Antibiotics and Antibiotic Resistance - NDPIA/IBA course -

26-30 November 2018 Hjortviken Konferens, Gothenburg, Sweden

National Graduate School in Infection Biology and Antimicrobials

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Program

Monday 26 November10.00 - Registration and poster mounting

12.15 - 13.15 Lunch

13.15 - 14.15 Welcome and one-minute introductions by course participantsÅke Forsberg, NDPIA, MIMS, UCMR, Umeå University

Chair person: Åke Forsberg14.15 - 15.15 An introduction to the evolution, spread, and management of antibiotic

resistanceDiarmaid Hughes, Uppsala University, Sweden / Joakim Larsson, CARe, Uni-versity of Gothenburg, Sweden / Arnfinn Sundsfjord, University of Tromsö, Norway

15.15 - 15.45 Coffee break

Chair person: Michael Koomey15.45 - 17.15 Introductory lectures continued

Antibiotic resistance in Neisseria gonorrhoeae Yonatan Grad, Harvard TH Chan School of Public Health, USA

M. tuberculosis resistanceTone Tønjum, Oslo University, Oslo University Hospital, Norway

17.15 - 18.30 Presentations of NDPIA/IBA and research centres followed by predinner mingleMichael Koomey, University of Oslo, Norway (IBA)Åke Forsberg, Umeå University, Sweden (UCMR/MIMS/NDPIA)Carl-Fredrik Flach, University of Gothenburg, Sweden (CARe) Diarmaid Hughes, Uppsala University, Sweden (UAC) Arnfinn Sundsfjord, University of Tromsö, Norway (CANS)

18.30 - 20.00 Dinner

Chair person: Michael Koomey20.15 - Evening talk

Ethics in antibiotic resistance managementChristian Munthe, CARe, University of GothenburgGothenburg, Sweden

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Program

Tuesday 27 NovemberModes of action and mechanisms of resistance of existing classes: Ribosomes

Chair persons: Örjan Samuelsen and Michael Koomey 08.30 - 09.15 Ribosome structure and function

Nora Vázquez-Laslop, Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, USA

09.15 - 10.00 Development of next generation tetracyclinesPatricia Bradford, Antimicrobial Development Specialists, LLC, Nyack, NY, USA

10.00 - 10.20 Coffee break

10.20 - 11.05 Macrolides-Lincosamides-Streptogramins, pleuromutilins, oxazolidi-nones Nora Vazquez-Laslop, University of Illinois at Chicago, USA

Modes of action and mechanisms of resistance of existing classes: Cell wall

Chair persons: Nora Vazquez-Laslop and Raimonda Viburiene11.05 - 11.50 Cell wall structure, biosynthesis, and targets

Felipe Cava, MIMS, UCMR, Umeå University, Sweden

11:50 - 12:45 Lunch

12:45 - 13:45 Poster session I - no. 1-14 3 poster walks in groups (5 min presentation + 5 min questions) in parallel: 1-5, 6-10, 11-14 - see “Poster Sessions” (page 82-85)

13.45 - 14.30 Free poster viewing of “posters of the day”

14.30 - 14.45 Coffee break

14.45 - 15.30 β-lactams and β-lactamasesÖrjan Samuelsen, University of Tromsø, Norway

15.30 - 16.15 Overview of new beta-lactam/beta-lactam inhibitor combinationsPatricia Bradford, Antimicrobial Development Specialists, LLC, US

16.15 - 16.30 Break

Chair persons: Patricia Bradford and Åke Forsberg16.30 - 17.15 Resistance inhibitors

Pål Rongved, University of Oslo, Norway

17.15 - 18.00 Glycopeptides, lipopeptides, lipoglycopeptidesGerry Wright, McMaster University, Canada

18.15 - 20.00 Dinner

Chair person: Åke Forsberg20.00 - Evening talk:

EU Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) and Swedish Research Council (VR) programme for funding AMR re-search 2019-2028Patriq Fagerstedt, Swedish Research Council (VR), Sweden

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Program

Wednesday 28 NovemberModes of action and mechanisms of resistance of existing classes: Nucleic acid synthesis, replication, transcription

Chair persons: Didier Mazel and Disa Larsson Hammarlöf08.30 - 09.15 Aminoglycosides: Mode of action and resistance

Gerry Wright, McMaster University, Canada

09.15 - 10.00 RifampicinGerry Wright, McMaster University, Canada

10.00 - 10.45 QuinolonesDiarmaid Hughes, UAC, Uppsala University, Sweden

10.45 - 11.05 Coffee break

11.05 - 11.50 Targeting bacterial membranesKlaas Martinus Pos, Goethe University Frankfurt, Germany

11.50 - 12.45 Lunch

12:45 - 13:45 Poster session II - no. 15-27 3 poster walks in groups (5 min presentation + 5 min questions) in parallel: 15-19, 20-23, 24-27 - see “Poster Sessions” (page 82-85)

13.45 - 14.30 Free poster viewing of “posters of the day”

14.30 - 14.45 Coffee break

Chair persons: Diarmaid Hughes and Carl-Fredrik Flach14.45 - 15.30 Detection of resistance mechanisms

Christian Giske, Karolinska Institutet, Stockholm, Sweden

15.30 - 16.15 Rapid diagnostics - Antibiotic susceptibility testingJohan Elf, Uppsala University, Sweden

16.15 - 16.30 Break

16.30 - 17.15 Structure-function of efflux systems and inhibitorsKlaas Martinus Pos, Goethe University Frankfurt, Germany

17.15 - 18.00 Genetics behind antibiotic resistanceDidier Mazel, Pasteur Institute, Paris, France

18.15 - 20.00 Dinner

Chair person: Michael Koomey20.00 - Evening talk

Public awareness of antibiotic resistance and how media influence un-derstanding and engagementAdam Shehata, CARe, University of Gothenburg, Sweden

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Program

Thursday 29 NovemberChair persons: Christina Stallings and Michael Koomey

08.30 - 09.15 Omics in diagnostics/detection of novel resistance genesErik Kristiansson, CARe, Chalmers University of Technology, Gothenburg, Sweden

Origins of resistance genes, selection, biological cost and compensation

09.15 - 09.45 The environment as a source for resistance genesJoakim Larsson, CARe, University of Gothenburg , Sweden

09.45 - 10.05 Coffee break

10.05 - 11.05 Mutations, selection (including co-selection), biological cost, compensa-tion Diarmaid Hughes, UAC, Uppsala University, SwedenPål Johnsen, University of Tromsö, Norway

11.05 - 11.50 Epistatic interactions/mutations that confer resistance to commonly used antibioticsIsabel Gordo, Instituto Gulbenkian de Ciência, Oeira, Portugal

11.50 - 12:45 Lunch

12:45 - 13:45 Poster session III - no. 28-40 3 poster walks in groups (5 min presentation + 5 min questions) in parallel: 28-32, 33-36, 37-40 - see “Poster Sessions” (page 82-85)

13.45 - 14.30 Free poster viewing of “posters of the day”

14.30 - 14.45 Coffee break

Chair persons: Michael Koomey and Raimonda Viburiene14.45 - 15.30 The challenges of discovering new antibiotics active on Gram-negative

bacteriaEric Bacque, Evotec ID Lyon, France

15.30 - 16.15 Natural products Mark Brönstrup, Department of Chemical Biology, Helmholtz Centre for Infec-tion Research, Braunschweig; Germany

16.15 - 16.30 Break

Chair persons: Isabel Gordo and Åke Forsberg16.30 - 17.00 Biofilm and targeting biofilm

Ute Römling, Karolinska Institutet, Stockholm, Sweden

17.00 - 17.30 Targeting virulenceFredrik Almqvist, UCMR, Umeå University, Sweden

17.30 - 18.15 Development of novel antimicrobials acting in synergy with antibioticsChristina Stallings, Washington University, St Louis, USA

18.30 - 20.30 Course dinner

20.30 - Free time

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Program

Friday 30 NovemberAntibiotic development and approval, key elements and optimizing leads

Chair persons: Sanna Koskiniemi and Carl-Fredrik Flach08.30 - 09.30 Antibiotic development at small and average sized companies

Ursula Theuretzbacher, Center for Anti-Infective Agents, Vienna, Austria (CE-FAIA,) and Sven Bergström, QureTechBio, Umeå, Sweden

09.30 - 10.00 Developing pharmacokinetic and pharmacodynamic models for novel antibioticsLena Friberg, Uppsala University, Sweden

10.00 - 10.30 National infrastructures for screening and drug development in Sweden Erik Chorell, CBCS/LCBU, SciLifeLab, Umeå University, Sweden

10.30 - 11.00 Coffee break

Chair persons: Sven Bergström and Michael Koomey11.00 - 11.30 Persisters/microbial antagonism

Sanna Koskiniemi, Uppsala University, Sweden

11.30 - 12.00 In vivo studies of transcriptional reprogramming during persistent infec-tion-implications for resistance Maria Fällman, MIMS, UCMR, Umeå University, Sweden

12.00 - 12.45 Panel discussion on persistence/resistance Sanna Koskiniemi and Maria Fällman

12.45 - 13.45 Lunch

Chair persons : Maria Fällman and Raimonda Viburiene13.45 - 14.30 Microbiome based strategies for decolonization of multidrug resistance

and infection preventionReetta Satokari, University of Helsinki, Finland

14.30 - 15.15 Future perspectives on infection prevention and alternatives to antibioticsMarc Bonten, University Medical Centre Utrecht, The Netherlands

15.15 - 15.45 Concluding remarks and on-line evaluation Åke Forsberg, NDPIA, Michael Koomey, IBA

16.15 Departure, bus to Landvetter airport (ca 15 minutes)