Vol. 9 0 EFFECTS OF GROWTH CHANGES O N PLANT LIPIDS 6 3 7 In roots a l l lipids were increased. A number o f lipid substances i n the total extractable materials were measured. 3 . Protein concentration w a s decreased i n treated plants a n d carbohydrate fraction concen- trations were increased reciprocally. 4. Th e esterified sterols of t he shoots exhibited fast-reacting characteristics t o t e Liebermann- Burchard reagent. This research w a s supported b y t h e Mary McMahon Memorial Grant f o r Cancer Research from t h e American Cancer Society a n d by t h e National Institutes o f Health Grant n o . H-4910 (U.S. Public Health Service). A gift o f gibberellic acid wa s donated through th e courtesy o f D r E. F. Alder o f t h e E l i Lilly Co., Greenfield, Ind., U.S.A. T h e authors are grateful f o r t h e technical assistance o f M rs Cathy Y e n an d Mrs Nadia Oleksyshyn Bulyk, a n d f o r t h e contribution ofthe nitrogen analyses by D r 0. B . Houchin, Oklahoma Medical Research Institute, a n d th e carbo- hydrate analyses b y D r M . R . Shetlar, Department o f Biochemistry, University o f Oklahoma School ofMedicine. REFERENCES Brian, P . W . , Elson, G. W . , H . G . & Radley, M . (1954). J . Sci. Fd Agric. 5 , 262. Dahlstrom, R . V. & Sfat, M . R. (1961). I n Advances i n Chemistry: Gibberellins, vol. 2 8 , p . 5 9 . E d . b y Gould, R . F . Washington: American Chemical Society. Fiske, C . H . & Subbarow, Y. (1925). J . biol. Chem. 6 6 , 375. Folch-Pi, J., Ascoli, I . , Lees, M . , Meath, J . A . & LeBaron, F . N . (1951). J . biol. Chem. 191, 833. Frantz, I . D., Dulit, E . & Davidson, A. G. (1957). J . biol. Chem. 226, 139. Hoagland, D . R . & Arnon, D . I . (1938). T h e Water Culture Method f o r Crowing Planrs without Soil (Cali- fornia Agricultural Experiment Station, Circular n o . 347). Idler, D . R . & Baumann, C . A. (1953). J . biol. Chem. 203, 389. Kates, M . & Eberhardt, F. M . (1957). Canad. J . Bot. 3 5 , 895. Luddy, F . E . , Barford, R . A . , Riemenschneider, R . W . & Evans, J . D . (1958). J . biol. Chem. 232, 843. M a , T . S . & Zuazaga, G . (1942). Industr. Engng Chem. (Anal.), 1 4 , 280. McCormick, E. C . , Cornwell, D . G . & Brown, J . B . (1960). J . Lipid Res. 1 , 221. Moore, P . R. & Baumann, C . A . (1952). J . biol. Chem. 195, 615. Nair, P. P . & Magar, N . G . (1954). Indian J . med. Res. 4 2 , 577. Nair, P . P . & Magar, N . G. (1956). J . biol. Chem. 220, 157. Sperry, W . M . & Webb, M . (1950). J . biol. Chem. 187, 9 7 . Stern, M . H . & Baxter, J . G . (1947). Analyt. Chem. 1 9 , 902. Stowe, B. B. (1961). I n Advances i n Chemistry: Gibberellins, vol. 2 8 , p . 142. E d . b y Gould, R . F . Washington: American Chemical Society. Wall, M . E . & Kelley, E . G . (1943). Industr. Engng Chem. (Anal.), 1 5 , 1 8 . Wall, M . E . & Kelley, E. G. (1946). Indu8str. Engng Chem. (Anal.), 1 8 198. Biochem. J . (1964) 90, 6 37 Ascorbic Acid a n d Aging i n t he R a t UPTAKE O F ASCORBIC ACID BY SKIN AND BONE MARROW, AND I TS CONCENTRATION I N VARIOUS ORGANS B Y M . S . KANUNGO AN D B . K. PATNAIK Physiology Laboratory, Department o f Zoology, Banaras Hindu University, Varanasi 5 , U.P., India (Received 1 5 July 1963) Ascorbic acid participates i n several metabolic reactions, a n d h a s been considered t o b e o f parti- cular significance i n t h e aging process. Even though i t i s n ot a n essential dietary requirement fo r mammals other than primates an d guinea pigs, i t s metabolic functions a r e t he same i n all. In m a n i t s concentration i n t h e blood cells declines with a g e i n the adult (Kirk & Chieffi, 1953). T h e hepatic ascorbic acid concentration i n rat increases rapidly during t h e first 3 weeks of extra-uterine life, declines sharply during t he next 5 weeks a n d then remains relatively constant (Mourhouse & Guerrant, 1952). Several workers (Piez & Likins, 1957; Sinex, Va n Slyke & Christman, 1959; Stetten, 1949; Stone & Meister, 1962) have shown that i t i s involved i n t h e mechanism o f hydroxylation of collagen. Th e administration of ascorbic acid t o deficient guinea pigs enhances collagen synthesis (Gould, 1960; Robertson, Hiwett & Herman, 1959), b u t there i s n o evidence that i t i s required f o r t h e synthesis o f other proteins. I t h a s been suggested b y Gross (1959) that ascorbic acid m a y b e required f o r t h e maintenance o f collagen. I n view o f t h e above observations, th e uptake o f ascorbic acid i n t h e skin a n d bone marrow a n d i t s concentration i n different organs o f rats o f various age groups have been studied t o elucidate i t s role in t he process.
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