Animal Nutrition Example 1: Nutrition Homeostatic Mechanisms 1 (function)

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Slide 2 Animal Nutrition Example 1: Nutrition Homeostatic Mechanisms 1 (function) Slide 3 Big Questions: How do the physiological systems of organisms help the organism maintain homeostasis? How have the physiological systems of organisms been adapted to the constraints of the environments that organisms live in? Slide 4 What does an organism need to do? Stay alive (at least until reproduction)! The physiological systems that an organism has are adapted to this purpose. Slide 5 Generalized Animal Body Plan: How does each system contribute to homeostasis? Slide 6 Generalized Plant Body Plan What do each of the following do to maintain homeostasis? root root tip/root hairs shoot (stem) Nodes/internodes Buds Terminal/apical/axillary buds Flower buds & flowers leaves mesophyll tissue/veins (vascular bundles) Slide 7 How does the environment influence an organisms physiology? Tremendously! Natural selection will tend to drive the adaptation of physiology to environmental contstraints. This has resulted in a variety of mechanisms for maintaining homeostasis Slide 8 Animal Nutrition Slide 9 Nutritional requirements Animals are heterotrophs need to take in food Why? fulfills 3 needs fuel = chemical energy for production of ATP raw materials = carbon source for synthesis essential nutrients = animals cannot make elements (N, P, K, Fe, Na, K, Ca...), NAD, FAD, etc. Slide 10 Kwashiorkor (a protein deficiency) in a Haitian boy Slide 11 How do animals get their food? filter (suspension) feedingsubstrate feeding fluid feedingbulk feeding Slide 12 Slide 13 Different diets; different lives All animals eat other organisms Herbivores eat mainly plants gorillas, cows, rabbits, snails Carnivores eat other animals sharks, hawks, spiders, snakes Omnivores eat animals & plants cockroaches, bears, raccoons, humans humans evolved as hunters, scavengers & gatherers Slide 14 Getting & Using Food Ingest taking in food Digest mechanical digestion Breaking food into smaller pieces chemical digestion breaking down food into small molecules to be absorbed into cells Absorb absorb across cell membrane Diffusion, active transport Eliminate undigested extracellular material passes out of digestive system intracellular digestion extracellular digestion Slide 15 Digestive systems Everybodys got one! Slide 16 Human digestive system Alimentary Canal Slide 17 Common processes & structures Movement & Control peristalsis push food along by rhythmic waves of smooth muscle contraction in walls of digestive system sphincters muscular ring-like valves, regulate the passage of material between sections of digestive system Accessory glands salivary glands, pancreas, liver & gall bladder secrete digestive juices (enzymes & fluid) Slide 18 Swallowing (& not choking) Epiglottis problem: breathe & swallow through same orifice flap of cartilage closes trachea (windpipe) when swallowing food travels down esophagus Esophagus move food along to stomach by peristalsis Slide 19 Ingestion Mouth mechanical digestion Teeth: breaking up food chemical digestion saliva Amylase: enzyme digests starch Mucin: slippery protein (mucus). Protects lining of digestive system, lubricates food. Buffers: neutralize acid to prevent tooth decay anti-bacterial chemicals: lysozyme. Slide 20 mouth break up food moisten food digest starch kill germs Slide 21 stomach kills germs store food break up food digest proteins cardiac sphincter pyloric sphincter mouth break up food moisten food digest starch kill germs Slide 22 Stomach Functions food storage: can stretch to fit ~2L food disinfect food HCl = pH 2 kills bacteria, breaks apart cells chemical digestion Pepsin: enzyme breaks down proteins secreted as pepsinogen activated by HCl But the stomach is made out of protein! What stops the stomach from digesting itself? mucus secreted by stomach cells protects stomach lining Ooooooh! Zymogen! Slide 23 Used to think ulcers were caused by stress tried to control with antacids Now know ulcers caused by bacterial infection of stomach Helicobacter pylori now cure with antibiotics Ulcers inflammation of stomach inflammation of esophagus Colonized by H. pylori Free of H. pylori white blood cells cytokines inflammatory proteins (CagA) cell damaging proteins (VacA) helper T cells neutrophil cells H. pylori Coevolution of parasite & host Slide 24 Revolutionizing healthcare "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease" J. Robin Warren Barry Marshall 1982 | 2005 Helicobacter pylori Slide 25 stomach kills germs break up food digest proteins store food pancreas produces enzymes to digest proteins & starch mouth break up food moisten food digest starch kill germs Slide 26 Small intestine Function major organ of digestion & absorption chemical digestion: digestive enzymes absorption through lining: over 6 meters! small intestine has huge surface area = 300m 2 (~size of tennis court) Structure 3 sections duodenum = most digestion jejunum = absorption of nutrients & water ileum = absorption of nutrients & water Slide 27 Duodenum 1st section of small intestines acid food from stomach mixes with digestive juices from accessory glands: pancreas liver gall bladder Slide 28 Pancreas Digestive enzymes peptidases trypsin trypsinogen chymotrypsin chimotrypsinogen carboxypeptidase procarboxypeptidase pancreatic amylase Buffers reduces acidity alkaline solution rich in bicarbonate (HCO 3 -) buffers acidity of material from stomach Explain how this is a molecular example of structure-function theme. Ooooooh! Zymogen! What stops pancreas from digesting itself small intestines Slide 29 Liver Digestive System Functions produces bile stored in gallbladder until needed breaks up fats act like detergents to breakup fats Circulatory System Connection bile contains colors from old red blood cells collected in liver = iron in RBC rusts & makes feces brown bile contains colors from old red blood cells collected in liver = iron in RBC rusts & makes feces brown Slide 30 pancreas produces enzymes to digest proteins & starch stomach kills germs break up food digest proteins store food liver produces bile - stored in gall bladder break up fats mouth break up food moisten food digest starch kill germs Slide 31 small intestines breakdown all foods - proteins - starch - fats - nucleic acids absorb nutrients stomach kills germs break up food digest proteins store food pancreas produces enzymes to digest proteins & starch liver produces bile - stored in gall bladder break up fats mouth break up food moisten food digest starch kill germs Slide 32 Digestive enzymes Slide 33 Absorption by Small Intestines Absorption through villi & microvilli finger-like projections increase surface area for absorption Ooooh Structure-Function theme! Slide 34 stomach kills germs break up food digest proteins store food small intestines breakdown food - proteins - starch - fats absorb nutrients pancreas produces enzymes to digest proteins & carbs liver produces bile - stored in gall bladder break up fats large intestines absorb water mouth break up food moisten food digest starch kill germs Slide 35 Large intestines (colon) Function re-absorb water use ~9 liters of water every day in digestive juices > 90% of water reabsorbed not enough water absorbed back to body diarrhea too much water absorbed back to body constipation Slide 36 Flora of large intestines Living in the large intestine is a rich flora of harmless, helpful bacteria Escherichia coli (E. coli) a favorite research organism bacteria produce vitamins vitamin K; biotin, folic acid & other B vitamins generate gases by-product of bacterial metabolism methane, hydrogen sulfide Youve got company! Slide 37 Rectum Last section of colon (large intestines) eliminate feces undigested materials extracellular waste mainly cellulose from plants roughage or fiber salts masses of bacteria Slide 38 Appendix Vestigial organ Slide 39 2006-2007 Animal Nutrition Variations, Adaptations & Regulation This obese mouse (L) has defect in gene which normally produces leptin, an appetite-regulating protein. Many herbivores have diets deficient in mineral salts. Must find other sources = salt licks, chewing on bones Slide 40 Energy budget food intake basal (resting) metabolism temperature regulation activity repair growth reproduction ATP production { synthesis { glycogen fat storage { Slide 41 Energy storage In humans glycogen storage glucose polymer in liver & muscle cells If glycogen stores are full & caloric intake still exceeds caloric expenditure excess stored as fat synthesis pathway from acetyl coA Why is glycogen highly branched? Slide 42 Balancing calorie needs with intake When fewer calories are taken in than are expended, fuel is taken out of storage deposits & oxidized (digested) breakdown (digest) glycogen from liver & muscle cells metabolize (digest) fat Just do it! Slide 43 Vegetarian diets Need to make sure you get enough protein 20 amino acids to make protein humans can synthesize 12 of the amino acids 8 have to be eaten = essential amino acids Grains (like corn) have 6 (missing 2) Beans (like soybean & red beans) have 6 (missing different 2) mix beans & grains for complete group of amino acids rice & beans taco/tortilla & beans tofu & rice peanut butter & bread What no fish! Slide 44 Eating a balanced diet What happens if an animals diet is missing an essential nutrient? deficiency diseases scurvy vitamin C (collagen production) rickets vitamin D (calcium absorption) blindness vitamin A (retinol production) anemia vitamin B 12 (energy production) kwashiorkor protein Slide 45 Different diets; different bodies Adaptations of herbivore vs. carnivore specialization in teeth length of digestive system number & size of stomachs Slide 46 Teeth Carnivore sharp ripping teeth canines Herbivore wide grinding teeth molars Omnivore both kinds of teeth Slide 47 Length of digestive system Carnivores short digestive system protein easier to digest than cellulose Herbivores & omnivores long digestive system more time to digest cellulose symbiotic bacteria in gut Remember the rabbits, George! Slide 48 Symbiotic organisms Ruminants additional mechanical digestion by chewing food multiple times after mixing it with enzymes How can cows digest cellulose efficiently? symbiotic bacteria in stomachs help digest cellulose-rich meals rabbit vs. cow adaptation: eat feces vs. chew cud ruminant caprohagy Slide 49 Liver Gallbladder Duodenum Pancreas Stomach Proteins Gastrin Acinar cells Regulation of Digestion Coordination of nervous system & endocrine system HCl Pepsin + CCK Secretin Chief cells Parietal cells + + + Gastric inhibitory peptide + + Fats Bile Enzymes Bicarbonate Slide 50 Quick Check: Make Sure You Can 1.Relate the structure and function of animal digestive systems to their role in nutrition. 2.Label/Identify all organs that play major roles in the digestive system. 3.Provide at least three examples of physical and chemical digestion and their locations. 4.Explain the causes of digestive system disruptions and how disruptions of the digestive system can lead to disruptions of homeostasis. Slide 51 Plant Nutrition Slide 52 Nutritional needs Autotrophic does not mean autonomous plants need sun as an energy source inorganic compounds as raw materials water (H 2 O) CO 2 minerals Slide 53 For what & from where? C macromolecule synthesisCO 2 O macromolecule synthesisCO 2 H macromolecule synthesis & proton pumpsH2OH2O N protein & nucleic acid synthesissoil P nucleic acids, ATP, phospholipidssoil K stomate control, water balancesoil Ca cell wall & membrane structure, regulationsoil Mg chlorophyllsoil S proteins, enzymessoil Slide 54 Macronutrients Plants require these nutrients in relatively large amounts C, O, H, N, P, K, Ca, Mg, S Slide 55 Micronutrients Plants require in very small amounts Cl, Fe, Mn, Bo, Zi, Ni, Mb primarily cofactors for enzyme function Slide 56 Nutrient deficiencies Lack of essential nutrients exhibit specific symptoms dependent on function of nutrient dependent on solubility of nutrient Slide 57 Magnesium deficiency Symptoms chlorosis = yellowing of leaves Why? What is magnesiums function? Take 2 fertilizer pellets & call me in the morning Slide 58 Chlorophyll Why does magnesium deficiency cause chlorosis? The chlorosis shows up in older leaves first, because plant moves Mg + to newer leaves. Why? Slide 59 Nitrogen uptake Nitrates plants can only take up nitrate (NO 3 - ) Nitrogen cycle by bacteria trace path of nitrogen fixation! What will the plant use N for? root Slide 60 Soybean root nodules N fixation by Rhizobium bacteria symbiotic relationship with bean family (legumes) Slide 61 Parasitic plants tap into host plant vascular system Indian pipe Mistletoe Slide 62 Carnivorous plants Are they really carnivores? Pitcher plantVenus fly trap Sundew Slide 63 Hungry for Information? Ask Questions! Slide 64 Quick Check: Make Sure You Can 1.Explain the function of major nutrients in plant physiology. 2.Relate the structure and function of plants to the nutritional process. 3.Explain the roles of symbiosis and parasitism in plant nutrition. 4.Compare the nutritional systems of plants and animals.