7/28/2019 Adrenergic Receptors Chart
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Receptor Function Mechanism
11. cardiac contractility & conduction velocity2. Renin
release in kidney3. Lipolysis along with 3 in fat cells4. Amylase
secretion5. aqueous humor
cAMP
21. Relaxation of liver & skeletal muscle arterioles2. Some
cardiac stimulation3. Relaxation of coronary & cerebral blood
vessels4. Relaxation of bronchial smooth muscle5. Relaxation of
uterine smooth muscle6. skeletal muscle contractility7. mast cell
granule release8. glycogenolysis & gluconeogenesis in liver
cAMP
1on postsynaptic plasma membrane of effect cells
1. Constrict arterioles of skin, mucosa. Liver, skeletal and
abdominal viscera2. Contrict coronary & cerebral blood
vessels3. Constrict veins4. Constrict bronchial, intestinal &
urinary bladder sphincter, spleen capsule, uterine, seminal
tract & iris radial smooth muscle
5. K+ & H2O secretion in salivary gland & secretion in
pancreatic acinar cells6. Relaxation of intestinal wall smooth
muscle
PLC
(IP3 & DAG)
2on presynaptic neuronal membrane of nerve
terminal
1. Presynaptic inhibition of NE release (negative feedback) and
some reduction in BP at lowdose because high dose can constrict at
postjunction receptors and counteract the presynaptic
effect
2. Constriction arterioles of kidney, abdominal viscera &
veins3. Platelet aggregation4. secretion of insulin
cAMP
