Assignment #Pedigrees

BiologyMrs. McCarthy

I. Studying human heredity

A. Time between generations is

B. Number of offspring produced is

C. Controlled experiments are

too long.

too small.

not possible.

II. Pedigree charts –

A. This is the symbol for a female:

B. This is the symbol for a male:

A diagram that shows thepresence or absence of a trait ineach member of each generation

C. A normal person (no disease) -

D. A person with a disease:

E. A carrier of the disease:

has a clear symbol

has a solid or colored symbol

has a symbol that is half colored

Pedigree Symbols

AlkaptanuriaAlkaptanuria is a rare inborn error of metabolism

of tyrosine due to deficiency of homogentisic acid (HGA) oxidase leading to accumulation of HGA in various tissues.The hallmark of the disorder is a triad of degenerative arthritis, ochronotic pigmentation and urine that turns black on alkalanization. Other manifestations of the disease include degenerative cardiovascular diseases. Treatment of the condition includes vitamin C that partially ameliorates the condition by impeding the polymerization of HGA.

METHEMOGLOBINEMIA is a disease caused by a blood disorder in

which the blood does not appear red. Individuals may appear to have chocolate-brown lips or

even blue skin.

Blue people of Kentucky

Blue Fugates of Kentucky

III. Example of a Pedigree

Look at your worksheet for the pedigree.

A. Are males or females more likely to have this disease?

B. How many females are carriers?C. How many males are carriers?D. Is this a sex-linked trait?

IV. Create a pedigreeA. Draw a pedigree of a family that has:

1. A mother that is a carrier for hemophilia

2. A father that is normal

  

   

   

XH Y

XH

Xh

XHXH XHY

XHXh XhY

IV. Create a pedigreeA. Draw a pedigree of a family that has:

1. A mother that is a carrier for hemophilia

2. A father that is normal3. They have 2 daughters and 2

sons

4. A carrier daughter marries a man with hemophilia

5. They have 2 daughters and 2 sons

   

   

Xh Y

XH

Xh

XHXh XHY

XhXh XhY

4. A carrier daughter marries a man with hemophilia

5. They have 2 daughters and 2 sons

Example of a Pedigree

Make a pedigree to the song

“I’m my own grandpaw”

I’m my own grandpa!

Can you make a Pedigree for this situation?

`

Many, many years ago when I was twenty-three

I was married to a widow who was pretty as could be.

This widow had a grown-up daughter who had hair of red.My father fell in love with her

and soon they, too, were wed.

This made my dad my son-in-law and changed my very lifeFor my daughter was my

mother, 'cause she was my father's wife.

To complicate the matter, even though it brought me joy

I soon became the father of a bouncing baby boy.

My little baby then became a brother-in-law to dad

And so became my uncle, though it made me very sadFor if he was my uncle, then that also made him brotherTo the widow's grown-up

daughter, who, of course, was my step-mother.

ChorusI'm my own grandpawI'm my own grandpawIt sounds funny I know

but it really is soOh, I'm my own grandpaw.

My father's wife then had a son who kept them on the run

And he became my grand-child, 'cause he was my daughter's

son.My wife is now my mother's

mother, and it makes me blueBecause, although she is my

wife, she's my grandmother too.

If my wife is my grandmother, then I am her grandchild

And every time I think of it, it nearly drives me wild

(This has got to be the strangest thing I ever saw)

As husband of my grandmother, I am my own grandpaw .

ChorusI'm my own grandpawI'm my own grandpawIt sounds funny I know

but it really is soOh, I'm my own grandpaw.

HOMEWORK:

Pedigree worksheet