William Shakespeare George Harrison

Walt Disney George Washington

PRESENTED BY:AFRIN SULTANA CHOWDHURYSADEKA BANU RIYAMD. ARIFUL ISLAM

AntiNicAnti-Nicotine Vaccine

for Smoking Cessation

Kill the Silent Killer Silently

Mission & Vision

Mission: To provide sustainable solution of the nicotine causing health risks to the smokers.

Vision: To catch the current demand and become the market leader in both domestic and regional level in next 10 years

Management

CEO: Afrin Sultana Chowdhury Head of Research: Md. Ariful Islam Head of Marketing: Sadeka Banu Riya

AntiNic• AntiNic is a vaccine, creates antibodies against nicotine• Contains Adeno Associated Viruses (AAV) that consist of

the genetic sequence, engineered from a nicotine antibody

• Intramuscular injection genetically modifies patient’s body to churn out nicotine antibodies

• Provide a lifetime nicotine antibody "factory" in the body. • The antibodies then work by targeting the nicotine cells

within seconds of exposure and preventing them from reaching receptors in the brain

Why Using AAV ??Wide host-rangeLack of pathogenicityAble to transduce a wide variety of cellsAllows permanent Genetic Implantations to

occurVirus encoded genes have been removed

Comparative Analysis

Current Drugs/ Treatments• Huge side-effects• Effectively is very less• Safety problem• Less available• Resistance• Age-specific (18- 55)• High cost• Long time course

AntiNic Vaccine• Very few side-effects• Highly effective• 100% safe

• No resistance• Wide age range (15- Higher)• Low cost• Inject once

Methods

• Use of Adeno virus for the replication of AAV• Transfection with human embryonic kidney cells• After the transfection, the cells are harvested and

purified using ultracentrifugation• Intramuscular injection of vaccine• Viruses insert genetic material at a specific site on

chromosome 19• Gene expression- monoclonal antibody production• Clinical benefits

Smoker’s Rate worldwide

Survey for Smoking TreatmentWorldwide Survey

In Bangladesh No Current Treatment is Available !!

SWOT Analysis

• New entry• Increase in

production and Labour cost

• Bio product• Technology

development and innovation

• Expensive• A few side

effects• Public

concern

• Target specific

• Non pathogenic

• AAV vectors used in gene therapy

Strong points

Weak points

ThreatsOpportunities

Market Attractiveness

• Huge demand worldwide• 50% of the patients are not responsive enough

to current treatments• Number of target patients in Bangladesh• Reduce the risks of vital diseases • Very little side-effect• Cost effective

Total seed fundingITEMS PROPOSED

Land Fixed Asset

Building Established

Research 5 m

Machineries and Equipment Established

Vehicle Established

Wages and labor cost .4 mUtility .3 mRepair/ Maintenance .7 mRaw Material 5 mOther .6 mTOTAL 12 m Taka

AntiNic Timeline

AntiNicin Lab Pilot Project FDA Review High Level

Production

Tk. 90 Lakh

12 mon

Tk. 40 Lakh Tk. 60 Lakh

12 mon 18 mon 12 mon

Market

Research & Development

• Research to revert a wide range of pathologies for more successful gene transfer without major side effects

• Research for new product for drug addiction• Research for eliminating smoking addiction

Target Audience & Customer

All the illiterate person who have at least basic knowledge on biological science and technology

Target Customer

Target Audience

• Middle class• Upper middle class• Upper class

Price

Target Market

2014 2017 2020 Bangladesh India, China, Thailand Europe

Promotion

Our Promoters

Dr. Mohit Kamal

Drug addiction treatment Specialist

and Psychiatrist

Ferdouse

Sources: http://archives.drugabuse.gov/NIDA_Notes/NNVol20N2/Site.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155067/ http://www.cbsnews.com/news/vaccine-stops-nicotine-from-reaching-the-brain-may-prevent-addiction/