American Heart AssociationResearch Program Overview

SouthWest AffiliateFebruary 2014

Mission

BUILDING HEALTHIER LIVES, FREE OF CARDIOVASCULAR DISEASES

AND STROKE

We will have an extraordinary impact on your life by empowering you and your loved ones to save lives, live healthier and enjoy more peace of mind about cardiovascular health.

Impact Goal

By 2020 to improve the cardiovascular health of all Americans by 20 percent while reducing deaths from cardiovascular diseases and stroke by 20 percent.

Research - AHA Top Priority

The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to

accomplish our mission.

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RESEARCH GOALSTo discover new

knowledge broadly related to the normal

function of the CV system and the causes,

prevention, treatment or control of CVD and

stroke.

• Ensure that highly meritorious research and discovery continues, including supporting early career investigators

• Increase the capacity of the research community to generate the highest quality research

• Promote a research infrastructure that expedites the translation of basic, clinical, behavioral and population research into practice

TYPES OF RESEARCH

Basic Research Clinical Research Population Health

Fundamental research is the study of life processes that are universal in their application to scientific knowledge

Example: Childhood Obesity

Early life determinants of metabolic syndrome in animal models: Interaction of perinatal environment and genetic predisposition

Addresses important questions of normal function and disease using human subjects

Example: Childhood Obesity

Binge eating, purging, and CV risk in adolescents; The effect of weight-loss diets varying in protein and carbohydrate content on markers of CV risk

Studies the distribution and determinants of health status as influenced by social, economic & physical environments, human biology, health policy & services, & disease prevention, prolonging life and promoting health at the population level

Example: Childhood ObesityWalking to school vs. riding a bus to increase physical activity and attenuate rising BMI of elementary school children

6

Donor Dollar

28¢

25¢ 75¢

National Center

SWA Affiliate

ResearchAllocation

15¢ Research60¢ Programs, Projects, Operations

13¢ Awards & Grants12¢ Programs, Projects, Operations

Publicly Donated Dollar

INVESTIGATOR-INITIATED RESEARCH FUNDING BY TYPE: BASIC/CLINICAL/POPULATION 2012-2013 AHA NATIONAL AND AFFILIATE FUNDING BY RESEARCH TYPE *PRELIMINARY FIGURES Clinical

13.4%$20M

Population3%

$4.5M

Basic83.6%$97.6M

Research Facts 2012

AHA-Funded Breakthroughs Our research funding has led to the discovery and

development of many treatments and procedures:

– First artificial heart valve– Techniques and standards for CPR– Implantable pacemakers– Treatment for infant respiratory distress syndrome– Cholesterol inhibitors– Drug-coated stents– Microsurgery– Links between dietary fat and cholesterol

Research Advancements

Funded by the American Heart Association:

1956 – Dr. Ancel Keys links dietary fat with cholesterol.

1957 – Dr. William Wierich joined by Drs. Vincent Gott and Walter Lillehei implant the first externally powered pacemaker.

1966 – Dr. Maurice Sokolow announces results of his 20-year study showing hypertension can decrease life expectancy.

1972 – Dr. Arthur Guyton provides evidence of the overriding dominance of the kidneys in long-term regulation of blood pressure and in hypertension.

1985 - Dr. Joseph Goldstein and Dr. Michael Brown provide new insights into the ways fatty cholesterol enters body cells and why cholesterol levels my become too high.

1992 – Dr. Edwin Krebs joined by Dr. Edmond Fischer discover how proteins are switched to perform functions within the cells.

1998 – Dr. Andrew Marks develops a method to reduce re-blocking of the arteries after angioplasty.

National Research Statistics

• AHA has spent > $3.5 billion on research since 1949 • AHA spent more than $134 million for new research

in 2013• Currently funds about 2,100 scientists in US• AHA is 2nd only to NHLBI in funding heart research• AHA has funded the winners of 13 Nobel Prizes• To avoid losing generations of researchers, AHA

awards more than 73% of the research dollars to early career investigators ($99.37 Million)

Advocate for NIH Funding• AHA advocates each year to increase research

funding for the National Institute of Healthy

• 2013 the NIH funded over $1.5 Billion in SWA Arkansas $ 47 Million

Colorado $ 316 MillionNew Mexico $ 90 MillionOklahoma $ 88 MillionTexas $ 956 Million Wyoming $ 8 MillionSWA Total $ 1.5 Billion

SWA Research Statistics Fiscal Year 2013

• AHA currently funds over $40 million in research in SWA • AHA currently funds 246 researchers in 36 institutions in

22 cities • SWA received over 634 applications in 2013• Overall success rate for 2013 applications is 16.2%• AHA has funded more than $442 million in research in

SWA states since 1951

SWA States: AR, CO, NM, OK, TX and WY

Affiliate Research FundingAs of February 2014, SWA currently funds over $40 million in active research awards.

Arkansas $ 925,000Colorado $ 9,020,338New Mexico $ 1,248,000Oklahoma $ 3,993,392Texas $25,464,220Wyoming

SWA Total $40,650,950

Arkansas Research Statistics

• Since 1951, AHA has funded more than $25 million in research in Arkansas

• AHA currently funds $925,000 in research in Arkansas

• AHA currently funds 10 projects in 1 institution

Colorado Research Statistics

• AHA currently funds $9,020,338 in research in Colorado• AHA currently funds 53 projects in 6 institutions

New Mexico Research Statistics

• Since 1951, AHA has funded more than $12 million in research in New Mexico

• AHA is currently funding $1,248,000 in research in

New Mexico• AHA currently funds 9 projects in 1 institutions

Oklahoma Research Statistics

• Since 1951, AHA has funded more than $38 million in research in

• AHA is currently funding $3,993,392 in research in Oklahoma

• AHA currently funds 27 projects in 3 institutions

Oklahoma

Texas Research Statistics

• Since 1951, AHA has funded more than $374 million in research in Texas

• AHA is currently funding $25,464,220 in research in Texas

• AHA currently funds 147 projects in 25 institutions

Wyoming Research Statistics

• Since 1981, we have funded $1,445,688 in Wyoming• In 2010, we funded 1 award totaling $90,772

Note: No change in funding

North Texas Research Statistics

• AHA has funded more than $191 million in research in DFW since 1951

• AHA is currently funding $5,781,448 million in DFW• AHA currently funds 33 projects in 2 institutions in DFW

Dallas $ 5,052,448 Arlington $ 140,000Fort Worth $ 729,000 Richardson $ 140,000

Note: No current funding in Denton

Houston Area Research Statistics

• Since 1951, AHA has funded more than $137 million in research in Houston & $20 million in Galveston

• AHA currently funds $ 10,279,538 in research in Houston • AHA currently funds 57 projects in 8 institutions• AHA currently funds $ 1,266,612 in research in Galveston• AHA currently funds 7 projects in 1 institution

$ 10,279,538 in Houston$ 1,266,612 in Galveston

San Antonio Research Statistics

• Since 1951, AHA has funded more than $46 million in research in San Antonio

• AHA is currently funding $2,364,232 in research in

San Antonio • AHA currently funds 15 projects in 4 institutions

Denver Research Statistics

• AHA is currently funding $8,016,348 in research in Denver

• AHA currently funds 43 projects in 3 institutions

Life Cycle of a Research Application

Hmm…

Application submitted

An idea begins

Peer Review Committee

E-mail notification

Research completed

Yea!

Reports Published

Findings translated

Assigned to reviewers

Critique developed

Rank-ordered list

Research Committee $ Funded

Research Programs

NATIONAL CENTER AWARDSo Fellow-to-Faculty Awardo Scientist Development Granto Innovative Research Granto Established Investigator Awardo Mentored Clinical & Population

Research Programo Strategically- Focused Research

Networkso Mentor/AHA Mentee Awardo Collaborative Science Awardo Merit Award

SWA AWARDS

o Predoctoral Fellowship

o Postdoctoral Fellowship

o Beginning Grant-in-Aid

o Grant-in-Aid

o Mentored Clinical & Population Research Program

o Undergraduate Student Program

The AHA supports research broadly related to cardiovascular function and disease, stroke or to related clinical, basic science, bioengineering or biotechnology, and public health problems.

SWA’S RESEARCH PROGRAMS

Program DescriptionAward Size

Award Duration

Undergraduate Research Fellowship (Pilot Program)

Help students initiate careers in cardiovascular & stroke research $4,000

total 10 wks.

Predoctoral Fellowship

Help undergraduate students initiate careers in cardiovascular & stroke researchTarget Audience: PhD, MD Students

$25,000per yr.

MAX= $50,000

1-2 yrs.

Postdoctoral Fellowship

Provide training for & encourages pursuit of research careersTarget Audience: PhD, MD not yet independent

$44,264-59,180 per yr.

2 yrs.

Mentored Clinical & Population Research Program

Encourage early career investigators to engage in high-quality introductory & pilot clinical or population studiesTarget Audience: Early career health care professionals with a Masters, M.D., D.O. or Ph.D. degree.

$70,000per yr.MAX=

$140,0002 yrs.

SWA’S RESEARCH PROGRAMS

Program DescriptionAward Size

Award Duration

Beginning Grant-In-Aid

Promote independent status of promising beginning scientistsTarget Audience: First faculty/staff appt through Asst Professor

$70,000per yr.MAX=

$140,0002 yrs.

Grant-In-Aid Support innovative, highly meritorious cardiovascular & stroke research projects from independent investigatorsTarget Audience: All levels of faculty/staff members

$70,000per yr.MAX=

$140,0002 yrs.

Scientist Development Grant

Help promising beginning scientists move from completion of research training to independent investigatorsTarget Audience: No more than 4 years since first faculty/staff appt

$60,000 per yr.

3 or 4 yrs.

AHA’S RESEARCH PROGRAMS

Program DescriptionAward Size

Award Duration

Innovative Research Grant (Pilot Program)

Support highly innovative, high-risk, high-reward research that could ultimately lead to critical discoveries or major advancements that will accelerate the field of cardiovascular & stroke researchTarget Audience: All levels of faculty/staff members

$75,000 per yr.

2 yrs.

Established Investigator Award

Support mid-term investigators with unusual promise, an established record of accomplishments, & a demonstrated commitment to cardiovascular & stroke researchTarget Audience: 4-9 yrs since first faculty/staff appt

$100,000 per yr.

5 yrs.

Fellow-to-Faculty Transition Award

Provide funding for beginning physician-scientists with outstanding potential for careers in cardiovascular & stroke researchTarget Audience M.D., M.D./PhD., D.O. or equivalent; not yet at faculty/staff position

$593,000 total

5 yrs.

Collaborative Science Award

Fosters innovative, new collaborations between two or more principal investigators from different science areas leading to unique and novel discoveriesTarget Audience: Target Audience: All levels of faculty/staff members

$250,000 per yr.

3 yrs.

AHA’S RESEARCH PROGRAMS

Program DescriptionAward Size

Award Duration

Mentor/AHA Mentee Award

Award to fund mentors working with mentees meeting specific criteria, including: underserved minorities, those working in new/difficult areas of inquiry and mentees at NIH AREA designated institutionsTarget Audience: Faculty /staff with proven mentoring success

$20,000 per yr.

3 yrs.

Strategically - Focused Research Networks

Provides a platform to address key strategic issues, chosen by the AHA Board of Directors, in CVD and stroke. Includes 3-4 institutions conducting 3 projects each.Target Audience: All levels of faculty/staff, members including Fellows

$3-5M per yr.

4 yrs.

AHA Merit Award(Available FY 15-16)

Funds highly competent individuals with an exceptional track record of success. Potential awardees must be renowned for creativity and embracing the unknownTarget Audience: 10 years but no more than 20 years since first faculty/staff appt

$200,000 per yr.

5 yrs.

SWA Success Rate by Program2013

Program Type Description

Number of Applications

Received

Number Funded Success Rate

Beginning Grant-in-Aid 140 14 10

Grant-in-Aid 200 32 16Postdoctoral Fellowship 163 28 17.2Predoctoral Fellowship 112 24 21.4

Clinical Research Program 6 0  

Undergraduate Fellowship 9 4 44.4

Grand Total 630 102 16.2%

The Process – SWA Spring Funding

January February March

April May July

• Application Deadline

• Applications assigned to Committees

• Committee Chairs review assignments

• Committee Chairs finalize assignments

• Reviewers input preference

• Assignments sent to reviewers

• Peer Review Committee meets

• Research Committees meet

• Award Notification

• Award activation

The Process – SWA Fall Funding

July August September

October November January

• Application Deadline

• Applications assigned to Committees

• Committee Chairs review assignments

• Committee Chairs finalize assignments

• Reviewers input preference

• Assignments sent to reviewers

• Peer Review Committee meets

• Research Committees meet

• Award Notification

• Award activation

Application Process

What can you do to prepare for the application process?– Notify your third parties that you plan to apply – Develop your research plan and specific aims– Begin to recruit referents if you are a fellow– Develop your training plan with your sponsor if you are a fellow – Check with your Grants Office for internal institutional deadlines

Go to www.heart.org/research

Please call our department at 214-712-1328 or email at research@heart.org with questions

RESEARCH INFORMATIONKey Websites

PROGRAMS, DEADLINES, APPLICATIONS & GRANTS@HEART LOGIN-IN http://my.americanheart.org/professional/Research/FundingOpportunities/Funding-Opportunities_UCM_316909_SubHomePage.jsp

GENERAL INFORMATION ABOUT RESEARCH http://my.americanheart.org/professional/Research/Research_UCM_316889_SubHomePage.jsp

EMAIL ADDRESS FOR PROGRAM OR TECHNICAL QUESTIONSapply@heart.org

Reminders• Research broadly related to cardiovascular function and disease,

stroke, or to related basic science, clinical, bioengineering or biotechnology, and public health problems

• Consider criteria and evaluation priorities• All basic disciplines as well as epidemiological, behavioral,

community and clinical investigations• Citizenship: US, permanent resident, Visa, E-3, etc.• Sponsor criteria and support (see application instructions)• Budget amounts for stipend/salary, project support, fringe benefits,

travel, indirect costs and maximum annual amount• Eligibility by virtue of degree, faculty rank, independence, years of

experience, percentage of effort, citizenship, sponsor support, restrictions, location of work and overlap of funding

• Repeat applications (up to 3 times including original)• Full assessment of peer review ongoing

AHA Professional Membership/Scientific Council

Scientific Statements/Guidelines

Scientific Sessions, Conferences and Workshops

AHA Scientific Journals

Other AHA Scientific Products

www.myamericanheart.org