwill be supplied with iron fortified cornmeal while the second
region will serve as a control Within each region 200-300 infants inthesp
cified age group will be selected randomly from bothrural andurban areas
Baseline laboratory measurements will include hematocri t(or hemoglobin)
free erythrocyte protoporphyrin and serum ferritin All of these microshy
method measurements can be performed on capillary blood samples After 14
months of fortification a second random sampling of infants inthe sameage
group (18-24 months)wil1 be6 performed inboththe control and the-fortifishy
cation regions Longitudinal changes in iron status resultingfromi factors
other than fortification of cornmeal such as more effective fortification of
wheat flour could be assessed by changes overtime inthe control region whereas the impact ofcornmeal fortificationcan be measured by serial
changes within the region receiving iron fortified products Finally by
including more specific-measurements Iof iron status rather than just
hemoglobin determinations the effect on iron balance rather than anemia can
be determined
Estimated cost for this preliminary monitoring activity for stage one ofia
fortification program isIncluded in the attached budget
D Quality Assurance
During stage one and throughout an iron fortification programiquality
assurance activities must be carried out to verify the iro cntent of the
fortified flours and corn meal Sampling and testing for iron content
should be carried out routinely at the mills during the production of the
products The in-plant quality testing should be the responsibility ofand
carried out by the companies since theyhave the laboratory facilities and
good technical personnel with which to do this
Samples of products should be drawn periodically from the market shelfby
designated government representatives and analyzed for iron content This
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
13
isneeded to verify-both the presence of added iron and inthe proper amount
These lsamples could be analyzed in the laboratories of theMinistries of
Health orAgriculture or inother suitable government facilities
This level of quality assurance activity isnecessary to ensure that there
ils a given level of iron intake each day based on expected consumption-A
successful intervention can be accomplished only when the iron ispresent
inthe food on a continuing basis inthe correct amount Anythingless than
this could lead to unsatisfactory results due to lack of proper control
rather than a failure of the interventiOniitself
E Nutrition Education
A nutrition education or public service informationactivity should be
carried out inconjunction with stage one of a program for the iron fortishy
fication of corn meal It should include information about iron in
nutrition the need-for iron inthe bodythe benefits to be derivedfrom
moreiron inthe diet and the consequences of too little iron In addition
it should explain that iron isbeing added to the corn meal available
in certain parishes stressing the fact thatit is iron that is being added
and that it isonly for nutritional improvement purposes The message should
be directed only to the test region that would receive iron fortified corn
meal during stage one if-possible and not tothe whole-nation initially
When the program goes national the same type of activities would be carried
out nationwide regarding cornmeal
The mechanism mightbe special announcements over radio stations flyers or
posters at the point of sale in the markets andA in the clinics and health
centers and by word-of-mouth inthe MCH centers etc Most of this informashy
tion dissemination should be able to b carried out free-of-charge d
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
14
public-service a healthnutrition measure etc There isno estimate at this time what itwould cost to print a sufficient number of posters etc
In regard to the addition of iron along withB-vitamins to counter-floura
part of the wheat flour- component of aprogram typical announcements or
advertisements by Jamaica- Flur Mill Ltdor other appropriate entity shoulc
be used to inform the people of the increased nutritional value of countershy
flour with emphasis o1n the added iron
F Safety of Fortification
The possible adverse effect ofadding largeamounts-of iron to thediiet incershy
tai segments of a population has been discussedI from time to time and deserves
comment Inreviewing studies inwhich possible adverse affects ofiron have
been reported it is important to define the route ofiron administration When
large doses of Imferon (iron dextran) were given by deep subcutaneous injection
to newborn infants an increased frequency of fatal septicemia was noted butit
was not clearwhether this was due to iron or dueto the intramuscular injecshy
tion There is some published evidence that the frequency of malaria may
increase when full doses of therapeutic oral iron are administered to a suscepshy
tible population
On the other hand it- must be stressed that noiadverse effects have iyet been
demonstrated when conventiona levels of iron fortification have been Imple-
mented inapopulation Homozygotes for the iron loading gene ie idiopathic
hemochromatosis have been demonstrated to occur in 1300-500 American whites
but this genetic disorder hasnever been clearly identified ina black indivishy
dual Countries such as Swedenare continuing to fortify the diet at a level
thatprovides approximattely 40 of-dietaryiron intake Without demonstrable
adverse effecs Therefore there seems to be little basis for concerns for a
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
15
fortification program that will double the intake of dietary iron even in iron
repleteindividuals Nevertheless because of the complete lack of information
on themaximal consumptionof corn meal by older childrenand adults it is
desirable to establish consumption patterns of thi sfood vehiclethroughout the
population
IV ADDITIONAL INFORMATiON INEEDED
Additional information of various types needs to be collected justprior to or
duringstage one of an ironfortification program The information will be used
in the planning and operation of stage one aswell as provide the basis to make
any adjustments that appear neededin the final planning for nationwideimpleshy
mentation of lthe program Descriptions of the kind of information needed and
how to obtain- it follow
A Corn Meal Consumption Data
Data is needed on the quantity and distribution of consumption of corn meal
among the family members To obain this information a survey of mothers
should be conducted in MCH centers andor public health centers across the
country Thesurvey should include thecompletion of a questionnaire
regarding all aspects of the use of corn meal in the home Interviewers
would contact the mothers upon their visit to the centers and obtain the
first-hand information It is estimated that interviewers working half-days
for a month at 14 centers across the country could complete approximately
2700 interviews This should represent an adequate sample size and crossshy
section for accurate information on household use of cornmeal
The questionnaire could contain a few questions reg rdingpurchase and us
of counter-flour by the household These questions wouldprovide inforshy
mation on the length of time counter-flour is held inthe home -This could
be important tothe expectedshelf life of counter-flOur containingferrous
sulfate
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
16
Mini stryof Health response to the suggestion of using the centers as data
collection points wa spositive and was expressed in cooperatinginterest
in the planningof sucha survey Personnel to conduct the survey would
have to be independent of the MOH however A cost estimate for asurvey 15
shown in the attached budget
B Response to Added Iron
Information is needed regarding the response of children tobullincreased daily
intake of iron from corn meal at iilthe levels used in stage one of anr
iron fortification program -To facilitate the collectionofsuch datait
is necessary to haveareas in which only iron fortified corn meal is
available and othersin which only non-fortified corn meal is available
Activities carried out to determine the iron nutriture status of children
would be part of the monitoring function for theprogram before it is exshy
panded to a nationwide Ibasis (See Section III CMonitoring)
The establishment of iron fortified and control areas for corn meal can be
-accomplished throughconrolled distributionof the proper corn meal to the
respective areas Representatives of Seprod Ltd indicated that they are
willing to cooperate in such an operation in order to establish the necessary
areas They suggested-thatthe two or three parishes in the eastern end
of the country ie Portland St Thomas etc be used as the test
(fortified) area because they lend themselves to far better1control of the
distributionof the corn meal due to-the marketing and distribution pattern
of the company in that area Details of such an activity for controllingshy
the distri bution of iron fortified corn-meal fromplant to-store shelf need
to beworked out with Seprod personnel This activity will helpin the
collection of baseline iron status measurements as well as the data relating
to the response to increased iron intake
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
17
C Quality of Corn Meal iwith Added Iron
Because there are differences in production use and conditions encountered
for any given food in different countries information should be obtained
on theretention of quality of corn meal which has had ferroussulfate
added to i t Corn meal should be fortified with iron to the suggestedlevel
of 40 mgb and placed in holding tests which duplicate the conditions the
corn meal willmeetduringdistribution and use The corn meal shouldbe
evaluatedforcolor odor and taste after-holding under typical Jamaican
conditions for periods1of time representingkexpected sheelf life Ietimeli
from prod uctiobn unt il use
Typical production corn meal should be used along with a source of ferrous
sulfate that would be used in a fortification program
D Quality of Counter-Flour with Added Iron
iThe-same philosophy and-need for information applies to the addition of
ferrous sulfate to counter-flour as for the addition of such Iron to corn
meal The testing should include the addition of 20mg of ferrous sulfate
(plus B-vitamins) per pound of flour followed by holding tests under expected
time and conditions Then organoleptic evaluation for odo color etc
should be carriedout on the stored product
No information was available about how long counter-flour i on the shelf
and inthe home before it is used Comments received during discussions
about counter-flour indicated that the flour ison the shelf only a short
time and on-occasion isnot available There was no indication of-how long
it was the homein before-use
21
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
18
Some measure of the storage time in the home could be obtained by having
a question or two on the questionnaire to-be used in the corn meal conshy
sumption survey
E Addition of Ferrous Sulfate to Bakery Flour
Theshelf life of bakery flour isreported to be3-4 days fromproduction
touse The presence of-ferrous sulfate in the flour should not affect the
qual ity of theflour Any concern wouldresidewith the special permix
itself which is added to the flourto provide the nutrients and otheringre
dients As indicated earlier this premix is a blend of more than the usual
naterialsused in an enrichment premix and the length oftimefrom its proshy
luction to use may be longer than usual for premixes
should estsbe carried out to check the stability of the special premix
ontaining ferrous sulfate subjected to conditions and time that will be
net between its production and its use inthe mill
99V
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
V RECOMMENDATIONS AND SUGGESTIONS
1 A national cereal fortification program should be instituted which has as
its goal the iron fortification of all corn meal and wheatflour consumed
in Jamaica The program could be the result of a project which provides
information on (1)theadequacy of the production distribution and qualit
assurance components of a fortification program (2)thesuitability of
ferrous sulfate as the iron source to fortify the foods and (3)theimproveshy
ment-in iron status ofrecipients of fortified corn meal as an indication
ofthe adequacy of the level of added ironshy
2 The source of iron used in the fortification of cereal foods should be a
highly available form such as ferrous sulfate The suggested levels are
20 mg per pound for wheat flour and 40 mg per pound for corn meal This
level for wheat flour is higher than that presently used in Jamaica and
equals the new level in some countries with iron fortification programs
The level for corn meal is higher than for wheat flour because of the
universal requirement for additionaldietary iron during the first two
years of life and the fact that corn mealis used almost exclusively as a
weaning food throughout Jamaica This level of iron will meetor exceed
the Jamaican RDA for iron (7mgday) in6-24 month old children based on
the present consumpt ion information
3 m 5urvey snuiuuecarrea ouLTo aeterminetne als rioution and amountof
consumption of corn meal in the family This should be done as soon as
possible andneed not be a part of-a project though itmi ght be The inshy
formation it wouldprovide is needed-for other considerations in child
health and nutriiion ifnot directly used iniron fortificationprograms
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
20
The information would be-valuable indetermining the daily intake of iron
by infants children andadults that could result from the consumption of
fortified corn meal Itwouldindicate whether the recommended levels of
iron additionwould be sufficientfor a child yet not lead to an excess
intake of iron by adul ts that could beharmful
4 A project should be carried out whichwould include the initial addition of
iron toall corn meal and wheat flour made in-country It could be
implemented inthree stages Step onewould include (a)limited-introduction
of iron fortifiedcornmeal and (b)initial in-country production of countershy
flour fortified with iron and B-vitamins Stagetwo would be the start of
use of ferrous sulfate as the iron source inbread flour produced intheshy
country and Stage three-would be theexpansion of the availability of iron fortified cornmeal t thewhole countrY pl any changes iniron level
iron source or otherfactors-found necessary to help assure the success of
a national cereal fortification program
5 Stage one should be started immediately after completion of the cornmeal
consumption survey or as soon as conditions allowafter that It should-
involve controlled distribution resulting inoIly iron fortified corn meal
beingavailable in a prescribed area This would be accompaniedby a monishy
toring activity to measure the response to added iron through this intervenshy
ion Baseline and 18month follow-up studies of iron status should be pershy
formed on randomly selected two year old infants both inthe fortified and
non-fortified areas Also it should include the production and distribution
of counter-flour fortified with ferrous sulfate and B-vitamins Samples
should be tested-routinely for iron content and consumer acceptability
These activitieswill provide information n any- needed changes in iron
level on-the acceptability of the-iron source and on the adequacy of the
production and distribution of fortified corn meal and counter-flour
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
21
6 Afnutrition education component should be included as part of a project Activities should-be-carried out before and during stage one in the area
receiving fortified corn meal It should informthe recipients of fortishy
fied corn meal about the nutritionalvalue of the added ironand the beneshy
fitsto be derived-from it
A general information campaign should be carried-out nationwide telling of
the improvednutritional value of counter-flour inregardsto iron dontent
whenitis introduced into the market
Similar informationshould be made avai lable in stage two about the changoe in
iron source in the bakery flour to one in a more useable form by the
consumer
In stagethree the information aboutfortified corn meal shuld e dis
nated nationwide accompanied by thecontinuing actiVities regarding countershy
flour and bakery flour
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
APPENDICES
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
APPENDIX A
Estimated Budget -StageOne -Iron Fortificaion Program
Activity Cost
Corn Meal Consumption Survey us 6000
Baseline Study and Monitor of IronStatus 69000
Technical Assistance for Preparation
of-Project Paper 1800
Iron for 18 monthCornMealFortification (Seprod)
Iron for Counter-Flour 0amaica Flour MillLtd
Total
$76800
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
APPENDIX B
People-Contacted
Many of the people mostl associated with the problem of anemia inJamaica were
presentat the-Workshop on irondeficiency anemia held Monday June 25 1984
(See attached meeting iagenda-) Alsoin attendance were representatives-of the
flour milling and corn meal production companies who described the industries
concern and willingness-to cooperate inefforts to redu6e anemia
Inaddition tothe discussionsduring the workshop indepth discussions were
held with the following people on matters related to a program to combat anemia
Jamaica Flour Mills Ltd
Mr Peter Pickett Director of Operations
Seprod Ltd
Mr A Summons Market Manager
Ministry of Health
Dr Bowenwright
Mrs K Rainford
Caribbean Food and Nutrition Institute
Dr Patterson Director
Dr B Simmons Nutritionist
Ms Sadie Campbell Nutritionist
Tropical Medicine Research Unit
Dr- Alan Jackson
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions
APPENDIX C
DRAFT AGENDA
IRONANEMIA SCREENiNG TREATMENT AND rPREVENTION
-900 910 WelcomingRemarks - Dr W Patterson Director CFNI
910 - 925 Anemia Studies in Jamaica - Dr BSimons CFNI
925 950 Screening TreatmentampPrevention Programs -Dr DAshle PMOMCH MOH
-950 -1005 Recent Research Findings Dr Alan Jackson-TMRU
1005 -1015 Dietary Iron Sources in Jamaica Ms Sadie Campbell Nutritionist CFNI
1005 -1030 Discussion
1030- 1045 Clinical Analysis of Anemia - Dr Goldman Department of Hematology UWI
1045-1100 International Anemia Programs - Dr James Cook Director Department of Hematology Kansas University Medical Center
1100 -1115 Anemia Programs in Jamaica - Dr Gibbs Director Department of Hematology UWI Medical Centershy
-111115 30 Discussion
1130 --1140 Refreshment Break
1140-1150 Present Fortification of Wheat Products in Jamaica - Mr Vassel Chief Chemist Director Pilot Bakery Jamaica Flour Mills
1150 1200 Present Fortification of Cornmeal inJamaica Mr B Thompson Manufacturing Manager Seprod Ltd
1200- 1215 Present Cereal Fortification in the United States - Dr Fred Barrett Fortification Specialist United States Department of Agriculture
1215 - 1230 Closing Discussions