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AquaxtremTM
Activates the own mechanisms of the skin for a long-lasting moisturization
Moisturizing
AQUAXTREMTM
Activates the own mechanisms of the skin for a long-lasting moisturization
AQUAXTREMTM is obtained from the roots of rhubarb (Rheum rhaponticum).
We used an in silico screening to evaluate and select rhaponticin, a molecule present in rhubarb that acts as a natural agonist of PPARγ.
AQUAXTREMTM works from the inside, stimulating hydration mechanisms of the skin, through the activation of PPARγ
By activating PPARγ, receptor that controls gene expression of different cells, AQUAXTREMTM:
1) Boosts keratinocyte differentiation 2) Stimulates barrier function and skin hydration from the inside
As years go by, keratinocyte movement slows down and skin becomes dry, weak and aged
Hydration is key
The skin has mechanisms and structures designed to maintain the hydration:Cutaneous barrier Natural moisturizing factor (NMF)
Keratinocytes, during the differentiation process, are responsible for the production of elements of these structures, such as:
FilaggrinInvolucrinLipids of cutaneous barrier
Increase of stratum corneum cohesion
In-vitro efficacy
Rhaponticin (RH 5) increases production of barrier lipids, thus protects the body and avoids skin dehydration.
* RH 5 (rhaponticin 5 ppm); RH 25 (rhaponticin 25 ppm)
AQUAXTREMTM improves natural mechanisms involved in the barrier function and provides a deep and long-lasting hydration.
Hydration evaluation
In-vivo efficacy
Improvement of skin barrier
Effects of rhaponticin on human epidermal keratinocytes were analysed to prove its capacity of modulating filaggrin and involucrin production, key elements for stratum corneum.
The more fluorescence intensity, the more filaggrin and involucrin levels:
Stratum corneum resistance and cohesion
Improvement of barrier function
Recovery of skin hydration
AQUAXTREMTM reduces water loss (TEWL) repairing the barrier function.
Inte
nsity
TEWL evaluation
Evaluation of skin dryness and stratum corneum cohesion (microscope images)
Barrier (TEWL)HydrationCohesion
Barrier recovery
Accumulated hydrationCohesion
Long- lasting
hydration
D0 D1 D28 D29 D31
End treatmentStart treatment
Inte
nsity
Percentage of lipids vs. control
0
100
200
300
400
500
600
ControlNiacinamide RH 5
RH 25
Involucrin
0
5
10
15
20
25
D29D31
AQUAXTREMTM
Placebo
+9.6%
+11.6%
Per
cent
age
-15-10
-50
-14.13%
-7.13%
Percentage of AquaxtremTM vs placebo
D29 vs D0
D29S4 vs D29S
050
100150200
250
300
350
ControlNiacinamide RH 5
RH 25
0
100
200
300
400
Totallipids CERF Cholesterol Free
fattyacids
Cholesterylesters
Per
cent
age
Filaggrin+62%
+32%+37% +59%+20%
+36%
In-vivo study protocol
AQUAXTREMTM normalizes stratum corneum desquamation, stimulating
differentiation of keratinocytes and natural hydration mechanisms.
D0 D29
* D29S (after stripping); D29S4 (4h after stripping)
Technical specifications
AquaxtremTM 75680
ACTIVES MOLECULES
APPEARANCE
SOLUBILITY
RECOMMENDED DOSE
www.provitalgroup.com
Transparent liquidBrown - dark brown color
Rhaponticin
Cosmetic applications
Facial and body care (shower gel, body milk, hand cream)
Specific treatments for dry, very damaged or mature skin
Hair care (shampoos, lotions, conditioners, masks)
Make-up
Sun care products
Stimulates the skin natural mechanisms of hydration through the activation of PPARγ.
PROPERTIES
0.5 - 1.5 %
V01-
2012
Soluble in aqueous solutions
Formulation
Perfect Moisture Gel
INCI / PCPC % (w/w)
B
A Aqua (Water)Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Alcohol Denat.AQUAXTREMTM
Polymethyl Methacrylate, Sodium Acrylate/Sodium Acryloyl Dimethyl Taurate Copolymer, Isohexadecane
C
81.270.60
10.001.50
2.00
Aqua (Water), Sodium HydroxideD 1.20
Polysorbate 20Parfum (Fragrance)Glycerin, Leuconostoc/Radish Root Ferment Filtrate, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Extract, Populus Tremuloides Bark Extract, Gluconolactone
E 0.500.151.75
Bismuth Oxychloride, Mica, Iron Oxides (CI 77491)F 0.03
MANGO - ECOG 1.00
