Pharmacology and Therapeutics Publications 2013 Alaoui-Jamali, Moulay (see Department of Medicine) Allen, Bruce (Centre de Recherche, Institut de Cardiologie de Montreal) Rasmussen NL, Van Allen BG, Rudolf VH. (2014) Linking phenological shifts to species interactions through size-mediated priority effects. J Anim Ecol. [Epub ahead of print]

Merlen C, Farhat N, Luo X, Chatenet D, Tadevosyan A, Villeneuve LR, Gillis MA, Nattel S, Thorin E, Fournier A, Allen BG. (2013) Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. J Mol Cell Cardiol. 62:189-202.

Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith BJ, Spitz DR, Fath MA. (2013) Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clin Cancer Res. 19(14):3905-13.

Vaniotis G, Glazkova I, Merlen C, Smith C, Villeneuve LR, Chatenet D, Therien M, Fournier A, Tadevosyan A, Trieu P, Nattel S, Hébert TE, Allen BG. (2013) Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. J Mol Cell Cardiol. 62:58-68. Farhat N, Thorin-Trescases N, Mamarbachi M, Villeneuve L, Yu C, Martel C, Duquette N, Gayda M, Nigam A, Juneau M, Allen BG, Thorin E. (2013) Angiopoietin-like 2 promotes atherogenesis in mice. J Am Heart Assoc. 2(3):e000201.

Van Allen BG, Rudolf VH. (2013) Ghosts of habitats past: environmental carry-over effects drive population dynamics in novel habitat. Am Nat. 181(5):596-608.

Lauzier B, Vaillant F, Merlen C, Gélinas R, Bouchard B, Rivard ME, Labarthe F, Dolinsky VW, Dyck JR, Allen BG, Chatham JC, Des Rosiers C. (2013) Metabolic effects of glutamine on the heart: anaplerosis versus the hexosamine biosynthetic pathway. J Mol Cell Cardiol. 92-100.

Almazan, Guillermina Hossain S, Liu HN, Fragoso G, Almazan G. (2014)Agonist-induced down-regulation of AMPA receptors in oligodendrocyte progenitors. Neuropharmacology. 79C:506-514. [Epub ahead of print]

De Paula ML, Cui QL, Hossain S, Antel J, Almazan G. (2014) The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors. Glia. 62(1):64-77. [Epub ahead of print]

Didar TF, Bowey K, Almazan G, Tabrizian M. (2014) A miniaturized multipurpose platform for rapid, label-free, and simultaneous separation, patterning, and in vitro culture of primary and rare cells. Adv Healthc Mater. 3(2):253-60. Didar [Epub ahead of print]

Cui QL, Kuhlmann T, Miron VE, Leong SY, Fang J, Gris P, Kennedy TE, Almazan G, Antel J. (2013) Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis. Am J Pathol. 183(2):516-25.

Pharmacology and Therapeutics Publications 2013 Mekhail M, Daoud J, Almazan G, Tabrizian M. (2013) Rapid, guanosine 5'-diphosphate-induced, gelation of chitosan sponges as novel injectable scaffolds for soft tissue engineering and drug delivery applications. Adv Healthc Mater. 2(8):1126-30.

Bernard, Daniel Fortin J, Boehm U, Weinstein MB, Graff JM, Bernard DJ. (2013) Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells. FASEB J. 2013 Dec 5.

Joustra SD, Schoenmakers N, Persani L, Campi I, Bonomi M, Radetti G, Beck-Peccoz P, Zhu H, Davis TM, Sun Y, Corssmit EP, Appelman-Dijkstra NM, Heinen CA, Pereira AM, Varewijck AJ, Janssen JA, Endert E, Hennekam RC, Lombardi MP, Mannens MM, Bak B, Bernard DJ, Breuning MH, Chatterjee K, Dattani MT, Oostdijk W, Biermasz NR, Wit JM, van Trotsenburg AS. (2013) The IGSF1 deficiency syndrome: characteristics of male and female patients. J Clin Endocrinol Metab. 98(12):4942-52.

Tran S, Wang Y, Lamba P, Zhou X, Boehm U, Bernard DJ. (2013) The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells. PLoS One. 8(10):e76642. Rejon CA, Hancock MA, Li YN, Thompson TB, Hébert TE, Bernard DJ. (2013) Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells. Cell Signal. 25(12):2717-26.

Nakamura A, Bak B, Silander TL, Lam J, Hotsubo T, Yorifuji T, Ishizu K, Bernard DJ, Tajima T. (2013) Three novel IGSF1 mutations in four Japanese patients with X-linked congenital central hypothyroidism. J Clin Endocrinol Metab. 98(10):E1682-91.

Stevenson TJ, Bernard DJ, McCarthy MM, Ball GF. (2013) Photoperiod-dependent regulation of gonadotropin-releasing hormone 1 messenger ribonucleic acid levels in the songbird brain. Gen Comp Endocrinol. 190:81-7. Fortin J, Kumar V, Zhou X, Wang Y, Auwerx J, Schoonjans K, Boehm U, Boerboom D, Bernard DJ. (2013) NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. PLoS One. 8(3):e59058. Rejon CA, Ho CC, Wang Y, Zhou X, Bernard DJ, Hébert TE. (2013) Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells. Cell Signal. 25(6):1403-12. Bernard DJ, Tran S. (2013) Mechanisms of activin-stimulated FSH synthesis: the story of a pig and a FOX. Biol Reprod. 88(3):78. REVIEW.

Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, Boehm U, Treier M, Boerboom D, Bernard DJ. (2013) Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Mol Endocrinol. 27(3):407-21.

Pharmacology and Therapeutics Publications 2013 Boucher, Matthieu Fan Q, Boucher M, Brinks H, Shang X, Lau WB, Zhang J, Koch WJ, Gao E (2013) Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model, PLoS ONE, Sep 13;8(9):e73537. Bowie, Derek Accardi MV, Daniels BA, Brown PM, Fritschy JM, Tyagarajan SK, Bowie D. (2013) Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun. 5:3168. Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D. (2013) Defining the structural relationship between kainate-receptor deactivation and desensitization. Nat Struct Mol Biol. 20(9):1054-61. Daniels BA, Andrews ED, Aurousseau MR, Accardi MV, Bowie D. (2013) Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. J Physiol. 591(Pt 16):3873-85. Čapek, Radan McLeod P, Steinert Y, Capek R, Chalk C, Brawer J, Ruhe V, Barnett B. (2013) Peer review: an effective approach to cultivating lecturing virtuosity. Med Teach. 35(4):e1046-51. Chemtob, Sylvain Hamel D, Sanchez M, Duhamel F, Roy O, Honoré JC, Noueihed B, Zhou T, Nadeau-Vallée M, Hou X, Lavoie JC, Mitchell G, Mamer OA, Chemtob S. (2014) G-protein-coupled receptor 91 and succinate are key contributors in neonatal postcerebral hypoxia-ischemia recovery. Arterioscler Thromb Vasc Biol. 34(2):285-93. [Epub ahead of print] Tremblay S, Miloudi K, Chaychi S, Favret S, Binet F, Polosa A, Lachapelle P, Chemtob S, Sapieha P. (2013) Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function. Invest Ophthalmol Vis Sci. 54(13):8125-39. Shao Z, Friedlander M, Hurst CG, Cui Z, Pei DT, Evans LP, Juan AM, Tahir H, Duhamel F, Chen J, Sapieha P, Chemtob S, Joyal JS, Smith LE. (2013) Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 8(7):e69552. [Correction in PLoS One. 8(8)] Tahiri H, Yang C, Duhamel F, Omri S, Picard E, Chemtob S, Hardy P. (2013) p75 neurotrophin receptor participates in the choroidal antiangiogenic and apoptotic effects of T-lymphocyte-derived microparticles. Invest Ophthalmol Vis Sci. 54(9):6084-92. Favret S, Binet F, Lapalme E, Leboeuf D, Carbadillo J, Rubic T, Picard E, Mawambo G, Tetreault N, Joyal JS, Chemtob S, Sennlaub F, Sangiovanni JP, Guimond M, Sapieha P. (2013) Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions. Aging (Albany NY). 5(6):427-44. Rivera JC, Sitaras N, Noueihed B, Hamel D, Madaan A, Zhou T, Honoré JC, Quiniou C, Joyal JS, Hardy P, Sennlaub F, Lubell W, Chemtob S. (2013) Microglia and interleukin-1β in ischemic

Pharmacology and Therapeutics Publications 2013 retinopathy elicit microvascular degeneration through neuronal semaphorin-3A. Arterioscler Thromb Vasc Biol. 33(8):1881-91. Honoré JC, Kooli A, Hamel D, Alquier T, Rivera JC, Quiniou C, Hou X, Kermorvant-Duchemin E, Hardy P, Poitout V, Chemtob S. (2013) Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents. Arterioscler Thromb Vasc Biol. 33(5):954-61. Leduc M, Hou X, Hamel D, Sanchez M, Quiniou C, Honoré JC, Roy O, Madaan A, Lubell W, Varma DR, Mancini J, Duhamel F, Peri KG, Pichette V, Heveker N, Chemtob S. (2013) Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure. Am J Physiol Regul Integr Comp Physiol. 304(1):R10-22. Clarke, Paul Wright JM, Dobosiewicz MRS, Clarke PB (2013) The role of dopaminergic transmission through D1-like and D2-like receptors in amphetamine-induced rat ultrasonic vocalizations. Psychopharmacology 225(4):853-868. Scardochio T, Clarke PB (2013) Inhibition of 50-kHz ultrasonic vocalizations by dopamine receptor subtype-selective agonists and antagonists in rats. Psychopharmacology 226(3):589-600. Cuello, A. Claudio Do Carmo S, Cuello AC. (2013) Modeling Alzheimer's disease in transgenic rats. Mol Neurodegener. 8:37. Osikowicz M, Longo G, Allard S, Cuello AC, Ribeiro-da-Silva A. (2013) Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats. Mol Pain. 9(1):37. Culty, Martine (See Department of Medicine) De Koninck, Yves Lavertu G, Côté SL, De Koninck Y. (2014) Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model. Brain. 137(Pt 3):724-38. [Epub ahead of print] Daou I, Tuttle AH, Longo G, Wieskopf JS, Bonin RP, Ase AR, Wood JN, De Koninck Y, Ribeiro-da-Silva A, Mogil JS, Séguéla P. (2013) Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J Neurosci. 33(47):18631-40.

Bégin S, Bélanger E, Laffray S, Aubé B, Chamma E, Bélisle J, Lacroix S, De Koninck Y, Côté D. (2013) Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach. Biomed Opt Express. 4(10):2003-14.

Pharmacology and Therapeutics Publications 2013 Barbeau A, Swift JL, Godin AG, De Koninck Y, Wiseman PW, Beaulieu JM. (2013) Spatial intensity distribution analysis (SpIDA): a new tool for receptor tyrosine kinase activation and transactivation quantification. Methods Cell Biol. 117:1-19.

Gagnon M, Bergeron MJ, Lavertu G, Castonguay A, Tripathy S, Bonin RP, Perez-Sanchez J, Boudreau D, Wang B, Dumas L, Valade I, Bachand K, Jacob-Wagner M, Tardif C, Kianicka I, Isenring P, Attardo G, Coull JA, De Koninck Y. (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 19(11):1524-8.

Ferrini F, De Koninck Y. (2013) Microglia control neuronal network excitability via BDNF signalling. Neural Plast. 2013:429815. Bonin RP, De Koninck Y. (2013) Restoring ionotropic inhibition as an analgesic strategy. Neurosci Lett. 557 Pt A:43-51. Dehez H, Piché M, De Koninck Y. (2013) Resolution and contrast enhancement in laser scanning microscopy using dark beam imaging. Opt Express. 21(13):15912-25. Arsenault D, Dal-Pan A, Tremblay C, Bennett DA, Guitton MJ, De Koninck Y, Tonegawa S, Calon F. (2013) PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ. J Neurosci. 33(26):10729-40. Doyon N, Ferrini F, Gagnon M, De Koninck Y. (2013) Treating pathological pain: is KCC2 the key to the gate? Expert Rev Neurother. 13(5):469-71. Thériault G, De Koninck Y, McCarthy N. (2013) Extended depth of field microscopy for rapid volumetric two-photon imaging. Opt Express. 21(8):10095-104.

Dufour S, Lavertu G, Dufour-Beauséjour S, Juneau-Fecteau A, Calakos N, Deschênes M, Vallée R, De Koninck Y. (2013) A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities. PLoS One. 8(2):e57703.

Barbeau A, Godin AG, Swift JL, De Koninck Y, Wiseman PW, Beaulieu JM. (2013) Quantification of receptor tyrosine kinase activation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SpIDA). Methods Enzymol. 522:109-31. Bories C, Husson Z, Guitton MJ, De Koninck Y. (2013) Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging. J Neurosci. 33(4):1344-56. Ferrini F, Trang T, Mattioli TA, Laffray S, Del'Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. (2013) Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. Nat Neurosci. 16(2):183-92. Di Battista, Giovanni (John) (See Department of Anatomy and Cell Biology)

Pharmacology and Therapeutics Publications 2013 Fellows, Lesley (See Department of Neurology and Neurosurgery) Gauthier, Serge (See Departments of Neurology and Neurosurgery, Psychiatry) Geary, Timothy (See Department of Parasitology) Hales, Barbara Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB. (2013) Harnessing Genomics To Identify Environmental Determinants Of Heritable Disease. Mutat Res. 752(1):6-9. Paradis FH, Hales BF. (2013) Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs. Toxicol Sci. 131(1):234-241. Delbes DG, Chan D, Hales BF, Trasler J, Robaire B. (2013) Selective Induction Of Glutathione S-Transferases In Round Spermatids From The Brown-Norway Rat By The Chemotherapeutic Regimen For Testicular Cancer. Reprod Toxicol. 36:24-32. Yauk CL, Bishop J, Dearfield KL, Douglas GR, Hales BF, Luijten M, O'Brien JM, Robaire B, Sram R, van Benthem J, Wade MG, White PA, Marchetti F. (2013) The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development. Environ Mol Mutagen. 54(2):79-81 Banh S, Hales BF. (2013) Hydroxyurea Exposure Triggers Tissue Specific Activation of p38 Mitogen-Activated Protein Kinase Signaling and the DNA Damage Response in Organogenesis Stage Mouse Embryos. Toxicol Sci. 133(2):298-308. Bardai GK, Hales BF, Sunahara GI. (2013) Glyceryl trinitrate metabolism in the quail embryo by the glutathione S-transferases leads to a perturbation in redox status and embryotoxicity. Comp Biochem Physiol B. 165(3):153-164. Schlisser A, Hales BF. (2013) Deprenyl Enhances the Teratogenicity of Hydroxyurea in Organogenesis Stage Mouse Embryos. Toxicol Sci. 134(2):391-399. Maselli J, Hales BF, Chan P, Robaire B. (2013) The Effects of Chemotherapy with Bleomycin, Etoposide, and Cis-Platinum (BEP) on Rat Sperm Chromatin Remodeling, Fecundity and Testicular Gene Expression in the Progeny. Biol Reprod. Oct 10;89(4):85. Kichine E, Di Falco M, Hales BF, Robaire B, Chan P. (2013) Analysis of the Sperm Head Protein Profiles in Fertile Men: Consistency Across Time in the Levels of Expression of Heat Shock Proteins and Peroxiredoxins. PLoS One. Oct 30;8(10):e77471.

Pharmacology and Therapeutics Publications 2013 Maselli J, Hales BF, Robaire B. Paternal Exposure to Testis Cancer Chemotherapeutics Increases Sperm Fertilizing Capacity and Affects Gene Expression in the Eight-Cell Stage Rat Embryo. (2014) Andrology. [Epub ahead of print] Hébert, Terrence Goupil E, Laporte SA, Hébert TE. (2013) A simple method to detect allostery in GPCR dimers. Methods Cell Biol. 117:165-79.

Rejon CA, Hancock MA, Li YN, Thompson TB, Hébert TE, Bernard DJ. (2013) Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells. Cell Signal. Dec;25(12):2717-26. [THE and DJB are co-corresponding authors]

Perlman R, Giladi H, Brecht K, Ware MA, Hebert TE, Joseph L, Shir Y. (2013) Intradialytic clearance of opioids: methadone versus hydromorphone. Pain. Dec;154(12):2794-800. Roy SJ, Glazkova I, Fréchette L, Iorio-Morin C, Binda C, Pétrin D, Trieu P, Robitaille M, Angers S, Hébert TE, Parent JL. (2013) Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol. Aug;27(8):1245-66. [THE and JLP are co-corresponding authors]

Vaniotis G, Glazkova I, Merlen C, Smith C, Villeneuve LR, Chatenet D, Therien M, Fournier A, Tadevosyan A, Trieu P, Nattel S, Hébert TE, Allen BG. (2013) Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. J Mol Cell Cardiol. Sep;62:58-68. [THE and BGA are co-corresponding authors]

Rejon CA, Ho CC, Wang Y, Zhou X, Bernard DJ, Hébert TE. (2013) Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells. Cell Signal. Jun;25(6):1403-12. [THE and DJB are co-corresponding authors]

Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, Labbé JC, Miller GJ, Hébert TE. (2013) The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action. Pharmacol Rev. Feb 13;65(2):545-77. Review.

Zylbergold P, Sleno R, Hébert TE. (2013) A novel, radiolabel-free pulse chase strategy to study Kir3 channel ontogeny. J Recept Signal Transduct Res. Jun;33(3):144-52. Chidiac P, Hébert TE. (2013) GPCR Retreat 2012: timing is everything. J Recept Signal Transduct Res. 2013 Jun;33(3):129-34. Commentary. Poursharifi P, Lapointe M, Pétrin D, Devost D, Gauvreau D, Hébert TE, Cianflone K. (2013) C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology. Cell Signal. Apr;25(4):910-8.

Pharmacology and Therapeutics Publications 2013 Richard-Lalonde M, Nagi K, Audet N, Sleno R, Amraei M, Hogue M, Balboni G, Schiller PW, Bouvier M, Hébert TE, Pineyro G. (2013) Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors. Mol Pharmacol. Feb;83(2):416-28.

Goupil E, Laporte SA, Hébert TE. (2013) GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery. Br J Pharmacol. Mar;168(5):1101-3. Commentary.

Jean-Claude, Bertrand (See Department of Medicine) Kimmins, Sarah (See also Department of Animal Science) Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, Boehm U, Treier M, Boerboom D, Bernard DJ. (2013) Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Mol Endocrinol. 27(3):407-21. Laird, Jennifer Arneric SP, Laird JM, Chappell AS, Kennedy JD. (2014) Tailoring chronic pain treatments for the elderly: are we prepared for the challenge? Drug Discov Today. 19(1):8-17. [Epub ahead of print] Gilbert AK, Puma C, Xu X, Laird JM. (2013) Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice. Eur J Pain. 17(8):1147-55. Laporte, Stéphane (See also Division of Experimental Medicine) Goupil E, Laporte SA, Hébert TE. (2013) A simple method to detect allostery in GPCR dimers. Methods Cell Biol. 117:165-79. Goupil E, Laporte SA, Hébert TE. (2013) GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery. Br J Pharmacol. 168(5):1101-3. Mancini, Joseph Wickrama KK, Mancini JA, Kwag K, Kwon J. (2013) Heterogeneity in multidimensional health trajectories of late old years and socioeconomic stratification: a latent trajectory class analysis. J Gerontol B Psychol Sci Soc Sci. 68(2):290-7. Maysinger, Dusica Moquin A, Hutter E, Choi AO, Khatchadourian A, Castonguay A, Winnik FM, Maysinger D. (2013) Caspase-1 activity in microglia stimulated by pro-inflammagen nanocrystals. ACS Nano. 7(11):9585-98.

Migita S, Moquin A, Fujishiro H, Himeno S, Maysinger D, Winnik FM, Taniguchi A. (2014) Quantum dots induce heat shock-related cytotoxicity at intracellular environment. In Vitro Cell Dev Biol Anim. [Epub ahead of print]

Avti PK, Maysinger D, Kakkar A. (2013) Alkyne-azide "click" chemistry in designing nanocarriers for applications in biology. Molecules. 18(8):9531-49.

Pharmacology and Therapeutics Publications 2013 Chang PK, Boridy S, McKinney RA, Maysinger D. (2013) Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid. J Aging Res. 2013:538979.

Hutter E, Maysinger D. (2013) Gold-nanoparticle-based biosensors for detection of enzyme activity. Trends Pharmacol Sci. 34(9):497-507.

Neibert K, Gosein V, Sharma A, Khan M, Whitehead MA, Maysinger D, Kakkar A. (2013) "Click" dendrimers as anti-inflammatory agents: with insights into their binding from molecular modeling studies. Mol Pharm. 10(6):2502-8.

Matokanovic M, Barisic K, Filipovic-Grcic J, Maysinger D. (2013) Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90. Eur J Pharm Sci. 50(1):149-58.

Moquin A, Winnik FM, Maysinger D. (2013) Separation science: Principles and applications for the analysis of bionanoparticles by asymmetrical flow field-flow fractionation (AF4). Methods Mol Biol. 991:325-41.

Winnik FM, Maysinger D. (2013) Quantum dot cytotoxicity and ways to reduce it. Acc Chem Res. 46(3):672-80. McKinney, R. Anne Gill R, Chang PK, Prenosil GA, Deane EC, McKinney RA. (2013) Blocking brain-derived neurotrophic factor inhibits injury-induced hyperexcitability of hippocampal CA3 neurons. Eur J Neurosci. 38(11):3554-66.

Machnes ZM, Huang TC, Chang PK, Gill R, Reist N, Dezsi G, Ozturk E, Charron F, O'Brien TJ, Jones NC, McKinney RA, Szyf M. (2013) DNA methylation mediates persistent epileptiform activity in vitro and in vivo. PLoS One. 8(10):e76299.

Ilie A, Weinstein E, Boucher A, McKinney RA, Orlowski J. (2013) Impaired posttranslational processing and trafficking of an endosomal Na+/H+ exchanger NHE6 mutant (Δ370WST372) associated with X-linked intellectual disability and autism. Neurochem Int. pii: S0197-0186(13)00248-9.

Chang PK, Boridy S, McKinney RA, Maysinger D. (2013) Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid. J Aging Res. 2013:538979.

Deane EC, Ilie AE, Sizdahkhani S, Das Gupta M, Orlowski J, McKinney RA. (2013) Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci. 33(2):595-610.

McLeod, Peter McLeod P, Steinert Y, Capek R, Chalk C, Brawer J, Ruhe V, Barnett B. (2013) Peer review: an effective approach to cultivating lecturing virtuosity. Med Teach. 35(4):e1046-51.

Pharmacology and Therapeutics Publications 2013 Miller, Gregory (See also Department of Chemistry, Catholic University of America) Gosein V, Miller GJ (2013) Conformational stability of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) dictates its substrate selectivity. J Biol Chem. 288(52):36788-95. Gosein V, Miller GJ. (2013) Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation. J Biol Chem. 288(37):26908-13. Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, Labbé JC, Miller GJ, Hébert TE. (2013) The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action. Pharmacol Rev. 65(2):545-77. Multhaup, Gerhard Munter LM, Sieg H, Bethge T, Liebsch F, Bierkandt FS, Schleeger M, Bittner HJ, Heberle J, Jakubowski N, Hildebrand PW, Multhaup G. (2013) Model peptides uncover the role of the β-secretase transmembrane sequence in metal ion mediated oligomerization. J Am Chem Soc. 135(51):19354-61.

Olsson F, Schmidt S, Althoff V, Munter LM, Jin S, Rosqvist S, Lendahl U, Multhaup G, Lundkvist J. (2014) Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions. J Biol Chem. 289(3):1540-50. [Epub ahead of print]

Pester O, Götz A, Multhaup G, Scharnagl C, Langosch D. (2013) The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics. Chembiochem. 14(15):1943-8. Holzhauser S, Freiwald A, Weise C, Multhaup G, Han CT, Sauer S. (2013) Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors. Angew Chem Int Ed Engl. 52(19):5171-4.

Badiola N, Alcalde V, Pujol A, Münter LM, Multhaup G, Lleó A, Coma M, Soler-López M, Aloy P. (2013) The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One. 8(3):e58837.

Kaden D, Multhaup G. (2013) Meeting report: 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology--regulated intramembrane proteolysis in cancer development and neurodegenerative diseases. Neurodegener Dis. 11(4):215-8. Munter, Lisa Munter LM, Sieg H, Bethge T, Liebsch F, Bierkandt FS, Schleeger M, Bittner HJ, Heberle J, Jakubowski N, Hildebrand PW, Multhaup G. (2013) Model peptides uncover the role of the β-secretase transmembrane sequence in metal ion mediated oligomerization. J Am Chem Soc. 135(51):19354-61.

Olsson F, Schmidt S, Althoff V, Munter LM, Jin S, Rosqvist S, Lendahl U, Multhaup G, Lundkvist J. (2014) Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions. J Biol Chem. 289(3):1540-50. [Epub ahead of print]

Pharmacology and Therapeutics Publications 2013 Badiola N, Alcalde V, Pujol A, Münter LM, Multhaup G, Lleó A, Coma M, Soler-López M, Aloy P. (2013) The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One. 8(3):e58837. Nattel, Stanley Guasch E, Nattel S. (2013) Rebuttal from Eduard Guasch and Stanley Nattel. J Physiol. 591(Pt 20):4947. Guasch E, Nattel S. (2013) CrossTalk proposal: Prolonged intense exercise training does lead to myocardial damage. J Physiol. 591(Pt 20):4939-41. Andrade JG, Pollak SJ, Monir G, Khairy P, Dubuc M, Roy D, Talajic M, Deyell M, Rivard L, Thibault B, Guerra PG, Nattel S, Macle L. (2013) Pulmonary vein isolation using a pace-capture-guided versus an adenosine-guided approach: effect on dormant conduction and long-term freedom from recurrent atrial fibrillation--a prospective study. Circ Arrhythm Electrophysiol. 6(6):1103-8. Guasch E, Benito B, Nattel S. (2014) Reply: Of mice and men: atrial fibrillation in veteran endurance runners. J Am Coll Cardiol. 63(1):89-90. [Epub ahead of print] Nattel S. (2013) Paroxysmal atrial fibrillation and pulmonary veins: relationships between clinical forms and automatic versus re-entrant mechanisms. Can J Cardiol. 29(10):1147-9. Gillis AM, Krahn AD, Skanes AC, Nattel S. (2013) Management of atrial fibrillation in the year 2033: new concepts, tools, and applications leading to personalized medicine. Can J Cardiol. 29(10):1141-6. Andrade JG, Khairy P, Nattel S, Vanella A, Rivard L, Guerra PG, Dubuc M, Dyrda K, Thibault B, Talajic M, Mondesert B, Roy D, Macle L. (2013) Corticosteroid use during pulmonary vein isolation is associated with a higher prevalence of dormant pulmonary vein conduction. Heart Rhythm. 10(10):1569-75. Le Quang K, Benito B, Naud P, Qi XY, Shi YF, Tardif JC, Gillis MA, Dobrev D, Charpentier F, Nattel S. (2013) T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice. Circ Arrhythm Electrophysiol. 6(4):799-808. Yeh YH, Kuo CT, Chang GJ, Qi XY, Nattel S, Chen WJ. (2013) Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-β. Circ Arrhythm Electrophysiol. 6(4):790-8. Jost N, Virág L, Comtois P, Ordög B, Szuts V, Seprényi G, Bitay M, Kohajda Z, Koncz I, Nagy N, Szél T, Magyar J, Kovács M, Puskás LG, Lengyel C, Wettwer E, Ravens U, Nánási PP, Papp JG, Varro A, Nattel S. (2013) Ionic mechanisms limiting cardiac repolarization-reserve in humans compared to dogs. J Physiol. [Epub ahead of print]

Pharmacology and Therapeutics Publications 2013 Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. (2013) Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol. 62(17):1596-606. Nattel S, Cairns J, Healey JS, Talajic M. (2013) Anticoagulation for atrial fibrillation: state of the art and recommendations for a quickly moving target. Can J Cardiol. 29(7 Suppl):S1-3. Chauvet C, Crespo K, Shi Y, Gelinas D, Duval F, L'Heureux N, Nattel S, Tardif JC, Deng AY. (2013) Unique quantitative trait loci in synergy permanently improve diastolic dysfunction. Can J Cardiol. 29(10):1302-9. Merlen C, Farhat N, Luo X, Chatenet D, Tadevosyan A, Villeneuve LR, Gillis MA, Nattel S, Thorin E, Fournier A, Allen BG. (2013) Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. J Mol Cell Cardiol. 62:189-202. Morales GX, Macle L, Khairy P, Charnigo R, Davidson E, Thal S, Ching CK, Lellouche N, Whitbeck M, Delisle B, Thompson J, Di Biase L, Natale A, Nattel S, Elayi CS. (2013) Adenosine testing in atrial flutter ablation: unmasking of dormant conduction across the cavotricuspid isthmus and risk of recurrence. J Cardiovasc Electrophysiol. 24(9):995-1001. Vaniotis G, Glazkova I, Merlen C, Smith C, Villeneuve LR, Chatenet D, Therien M, Fournier A, Tadevosyan A, Trieu P, Nattel S, Hébert TE, Allen BG. (2013) Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. J Mol Cell Cardiol. 62:58-68. doi: Obeyesekere MN, Klein GJ, Nattel S, Leong-Sit P, Gula LJ, Skanes AC, Yee R, Krahn AD. (2013) A clinical approach to early repolarization. Circulation. 127(15):1620-9. Guasch E, Benito B, Qi X, Cifelli C, Naud P, Shi Y, Mighiu A, Tardif JC, Tadevosyan A, Chen Y, Gillis MA, Iwasaki YK, Dobrev D, Mont L, Heximer S, Nattel S. (2013) Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. J Am Coll Cardiol. 62(1):68-77. Luo X, Pan Z, Shan H, Xiao J, Sun X, Wang N, Lin H, Xiao L, Maguy A, Qi XY, Li Y, Gao X, Dong D, Zhang Y, Bai Y, Ai J, Sun L, Lu H, Luo XY, Wang Z, Lu Y, Yang B, Nattel S. (2013) MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J Clin Invest. 123(5):1939-51. Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, Nattel S. (2013)Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. Circ Res. 112(10):1310-22.

Pharmacology and Therapeutics Publications 2013 Dawson K, Wakili R, Ordög B, Clauss S, Chen Y, Iwasaki Y, Voigt N, Qi XY, Sinner MF, Dobrev D, Kääb S, Nattel S. (2013) MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Circulation. 127(14):1466-75, 1475e1-28. Crespo K, Chauvet C, Ménard A, Roy J, Shi Y, Gelinas D, Duval F, L'heureux N, Nattel S, Tardif JC, Deng AY. (2013) Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. J Hypertens. 31(5):927-35. Tsuji Y, Heijman J, Nattel S, Dobrev D. (2013) Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic Res Cardiol. 108(2):336. Zhu L, Qi XY, Aoudjit L, Mouawad F, Baldwin C, Nattel S, Takano T. (2013) Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes. Am J Physiol Renal Physiol. 304(7):F849-62. Gay-Jordi G, Guash E, Benito B, Brugada J, Nattel S, Mont L, Serrano-Mollar A. (2013) Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. PLoS One. 8(2):e55427. Andrade JG, Nattel S, Macle L. (2013) Late pulmonary vein reconnection: insights into mechanisms of atrial fibrillation recurrence after pulmonary vein isolation. Europace. 15(8):1143. Nattel S. (2013) Canadian Journal of Cardiology January 2013: genetics and more. Can J Cardiol. 29(1):1-2. Dawson K, Aflaki M, Nattel S. (2013) Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. J Physiol. 591(Pt 6):1409-32. Yeh YH, Kuo CT, Lee YS, Lin YM, Nattel S, Tsai FC, Chen WJ. (2013) Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation. Heart Rhythm. 10(3):383-91. O’Flaherty, Cristian(See also Department of Urology) Papadopoulos, Vassilios (See also Department of Medicine) Li J, Daly E, Campioli E, Wabitsch M, Papadopoulos V. (2014) De novo synthesis of steroids and oxysterols in adipocytes. J Biol Chem. 289(2):747-64. [Epub ahead of print] Prichard, Roger (See Department of Parasitology) Ribeiro-da-Silva, Alfredo I. Daou, A. H. Tuttle, G. Longo, J. S. Wieskopf, R. P. Bonin, A. R. Ase, J. N. Wood, Y. De Koninck, A. Ribeiro-da-Silva, J. S. Mogil, and P. Seguela. (2013) Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J.Neurosci. 33 (47):18396-18401.

Pharmacology and Therapeutics Publications 2013 G. Longo, M. Osikowicz, and A. Ribeiro-da-Silva (2013) Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis. J.Neurosci. 33 (24):10066-10074.

M. Osikowicz, G. Longo, S. Allard, A. C. Cuello, and A. Ribeiro-da-Silva (2013) Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats. Mol.Pain 9 (1):37. A correction for this article has been published in Molecular Pain. 2013, 9:55.

S. Pawlowski, S. Gaillard, I. Ghorayeb, A. Ribeiro-da-Silva, R. Schlichter, and M. Cordero-Erausquin (2013) A novel population of cholinergic neurons in the macaque spinal dorsal horn of potential clinical relevance for pain therapy. J.Neurosci. 33 (9):3727-3737.

A. W. Saeed, and A. Ribeiro-da-Silva (2013) De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a neuropathic lesion. J.Comp.Neurol. 521 (8):1915-1928.

G. Mo, J. C. Peleshok, C. Q. Cao, A. Ribeiro-da-Silva, and P. Seguela (2013) Control of P2X3 Channel Function by Metabotropic P2Y2 UTP Receptors in Primary Sensory Neurons. Mol.Pharmacol., 83 (3):640-647.

A. Charrua, R. Pinto, A. Taylor, A. Canelas, A. Ribeiro-da-Silva, C. D. Cruz, L. A. Birder, and F. Cruz. (2013) Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? A clinical and experimental study. Neurourol.Urodyn., [e-pub ahead of print].

Robaire, Bernard Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB.(2013) Harnessing genomics to identify environmental determinants of heritable disease. Mutat Res. 752:6-9. Delbès G, Chan D, Hales BF, Trasler JM, Robaire B. (2013) Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer. Reprod Tox. 36:24-32. Yauk CL, Bishop J, Dearfield KL, Douglas GR, Hales BF, Luijten M, O'Brien JM, Robaire B, Sram R, van Benthem J, Wade MG, White PA, Marchetti F. (2013) The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development. Environ Mol Mutagen. 54:79-81. Paul C, Robaire B. (2013) Ageing of the male germ line. Nat Rev Urol. 10:227-234. Maselli J, Hales BF, Chan P, Robaire B. (2013) The effects of chemotherapy with bleomycin, etoposide, and Cis-platinum (BEP) on rat sperm chromatin remodeling, fecundity and testicular gene expression in the progeny. Biol Reprod. 89:85.

Pharmacology and Therapeutics Publications 2013 Kichine E, Di Falco M, Hales BF, Robaire B, Chan P. (2013) Analysis of the Sperm Head Protein Profiles in Fertile Men: Consistency across Time in the Levels of Expression of Heat Shock Proteins and Peroxiredoxins. PLoS One. 8:e77471. Paul C, Nagano M, Robaire B. (2013) Aging Results in Molecular Changes in an Enriched Population of Undifferentiated Rat Spermatogonia. Biol Reprod. 89:147. Paul C, Robaire B. (2013) Impaired Function of the Blood-Testis Barrier during Aging Is Preceded by a Decline in Cell Adhesion Proteins and GTPases. PLos One. 8:e84354. Maselli J, Hales BF, Robaire B. Paternal Exposure to Testis Cancer Chemotherapeutics Increases Sperm Fertilizing Capacity and Affects Gene Expression in the Eight-Cell Stage Rat Embryo. Andrology. In press. Rousseau, Simon (See also Department of Medicine) Beaudoin T, LaFayette S, Roussel L, Bérubé J, Desrosiers M, Nguyen D, Rousseau S. (2013) The level of p38α mitogen-activated protein kinase activation in airway epithelial cells determines the onset of innate immune responses to planktonic and biofilm Pseudomonas aeruginosa. J Infect Dis. 207(10):1544-55. Roussel L, Farias R, Rousseau S. (2013) IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment. J Allergy Clin Immunol. 131(3):913-6. Sanderson, Thomas Sanderson JT, Clabault H, Patton C, Lassalle-Claux G, Jean-François J, Paré AF, Hébert MJ, Surette ME, Touaibia M. (2013) Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells. Bioorg Med Chem. 21(22):7182-93. Goldberg AA, Titorenko VI, Beach A, Sanderson JT. (2013) Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells. PeerJ. 1:e122. Gasmi J, Thomas Sanderson J. (2013) Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 20(8-9):734-42. Goldberg AA, Titorenko VI, Beach A, Abdelbaqi K, Safe S, Sanderson JT. (2014) Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. Invest New Drugs. 32(1):25-36. [Epub ahead of print] Saragovi, H. Uri Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB. (2013) Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats. Diabetologia. 56(10):2329-39.

Pharmacology and Therapeutics Publications 2013 Garcia AG, Nedev H, Bijian K, Su J, Alaoui-Jamali MA, Saragovi HU. (2013) Reduced in vivo lung metastasis of a breast cancer cell line after treatment with Herceptin mAb conjugated to chemotherapeutic drugs. Oncogene. 32(20):2527-33. Shir, Yoram (See also Department of Anesthesia) Perlman R, Giladi H, Brecht K, Ware MA, Hebert TE, Joseph L, Shir Y. (2013) Intradialytic clearance of opioids: methadone versus hydromorphone. Pain. 154(12):2794-800. Stone, Laura (See also Faculty of Dentistry) Alvarado S, Tajerian M, Millecamps M, Suderman M, Stone LS, Szyf M. (2013) Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex. Mol Pain. 9:21. Tajerian M, Alvarado S, Millecamps M, Vachon P, Crosby C, Bushnell MC, Szyf M, Stone LS. (2013) Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex. PLoS One. 8(1):e55259. Stone LS, Szyf M. (2013) The emerging field of pain epigenetics. Pain. 154(1):1-2. Szyf, Moshe Szyf M. (2013) The genome- and system-wide response of DNA methylation to early life adversity and its implication on mental health. Can J Psychiatry. 58(12):697-704. Alvarado S, Wyglinski J, Suderman M, Andrews SA, Szyf M. (2013) Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line. PLoS One. 8(10):e74009. Schwimmer H, Metzer A, Pilosof Y, Szyf M, Machnes ZM, Fares F, Harel O, Haim A. (2014) Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation. Chronobiol Int. 31(1):144-50. [Epub ahead of print] Machnes ZM, Huang TC, Chang PK, Gill R, Reist N, Dezsi G, Ozturk E, Charron F, O'Brien TJ, Jones NC, McKinney RA, Szyf M. (2013) DNA methylation mediates persistent epileptiform activity in vitro and in vivo. PLoS One. 8(10):e76299. Crudo A, Petropoulos S, Suderman M, Moisiadis VG, Kostaki A, Hallett M, Szyf M, Matthews SG. (2013) Effects of antenatal synthetic glucocorticoid on glucocorticoid receptor binding, DNA methylation, and genome-wide mRNA levels in the fetal male hippocampus. Endocrinology. 154(11):4170-81. Chik F, Machnes Z, Szyf M. (2014) Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine. Carcinogenesis. 35(1):138-44. [Epub ahead of print]

Pharmacology and Therapeutics Publications 2013 Provençal N, Suderman MJ, Caramaschi D, Wang D, Hallett M, Vitaro F, Tremblay RE, Szyf M. (2013) Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression. PLoS One. 8(8):e71691. Stefanska B, Suderman M, Machnes Z, Bhattacharyya B, Hallett M, Szyf M. (2013) Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2. Carcinogenesis. 34(12):2738-49. Stefanska B, Bouzelmat A, Huang J, Suderman M, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Szyf M. (2013) Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes. PLoS One. 8(8):e68439. Szyf M. (2013) The dialogue between social environments and the genome. Am J Public Health. 103 Suppl 1:S9-11. Provençal N, Suderman MJ, Vitaro F, Szyf M, Tremblay RE. (2013) Childhood chronic physical aggression associates with adult cytokine levels in plasma. PLoS One. 8(7):e69481. Szyf M. (2013) DNA methylation, behavior and early life adversity. J Genet Genomics. 40(7):331-8. Alvarado S, Tajerian M, Millecamps M, Suderman M, Stone LS, Szyf M. (2013) Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex. Mol Pain. 9:21. Labonté B, Suderman M, Maussion G, Lopez JP, Navarro-Sánchez L, Yerko V, Mechawar N, Szyf M, Meaney MJ, Turecki G. (2013) Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry. 170(5):511-20. Suderman M, Borghol N, Pappas JJ, McArdle W, Racine A, Hallett MT, Pembrey ME, Hertzman C, Power C, Szyf M. (2013) Epigenomic socioeconomic studies more similar than different. Proc Natl Acad Sci U S A. 110(14):E1246. Booij L, Wang D, Lévesque ML, Tremblay RE, Szyf M. (2013) Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression. Philos Trans R Soc Lond B Biol Sci. 368(1615):20120251. Crudo A, Suderman M, Moisiadis VG, Petropoulos S, Kostaki A, Hallett M, Szyf M, Matthews SG. (2013) Glucocorticoid programming of the fetal male hippocampal epigenome. Endocrinology. 154(3):1168-80. Tajerian M, Alvarado S, Millecamps M, Vachon P, Crosby C, Bushnell MC, Szyf M, Stone LS. (2013) Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex. PLoS One. 8(1):e55259. Szyf M. (2013) How do environments talk to genes? Nat Neurosci. 16(1):2-4.

Pharmacology and Therapeutics Publications 2013 Stone LS, Szyf M. (2013) The emerging field of pain epigenetics. Pain. 154(1):1-2. Tanny, Jason Mbogning, J., S. Nagy, V. Pagé, B. Schwer, S. Shuman, R.P. Fisher, and J.C. Tanny. (2013) The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. PLoS Genet. 9(12): e1004029. Trasler, Jacquetta McGraw S, Oakes CC, Martel J, Cirio MC, de Zeeuw P, Mak W, Plass C, Bartolomei MS, Chaillet JR, Trasler JM. (2013) Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females. PLoS Genet. 9(11):e1003873. Garner JL, Niles KM, McGraw S, Yeh JR, Cushnie DW, Hermo L, Nagano MC, Trasler JM. (2013) Stability of DNA methylation patterns in mouse spermatogonia under conditions of MTHFR deficiency and methionine supplementation. Biol Reprod. 89(5):125. Kooistra M, Trasler JM, Baltz JM. (2013) Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos. Biol Reprod. 89(3):63. Delbès G, Chan D, Hales BF, Trasler JM, Robaire B. (2013) Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer. Reprod Toxicol. 36:24-32.

Niles KM, Yeh JR, Chan D, Landry M, Nagano MC, Trasler JM. (2013) Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline. Hum Reprod. 28(2):519-30.

Trempe, Jean-Francois Trempe JF, Sauvé V, Grenier K, Seirafi M, Tang MY, Ménade M. Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K (2013) Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science, 340, 1451-1455. Trempe JF and Fon EA (2013) Structure and function of Parkin, PINK1 and DJ-1, the three musketeers of neuroprotection. Frontiers in Neurology, 4, 38. Grishin AM, Ajamian E, Tao L, Bostina M, Zhang L, Trempe JF, Menard R, Rouiller I, Cygler M. (2013) Family of phenylacetyl-CoA monooxygenases differs in subunit organization from other monooxygenases. Journal of Structural Biology, 184, 147-154 Varma, Daya Konanki R, Varma DR, Lingappa L, Shenoy BH. (2013) Midbrain neurocysticercal granuloma appearing as "face of panda". Neurology. 80(21):1999. Leduc M, Hou X, Hamel D, Sanchez M, Quiniou C, Honoré JC, Roy O, Madaan A, Lubell W, Varma DR, Mancini J, Duhamel F, Peri KG, Pichette V, Heveker N, Chemtob S. (2013) Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure. Am J Physiol Regul Integr Comp Physiol. 304(1):R10-22.

Pharmacology and Therapeutics Publications 2013 Ware, Mark (See also Department of Anesthesia) Perlman R, Giladi H, Brecht K, Ware MA, Hebert TE, Joseph L, Shir Y. (2013) Intradialytic clearance of opioids: methadone versus hydromorphone. Pain. 154(12):2794-800. Wong, Tak-Pan (See Department of Psychiatry) Zorychta, Edith (See Department of Pathology)