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ADVANCEMENT ADVANCEMENT IN AEROSOLS IN AEROSOLS
Dharamjit PattanayakDharamjit Pattanayak Pharmaceutical Technology Pharmaceutical Technology
M.Pharm 2M.Pharm 2ndnd Sem Sem Jeypore College of Pharmacy Jeypore College of Pharmacy
DEFINITION DEFINITION
Aerosols have been defined as colloidal Aerosols have been defined as colloidal system consisting of very finely system consisting of very finely subdivided liquid or solid particles subdivided liquid or solid particles dispersed in and surrounded by gas.dispersed in and surrounded by gas.
A system that depends on the power of a A system that depends on the power of a compressed or liquefied gas to expel compressed or liquefied gas to expel the contents from the container. the contents from the container.
ADVANTAGESADVANTAGES
Rapid action. Rapid action. Avoidance of degradation in GI tract.Avoidance of degradation in GI tract. Directly applied to the affected area.Directly applied to the affected area. Prevents OxidationPrevents Oxidation Easier application Easier application Sterility can be maintained Sterility can be maintained Avoid the Manual contact Avoid the Manual contact Not affected by Moisture Not affected by Moisture
DISADVANTAGE DISADVANTAGE
Costly PreparationCostly Preparation Volatile propellant cause discount to Volatile propellant cause discount to
skin.skin. Difficult formulation Difficult formulation
COMPONENTS OF COMPONENTS OF AEROSOLSAEROSOLS
PROPELLENT PROPELLENT – Propellant is responsible for developing Propellant is responsible for developing
the proper pressure within the container the proper pressure within the container and it expels the product when the valve and it expels the product when the valve is opened and aids in atomization or is opened and aids in atomization or foam production of the product.foam production of the product.
Chemical Name Chemical Name NumeriNumerical cal
DesignDesignation ation
Vapour pressance Vapour pressance pair pair
Boiling PolloBoiling Pollo Liquid Liquid Density Density
707000 13013000FF 00FF 00CC 7700FF
Trichloromono Trichloromono fluoromethane fluoromethane
1111 13.413.4 39.039.0 74.774.7 23.723.7 1.491.49
Dichloro Dichloro difluoromethanedifluoromethane
1212 84.984.9 196.0196.0 -21.6-21.6 -29.8-29.8 1.331.33
Dichloro tetrafluoro Dichloro tetrafluoro ethaneethane
114114 27.627.6 63.563.5 38.438.4 3.63.6 1.471.47
DifluoroethaneDifluoroethane 152a152a 76.476.4 191.0191.0 -11.2-11.2 -24.0-24.0 0.910.91
Butane Butane A-17A-17 31.631.6 82.082.0 31.131.1 -0.6-0.6 0.580.58
IsobutaneIsobutane A-31A-31 45.845.8 111.0111.0 10.910.9 -11.6-11.6 0.560.56
PropanePropane A-108A-108 122.8122.8 270.7270.7 -43.7-43.7 -44.6-44.6 0.500.50
PHYSICOCHEMICAL PROPERTIES PHYSICOCHEMICAL PROPERTIES OF FLUROCARBON AND OF FLUROCARBON AND
HYDROCARBONHYDROCARBON
PHYSICOCHEMICAL PRPERTIES OF PHYSICOCHEMICAL PRPERTIES OF FLUROCARBON AND HYDROCARBON FLUROCARBON AND HYDROCARBON
Containers Containers
A Metal A Metal 1.1. Tin plated sheet Tin plated sheet
2.2. Aluminum Aluminum
3.3. Stainless steel Stainless steel
B.B. Glass Glass 1.1. Uncoated glass Uncoated glass
2.2. Plastic coated glass Plastic coated glass
VALVES VALVES
1.1. Continuous spray valve Continuous spray valve - Mounting Cup Mounting Cup - Valve body or Housing Valve body or Housing - Stem Stem - Gasket Gasket - Spring Spring - Dip Tube Dip Tube
2.2. Metering valvesMetering valves
ACTUATORS ACTUATORS
- Spray Actuators Spray Actuators - Foam Actuators Foam Actuators - Solid Stream Actuators Solid Stream Actuators - Special Actuators Special Actuators - Metered dose inhaler Metered dose inhaler
FORMULATION OF FORMULATION OF PHARMACEUTICAL AEROSOLS PHARMACEUTICAL AEROSOLS
TYPES OF SYSTEM TYPES OF SYSTEM - Solution system Solution system - Water based system Water based system - Suspension or dispersion system Suspension or dispersion system - Foam system Foam system
- Aqueous stable foam Aqueous stable foam - Non-Aqueous stable foam Non-Aqueous stable foam - Quick Breaking Foam Quick Breaking Foam - Thermal foam Thermal foam
-- Intranasal foam Intranasal foam
STEBILITY TESTING OF STEBILITY TESTING OF PHARMACEUTICAL AIROSOLPHARMACEUTICAL AIROSOL
Concentration and Propellant Concentration and Propellant Container Container Valve Valve
MANUFACTURE MANUFACTURE Pressure Filling Apparatus Pressure Filling Apparatus Cold Filling Apparatus Cold Filling Apparatus Compressed Gas Filling Apparatus Compressed Gas Filling Apparatus
QUALITY CONTROL FOR QUALITY CONTROL FOR PHARMACEUTICAL AEROSOLS PHARMACEUTICAL AEROSOLS
Propellant Propellant Valve, Actuators, Dip tube Valve, Actuators, Dip tube Container Container Weight checking Weight checking Leak testing Leak testing Spray testingSpray testing
NEWER DEVELOPMENTS NEWER DEVELOPMENTS
At present there is much interest in At present there is much interest in developing MDI’s for a variety of developing MDI’s for a variety of conditions including asthma, conditions including asthma, diabetes, AIDs, Cancer, heart, many diabetes, AIDs, Cancer, heart, many of these compound have been of these compound have been developed by using biotechnology developed by using biotechnology process and their delivery to the process and their delivery to the respiratory system via MDI is an respiratory system via MDI is an extremely challenging undertaking.extremely challenging undertaking.
REFERENCEREFERENCE1.1. The theory and Practical of Industrial The theory and Practical of Industrial
Pharmacy, By L.Lachman, H.a.Liberman, Pharmacy, By L.Lachman, H.a.Liberman, J.L.Kaning. J.L.Kaning.
2.2. Remington : The Science and Practice of Remington : The Science and Practice of Pharmacy vol-I.Pharmacy vol-I.
3.3. Pharmaceutical Dosage Forms and Drug Pharmaceutical Dosage Forms and Drug Delivery System By: H.C. Ansel, L.V.Allen, Delivery System By: H.C. Ansel, L.V.Allen, NG Popovich. NG Popovich.
4.4. Pharmaceutics: The Science of Dosage Pharmaceutics: The Science of Dosage Form Design By : Michael E.Aulton. Form Design By : Michael E.Aulton.
5.5. Pharmaceutics I by: R.M.MehetaPharmaceutics I by: R.M.Meheta6.6. www.pharma.edu.comwww.pharma.edu.com
Thank You Thank You