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Supplementary table 1 Exercise intervention characteristics of included studies in skeletal muscle atrophy.
Disease Training WeeksDays / Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Skeletal muscle atrophy (5)
Treadmill exercise
a single bout
— 25 min, 20 m/min, at a 20° incline
Wistar male rats (9–10 weeks old), 2 weeks hindlimb unloading-induced atrophy
Positive 1
5 5 Moderate intensity: 15 m/min for 60 mins; high intensity: 30 m/min for 30 mins
8-week-old male Wistar rats; 5 weeks after triamcinolone injection, the soleus muscle and extensor digitorum longus muscle were removed and stained for adenosine trihosphatase.
Positive (moderate intensity);
negative (high intensity)
2
Resistance training
2 7 Climbing 1 m at an 80° incline, weights in a plastic bag were attached with Velcro to the base of the tail during exercise. Weights were calculated as percent body mass of each rat and gradually increased by 10% every few days as tolerated with a maximum weight of 50% body mass.
Adult male Sprauge-Dawley rats, the burned animals were resuscitated with 20 ml of intraperitoneal Lactated Ringer's; the hindlimb unloading animals were placed in a tail harness and attached to a hindlimb unloading system
Positive 3
8 5 At 80% of maximal voluntary carrying capacity, 9 or 10 climbs per session
Male rats (200–250 g), 10 days DEX induced muscle atrophy
Positive 4
Swimming and resistance training
3/7 days
— Swimming: 20 min/day, intensity (load) with 2.3% of BW (anaerobic threshold); Resistance training: comprised 3 sets of 10 jumps (1 min of rest) using 60% of the 1 repetition maximum test
Old male Wistar rats Positive 5
Supplementary table 2 Exercise intervention characteristics of included studies in muscle injury
Disease Training WeeksDays / Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)References
Muscle injury (2)
Treadmill exercise
2/6 5 With a progressive increase in speed (from 10 m/min to 30 m/min), time (from 1 to 2 h), and slope (from 5% to 8%)
Female Wistar rats initially weighing 180–200 g, degeneration of the left soleus muscle was induced by notexin injection. Positive 6
Resistance training
10 3
Week 1: ST protocol began with an overload corresponding to 60% of the maximal voluntary carrying capacity, increased to 70% in the Week 2 and to 80% in the Week 3. The 80% of maximal voluntary carrying capacity was maintained until the end of the protocol.
4 months old male Wistar rats, the animals were deeply anesthetized, and the skin around the tibialis anterior muscle area was shaved and cleaned with Polyvinylpyrrolidone iodide, a transverse incision (1 cm) of the skin over in the middle of the TA muscle was created using a surgical blade. The fascia was carefully removed, and the center of the TA muscles was surgically exposed. A hexagonal iron bar (4.5 mm), previously cooled for 10 s in liquid nitrogen, was kept for 10 s on the center of the TA muscles.
Positive 7
Supplementary table 3 Exercise intervention characteristics of included studies in tendon injury
Disease TrainingWeek
s
Days /
Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Tendon injury (2)
Treadmill exercise 5 3
60 min/day, 17 m/min, 15° inclination
2-month-old Male Sprague-Dawley rats, the skin of the left patellar tendon was incised laterally. The patellar tendon was exposed after dissection of the surrounding fascia, 5 mm proximal to its insertion on the patella, the patellar tendon was partly cut (50%).
Positive 8
Resistance training
12 3 8–12 times/climb; progressive loads of 65%, 85%, 95%, and 100% of the maximum carrying capacity of each; Resistance training sessions consisted of 5–8 movements per climb over 6–8 s.
3-month-old (young, 308 ± 11 g) and 21-month-old (old, 523 ± 22 g); male Wistar rats.
Positive 9
Supplementary table 4Exercise intervention characteristics of included studies in osteoporosis
Disease Training WeeksDays / Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Osteoporosis (3)
Treadmill exercise
12 4 60–100 min/day, 25 m/min, at a 10 % grade, approximately 70 % VO2max
5-month-old virgin female Sprague-Dawley rats Positive 10
Voluntary running wheel
10/14/18 months
7free to exercise
5 months male Sprague-Dawley rats
Positive 11
Jumping exercise
5 5 20 jumps/day, the initial jump height was 25 cm, which was gradually increased to 40 cm by the end of the 1st week
Eight-week-old female Wistar rats (190–210 g), rat tail suspension model, rats were kept in suspension for 3 weeks.
Positive 12
Supplementary table 5 Exercise intervention characteristics of included studies in osteoarthritis
Disease Training WeeksDays / Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Osteoarthritis(5)
Treadmill exercise
4 5 30 min/day; Moderate:12 m/min; Intense:21 m/min
12-week-old male Wistar rats, a destabilized medial meniscus was created in the right knee.
Positive 13
4 4 Week 1: 12 m/min of exercise (post-injection days 10–13); Week 2–4: 16 m/min
Male Sprague-Dawley rats weighing 175–200 g, intra-articular monosodium iodoacetate induced tactile hypersensitivity and weight asymmetry.
Positive 14
4 5 60 min/day; osteoarthritis with low-intensity treadmill exercise: 15.2 m/min with 0° of inclination, osteoarthritis with moderate-intensity treadmill exercise: 19.3 m/min with 5° of inclination, osteoarthritis with high-intensity treadmill exercise: 26.8 m/min with 10° of inclination
Male Sprague-Dawley rats (230 ± 10 g), 8 weeks of age; knee osteoarthritis model
Positive 15
8 3 50 min/day, 16 m/min Adult male Wistar rats, 6 wks old; osteoarthritis induction was performed under intraperitoneal
Positive 16
anesthesia with 40 mg/kg of ketamine and 20 mg/kg of xylazine
Voluntary wheel running
1/3 7 Free to exercise Adult male Sprague-Dawley rats , 200–250 g, A single intra-articular injection of MIA (3.2 mg/25 μl) into the left hind knee was administered to induce a localized arthritis of the knee joint
Positive 17
Supplementary table 6 Exercise intervention characteristics of obesity
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative)References
Obesity
(21)
Treadmill exercise 2 5 10 min/day, 6 m/min 12-week-old male obese
Zucker ratsPositive 18
2 6 60 min/day,15 m/min One hundred and twenty Male
Wistar rats (125–150 g; 5 weeks
of age)
Positive 19
4 5 1–2 session, 30
min/session, 20 m/min
21-week-old male Fischer rat,
diet-induced obesityPositive
20
6 5 2 ×15 min/day, 25
m/min, 5% grade
200 g diet-induced obesity
female WistarPositive
21
8 6 15 m/min; 30 min/day Male Wistar rats (125–150 g) Positive 22
8 5 50 min/day, 10 m/min 15-month-old diet-induced
obesity Wistar malePositive 23
8 5 60 min/day, 32 m/min,
10% grade
6-week-old diet-induced obesity
male Sprauge-Dawley ratsPositive 24
8 5 40 min/day, 18 m/min 7-week-old male Sprauge-
Dawley ratsPositive 25
8 5 60 min/day, high-intensity
interval aerobic–
4-week-old male Zucker ratsPositive 26
anaerobic training
9 5 60 min/day, 15 m/min 7-week-old Wistar rats Positive 27
10 5 35 min/day: 8 m/min, 5
min; 11 m/min,5 min; 15
m/min, 20 min; 8 m/min,
10 min
43-week-old male Sprauge-
Dawley rats, 35-week diet-
induced obesityPositive 28
Voluntary wheel
running
14 7 Free to exercise 4-week-old Male JCR:LA-cp
(cp/cp)Positive 29
14 7 Free to exercise 4-week-old male Otsuka Long-
Evans Tokushima FattyPositive 30
16 7 Free to exercise 4-week-old male Otsuka Long-
Evans Tokushima FattyPositive 31
24
days
7 Free to exercise 3-week-old male/female Otsuka
Long-Evans Tokushima Fatty-
hyperphagia-induced obesity,
offspring
Positive 32
36 7 Free to exercise 4-week-old male Otsuka Long-
Evans Tokushima FattyPositive 33
Swimming 4 5 45 min/day, aerobic
exercise
130 g Male albino Wistar ratsPositive 34
8 5 60 min/day, with 5%
overload of the body 4-week-old Wistar rats , high-
Positive 35
weight fat diet
10 3 30 min/day with an
overload of 5% of body
weight
monosodium glutamate
(MSG)-obese rats Positive 36
2 days 10 min
for 2 days
Free to exercise 4-week-old Wistar rats were fed
on an obesity-inducing diet for
3 months (diet-induced obesity)
Positive 37
Resistance Exercise 1 7 Free to exercise 16-week-old Lean (fa/-; n = 16)
and obese (fa/fa; n = 14) Zucker
rats
Positive 38
Supplementary table 7 Exercise intervention characteristics of included studies in diabetes
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative)References
Diabetes
(49)
Treadmill
exercise
2 5 5 m/min for the next 5 min, and then 8
m/min for the last 20 min
female Sprague-Dawley rats
weighing 220 ± 10 g and adult
male Sprague-Dawley rats
weighing 300 ± 10 g diabetic
rats
Positive 39
4 5 1 m/min increments every 3 min up to
the rat reached exhaustion
female Wistar rats weighing
180–200 g
Positive 40
4 7 30 min/day, 10 m/min 24 healthy male Sprague-
Dawley rats
Positive 41
5 5 60 min/day, 23-25 m/min 150–300 g Wistar strain albino
male rats
Positive 42
5 5 60 min/day, 20 m/min 8-week(weighing 290 g) Male
Crl:ZUC-Leprfa Obese Zucker
rats
Positive 43
5 5 60 min/day, 20 m/min 3-month old male Wistar rats,
270–400 g
Positive 44
6 5 60 min/day, 10 m/min 32 male Sprague Dawley rats
weighing approximately 250–
Positive 45
280 g6 5 10 min, at 10 m/min, 2ND week, 20
min, third week, increased to 20 min
of running at 15 m/min. week 4, 5, and
6, trained for 30 min at 15, 18, and 18
m/min
46 male Wistar rats (aged 8–10
weeks)
Positive 46
6 5 60 min/day, 12 m/min Male Sprague-Dawley rats
(243 ± 7 g, 8 weeks)
Positive 47
7 5 40 min/day 11-week male Zucker Diabetic
Fatty (fa/fa) rats
Positive 48
8 5 60 min/day 12-week-old rats with
streptozocin-induced
diabetes,Wistar rats
Positive 49
8 5 60 min/day, 20 m/min Five-week-old male Zucker
diabetic fatty
Positive 50
8 6 60 min/day, 20 m/min 10–12 week 270–290 g Goto-
Kakizaki rats
Positive 51
8 4 0 m/min for 10 min in the 1st week; to
10 m/min for 20 min in the 2nd week;
14 to 15 m/min for 20 min in the 3rd
week; 14 to 15 m/min for 30 min in the
195–200 g Wistar albino rats Positive 52
fourth week; and 17 to 18 m/min for
30 min in the 5th week; 17 to 18
m/min for 40 min in the 6th week; 20
to 21 m/min for 40 min in the 7th
week; and 20 to 21 m/min for 50 min
in the 8th week8 5 90 min/day, 1.45 km/h 12-week old male outbred
Wistar rats
Positive 53
8 5 60 min/day, 40%-60% of the
maximum speed
32 female Wistar rats (10
weeks-old)
Positive 54
8 5 40 min/day, 20 m/min 8-week-old adult male Wistar
rats
Positive 55
8 5 21 m/min to 35 m/min. Male Wistar rats, weighing
between 230–280 g
Positive 56
10 5 60 min/day, 27 m/min, 6% grade 8-week-old male Sprague–
Dawley rats
Positive 57
10 5 60 min/day, 0.3 km/h Wistar rats Positive 58
10 5 27 m/min, 6% gradient 8-week-old male Sprague-
Dawley rats
Positive 59
12 5 60 min/day, 20 m/min 20-week-old male Wistar-
Kyoto spontaneously type 2
diabetes (T2D) mellitus rats,
Positive 60
high-caloric diet and 30%
sucrose hastened (blood
glucose level: from 200 to 300
mg/dl)12 5 60 min/day, 20 m/min, 15% incline 4-week Male LETO and
Otsuka Long-Evans
Tokushima Fattyrats
Positive 61
12 5 60 min/day, 15 to 20 m/min Zucker diabetic fatty (Zucker
Diabetic Fatty , fa/+) rats
Positive 62
10 5 50%–70% maximal running speed 48 male Wistar rats (251 ± 10
g)
Positive 63
10 5 60 min/day, 75%-85% VO2max 64 male Sprague–Dawley rats
(8 weeks old)
Negative 64
10 5 60 min/day, 40%–60 % maximal
running speed
Male Wistar rats weighing
approximately 250–300 g
Positive 65
12 5 60 min/day, 27 m/min on a 6% grade 8-week-old male Sprague-
Dawley rats
Positive 66
12 5 60 min/day, 60% of maximal velocity
obtained
Wistar rats Positive 67
12 5 60 min/day, 20 m/min, 15% incline 20-week male Otsuka Long-
Evans Tokushima Fatty , type
2 diabetes with hyperglycemia
Positive 68
and hyperinsulinemia14 5 60 min/day 6-8 week, 200 g Wistar male
rats
Positive 69
Voluntar
y wheel
running
Swimmin
g
5 7 Free to exercise 24-week-old male Otsuka
Long-Evans Tokushima Fatty
Positive 70
6 7 Free to exercise 20 eight male wistar rats Positive 71
6 7 Free to exercise Wistar male rats (200–250 g) Positive 72
14 5 Free to exercise Male SpragueDawley
rats (8 weeks old)
Positive 73
18 18 Free to exercise Male RHA and male RLA rats Positive 74
20 Free to exercise 4-week-old male Otsuka Long-
Evans Tokushima Fatty
(OLETF; n = 21) rats
Positive 75
36 7 Free to exercise 4-week-old male Otsuka Long-
Evans Tokushima Fatty
Positive 76
4/16/3
6
7 Free to exercise 4-week-old male Otsuka Long-
Evans Tokushima Fatty
Positive 77
6 3 60 min/day 24 male homozygous Zucker
diabetic fatty (Zucker Diabetic
Fatty ) rats
Positive 78
6 2–5 150 min/week adult male Sprague-Dawley
rats, 300–350 g, mild type 2
diabetes (blood glucose
Positive 79
concentrations between 7 and
17 mmol/L),
nicotinamide/streptozocin-
induced7 5 60 min/day Male Wistar rats (175–200 g;
38 days old)
Positive 80
8 — 1st week, the animals exercised in the
water, no overload, over 10–50 min,
the duration increased by 10 min/day.
2nd week, the animals exercised with a
load of 1.0% of their body weight and
exercise duration was increased by 10
min/day until 90 min of continuous
swimming. From the 3rd week, the
load was increased weekly (0.5% of
body weight) up to 4.0% of body
weight in 8 weeks.
Wistar rats (age 30 days; mean
body weight of 84.19 g)
Positive 81
8 5 10 min in the 1st day, increasing 10
min daily until the end of 6 days 60
min
195.0 ± 15.7 g adult male
Wistar rats
Positive 82
8 5 1 h/day 75-days-old male Wistar rats Positive 83
8 7 The load was progressively increased 30 days old, 87.40 ± 13.03 g Positive 84
by 1% of the animal's BW from the
fourth week on, such that at the 8th
week, animals swam with a total load
of 5% of their BW.
Male Wistar rats
8 5 Week 1: 10–50 min/day, increase 10
min/day, no load; Week 2: 50–90
min/day, increase 10 min/day, load
with 1% of BW; Week 3–8: 90
min/day, load with 1–5% of BW
37-day-old Male Wistar rats,
streptozocin induced type 1
diabetes (ip. injection) (blood
glucose (BG) above 300
mg/dl)
Positive 85
8 5 1 h/day, 5 days/week, 8-week period Male Wistar rats (180–210 g,
45 days old)
Positive 86
8 5 After adaptation training, 38 rats were
randomly divided into 3 groups: less-
intensive group (LM group, rats
swimming for 30 min), moderate-
intensive group (MM group, rats
swimming for 60 min), high-intensive
group (HM group, rats swimming for
120 min)
56 male Sprague Dawley rats,
aged between 8–10 weeks.
Positive 87
8 7 In the 1st week, animals swam for 10–
50 min, with no load, while duration
was increased by 10 min/day. In the
Male Wistar rats weighing
90.0 ± 5.0 g, 30 days old,
Positive 88
2nd week, animals remained
exercising with no load and with the
duration incremented by 10 min/day
until a maximum of 90 min of
continuous swimming. From the 4th
week, animals began swimming with a
load until the end of the training
program (8 weeks).11 3 60 min/day 48 male 6-wk-old Zucker
Diabetic Fatty rats,
Positive 89
12 3 60 min/day obese Zucker Diabetic Fatty
rats
Positive 90
Supplementary table 8 Exercise intervention characteristics of included studies in prediabetes
Disease TrainingWeek
s
Day/
week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negativ
e)
Reference
Pre-
diabetes
(18)
Treadmill
exercise
4 5 week 1: 60 min/day, 15 m/min on a 5%
gradient; week 2: 60 min/day, 16 m/min on
a 10% gradient; week 3: 60 min/day, 17
m/min on a 10% gradient; week 4: 60
min/day, 18 m/min on a 10% gradient
18-week-old male Otsuka
Long-Evans Tokushima Fatty
Positive 91
4 5 60 min/day, 32 m/min, 15% grade 8-week-old Sprague-Dawley
(Sprauge-Dawley) rats
Positive 92
4 6 Week 1: 30 min/day, 15 m/min; week 2: 60
min/day, 15 m/min; week 3: 60 min/day,
20 m/min; week 4: 90 min/day, 20 m/min
8-week-old male Sprague-
Dawley rats, diet-induced
obesity and streptozocin (ip.
injection)-induced type 2
diabetes (fasting blood
glucose concentration higher
than 11.1 mmol/l)
Positive 93
6 5 15 min/day, 11 m/min 3-week-old offspring from
Nutrient Restriction or normal
Sprauge-Dawley female
Positive/- 94
8 3 10-30 min/day, 10 cm/s-30% VCO2max 70-day pregnant Wistar
female and their offspring
Positive 95
8 5 60 min/day, 60% VCO2max, Endurance
training
7–8-week-old Healthy male
Wistar
Positive 96
10 5 week 1: 60 min/day, 17 m/min, 2% grade;
week 2: 60 min/day, 24 m/min, 2% grade;
week 3–10: 60 min/day, 27 m/min, 2%
grade
9-week-old Sprauge-Dawley
male, 5-day multiple low dose
streptozocin injection induced
type 1 diabetes with insulin
(blood glucose concentration
>18 mM)
Negative 97
10 5 60 min/day, 27 m/min, 6% grade 8-week-old Sprauge-Dawley
male, multiple streptozocin
injection induced type 1
diabetes with insulin
Positive 98
12 5 30 min (low exercise volume), 60 min (high
exercise volume)
38-week-old Male Wistar-
Kyoto rats
Positive 99
Voluntary
wheel
running
1 7 free to exercise 14-week-old Sprauge-Dawley
male, healthy
Positive 100
1 7 free to exercise 14-week-old Sprauge-Dawley
male, 9-week 35% sucrose
solution prediabetic
Positive 100
4 7 free to exercise 7-week-old Sprauge-Dawley Positive 101
male, CORT-high-fat diet
induced type 2 diabetes6 7 free to exercise 33-day-old Zucker Diabetic
Fatty female, bilateral
ovariectomy
Positive 102
9 7 free to exercise 13-week-old female CD/IGS
Sprauge-Dawley rats
Positive 103
12 5 Weeks 1-7: 4 m/min for 200 m/day
increased to 8.7 m/min for 1200 m/day;
weeks 8–12: 8.7 m/min for 1200 m/day
18-week-old Sprauge-Dawley
male, 12-week diet-induced
obesity
Negative 104
20 7 free to exercise 5-week-old Otsuka Long-
Evans Tokushima Fatty
Positive 105
Swimmin
g
— — 1 or 2 h/day, 2 or 4 × 30 min/session, 5-min
rest between sessions
120–200 g Wistar male Positive 106
— — 4 × 30 min/session 250 g Male Wistar rats Positive 107
Supplementary table 9 Exercise intervention characteristics of included studies in metabolic syndrome
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative
)
References
Metabolic
Syndrome(19)
Treadmill
exercise
1 1 120 min/day, 20 m/min 150–200 g, female / male
Sprauge-Dawley ratsPositive
108
1 2 60 min/day, 10–12.5 m/min,
acute exercise
12-week-old Zucker
Diabetic Fatty (fa/fa) maleNegative
109
5 5 20–60 min/day, 80% of MAV,
Endurance
4-month-old Male Wistar
normalPositive
110
6 5 40–90 min/day, 5–25 m/min, 5–
15% grade
4-week-old male Sprauge-
Dawley rats,Positive
111
6 5 31.5 min/day, 20 m/min 35th generation of Koch
and Britton, low capacity
runner and high capacity
runner rats
Positive
112
8 5 20–60 min/day, 10–20 m/min,
aerobic exercise
6–7-week-old OZR (Obese
Zucker rats) male; LZR
male
Positive
113
8 5 30–120 min/day, 21–31 m/min,
intense EE
4-week-old Sprauge-
Dawley female, diet-
Positive 114
induced obesity8 5 interval aerobic training +
strength-endurance training
adult Zucker Diabetic Fatty
malePositive
115
9 5
days/week
run: moderate intensity (50%–
60% of maximum speed
achieved); walking: constant
speed of 0.3 km/h until the end
of the protocol (training of light
intensity)
20 male rats of Wistar
strain, aged 4 weeks MS
Rats
Positive 116
9 5 90 min/day, 30 m/min, 5% grade 5-week-old Wistar rats Positive 117
9 5
days/week
increased up to 45 min/day male Wistar rats in fructose
fedPositive 118
10 5 60 min/day, 55% VO2max 22-week-old Wistar male,
diet-induced obesityPositive
119
14 5
days/week
25–35 min/day, 35 cm/s32 obese Zucker rats Positive 120
14 5
days/week
25–35 min/day, 35 cm/smale Zucker rats Positive 121
Voluntary
wheel
running
3 7 free to exercise 24-week-old genetically
heterogeneous ratsPositive
122
8 7 free to exercise 4-week-old Sprauge-
Dawley female, 1-week N-
Positive 123
methyl-N-nitrosourea
injectingSwimming 4 5
days/week
60 min/day 32 male Sprague-Dawley
rats (200–220 g) with a 21-
day CUMS procedure
Positive 124
4 7 120 min/day 200 g, Male Wistar rats Positive 125
Swam/
strength
8 5
days/week
60 min/day 32 freshly weaned Wistar
rats (120 days old).Positive 126
Supplementary table 10 Exercise intervention characteristics of included studies in metabolic syndrome, non-alcoholic fatty liver disease
Disease Training WeeksDays /
week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative)
Referenc
e
non-
alcoholic
fatty liver
disease
(3)
Treadmill
exercise
8 5 45–60 min/day, aerobic interval
exercise
5-week-old Obese Zucker
rats male
Positive 127
12 5 60 min/day, 20 m/min, 15% grade,
moderate intensity
8-week-old Otsuka Long-
Evans Tokushima Fatty
male
Positive 128
Voluntary
wheel
running
4 7 24 h/day, free to exercise 8-week-old female Sprauge-
Dawley
Positive 129
Supplementary table 11 Exercise intervention characteristics of included studies in myocardial infarction
Disease Training WeeksDays / Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)References
Myocardial infarction (28)
Treadmill exercise
2 2 60 min/day, 15 m/min 6–8-week-oldmale Wistar rats, myocardial infarction was produced, a 9–0 Ethilon suture was placed under the left main coronary artery at a point 1–2 mm distal to the edge of the left atrium, and the artery was ligated.
Positive 130
2 5
MIT: 60 min/day, 15 m/min, 60% MAS; HIT: 2 time/day, 24-min/time, 30 min recovery. 1st step: 15 m/min, 6-min warm up (50% MAS) , 6 steps : 3 min with increased intensity to reach 30 m/min (corresponding to 65%, 70%, 75%, 80%, 85%, and 90% MAS).
Adult male Wistar rats (2 moth old, 300–350 g), exposed to 21 days of IH (21%–25% fraction of inspired O2, 60-s cycle, 8 h/day)
Positive 131
4 7 Begaining: 8 m/min, 5 min/day. then:from 11 m/min for 5 min, finally 20 min/day, 22 m/min.
Male Wistar rats (9 weeks of age); to create the myocardial infarction model, rats were anesthetized and the ligation point was between the apex and the junction of the left
Positive 132
atrial appendage and pulmonary conus, 2–3 mm under the left atrial appendage.
4 5
days1–3: 10 m/min , gradient 0%, 10-15 min/day, days 4–5 : gradually increased to 20 m/min , 5 10% and 60 min/day , weeks3-4, maximal levels
Male Wistar rats weighing 200–250 g; Anaesthetized rats were intubated with a 51 mm long and 1.7 mm diameter polyethylene tube and connected to a Harvard Rodent Respirator
Positive 133
6 5
45 min/day, 30 m/min, rats (225–250 g) , myocardial infarction by surgical occlusion of the left anterior descended coronary artery
Positive 134
6 560 min/day, 18 m/min and 5% inclination
12-week-old male Dahl salt-sensitive rats
Positive 135
8 260 min/day,1.2 km/h with a slope of 4%
19-week-old male Wistar rats/diabetic rats
- 136
8 5
During the 2nd week, the speed and duration were gradually increased to 16 m/min and 50 min/day (including a 5-min warm-up at 10 m/min), approximately 55% of maximal oxygen uptake (VO2max).
Male Sprague-Dawley rats (8-weeks old, myocardial infarction was induced by ligation of the left anterior descending coronary artery.
Positive 137
8 550 min/day, 16 m/min Seven-week-old male
Sprague-Dawley rats, Positive 138
myocardial infarction was created by ligation of the left anterior descending coronary artery.
8 5
13–24 m/min 3–4-month-old female Sprague-Dawley; for induction of post-myocardial infarction HF, left coronary artery ligation
Positive 139
8 5
15% grade for up to 6 x 60 min-week
Male rats (Sprague-Dawley, weight 250–300 g); for myocardial infarction Induction, rats anesthetized with ketamine 85 mg/kg and xylazine 15 mg/kg. Thoracotomy in the fourth intercostal space was obtained, the heart was suspended on the pericardial cradle, and the LAD artery was ligated for 45 minutes.
Positive 140
8 5
Week 1: from 10 min to 60 min. Week 2–8:60min/day; from 0.3 to 1.2 km/h
Female normotensive Wistar rats (8 weeks of age); ovariectomy was performed under general anesthesia with a mixture of ketamine (50 mg/kg) and xylazine (10 mg/kg) i.p. A bilateral
Positive 141
dorsolateral incision was made through skin, and the underlying muscle was dissected to locate the ovaries and fallopian tubes.
8 5
Week 1: 10 m/min (40%–50% VO2max), 30 min/day , a 5 incline.week2: it alternated between 7 min , 25 m/min (85% 90% VO2max) and 3 min at 15 m/min (50%–60% VO2max), 60min/day
Male Sprague–Dawley rats (8-weeks old), the rats were anesthetized with pentobarbital (30 mg·kg −1), the LAD was ligated approximately 2.0 mm from its origin using a 6.0 silk suture
Positive 142
8 5
70 min/day, 4 min running at 85–90% VO2max and 2 min of active recovery at 50%–60% of VO2max, rest time: 2 min, 25° inclination
230–290 g female Sprauge-Dawley rats, heart failure
Positive 143
8 5
Beginning: 10 m/min, 5 incline, 10 min/session. then: 16 m/min and 50 min / session (including a 5 min warm-up at 10 m/min)
7-week-old male Sprague-Dawley rats; myocardial infarction was made by permanent ligation of the left anterior descending coronary artery
Positive 144
10 5 ET : 60 min/day, 3% body overload
Male Wistar rats (10 weeks old) ;rats were anesthetized, intubated via tracheotomy, and placed under a rodent
Positive 145
respirator apparatus
10 5
Beginning: 10 m/min, 5 inclines for 10 min/session. gradually increased to 17 m/min and 50 min/session
6–8-week-old Wistar male rats (initial body mass of 191 ± 24 g); myocardial infarction was induced by ligation of the left anterior descending coronary artery
Positive 146
10 25 min/day, 10 m/min; 15% grade
young adult (4–6 months old) Charles River rats;
Positive 147
12 5
10-50 min/day, 10 m/min 8-week-old male Wistar rats, infarction induced by injection of 80 mg/kg/day isoproterenol hydrochloride.
Positive 148
28 3
30 min, 4 intervals for 4 min corresponding to 90% VO2
peak, with 3 min of active rest at 60% VO2 peak separating intervals, 25° inclination
7-week-old female Dahl salt-sensitive rat model
Positive 149
36 530 min/day, 20 m/min; slope of 10°
severe aortic valve regurgitation model
Positive 150
Resistance training
4 5 Week 1: the load from 0% to 75% body weight (BW), 20 climbs/session , 3 session/day, with 2 min rest between each session. Week 2: 75% BW, and then an additional 15% BW was added to rats until they failed to climb the ladder completely. 20
3- months-old sprague Dawley rats; myocardial infarction model was established by ligating the left anterior descending coronary artery of the heart.
Positive 151
climbs /session ,3 sessions/day with 2 min rest between each session.
8 5
Aerobic exercise training: from 0.3 to 1.5 km/h .Resistance exercise training: with 15–20 climbing /session, with a 1-min res , 40%–60% of the normalizedmaximum load test
Adult male Wistar rats (250–300 g); rats were underwent surgical occlusion of the left coronary artery, which resulted in myocardial infarction
Positive 152
Swimming
7 6
90 min/day Male Sprague-Dawley rats, myocardial infarction was induced by permanent ligation of the left anterior descending coronary artery
Positive 153
7 6
90 min/day Male Sprague-Dawley, the pericardium was opened and the left coronary artery was distally ligated at 2 mm of its origin.
Positive 154
8 5
60 min/day Female Wistar rats ( weighing 170–190 g), myocardial infarction was induced by left coronary artery ligation.
Positive 155
8 51st session: 15 min, the next sessions: increased by 15 min
Female Wistar rats weighing 250–290 g; Rats had their
Positive 156
each, on the 4th day: reaching 60 min until the end of training.
left anterior descending coronary artery anesthetized (intramuscular xylazine, 10 mg/kg, and ketamine, 90 mg/kg), ventilated with Harvard 683 respirator (Harvard Apparatus, Holliston, Massachusetts, USA), 2.5 ml, 75–78 strikes/min and permanently ligated with a 5.0 silk thread.
10 5
mild-intensity long-period training (60 min/day, with 3% body overload)
Male Wistar rats (10 weeks old), myocardial infarction was induced by the artery ligation.
Positive 157
Supplementary table 12 Exercise intervention characteristics of included studies in stroke
Disease
Training Weeks
Days /
Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)References
Stroke (28)
Treadmill exercise
5/6 days
— 30 min/day; (0 m/min); mild (6 m/min); moderate (10 m/min); or heavy exercise (15–18 m/min) :
Adult (3-month old), male Sprague-Dawley rats, focal cerebral ischemia was achieved with intraluminal suture blockage of the middle cerebral artery for 90 minutes. Global cerebral ischemia was induced with 8-minute asphyxia cardiac arrest.
Positive 158
1 7 30 min/day, 1st day: 9 m/min; subsequent days:11 m/min
Male Wistar rats (180–220 g, after intraperitoneal injection ofsodium pentobarbital (45 mg/kg), a small hole was drilled 3.0 mm lateral to the midline and .5 mm anterior to the bregma, and 1.2 mL saline containing .24 U of bacterial collagenase
Positive 159
1/2/3 5 30 min/day;10–20 m/min; not inclined
Male Sprague Dawley rats (3–4 months old); rat cerebral ischemia reperfusion injury was performed according to the Longa method of MCAO.
Positive 160
12 days
7 30 min/day ; day1: 10 m/min ; day2: 15 m/min ; On the third and subsequent days:20 m/min;
adult Sprague-Dawley rats (275 –325 g); Initially, 3% isoflurane within 30% O2 and 70% N2O was used for induction.
Positive 161
0 ° Isoflurane (1.5%) was used for maintenance
2 5 30 min/day, 20 m/min 250-280 g, Male Sprague-Dawley (Sprauge-Dawley) rats, Middle Cerebral Artery Occlusion model
Positive 162
2 — 30 min/day,10,15,20 m/min Adult 275–325 g, Male Sprauge-Dawley rats, MCAO
Positive 163
2 5 30 min/day,12 m/min Adult 250-350 g, Male Wister rats, Middle Cerebral Artery Occlusion-Reperfusion
Positive 164
2 7 30 min /day ; the first day, 4 m/min; the second day: 8 m/min, then 12 m/min for the remaining days
Adult male Sprague-Dawley rats (weighed 220–250 g); a middle cerebral artery occlusion was established with the modified Longa method.
Positive 165
2 7 Day1–2: gradually increased from 5 m/min to 12 m/min ; third day and persisted to 14th day,
Adult male Sprague-Dawley rats (250–270 g), rats were anesthetized with 10% chloral hydrate, the left middle cerebral artery was occluded by the intraluminal suture technique.
Positive 166
3 7 20 min/day; day1: 6 m/min; gradually increased to 15 m/min until maximum speed
Male Sprague-Dawley rats, 11 wks of age; transient middle cerebral artery occlusion leading to focal cerebral infarction was achieved under anesthesia with sodium pentobarbital.
Positive 167
3 5 30 min/day; 30 m/min. Sprague-Dawley rats (3-month-old), middle cerebral artery occlusion was induced using an intraluminal filament
Positive 168
model.3 5 30 min/day ; 30 m/min; 900
m/day
Adult male Sprague-Dawley rats (260–300 g); A 2 hour middle cerebral artery occlusion was induced with an intraluminal filament model, which was followed by 24 hours of reperfusion.
Positive 169
3 5 30 min / day,30 m/min; Sprague-Dawley rats (3 months old); stroke was induced by transient middle cerebral artery occlusion.
Positive 170
3 5 30 min/ day,30 m/min; Adult male Sprague-Dawley rats; middle cerebral artery occlusion was induced with an intraluminal filament model
Positive 171
3 5 30 min /day, 30 m/min Adult male Sprague–Dawley rats (260–300 g); stroke was induced by a 2-h middle cerebral artery occlusion using an intraluminal filament.
Positive 172
3 5 10 min/ day; 5–25 m/min Male Sprague-Dawley rats (291.3 ± 38.0 g), middle cerebral artery occlusion model.
Positive 173
3 6 30 min/day, 6–20 m/min Male Sprauge-Dawley rats, 200–220 g, Middle Cerebral Artery Occlusion model
Positive 174
3 6 20 min/day,10 m/min, on a 0 incline
Male Sprague-Dawley rats, aged 8–10 weeks, stroke was induced by a 60-minleft MCAO using an intraluminal filament.
Positive 175
4 6 30 min/day, 25 m/min 250–300 g, Male Sprauge-Dawley rats, Middle Cerebral Artery Occlusion model
Positive 176
4 — 30 min/day, 10%–30% of maximum enduration
Transient ischemic Middle Cerebral Artery Occlusion model
Positive 177
4 5 35–45 min/day, 18m/min Male Wistar rats (260–300 g), surgical dissection was performed to expose the common carotid arteries and then the vagus nerve was carefully separated from these arteries. Common carotid arteries were occluded for approximately 20 minutes using Yashargil Aneurism microclips.
Positive 178
4 — 30 min/day, 4,8,12m/min Adult 250–280 g, Male Sprauge-Dawley rats, Middle Cerebral Artery Occlusion model
Positive 179
4 5 30 min/day, 20 m/min, 0 slope Male Sprague-Dawley rats (250–270 g); with 3% sodium pentobarbital (2 ml/kg), a filament was gently inserted into the internal carotid artery (ICA) to block the middle cerebral artery (MCA).
Positive 180
8 7 30 min/day, 1st 5 min, 2 m/min , following 5 min, 3 m/min, last 20 min, 5 m/min; at 0 ° of inclination.
Male Wistar rats weight 80 ± 10 g, 3-weeks old; BCCAO was performed to induce chronic cerebral hypoperfusion
Positive 181
— 5 30 min/ day; 2–20 m/min and, at a 0◦ slope.
Male Sprague-Dawley rats weighing 240-280 g; intracerebral hemorrhage was induced by intrastriatal administration of bacterial collagenase.
positive 182
voluntary running
4 days — 12 h/day; 3 to 30 rpm over 5 min
Male Sprague-Dawley rats, 11 weeks of age, photo thrombosis leading to focal
Positive 183
wheel cerebral infarction.4 7 Free to exercise Male Wistar rats (280–320 g), chronic
cerebral hypoperfusion established by bilateral carotid artery occlusion.
Positive 184
swimming 4 5 5 min/ day in group B, 10 min/ day in group C, and 20 min /day in group D.
10 weeks old male Sprague-Dawley rats, photothrombotic cerebral infarction rat model
Positive 185
Supplementary table 13 Exercise intervention characteristics of included studies in cardiac hypertrophy
Disease Training WeeksDays / Week
Intensity[Time/Day, Speed,
Slope]Rat model
Effect(Positive/Negative)
References
Cardiac hypertrophy (4)
Treadmill exercise
4 5 1st 5 days, 40 min/day 0% grade, at 15 m/min, the duration and intensity increased daily until the animals were trained for 60 min at 18 m/min, 0% grade.
Male Spraguee Dawley rats (ages 10 wks; rats from the EP þ TAC and TAC groups were anesthetized with barbital sodium administered intraperitoneally at 200 mg/kg body weight and completed by tying a 3-0 silk suture over an 8 gauge needle to produce pressure overload-induced pathological cardiac hypertrophy
Positive 186
4 5 EP group: 60% of VO2
1st 5 days: 0% grade, 40 min/day, 15 m/min, next days: 60 min/day 18 m/min, 0% grade.
Male 10-wk-old Sprague-Dawley rats, 8 gauge needle to produce pressure overload-induced pathological cardiac hypertrophy.
Positive 187
Swimming 8 5 90 min/day 4-month-old male spontaneously hypertensive
Positive 188
rats and Wistar rats10 5 60 min, 5% of their body
weight12–22 weeks old male spontaneously hypertensive rats
Positive 189
Supplementary table 14Exercise intervention characteristics of included studies in myocardial injury
Disease TrainingWeek
s
Days /
Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Myocardial injury (5)
Treadmill exercise
1 3 60 min/day, 30 m/min, 0% grade 16-week-old male Sprauge-Dawley rats/Injection 5-hydroxydecanoate group or HMR1098
Positive 190
9 5 55 min/day, 20 m/min or 24 m/min , 0% grade
16-week-old obese Zucker rats or lean Zucker rats
Positive 191
10 5 60 min, 24 m/min, 0° inclination 16-week-old female Sprauge-Dawley rats/bilateral ovariectomized model
Positive 192
13 6 60 min/day, 1st 30 min, 18 m/min, remaining 30 min, 22 m/min
Male Wistar rats weighing 150–180 g, beta-adrenergic hyperactivity-induced cardiac hypertrophy and structural injury.
Positive 193
Voluntary wheel exercise
6 7 free to exercise Male Wistar rats (weighing 200–230 g), ischemia/reperfusion induced injury
Positive 194
Supplementary table 15 Exercise intervention characteristic of included studies in atherosclerosis
Disease Training Weeks
Days /
Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Atherosclerosis (2)
Swimming 8 5 60 min/ day Male Sprague-Dawley rats (2 month old); aging was induced by D-gal and atherosclerosis was induced by high-fat diet (60% fat) for 9 weeks.
Positive 195
8 5 30 min or 60 min/day 180–200 g male Sprauge-Dawley rats/early Atherosclerosis model
Positive 196
Supplementary table 16 Exercise intervention characteristics of included studies in hypertension
Disease Training WeeksDays
/ Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)
References
Hypertension (78)
Treadmill exercise one single bout
— 30 m/min until exhaustion (high-intensity exercise)
16-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 197
0, 1, 2, 4, 8 and 12 weeks.
5 60 min/day, 50%–60% of maximal exercise capacity
3-month old male spontaneously hypertensive rats
Positive 198
1 daily 30 min/day , 18 m/min 13-week-old spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 199
4/2 5 60 min/day, with a running speed of 30 m/min, no grade,
4-week-old male Wistar rats pulmonary arterial hypertension induced by monocrotaline (MCT, 60 mg/kg)
Positive 200
4 5 30 min/day, at an average (±5%) of the anaerobic threshold, at 90% of the AT.
6-week-old and 40-week-old male spontaneous hypertensive rats
Positive 201
4 5 20 m/min and 0 elevation, for 40 min/day
Male spontaneously hypertensive rats (200–250 g)
Negative 202
4 5 moderate [corresponded to a speed of 20–22 m/min, equivalent to approximately
3-month-old male rats spontaneously hypertensive rats and Wistar-Kyoto rats,
Positive 203
60% of VO2max, each training session began with 5 min of heating at 12–15 m/min, and the duration of each session was 30 min (20–22 m/min)]
weighted 260–310 g
4 7 30 min/day, 10 m/min, 20 angle
12–14 -week-old male stroke-prone spontaneously hypertensive/Izm rats and Wistar-Kyoto rats
Positive 204
4 5 weeks1–2:1 min/day ;13.3 m/min; a slope of 0; After these 2 weeks: 30 min/day, 13.3 m/min ,with no slope; 50% VO2max
Male Wistar rats ; weight, 150–175 g; injected accordingly with monocrotaline or saline
positive 205
5 — 60% VO2 max Male Wistar rats (100 ± 20 g) with Pulmonary arterial hypertension induced by monocrotaline, injection of monocrotaline (60 mg/kg i.p.) for 3 weeks
Negative 206
5 5 Started with 15 min at 0.6 km/h and finished with a session of 60 min at 0.9 km/h
male Wistar rats (315 ± 34 g at the end of experimental procedures)At the end of the 2 week of training, the monocrotaline groups (SM and TM) received a single injection of
Positive 207
monocrotaline (60 mg/kg i.p.)6 5 45 min/day ,21 m/min, 4.5%
gradeMale Wistar Kyoto and spontaneously hypertensive rats
positive 208
6 5 60 min/day,18 m/min, 0 inclination, (moderate intensity exercise)
male Sprague-Dawley rats (250–350 g) Angiotensin II (AngII)-induced hypertensive rat model
Positive 209
8 7 60 min/day, 60% VO2max, 0% grade
250–300 g male Wistar rats/dexamethasone-induced hypertension model
Positive 210
8 5 60 min/day, 0.8 km/h 12–13 week-old male spontaneously hypertensive rats
Positive 211
8 5 60 min/day, 5 m/min 16-week-old spontaneously hypertensive rats and normotensive Wistar rats
Positive 212
8 5 60 min/day, 0.3 km/h Female normotensive Wistar rats
Positive 213
8 5 60 min/day, 18–20 m/min 12-week-old male normotensive Wistar Kyoto rats
Positive 214
8 5 60 min/day, 50%–60% of maximal exercise capacity, 0% inclination
11–12-week-old male spontaneously hypertensive rats and Wistar Kyoto rats
Positive 215
8 5 60 min/day; 20 m/min;0° slope
male spontaneouslyhypertensive rats (SHRs);(aged
positive 216
12 weeks)8 5 60 min/day, 0% grade, 50-
60% of maximal exercise capacity (low-intensity endurance training)
4-month old male spontaneously hypertensive ratss and Wistar-Kyoto rats
Positive 217
8 5 Low intensity exercise: 30 min/day, 16 m/min, 20% under maximal lactate steady state; high intensity exercise: 24 m/min, 15% above
21-week-old hypertensive rats (SHR)
Positive 218
8 5 Week 1, 15 min/day, 10 m/min, 0% grade. Week 2, treadmill speed and exercise duration were progressively increased to 14 m/min for 30 min/day. Week 3, 60 min/day, 16 m/min, 0% grade, then was maintained until week 8.
4-month-old male spontaneously hypertensive rats
Positive 219
8 5 Week 1: 15 min/day, 12 m/min, 0% grade. Week 2, treadmill speed and exercise duration were progressively increased to 14 m/min for 30 min/day. Week 3–8, 60 min/day, 16 m/min, 0%
4-month-old male spontaneously hypertensive rats and Wistar rats
Positive 220
grade.8 5 Low-intensity aerobic
training: 60 min/day, 14 m/min, at 0 slope~40%–49 % of maximal aerobic velocity; moderate-intensity aerobic training: 20 m/min, ~55–65 % of maximal aerobic velocity
3-month-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 221
8 6 60 min/day, 20 m/min, corresponded to approximately 50%–60% of the peak VO2.
5-week-old male (110–130 g) spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 222
8 5 60 min/day, 50%–60% of maximal exercise capacity, 0% grade.
12-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 223
8 5 60 min/day, 0% grade, at 50–60% of maximal running speed
4-month-old male spontaneously hypertensive rats and Wistar rats
Positive 224
8 5 60 min/day, 18–20 m/min, 0% grade, about 55%–65% of maximal aerobic velocity
13-month-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 225
10 5 60 min/day, 50%–70% of maximal exercise test
Acute myocardial infarction by ligation of the left coronary artery in 3-month-old male spontaneously hypertensive rats.
Positive 226
12 5 60 min/day, gradually 3-month-old males Positive 227
progressing towards 55–65% (15–20 m/min) of maximal running speed
spontaneously hypertensive rats and Wistar Kyoto rats
12 5 60 min/day, 15–20 m/min, 50–60% of maximal exercise capacity
8-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 228
12 5 60 min/day, gradually progressing running speed 15–20 m/ min, 55%–65% of maximal running speed
13-month-old male spontaneously hypertensive rats
Positive 229
12 5 60 min/day, 15-20 m/min, training intensity was based on 50%–60% of each animal's maximal running speed
8-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats Positive 230
12 5 60 min/day, 20 m/min 6 week-old Male Wistar rats Positive 231
12 5 60 min/day, 27 m/min 6-week-old male Wistar-Kyoto rats
Positive 232
12 — Exercise training on treadmill was performed as indicated in the published protocol
Male 22-week-old spontaneously hypertensive rats and age-matched normotensive Wistar-Kyoto rats
Positive 233
13 5 60 min/day, 55 % of maximal speed
8–21 weeks male spontaneously hypertensive rats and Wistar rats
Positive 234
16 5 30 min/day, 5–12 m/min male spontaneously hypertensive rats and
Positive 235
normotensive Wistar-Kyoto rats; 16-month-old
16 5 60 min/day,18 m/min, 0° inclination
7-week-old male spontaneously hypertensive rats and Wistar Kyoto rats
Positive 236
Voluntary running wheel
2 days / Free to exercise Male Wistar rats (200 g); animals received either a single intraperitoneal injection of 60 mg/kg monocrotaline to induce RV failure
Positive 237
6 7 Free to exercise 3-week-old female Sprauge-Dawley rats /Reduced Uterine Perfusion Pressure model
Positive 238
10 7 Free to exercise 14-week-old male spontaneously hypertensive rats, 15-week-old spontaneously hypertensive rats, weighted 318 ± 8 g
Positive 239
13 7 Free to exercise Male Wistar-Kyoto rats and spontaneously hypertensive rats ( 21 days of age )
Positive 240
85–95 days
7 Free to exercise Age-matched (14–29 wk) male Wistar Kyoto and SHR
Positive 241
Resistance training
a signle — Rats were wearing a canvas jacket able to regulate the twisting and flexion of their torsos and were fixed by a holder in a standing position
Male spontaneously hypertensive rats that weighed 250–300 g Positive 242
on their hindlimbs. An electrical stimulation (20 V for 0.3-s duration and at 3-s intervals) was applied to the rat's tail through a surface electrode.
one single — 10 sessions of 10 repetitions, with 60-s rest intervals, and intensity of 40% of the load established by using the RM test.
Wistar rats (250–300 g) received orally Nω-nitro-L-arginine methyl ester hydrochloride (20 mg/kg, daily) for 7 days
Positive 243
acute — 50% of 1 RM; 20 sets, 15 repetitions/set, 2-s intervals, 1-min rest /set
male spontaneously hypertensive rats, weighing 250–300 g.
Positive 244
4 3 50% of 1RM, 3 sets of 10 repetitions
Male Wistar rats (200–250 g) were given Nω-nitro-L-arginine methyl ester hydrochloride in their drinking water at a concentration of 0.4 mg/ml for a total daily intake of 40 mg/kg 13 for 4 weeks
Positive 245
8 5 1st–2nd week: 30%-40% of maximal load; 3rd–5th week: 40%–50% of maximal load; 6th–8th week: 40%–60% of maximal load;15 climbs per session with a 1-min time interval between
Female Wistar rats and spontaneously hypertensive (SHR; 3 months) female rats;the animals were anesthetized with ketamine and xylazine and ovariectomy was
Positive 246
climbs. performed.12 3 6–8 climbing sets of 10–12
repetitions, 1 pause between sets, with a mean duration of each training session of ~10–12 min.
17-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats Positive 247
Swimming 20 days/13 days
6 Exercise on the 1st day under these conditions lasted about 20 min, with progressive increases of 10 min/day until the duration reached 60 min.
9-week+15 days-old pregnant female spontaneously hypertensive rats
Positive for lower pressure
Negative for embryo
248
2, 4, 6, 8 or 10 weeks
5 60 min/day Male Fischer rats (10 weeks of age; 150–180 g), Renovascular hypertension was induced by placed around the left renal artery through a midline incision
Positive 249
4 5 60 min/day Male Fischer rats (weighing 160–190 g) were anesthetized and a silver clip was placed around the left renal artery through a midline incision.
Positive 250
5 5 1 h/day, from the 6th to the 8th session of swimming, the load used was 2% of body weight. From the 9th
Renovascular hypertensive (2-kidney 1-clip) male Fisher rats
Positive 251
session on, the load used was 3% of the animal’s body weight
6 560 min/day, gradually increased up to 5% of the animal’s body weight
Adult male Wistar rats (70–90 days; 220–300 g); Hypertension was induced by the oral administration of Nω-nitro-L-arginine methyl ester hydrochloride, a nitric oxide synthase inhibitor.
Positive 252
6 5 Day1: 10 min, day 2: 15 min, Day 3–4: 30 min, subsequent days: 1 h. After the 1st week: 2% of the body weight
Adult male spontaneously hypertensive rats and normotensive Wistar Kyoto rats (250–300 g, 14–16 wk old)
Positive 253
6 5 60 min/day 6-week-old male Wistar albino rats
Positive 254
6 5 60 min/day 4-month old male spontaneously hypertensive rats and Wistar rats
Positive 255
6 5 The duration of the sessions gradually increased: 1st day: 10 min, 2nd day: 15 min, 3rd and 4th day: 30 min, subsequent days: 1 h). After the 1st week, exercise intensity was increased by placement of a small extra
Adult male spontaneously hypertensive rats and Wistar rats (250–300 g, 14–16 weeks old)
Positive 256
load (2% of the body weight) around the chest of the rat during swimming.
6 5 60 min/day Fischer rats with renovascular hypertension 2-kidney 1-clip (2K1C)
Positive 257
6 5 60 min/day, the workload (weight on the back) was gradually increased to up to 5% of the animal’s body weight
Adult male Wistar rats (aged 70–90 days) hypertension was induced by the oral administration of NO synthase inhibitor (Nω-nitro-L-arginine methyl ester hydrochloride), (30 mg/kg/day) for 1 week
Positive 258
6 5 After the 1st week, exercise intensity was increased by placement of a small weight (2% of the body weight) around the chest of the rat during swimming, 1h/day
14–16-week-old male spontaneously hypertensive rats
Positive 259
6 6 60 min/day 3-week-old Male spontaneously hypertensive rats
Positive 260
8 5 Swimming time was increased daily until reaching 60 min at the end of the 5th day, From the second week, the exercise duration was kept constant
3-month-old female ovariectomized spontaneously hypertensive rats
Positive 261
(60 min/day)8 5 interval that was increased
by 10 min each day until 60 min was reached on the 5th day. Beginning during the 2nd week, the duration of exercise remained constant (60 min/day, 5 days/week)
8-week-old female ovariectomized Spontaneously Hypertensive Rats (110–150 g)
Positive 262
8 5 60 min/day 11–12-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 263
9 5 20-min adaptation period on the 1st day, with increases of 10 min/day until reaching 1 h on the 5th day, toward a 2-h session during 9 weeks
male spontaneously hypertensive rats and Wistar Kyoto rats aged 45–50 weeks Positive 264
9 5 60 min/day 6 weeks of age Male inbred Dahl salt-sensitive rats fed an 8% NaCl diet after
Positive 265
9 5 A progressive training time every week of 10 min in the 1st week and 120 min in the last week
245±2-day-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Negative 266
9 5 120 min/day (low-intensity ) 48-50-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 267
9 6 60 min/day 6-week-old male spontaneously hypertensive rats and Wistar-
Positive 268
Kyoto rats, weighed 170–200 g10 5 60 min/day with 4% caudal
body weight workload12-week-old malee spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 269
10 5 60 min/day 5-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Negative 270
10 5 60 min/day 8-week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 271
10 5 60 min/day, 10 min on the first day and increased by 10 min/ day, until 60 min was reached
8 week-old male spontaneously hypertensive rats and Wistar-Kyoto rats
Positive 272
12 5 60 min/day, swimming duration was progressively increased to 60 min/day in 1 week.
4-week-old and 16-week-old SHR and Wistar-Kyoto rats
Positive 273
Swimming trainingtreadmill exercise
8 5 Swimming: 60 min/day, from the 2nd week onwards, and the rats were worn caudal dumbbells that weighed 2% of their body weight. The caudal weight was gradually increased until it was 5%; running: week 1–5, 60
14-week-old male spontaneously hypertensive rats
Positive 274
min/day, 15 m/min, week 6–8, 60 min/day, 24 m/min
Supplementary table 17 Exercise intervention characteristics of included studies in Heart failure
Disease TrainingWeek
sDays / Week
Intensity[Time/Day, Speed, Slope]
Rat modelEffect
(Positive/Negative)Reference
sHeart failure(26)
Treadmill exercise
3 — The speed, duration, and grade were gradually increased to 20–25 m/min, 60 min/day, and 5–10%, respectively.
Male Sprague-Dawley rats weighing 220–250 g, heart failure was induced by ligation of the left coronary artery
Positive 275
3 5 60 min/day, 20–23 m/min, at a 5% grade Male Sprague-Dawley rats weighing 120–150 g (5–6 weeks old), myocardial infarction was induced by ligation of the left coronary artery
Positive 276
4 5 60 min/day, 25 m/min, corresponded to 60–80% of peak VO2. (Treadmill speed was increased gradually over a period of 1 week to 25 m/min and the duration of exercise was increased to 60 min/day.)
Male Sprague-Dawley rats (8 weeks old), rats underwent left coronary artery ligation to induce myocardial infarction.
Positive 277
5 540 min/day, 16 m/min 18-week-old male
Wistar rats, Positive 278
myocardial infarction model
6 5 60 min/day, training intensity ranged from 50% (in the beginning of the 1st week) to 60% (at the end of the 3rd week) of the average maximal speed.
8‐week‐old male Wistar rats, for the Heart failure induction, left thoracotomy was performed and the anterior descendent coronary artery was ligated.
Positive 279
6–8 7 60 min/day, 20–25 m/min, 5–10% grade Male Sprague-Dawley rats weighing 220–280 g, Induction of heart failure
Positive 280
8 3/5 HIIT: 4 intervals at 90% peak oxygen uptake (V˙O2peak) for 4 min, with 3 min recovery at 60% VO2peak); monocrotaline : 60min/day, at 60% V˙O2peak, at a gradient of 25°
Heart failure with preserved ejection fraction model; Obese diabetic Zucker fatty/spontaneously hypertensive heart failure F1 hybrid rats were used as a model for heart failure with preserved ejection fraction, which occurs by 20 weeks
Positive 281
of age.8 4
MAT: 30 min, VO2max 60%; HIT: 33 min, 90% VO2 max 4-minfollowed by a 4-min 50% VO2max speed. 4 repetitions
275–325 g male Sprauge-Dawley rats, congestive heart failure model
Positive 282
8 5 60 min/day, at 60% of maximal speed Male Wistar rats weighting 200–300 g, followed by left thoracotomy, and the left anterior descending coronary artery was occluded with 6/0 thread.
Positive 283
8 3 The continuous training trained at 70% of Velmax; The moderate interval training was performed 30 min/day, rats ran during 5 min at 80% Velmax, followed by 5 min intervals at 60% Velmax, which was repeated 3 times; intense interval training, rats ran 30 min/day, 1 min at 90% Velmax, 1 min at 50% Velmax, 15 times
Male Wistar rats (12 weeks), to induce coronary artery occlusion, the rats were anesthetized and the left anterior descending coronary artery was occluded with a 6–0 thread.
Positive 284
8 5 Week 1: 10 min/day, 5 m/min; week 2: 14 min/day, 7.5 m/min; week 3: 18 min/day, 10 m/min; week 4: 22 min/day, 10 m/min; week 5: 26 min/day, 10 m/min; week 6: 30 min/day, 10 m/min.
Male Wistar rats weighing 90–100 g, and aortic stenosis was induced by placing a 0.6 mm stainless-steel clip on
Positive 285
the ascending aorta via a thoracic incision
8 5 Aerobic continuous training: 50 min/day, 15 m/min (60% of maximal speed) ; aerobic interval training: 40 min/day, 8 min of warm-up at 10 m/min and exercise at 15 m/min 4 × 4 min interspersed with 4 × 4 min at 23 m/min (92% of maximal speed).
Male Wistar rats weighing 250–270 g, myocardial infarction was induced by exposed and artery coronary ligation.
Positive 286
8–12 5 60 min/day, 20 m/min, on a 5% incline 5–6 weeks male Sprague-Dawley rats, coronary artery ligation surgery to induce myocardial infarction
Positive 287
8 5 70 min/day, 10 min of warm-up at 40%–50% of VO2max and 60 min of interval running. Each interval consisted of 4 min of high-intensity running (12.5 m/min at first week of training at approximately 85%-90% of VO2max) and 2 min of active recovery (6 m/min at first week of training at approximately 50%-60% of VO2max).
Adult female Sprague-Dawley rats weighing 230–290 g, myocardial infarction was induced by permanent occlusion of the left coronary artery with nonabsorbable 8–0 suture.
Positive 288
8 5 The speed and duration were gradually increased to 16 m/min and 60 min per session, corresponding to an intensity of
Male Wistar rats weighing 220–270 g, coronary artery
Positive 289
55% VO2max ligation was performed to induce myocardial infarction.
8 5 60 min/day, at moderate intensity (50%–60% of the average maximum speed
Male Wistar rats (230–280 g) were subjected to myocardial infarction by permanent occlusion of the left coronary artery
Positive 290
8 5 60 min/day, 16 m/min Male Wistar rats weighing 220–270 g, coronary artery ligation was performed to induce myocardial infarction.
Positive 291
8 5 Week 1: 20 min/day, 16 m/min; Week 2: 30 min/day, 16m/min; Week 3: 40 min/day, 16 m/min; Week 4: 50 min/day, 16m/min; Week 5-8: 60 min/day, 16 m/min, corresponding to 55% VO2max
Male Wistar rats weighing 230–280 g, myocardial infarction was induced via left anterior descending coronary artery ligation.
Positive 292
8 5 60 min/day, at 60% of peak VO2 (At the end of the 4th week, training rats underwent another exercise test to adjust
Two-month-old, male Wistar rats, underwent left
Positive 293
the intensity of exercise training. ) coronary artery ligation to induce myocardial infarction
8 5 60 min/day, 4 min at 85%-90% of VO2max and 2 min at 50% of VO2max (VO2max was determined every 2nd week to account for the improved training status, then the workload was adjusted to keep high intensity intervals at 85%–90% of VO2max) (Uphill running, 25°)
Female Sprague Dawley rats, myocardial infarction was induced by ligation of the left coronary artery.
Positive 294
10 5 5 min/day, 5 m/min (1st week); 10, 12, and 14 min/day, 6 m/min (2nd–4th week); 16, 18, and 20 min/day, 12 m/min (5–7 week); 20, 22, and 22 min/day, 15 m/min (8–10 week).
Male Wistar rats weighing 90–100 g, aortic stenosis surgery
Positive 295
10 5 50 min/day, 60% VO2max Male Wistar rats (6–8 week old), myocardial infarction was induced by permanent ligation of the left anterior descending coronary artery
Positive 296
25 3 45 min/day, 14.5 m/min, 10% grade 16-month-old female rats
Positive 297
Swiming 8 5
60 min/day
17-week-old male Wistar rats, myocardial infarction model
Positive 298
Respiratory muscle training
6 5 Week 1, the animals were conditioned to breathe through the orifice at the inspiratory port attached to a rigid mask while restrained in a whole-body cylinder. The inspiratory port was set at an internal diameter of 0.8 mm and was progressively decreased, reaching after 2 week of training a final internal diameter of 0.3 mm (maximal resistance)
Male Wistar rats (250–290 g), ligation of the left coronary artery to induce myocardial infarction.
Positive 299
Resistance training
8 3 Resistance training: a neoprene vest attached to apparatus was used by animals to remain in the standard position on their lower limbs. An electric stimulus (4–5 mA, 1-s duration, with an interval between each repetition) was applied to the rats’ tails. Continuous aerobic training: 50 min/day; at 10 m/min, which was progressively increased up to 15 m/min (0%
90 days of age Male Wistar rats , the ligature of coronary artery was performed to induce acute myocardial infarction
Positive 300
inclination).
Supplementary table 18 Exercise intervention characteristics of included studies in Parkinson's disease
Disease Training Weeks Days / Week
Intensity
[Time/Day, Speed,
Slope]
Rat model Effect
(Positive/Negative
)
References
Parkinson's
disease (12)
Treadmill
exercise
2 7 30 min/day, 2,5,8
m/min
Adult female Sprague-Dawley
rats;6-hydroxydopamine-
induced Parkinson’s disease
Positive 301
2 7 30 min/day, 20
cm/s
Male Wistar rats (200–250 g); 6-
OHDA-lesioned Parkinson’s
disease
Positive 302
16d — 30 min/day,
twice/day, 10
m/min, at a grade of
10
Male Sprague-Dawley rats, 8
weeks; 6-OHDA Lesioned
Parkinson’s diseasePositive 303
4 7 30 min/day, 2,3,5
m/min, no
inclination
Sprague-Dawley male rats, 4
weeks; Rotenone induced
Parkinson’s disease
Positive 304
4 — 30 min/d, 11 m/min Male Sprague−Dawley rats, 8
weeks; 6-OHDA-Induced
Parkinson’s disease
Positive 305
4 5 30 min/d, 11 m/min Adult female Sprague-Dawley Positive 306
rats; 6-OHDA induced
Parkinson’s disease
4 5 1st day: 20 min; Male 90-day-old Wistar rats; 6-
OHDA-induced Parkinson’s
diseasePositive
307
5th day: 50 min;
next 3 weeks: 60
min
4 5 30 min/day, 11
m/min
Male adult Sprague-Dawley
rats;6-OHDA lesioned
hemiparkinsonism
Positive 308
8 4 50 min/session, 13–
17 m/min, no
inclination, 48-h
interval/session
Male Wistar rats, 2-month-old;
6-OHDA induced Parkinson’s
diseasePositive 309
— 3 40 min/day, 10
m/min, 400 m/d
Male Wistar rats, 6-OHDA-
induced Parkinson’s diseasePositive 310
— 30 40 min/day; 10
m/min
3-months-old; hannover-wistar;
Parkinson’s disease ratPositive
311
Voluntar
y wheel
wheels
4 5 20 min/day Sprauge-Dawley, 3-month old
rats; Parkinson’s disease Positive 312
Supplementary table 19 Exercise intervention characteristics of included studies in Alzheimer's disease
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed,
Slope]
Rat modelEffect
(Positive/Negative)References
Alzheimer's
(10)Treadmillexercise
4 5 30 min/day; 10 min/m 176–200 g, male Wistar
rats weighing,
Alzheimer's disease
Positive
313
4 5 1st 2 weeks: 2×15 min 7-week-old, male Wistar
rats, Alzheimer’s diseasePositive
314
3rd weeks: 3×15 min4th weeks: 4×15 min1st 2 weeks: 10 m/min;Last 2 weeks: 15 m/min
4 7 30 min/day; 176–200 g, Wistar male
rats, Alzheimer’s disease Positive
315
1st 2 weeks: 10 m/min;
Last 2 weeks: 15 m/min4 7 1st week: 30 min/day 176–200 g, male Wistar
rats weighing,
Alzheimer's disease Positive
316
2nd week: 45 min/day3rd week: 60 min/day1st 2 weeks: 10 m/min;Last 2 weeks: 15 m/min
4 5 30 min/day; 250–280 g, Male Positive 317
Sprauge-Dawley rats,
Alzheimer's disease
8 m/min for 5 min, and
then 14 m/min for 5
min, and finally to 18
m/min for 20 min4 5 30 min/day; 3,5,8
m/min, 0% grade of
inclination
Male Sprague-Dawley
rats 7 weeks; amyloid
beta-induced
Alzheimer’s disease
Positive 318
4 5 1st 2 weeks: 2
sessions,10 m/min;
Adult male Wistar
rats;Aβ1-42-produced
Alzheimer’s disease Positive
319
3rd and 4th weeks:3 and
4 sessions respectively,
15 m/minClimbing
ladder,Swimming
6 3 Climbing ladder:
50%,75%,100% of the
body weight, 120-s
intervals; 80° incline;
Swim:1 h/day
Female Wistar rats, 6–7
months; d-galactose
induced Alzheimer's
Disease-like model
Positive 320
Swimming — — 15 min/day Wistar Rats, Alzheimer's
diseasePositive
321
4 7 from 10 min to 1 h/day 2.5-months-old, male
Sprauge-Dawley rats,
Positive 322
Alzheimer's disease
Supplementary table 20 Exercise intervention characteristics of included studies in depression
Disease Training Weeks Days / Week
Intensity
[Time/Day, Speed,
Slope]
Rat model
Effect
(Positive/Negative
)
References
Depression
(6)
Treadmill
exercise
2 7 30 min/day, 2,5,8
m/min,0°inclination
Sprague-Dawley
rats , Seven weeks ;intracerebral hemorrhage-
induced depression
Positive 323
4 7 30 min/day, 5,8,15
m/min,0° inclination
Sprague-Dawley rats,5
weeks; Stress-Induced
depression
Positive 324
4 5 moderate intensity
continuous training:
80%–90% SLT;
High-intensity interval
training: 4 × 4
min/session
Male Wistar rats between 2
and 3 months, Middle
Cerebral Artery
Occlusion/Reperfusion
Surgery induced poststroke
depression
Positive 325
4 — 30 min/day, 9m/min at
80% SLTPositive 326
8 5 1st week:10–12 m/min Male Sprague-Dawley Positive 327
for 10 min (grade 0%);
2nd week : 10–12
m/min for 20 min
(grade 0%); 3rd
week : 18–20 m/min
for 20 min (grade
0%); 4th week:
18–20 m/min for 30 min
(grade 0%); 5th
week onwards:18–20
m/min for 50 min
(grade 0%)
rats,4 weeks; social
isolation induced
depression behaviors
Swimmin
g
2 7 15 min–1 h/d Male Wistar rats, 2 months
old; Physical activity
induces depression-like
behavior Negative 328
3 5 60 min/day 127-day-old Male Wistar
ratsPositive
Supplementary table 21 Exercise intervention characteristics of included studies in anxious rats
Disease Training WeeksDays/
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative
)
References
Anxiety (4) Treadmill
exercise
3 5 30 min/day; moderate exercise Newborn male and female
Wistar rats
Positive 329
4 7 30 min/day; 15 m/min 7–8-week-old Male Sprauge-
Dawley rats
Positive 330
Voluntary
wheel
exercise
3 — 24-h free exercise 2-months-old male Sprauge-
Dawley rats
Positive 331
4 — 24-h free exercise 140–160 g male Sprauge-
Dawley rats
Positive 332
Supplementary table 22 Exercise intervention characteristics of included studies in neuroma pain
Disease Training Weeks Days / WeekIntensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative)References
Neuropathic
pain
(3)
Treadmill
exercise
3 5 30 min/day,16 m/min Wistar adult male
rats;chronic constriction
injury with using catgut
chromic sutures 4.0 around
the common sciatic nerve
Positive 333
5 5 or 3 30 min/day, 20 m/min Male Sprague Dawley
rats,8 weeks;sciatic nerve
chronic constriction injury
model
Positive 334
Swimming 4 5 60 min/day, 10 m/min 200–250 g Male Sprague-
Dawley rats, tibial neuroma
transposition
Positive 335
Supplementary table 23 Exercise intervention characteristics of included studies in nerve injury
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed,
Slope]
Rat modelEffect
(Positive/Negative)References
Nerve
injury
(21)
Treadmill
exercise
2 5 45 min; 10 m/min Adult 251–275 g Female
Sprauge-Dawley rats, low
C6/7 moderate contusion
Contusive spinal cord
injury in a rat model
Positive
336
4 5 1st week: 30 min 180–200 g male Wistar
rats, mechanical injuredPositive
337
2nd week: 45 min3rd week: 60 min;1st 2 week: 10 m/min;Last 2 week: 15 m/min
4 5 30,45,60 min, 10–15
m/min
200–250 g,
ovariectomized female
Wistar rats, synaptic
plasticity impairments
Positive
338
4 5 8 m/min, 30 min/day Male Sprague-Dawley
rats, 200–250 g, contusive
spinal cord injury
Positive 339
4 5 6.3–8.6 m/min Sprague–Dawley rats (6-
week-old,
female);contusion-injured
at the thoracic level,
spinal cord injury
Positive 340
5 5 20 min/session, 28
training sessions, 6–13.5
cm/s
Adult female Sprague–
Dawley rats; spinal cord
injury with Spinal cord
transection
Positive 341
6 5 10 min/day,0.4 m/s Adult male (300–400
g)rats; spinal cord injury
with cervical or high
thoracic injur Negative 342
6 5 15 min/day, 6–21 cm/s Male Wistar rats,20–21
weeks,spinal cord injury
with NYU impactor
Positive 343
6 5 1 session/day,10.5 m/min Adult male Wistar rats,2
months,spinal cord injury
with NYU impactor
Positive 344
6 6 6 m/min, 4–6 times/week Adult male Sprague-
Dawley rats,6
weeks;spinal cord injury
Positive 345
with laminectomy at the
T9–T10 level8 5 10 min/d,11 cm/s Adult female Sprague–
Dawley rats; spinal cord
injury induced thoracic
spinal cord contusion
injury
Positive 346
8 5 20 min/session 6,13.5,21
cm/s
Adult Sprague-Dawley
female rats, 3-5 moth-old;
spinal cord injury with
severe contusion injury
Positive 347
8 5 25–64 min/day; 15–22
m/min
50-day-old, male Wistar
rats, oxidative stressPositive 348
9 5 once a day, 6–7 m/min, 5
—30 min/day
Adult male Wistar rats,
2.5-month-old;spinal cord
injury below a complete
spinal cord transection at
T8–9
Positive 349
10 5 20 ± 10 min/day, 3
m/min-11 ± 13 m/min
Adult female specific
pathogen free Sprague-
Dawley rats, 75 ± 1 days
of age; incomplete spinal
Positive 350
cord injury model with
complete spinal cord
transection16 5 15 min/session, twice a
day, 5–12 m/min
Adult female Sprague-
Dawley rats,180–200 g;
spinal cord injury induced
by moderate contusive
spinal cord injury
inflicted at the 9th
thoracic vertebral level
using an Infinite Horizon
(200 kDyne) impactor
Positive 351
3 months 5 2 sessions/day, 20
min/session
Sprague–Dawley
rats,female,228–260 g,
contusion spinal cord
injury
Positive 352
3 months 5 40 min/day Sprague Dawley specific
pathogen free rats,12-
week old; spinal cord
injury by contused
Positive 353
6–8
months
5 3 min/day,6.5 m/min Sprague Dawley
pups,spinalized rats with
Positive 354
neonatal spinal
transectionSwimming 12 5 2 h/day 170–190 g, female
Sprauge-Dawley ratsPositive
355
Voluntary
wheel
exercise
1 — — 12-week-old, male naïve
Wistar ratsPositive
356
4 7 30 min/day Adult female Lewis rats
(180–300 g); T-shaped
lesions of the thoracic
(T8) spinal cord, spinal
cord injury
Positive 357
5 or 20 5 30 min/day Adult(225–250 g), female
Sprauge-Dawley rats,
Spinal cord injury
Positive 358
Supplementary table 24 Exercise intervention characteristics of included studies in traumatic brain injury
Disease Training Weeks
Days
/
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative
)
References
Traumatic brain
injury(3)
Treadmill
exercise
1 7 30 min/day; 22 m/min 10-week-old-male Wistar rats,
traumatic brain injury
Positive 359
Swimming 7–9 5 90 min/day 4-month-old, male Wistar rats, N-
methyl-D-aspartate lesion
Positive 360
3 7 20 min/day Wistar rats Positive 361
Supplementary table 25 Exercise intervention characteristics of included studies in cerebellar ataxia
Disease TrainingWeek
sDays / Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative
)
References
Cerebellar
ataxia(2)
Treadmill exercise 4 5 30 min/session, 15 m/min, 10%
slope
30 days of age, Spastic Han
Wistar male rats, ataxia
Positive 362
— 5 30 min/day, 15 m/min, 10%
incline
20–30 days old, Spastic Han
Wistar male rats, ataxia
Positive 363
Supplementary table 26 Exercise intervention characteristics of included studies in Epilepsy
Disease Training Weeks Days / Week
Intensity
[Time/Day, Speed,
Slope]
Rat model
Effect
(Positive/Negative
)
References
Epilepsy (7) Treadmill
exercise
2 — 30 min/day,
2,3,5m/min, 0 ° of
inclination
Adult male rats (250 ± 10 g);
pilocarpine-induced epilepsy
model
Positive 364
4 — 1 session/day, 8–16
m/min, 5–25 min/day
Adult rats,adult rats subjected
to a chronic model of epilepsyPositive 365
30 d — 20 min/day, 12–15
m/min, 0% decline
Male 30-day-old Wistar rats;
pilocarpine-induced seizures in
the injured rat
Positive 366
30 d — 1st week: 12–14
m/min; 2nd
week: 15–17 m/min,
25 min;
3rd and 4th weeks: 18–
22 m/min
Male Wistar rats, 60 days old;
pilocarpine-induced epilepsy
Positive 367
13 5 short- (15 min),
moderate- (30 min)
and long-duration (60
Male Wistar albino rats, 20–
24-week-old;penicillin-
induced epileptiform activityPositive 368
min); 17 cm/s, 5° in
the grade incline, 45
cm/s with increments
of 2.5°–18° in the
grade incline— — 30 min/day, 12 m/min,
0 grade inclination
Male adult Wistar rats, 2
months; temporal lobe epilepsyPositive 369
Climbing
ladder
4 5 8 climbing
series/session, 20–30
min, 50%–100% load
Male Wistar rats, 60-day old;
Pilocarpine-induced epilepsy Positive 370
Supplementary table 27 Exercise intervention characteristics of included studies in Autistic
Disease Training Weeks Days / Week
Intensity
[Time/Day, Speed,
Slope]
Rat modelEffect
(Positive/Negative)References
Autistic
(1)
Treadmill
exercise
4 5 30 min/day, 2,5,8
m/min, 0° inclination
Male Sprague-Dawley rat
pups,2 weeks old; valproic
acid-induced autism-like
rat models
Positive 371
Supplementary table 28 Exercise intervention characteristics of included studies in Chronic kidney disease
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed,
Slope]
Rat model
Effect
(Positive/Negativ
e)
References
Chronic
kidney
disease
(2)
Treadmill
exercise
4 5 30 min/day, 17 m/min,
15° incline
20-day-old male Sprague Dawley
rats, underwent 5/6 nephrectomy,
chronic kidney
Positive 372
6 5 60 min/day, 16 m/min Male Wistar rats (280 g), A dose
of 100 mg/kg/day ip of G
(Gentatec, Sao Paulo, Brazil) was
applied for 10 days, acute kidney
injury
Positive 373
Supplementary table 29 Exercise intervention characteristics of included studies in breast cancer
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative
)
References
Breast Cancer
(15)
Treadmill
exercise
19 days 5 30 min/day, 17.5–20
m/min,15% grade
Sprague-Dawley pup female
rats, MNU-inducedPositive 374
12 5 Period of training (1–4 week),
Speed of treadmill (0.6, 0.96,
1.2, 1.44 km/h), period of
training (5–12 week), Speed
of treadmill (1.68 km/h) 1
week exercise 10 min, then
increased 10 min/week
28 days female Sprague–Dawley
rats, MNU-induced
carcinogenesis
Positive 375
35 5 60 m/day, 20 m/min 38 days old female Sprague-
Dawley rats, N-methyl-N-
nitrosourea-induced mammary
carcinogenesis
Positive 376
35 5 60 min/day, 20 m/ min 4–5 weeks female Sprague-
Dawley rats, N-methyl-N-
nitrosourea-induced mammary
carcinogenesis
Positive 377
35 5 60 min/day, 20 m/ min 4–5 weeks female Sprague-
Dawley rats, MNU-induced
mammary carcinogenesis
Positive 378
35 5 60 min/day, 20 m/ min 4–5 weeks female Sprague-
Dawley rats, MNU-induced
mammary carcinogenesis
Positive 379
35 5 60 min/day, 20 m/ min 38 days Female Sprague-
Dawley rats, MNU-inducedPositive 380
35 5 60 min/day, 20 m/min, 52-day-old female Sprauge-
Dawley, N-Methyl-N-
nitrosourea injection 2-day
before training
Positive 380
Voluntary
wheel
exercise
3 7 2000 ± 200 m/day, freedom
exercise
pregnant female Sprauge-
Dawley, MNU-inducedPositive
381
6 7 7673 ± 525 m/day, freedom
exercise
4-week-old female Sprauge-
Dawley,1-wk N-methyl-N-
nitrosourea injecting
Positive
382
6 7 low PA: <3 km/day; high PA:
>3 km/day; freedom exercise
8-week-old male Sprauge-
Dawley, MNU-inducedPositive
383
Forced
wheel
exercise
4 7 5048 ± 430 m/day, freedom
exercise
4-week-old female Sprauge-
Dawley, 1-methyl-1-nitrosourea
injection
Positive 384
5 7 12 h/day or 1750 m/day or
3500 m/day, 37 m/min
4-week-old female Sprauge-
Dawley (Sprague-Dawley), 1-
wk N-methyl-N-nitrosourea
injecting
Positive
385
5 7 12 h/day or 1750 m/day or
3500 m/day, 37 m/min
4-week-old female Sprauge-
Dawley, 1-methyl-1-nitrosourea
injection
Positive
386
Supplementary table 30 Exercise intervention characteristics of included studies in colonic cancer
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative)References
Colonic
cancer (3)
Swimming 5 4 12 groups; 20s; 60% body
weightF334 rat, neoplasic induction Positive 387
9 5 90 min/day 4-week-old male Wistar rats,
1,2-dimethylhydrazine-
induced colon carcinoma
Positive 388
Voluntary
wheel
exercise
4 7 free to exercise6-week-old male Wistar rats,
neoplasic inductionPositive 389
Supplementary table 31 Exercise intervention characteristics of included studies in other cancer
Disease Training WeeksDays /
Week
Intensity
[Time/Day, Speed, Slope]Rat model
Effect
(Positive/Negative
)
References
Tumor/Cancer
cachexia
(3)
Treadmill
exercise
8 5 20 m/min, intensity maintained
between 60 and 65 % VO2 max
Male adult Wistar rats
(150–200 g), tumor-
bearing rats
Positive 390
Ladder-climbing 8 — The initial climb consisted of
carrying a load that was 75% of
the animal’s body mass. After
this, an additional 30 g weight was
added until a load was reached
with which the rat could not climb
the entire length of the ladder.
70 day Wistar male rats,
tumor-bearing rats
Positive 391
Swimming 8 5 45 min/day 21 day male Wistar rats,
tumor-bearing ratsPositive 392
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