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AGENDA!!Wednesday!May!28th:!!16h00!'!19h30! ! ! Registration!!18h00!'!19h30!! ! ! BBQ!!!!20h00!! ! ! Meeting!Opening!!20h00!'!20h05! ! Welcome!Notes:!Jean'Yves!Masson!!20h05!–!20h15! ! Introduction!of!Keynote!Speaker:!Dan!Durocher!!20h15!–!21h15! ! Keynote!Address:!Roger!A!Greenberg!(University!of!Pennsylvania)!

Interchromosomal!Homology!Searches!Drive!Directional!ALT!Telomere!Movement!and!Synapsis!

!21h15!'!! ! ! Social!!!

Thursday!May!29th:!!07h00!! ! ! ! Breakfast!(until!10!am)!!!8h00!'!8h55!! ! ! Registration!!! ! ! Get!to!the!break!(1)!!08h55!'!09h00! ! Introduction!by!the!Chair:!Grant!Brown!!09h00!–!09h25! ! Jacques!Côté!(Université!Laval)!

Regulation!of!genome!stability!by!the!NuA4!acetyltransferase!complex:!!chromatin!and!beyond!

09h25!–!09h50! ! Victoria!Fell!(Schild'Poulter!Lab;!University!of!Western!Ontario)!! ! ! Ku70!S155!regulates!cell!cycle!checkpoints!and!DNA!damage!signaling!09h50!–!10h15! ! Nicole!L.!Batenburg!(Zhu!lab;!McMaster!University)!

Role!of!Cockayne!Syndrome!Group!B!(CSB)!Protein!in!Regulating!ATM!Activation!and!DNA!Double!Strand!Break!Repair!

10h15!–!10h40! ! Aaron!A.!Goodarzi!(University!of!Calgary)!! ! ! Opposing!ISWI'!and!CHD'class!chromatin!remodeling!activities!orchestrate!Artemis'!! ! ! dependent!heterochromatic!DNA!double!strand!break!repair!!10h40!–!11h05! ! ! Coffee!Break!!! ! ! New!ways!to!look!at!cancer!cells!!

! 3!

11h05!'!11h10! ! Introduction!by!the!Chair:!Yannick!Doyon!!

11h10!–!11h35! ! Ester!Falconer!(Lansdorp!lab;!BC!Cancer!Agency)!! ! ! High'resolution,!high'throughput!profiling!of!genomic!structural!heterogeneity!of!!

!! ! ! single!cancer!cells!using!Strand'seq.!

11h35!–!12h00! ! Sabine!Mai!(University!of!Manitoba)!

! ! ! Telomere!dysfunction!and!genomic!instability!

12h00!–!12h25!!! Stephen!Meyn!(University!of!Toronto)!Quantitative!analysis!of!extrachromosomal!telomere'repeat!DNA!in!individual!!

human!cells!by!Halo'FISH!

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12h25!–!13h45! ! ! Lunch!!

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13h50!–!15h00! ! Poster!Session!A!(EVEN!numbers!are!presented)!

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15h00!–!16h10! ! Poster!Session!B!(ODD!numbers!are!presented)!

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16h10!–!16h25!!! ! Coffee!Break!

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! ! ! Tales!of!chromosomes!and!telomeres!!

16h25!–!16h30! ! Introduction!by!the!Chair:!Momchil!Vodenicharov!!

16h30!–!16h55! ! Damien!D’Amours!(Université!de!Montréal)!

! ! ! The!polo'box!domain!of!Cdc5!promotes!adaptation!to!DNA!damage!by!targeting!polo!!

! ! ! kinase!activity!to!centrosomes!

16h55!–!17h20! ! Tina!L.!Sing!(Brown!lab;!University!of!Toronto)!! ! ! The!RSC!complex!functions!to!maintain!ploidy!in!Saccharomyces!cerevisiae!

17h20!–!17h45! ! Emilio!Cusanelli!(Chartrand!lab;!Université!de!Montréal)!

! ! ! Loss!of!sister'chromatid!cohesion!at!short!telomeres.!

17h45!–!18h00! ! Emmanuel!Bajon!(Wellinger!lab;!Université!de!Sherbrooke)!

! ! ! Yeast!telomerase!finally!ends!up!a!single!

18h00!–!18h15! ! Pierre!Billon!(Côté!lab;!Université!Laval)!! ! ! PCNA!acetylation!regulates!error'prone!TLS!activities!

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18h15!–!19h55! ! ! Supper!!

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! ! ! Consequences!of!impairing!DNA!repair!!

19h55!–!20h00! ! Introduction!by!the!Chair:!Kirk!McManus!!

20h00!–!20h25! ! Niraj!Joshi!(Masson!lab;!Université!Laval)!

! ! ! The!identification!of!Fancd2!DNA!binding!domains!reveals!hidden!nuclear!localization!!

!! ! ! sequences!

20h25!–!20h40! ! Frédérick!Bouffard!(F.!Durocher!lab;!Université!Laval)!

! 4!

Analysis!of!a!splicing!isoform!of!the!FancE!gene!and!its!impact!on!DNA!repair!!efficiency.!!

20h40!–!21h05! ! Nicolas!Malaquin!(Rodier!lab;!Université!de!Montréal)!Chromatin!stress!trigger!cellular!senescence!and!rapid!inflammatory!secretion!!without!DNA!damage.!!

21h05!–!21h30!!! Dindial!Ramotar!(Université!de!Montréal)!The!histone!H2B!R95A!mutant!is!defective!in!recruiting!the!FACT!complex!protein!!Spt16!and!causing!telomeric!dysfunction!that!alters!drug!responses!

21h30!–!21h45! ! Hao!Ding!(University!of!Manitoba)!! ! ! Mouse!modeling!of!RTEL1!function!!21h45!'!! ! ! Social!!!

Friday!May!30th:!!07h00!! ! ! ! Breakfast!(until!10!am)!!! ! ! Get!to!the!break!(2)!!08h55!–!09h00! ! Introduction!by!the!Chair:!Raymund!J.!Wellinger!!09h00!–!09h25! ! Guy!Poirier!(Université!Laval)!! ! ! Towards!systematic!identification!of!ADP'ribosylated!residues!in!mammalian!PARPs!09h25!–!09h50! ! Girish!M.!Shah!(Université!Laval)!

Poly(ADP'ribose)!polymerase'1!and!PARylation:!New!players!in!mammalian!!nucleotide!excision!repair!

09h50!–!10h15! ! Zubaidah!Ramdzan!(Nepveu!lab;!McGill!University)!RAS'Transformation!in!Cancer!Cells!Requires!CUX1'Dependent!Repair!of!!Oxidative!DNA!Damage!

10h15!–!10h40! ! Javier!M.!Di!Noia!(IRCM!Montréal)!! ! ! AID!coordinates!DNA!breaking!and!repair!during!antibody!class!switch!recombination.!!10h40!–!11h05! ! ! Coffee!Break!!! ! ! Telomerase!function!in!health!and!disease!!11h05!–!11h10! ! Introduction!by!the!Chair:!Francis!Rodier!!11h10!–!11h25! ! Pedro!Castelo@Branco!(Tabori!lab;!University!of!Toronto)!

THOR!methylation!provides!insight!into!the!telomere!maintenance!landscape!of!!malignant!gliomas.!

11h25!–!11h40! ! Johanna!Mancini!(Autexier!lab;!McGill!University)!Selective!telomere!shortening!in!cancer!cells!by!a!!Pt!(II)!Phenanthroimidazole!G'quadruplex!ligand.!

11h40!–!11h55! ! Tara!Beattie!(University!of!Calgary)!Influence!of!telomere!dynamics!on!disease!progression!and!response!to!!therapeutics!in!bone!marrow!failure!syndromes.!

! 5!

11h55!–!12h10! ! Judy%M.%Wong!(University!of!British!Columbia)!! ! ! Non=canonical!telomerase!functions,!to!protect!against!genotoxic!events.!12h10!–!12h25! ! Nezaha%Ozlem%Arat!(Harrington!lab;!Université!de!Montréal)!! ! ! The!importance!of!telomere!integrity!in!the!stability!of!stem!cell!differentiation!!!12h25!–!13h55! ! ! Lunch%!!

What%happens%at%the%break%..!!13h55!–!14h00!!! Introduction!by!the!Chair:!Louis%Flamand!!14h00!–!14h25! ! Amélie%Fradet@Turcotte!(D.!Durocher!lab;!University!of!Toronto)!

RNF168!and!RNF169!directly!interact!with!histone!H2A!!ubiquitylated!on!lysine!13!and!15!

14h25!–!14h40! ! Razq%Hakem!(University!of!Toronto)!! ! ! RNF168!Substrates!and!Its!In!Vivo!Functions!!14h40!–!15h05! ! Michael%J.%Hendzel!(University!of!Alberta)!! ! ! Ubiquitin=dependent!regulation!of!ATM!retention!in!double=strand!!

break=associated!foci.!15h05!–!15h30! ! El%Bachir%Affar!(Université!de!Montréal)!! ! ! Role!of!The!Tumor!Suppressor!and!Deubiquitinase!BAP1!in!DNA!Double=Strand!!

Break!Repair.!15h30!–!15h45! ! Hemanta%Adhikary!(Masson!lab;!Université!Laval)!! ! ! Formation!of!DNA!double=strand!breaks!by!the!meiotic!recombination!protein!Spo11.!!15h45!–!16h10!!! ! Coffee!Break!!16h10!–!16h15! ! Introduction!of!Keynote!Speaker:!Raymund!J.!Wellinger!!16h15!–!17h15! ! Keynote%Presentation:%Peter%Baumann%(Stowers%Institute%for%Medical%Research)%% % % Telomerase!Biogenesis!and!Telomere!Architecture!!18h30!–! ! ! Banquet!–!Social!=!Prizes!!!

Saturday%May%31st:%%!07h00!! ! ! ! Breakfast!(until!10!am)!and!lunchbox!pickup!!!!10h30!! ! ! ! Coach!to!the!airport%

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Canadian&Symposium&on&Telomeres&and&Genome&Integrity&

!Official'documents:!Visitors!to!Canada!must!hold!a!valid!passport!and,!in!some!cases,!a!visa.!For!more!information,!please!visit!the!Citizenship!and!Immigration!Canada!web!site:!http://www.cic.gc.ca/english/visit/index.asp!'Getting'to'Québec'City':'

By' air:'Visitors! can! fly! to!Québec! City,! located! in! the! northeastern! region! of! North!America.!Québec!City,!in!fact,!is!a!mere!90!minutes!flight!from!Toronto.!Efficient!rail!and!road!networks! link! Québec! City! to! bordering! provinces! and! states.! For! international! travelers,!Québec!CityJJean!Lesage!Airport! is! the!most! convenient!way! to! reach! the!city.! In!order! to!find!a!taxi,!a!limousine!or!other!means!of!transportation,!please!go!to!the!information!desk!inside!the!terminal!before!the!security!checkpoint.!Travelling!in!Taxi!to!Manoir!du!Lac!Delage!is!about!60$.!!

!Free! shuttle! from! the! airport! to!Manoir! du! Lac! Delage:! A! shuttle! bus! will! leave! from! the!airport! on! May! 28th! at! 13h15! and! 16h15! to! Manoir! du! Lac! Delage.! ! Please! follow! the!indications! for! Canadian& Symposium& on& Telomeres& and& Genome& Integrity& just! outside! the!arrivals.!The!airport!is!fairly!small,!it!will!be!easy!to!find.!! &!

By' train:' VIA! Rail! Canada! trains! run! daily! from! Toronto,! Ottawa! and! Montréal! to!Québec!City.!There!are!two!train!stations!in!Québec!City:!Gare!du!Palais!(Central!Station)!and!Gare!de!SainteJFoy.!From!there,!you!will!need!to!take!a!Taxi!to!Manoir!du!Lac!Delage.!'!Meeting' location:! Manoir! du! Lac! Delage.! (http://www.lacdelage.com/en/?lang=en).! Please!see!directions!from!the!airport!to!Manoir!du!lac!Delage!in!the!following!pages.!!!!!!

40, avenue du Lac, Lac-Delage, G3C 5C4 Tél. : 418-848-2551 / Sans frais 1-888-202-3242

De $’a'r)p)rt ,ea-./esage (YQB) 7 fr)9 ,ea-./esage airp)rt

Tourner à droite sur Route de l’Aéroport. Tur$ right *$t* R*ute de .’A1r*p*rt3

Tourner à gauche sur boul. Wilfrid-Hamel. Tur$ .eft *$t* B*u.3 Wi.frid7Ha:e.3

À gauche, rejoindre Autoroute 40 E/Autoroute 73 N en direction de Saguenay/Sainte-Anne-de-Beaupré. Tur$ .eft t* :erge *$t* Aut*r*ute 40 E>Aut*r*ute 73 A t*wardSague$ay>Sai$te7A$$e7de7Beaupr13

Suivre Autoroute 40 E/Autoroute 73 N. Eerge *$t* Aut*r*ute 40 E>Aut*r*ute 73 A3

40, avenue du Lac, Lac-Delage, G3C 5C4 Tél. : 418-848-2551 / Sans frais 1-888-202-3242

Prendre la sortie 142E pour Autoroute 40E/Autoroute 73N en direction de

Saguenay/Sainte-Anne-de-Beaupré. Ta#e exit 142E t- stay -0 Aut-r-ute 40 E5Aut-r-ute 73 8 t-wardSague0ay5Sai0te A00e de Beaupre?

Prendre la sortie 167, direction Stoneham/Tewkesbury/Lac-Delage. Ta#e exit 167 f-r QuCbec 371 t-ward St-0ehaG5Tew#esbury5HacIDeKage?

Tournez à gauche sur 1re Avenue (panneaux pour Québec 371 S). Tur0 Keft -0t- 1e Ave0ue (sig0s f-r QuCbec 371 S)?

Continuez sur Avenue Tewkesbury/QC-371 S (panneaux pour Lac-Delage /Stoneham

/Tewkesbury). C-0ti0ue -0t- Av Tew#esbury5QCI371 S (sig0s f-r Hac DeKage5St-0ehaG)?

Tournez à gauche sur Chemin de la Grande Ligne. Tur0 Keft -0t- CheGi0 de Ka Gra0de Hig0e?

Tournez à droite sur Avenue du Lac? Tur0 right -0t- Av du Hac?

Tournez à gauche sur Rue du Pied des Pentes. Tur0 Keft -0t- Rue du Pied des Pe0tes?

Le stationnement se trouve à votre gauche. The par#i0g is -0 y-ur Keft?