An intra-operative beta probe for brain tumor surgery Interfaces Physique Biologie group, University...
If you can't read please download the document
An intra-operative beta probe for brain tumor surgery Interfaces Physique Biologie group, University of Paris XI S. Bonzom, L. Ménard, M.A Duval, S. Pitre,
An intra-operative beta probe for brain tumor surgery
Interfaces Physique Biologie group, University of Paris XI S.
Bonzom, L. Mnard, M.A Duval, S. Pitre, L. Blanc R. Siebert, Y.
Charon Neurosurgery group of the Henri Mondor hospital (Crteil) S.
Palfi PSD7 Liverpool 1
Slide 2
Treatments of brain tumors 40 % of adult brain tumors are
glioma (5 to 10/100 000 cases each year) Gliomas have high
diffusion and proliferation capabilities High-grade gliomas have a
poor vital pronostic (survival under 1 year) Surgery is still the
more efficient treatment Current medical imaging systems arent
sensitive enough to detect the entire extent of the tumor
Development of new intraoperative systems to help in real time the
surgeon during the excision PSD7 Liverpool 2
Slide 3
Two complementary families of intraoperative detectors New
miniaturized tools dedicated to cancer surgery Standard imaging
systems adapted to the surgical room (ultrasound, scanner,
low-field MRI) Systems using a pharmaceutical tracer (labelled with
radioactivity or fluorescence) coupled to a miniaturized detection
probe. PSD7 Liverpool 3
Slide 4
Instrumentals constraints imposed by the detection of brain
tumors Very high sensitivity (detection of tumor edges) Compactness
(small operative wound) Gamma background noise discrimination
Correlation between the image and the real position of the tumor
Development of an intraoperative probe dedicated to the detection
of Development of an intraoperative probe dedicated to the
detection of particles and built around plastic scintillating
fibers. PSD7 Liverpool 4
Slide 5
Optic fiber -sensitive fiber Resistive network Detection head
Clear optical fiber bundle -shielded fiber External detection and
acquisition module Multi anode photomultiplier Principle of the
beta intraoperative probe PSD7 Liverpool 5
Slide 6
Geometrical phantom Voxelised anthropomorphic phantom (Mc Gill
University) Numerical phantoms Optimization of the detector
geometry by Monte Carlo simulations (MCNP 4C) PSD7 Liverpool 6
Slide 7
Radioactif tracers SUV= Standard Uptake Value SUVTumorSUV White
matter SUVCortex 18 F-FDG 5.23.33.7 18 F-FET 2.50.650.9 18
F-Choline 1.50.150.15 of the detector geometry by Monte Carlo
simulations (MCNP 4C) Optimization of the detector geometry by
Monte Carlo simulations (MCNP 4C) PSD7 Liverpool 7
Slide 8
Detector geometry Brain Tumor edges Surgical cavity sensitive
fiber shielded fiber Optimization of the detector geometry by Monte
Carlo simulations (MCNP 4C) PSD7 Liverpool 8
Slide 9
Gamma background noise characterization 18 F-FDG 18 F-Choline
Optimization of the detector geometry by Monte Carlo simulations
(MCNP 4C) PSD7 Liverpool 9
Slide 10
-sensitive fiber Choice of a 2mm diameter and 0.5mm length
-sensitive fiber Optimization of the detector geometry by Monte
Carlo simulations (MCNP 4C) PSD7 Liverpool 10
Slide 11
Optimization of the detector geometry by Monte Carlo
simulations (MCNP 4C) -shielded fiber Choice of a 2mm length
-shielded fiber PSD7 Liverpool 11
Slide 12
Expected theoretical performances Overall sensitivity of 72cps/
Ci/ml Sensitivity volume of 48 ml Gamma ray discrimination
efficiency of 99.6 % for 18 F-FET Minimum detectable radiotracer
concentration: Radiotracer Minimum detectable concentration (
Ci/ml) Bulk tumor concentration ( Ci/ml) 18 F-FDG0.350.59 18
F-FET0.100.29 18 F-Choline0.040.17 PSD7 Liverpool 12