ACTIVITY AND ESSENTIAL USES OF HERBAL DRUG IN LAL DANT

www.wjpps.com Vol 8, Issue 6, 2019.

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Bhatt et al. World Journal of Pharmacy and Pharmaceutical Sciences

ACTIVITY AND ESSENTIAL USES OF HERBAL DRUG IN LAL DANT

MANJAN PREPARATION-A SYSTEMATIC REVIEW

Pankaj Bhatt*, Piyush Pankaj and Abhishek Marwari

Vivek College of Technical Education, Dist. – Bijnor, U.P, India.

ABSTRACT

Ayurveda could be a science of life with a holistic approach to health

and personalized medication. It’s one in all the oldest medical systems

that contains thousands of medical ideas and hypothesis. Curiously,

piece of writing has ability to treat several chronic diseases like cancer,

diabetes, arthritis, and asthma, that square measure untreatable in

fashionable medication. Sadly, attributable to lack of scientific

validation in varied ideas, this precious gift from our ancestors is

trailing. Hence, evidence-based analysis is extremely required for

world recognition and acceptance of written material that wants

additional advancements within the analysis methodology. The current review highlights

varied fields of analysis together with literary, elementary, drug, pharmaceutical, and clinical

analysis in piece of writing. The review additional focuses to enhance the analysis

methodology for piece of writing with main stress on the elemental analysis. This try will

definitely encourage young analyzers to figure on numerous areas of research for the event

and promotion of written material.

KEYWORDS: Ayurveda, herbal drug, sonth, Lavanga, Haritaki, Pudina.

INTRODUCTION

Churna is characterized as a fine powder or medications in Ayurvedic arrangement of

pharmaceutical. Medications said in patha, are cleaned legitimately, dried altogether,

pummeled and after that sieved. The churna is free streaming and holds its power for one

year, if protected in water/air proof compartments. Thus there is a requirement for

institutionalization of home grown detailing as endorsed by WHO.[1]

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

SJIF Impact Factor 7.421

Volume 8, Issue 6, 663-674 Review Article ISSN 2278 – 4357

Article Received on

10 April 2019,

Revised on 01 May 2019,

Accepted on 22 May 2019,

DOI: 10.20959/wjpps20196-14013

*Corresponding Author

Pankaj Bhatt

Vivek College of Technical

Education, Dist. – Bijnor,

U.P, India.


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Ayurveda is a Sanskrit expression, made up of words "ayur" and "Veda". "Ayur" implies life

and "Veda" implies learning or science. Ayurveda is the conventional recuperating

methodology of the Vedic culture from India. It is said to be 2000 to 5000 years of age,

which means it has stood the trial of time. Ayurvedic medication sees wellbeing as

considerably more than nonattendance of malady. The insightful diviners and sages of the

time, naturally understanding the physiology and working of the mind-body-soul some time

before the approaches of present day drug, clarified the fundamental standards of

Ayurveda.[2]

Ayurvedic prescription was initially an oral custom instructed and passed straightforwardly

from instructor to disciple, who might learn and work next to each other. The most seasoned

composed codification of Ayurvedic standards is found in the Rigveda. The basics are then

laid out in a few noteworthy treatises, including the writings from Charaka, Sushruta, and

Vaghbhat. There are likewise various other littler works, composed after some time to The

excellence in the way these have been clarified is that they depend on fundamental standards

which can be connected for all intents and purposes in quickly and age. Clarify the different

branches of Ayurveda, which incorporate teaches, for example, general solution, pediatrics,

surgery, toxicology, fruitfulness, and revival.[3]

Pharmaceutical ayurvedic look into is gone for meeting the restorative needs of the populace

for whom proper helpful cures are not accessible or at those that are accessible are however

not powerful for different scatters. While addressing medicinal requirements of a polyherbal

plan set a few parameters to guarantee that the definition indicates wanted pharmacological

activity against different maladies. The choice of a fitting medication should consider

separated from restorative needs and inventive potential for progress.[4]

PLANT PROFILE

Haritaki Sonthi Kali Mircha


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Pippali Lavanga Kasni

Pudina Karpura Tejovati

Fig. 1: Structure of herbal drug.

HARITAKI[5,6]

Synonyms: - Harad, Chebulicmyrobalan, Halelaazard.

Biological Source: - It consists of dried small fruit of cultivated plant known as

Terminaliachebula.

Description:- The deciduous haritaki tree develops at a height of 1,800 meters. The long

applaud leaves are intense, in inverse combines around 10 to 20cm long. The blooms are dull

white with spikes and can be found toward the finish of the branches. The natural product is

hard and yellowish green in shading. Each organic product has a solitary seed that is light

yellow in color.

Phytochemical Constituents:-Its fruit constituents contain 24-32% of tannins, chebulic acid,

ellagic acid, gallic acid. Yellow oil comes from the kernel of the seed which is up to 36.4%.

Stem contain triterpenoid glycosidechebuloside I, II, leaves contains terflavins B, C, D,

punicalagin, punicalatin, maslinic acid, chebulinic acid. In addition 18 amino acid and small

amounts of phosphoric, succinic, quininc and shikimik acid, mucilage (Mukherjee, 2008,

Saroya, 2006).


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Gallic acid Chebulic acid

Medicinal Uses: Haritaki is used for relieving chronic constipation and gastric acidity. Fruits

are highly nutritive and used as laxative. Its powder is useful for treating obesity, liver

swelling, and diarrhea, internally in the treatment of chronic ulcers and wounds in stomatitis.

It is the chief ingredient of triphala.

SONTH[7,8]

Synonyms: Saunth, Ginger, Soonth.

Biological Source:-Ginger consists of the dried rhizomes of Zingiber officinale.

Family: - Zingiberaceae.

Description :-(i) General appearance: Sympodial branching, horizontal rhizome.

(ii) Size – Length 5-15 cm; width (height) 3 to 6 cm; thickness 0.5 to 1.5 cm.

(iii) Shape – Laterally flattened on the upper side with short flattened oblique, obviate

branches or fingers.

(iv) Surface – Longitudinally striated with occasional projecting fibers.

(v) Fracture – Short, starchy, fibrous.

(vi) Fractured surface – Show a narrow bark, a well-marked endodermis and a wide stele,

showing numerous scattered grayish points (fibro vascular bundles) and smaller yellowish

points (secretion cells).

(vi) Colour – Buff.

(vii) Odour – Agreeable and aromatic.

(viii) Taste – Agreeable and aromatic.

Chemical Constituents: Ginger contains 1 to 2% unstable oil. Unpredictable oil is in charge

of the sweet-smelling smell and comprises of zingiberene, sesquiterpenes, hydrocarbon

zingiberol, sesquiterpenes and besaabolene.

Gingirol is a yellow impactful slick fluid and yields gingirone a ketone and aliphatic

aldehyde. Shagaol is shaped by loss of water from gingerol. Shagaol and gingirone are less


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impactful. The sharpness of gingerol and ginger is demolished, when overflowed with 5%

potassium hydroxide or different alkalies.

Fig 2: Chemical structure of Sonth.

Uses

1. Ginger is stomachic, stimulant and sweet-smelling carminative.

2. It is utilized more as a zest.

3. Ginger oil is utilized as a part of mouth washes, ginger refreshments and alcohols.

4. It is utilized as Flavoring operator.

5. Ginger powder has been accounted for to be viable in movement infection.

BLACK PEPPER[1,9,10]

Synonyms:- Kalimirch; Golmirch.

Biological source:- Black pepper consist of the dried, fully developed unripe fruits of piper

nigrum L.

Family:- Piperaceae.

Description:- Black pepper consists of small dark brown or nearly black spherical fruits,

measuring about 5 mm. in diameter, with a more or less regularly and deeply reticulate,

wrinkled surface. At the apex the remains of the sessile stigmas can be traced; the base bears

a scar indicating the point of attachment to the rachis, but, the fruits being sessile, there is no

stalk.

If a fruit be cut in halves and examined with a lens, the pericarp will be seen to be thin and

dark and completely filled with a seed to which it is closely adherent. The seed is globular

and covered with a brown seed-coat. It contains a small endosperm, near the apex of the fruit,

in which the minute embryo is situated; but the major part of the seed is composed of

http://chestofbooks.com/health/materia-medica-drugs/Textbook-Materia-Medica/Section-IV-Seeds.html


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perisperm, which is yellowish and horny near the periphery, whitish, mealy, and frequently

hollow in the centre.

Both pericarp and seed have an aromatic Odour and pungent taste; they both contain oil-cells,

visible under the microscope.

The student should observe

(a) The nonappearance of stalk,

(b) The seed totally filling the pericarp and follower to it.

(c) The trademark Odor and taste,

(d) In white pepper the follower inward piece of the pericarp, with its fibro-vascular packs.

Chemical constituents:- Black pepper contains the alkaloids piperine, chavicine, piperidine

and piperetine. The trademark sweet-smelling Odor of pepper is because of the nearness of a

dry unstable oil (1-2.6%) in the cells of pericarp with contains phellandrene, caryophyllene,

piperonal, dihydrocarveol, caryophyllene oxide, crypton, alpha and beta pinenes,

epoxydihydro-caryophyllene, phenylacetic corrosive, and citronellol. Starch (45-63%) is the

overwhelming constituent of pepper. It likewise contains thiamine, riboflavin, nicotinic

corrosive, ascorbic corrosive and carotene.

Structure

Fig. 3: Chemical structure of black pepper.

Uses:- Black pepper is for the most part utilized for its trademark sensitive infiltrating

fragrance and impactful, severe taste. It is utilized as a sweet-smelling stimulant in cholera,

shortcoming following fevers, vertigo, unconsciousness, and so forth as a stomachic in

dyspepsia and fart, as an antiperiodic in malarial fever and as an option in paraplegia and

joint infections. Remotely it is esteemed for its rubefacient properties and as a nearby

application for loose sore throat, heaps and some skin infections.


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PEPPER LONGUM[11,12]

Synonyms:- Piplamul, Pippali.

Biological source:- The drug consist of transversely cut pieces of roots or underground stems

or of fruits of piper longum Linn.

Family:-Piperaceae.

Description:- It is having thin, sweet-smelling, enduring climber, with woody roots and

various wide applaud, cordate clears out. The inflorescence is a round and hollow,

pedunculate spike, the female bloom is up to 2.5 cm long and 4-5 mm in measurement

however the male blossom is bigger and slim. The organic products are little, ovoid berries,

sparkling blackish green, implanted in plump spikes.

Chemical constituents:- Both leafy foods have alkaloids like piperine, piperlonguminine,

piplartine and piperlongumine. Natural products likewise contain unpredictable oil, resin, a

waxy alkaloid N-isobutyl 2, 4-decadienamide, and sesamine. Alternate constituents of the

medication are triacontane, dihydrostigmasterol, diminishing sugar and glycosides.

Structure

Fig. 4: Chemical structure of Pepper Longum.

Uses:- Both piplamul and organic products are utilized for malady for respiratory track like

hack, bronchitis, asthma, cool, and so forth; as counter-aggravation and pain relieving when

connected locally for strong agony and irritation; inside as carminative, calming and general

tonic.

LAVANGA[13,14]

Synonyms:- Caryophylli; Clove buds; Clove flower; Lavang (Hindi); Laving (Guj).

Biological source:-It consists of the dried flower buds of Syzygium aromaticum.

Family:-Myrtaceae.


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Chemical constituents

1. Volatile oil (16-21%):- Phenol chiefly Eugenol (80-88), acetyl eugenol (10- 15%); α and β

-Caryophyllene.

2. Tannins (10-13%) – Pyrogallol tannins.

3. Other substances are methyl furfural and dimethyl furfural.

Fig. 5: Chemical structure of Lavanga

KASNI[10,15]

Synonyms:-- Chicory, Kasni, Hinduba

Botanical Source:- It is obtained from Whole plant of Cichorium intubus and C. endive.

Family:- Asteraceae.

Chemical Constituents:- Their seed contains oil. Roots has sticky substance which is around

7.5 %, glucose 1.1 %, unpleasant substance 4 %, fat 0.6 %, cellulose, insulin and pitches and

so forth cinder contains a greater amount of potassium. It likewise contains lackluster

potassium glycosides, cichorin and lactucina and intybin. There is extremely impossible to

miss notice when the root is simmered and is frequently utilized as coffee.

Uses:- It is kapha and pitta suppressant. It is relaxant and initiates rest. It goes about as

torment reliever and calming operator. It fills in as canapé, liver stimulant and expands

stomach related forces. It goes about as blood purifier and gives quality to heart. It is a

diuretic. Its underlying foundations decrease menstrual unsettling influences. It has great

impact in letting down the consuming sensations in the body. It likewise helps in bringing

down the circulatory strain. It diminishes the brought body temperature up in fevers.

Podina[10,16]

Synonyms:-Field Mint, Corn Mint, Japanese Mint, Podina.

Botanical Source:- It is obtained from the leaves of plant Mentha Arvensis.

Family:- Lamiaceae.


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Description: It is a fanned, wool plant. From the low, spreading, quadrangular stems that lie

close to the ground, the blossoming stems are every year hurled, 6 to 12 inches high. The

leaves, springing from the stems, in sets, are stalked, their layouts unreservedly toothed. The

upper leaves are littler than the lower, and the blooms are organized in rings (whorls) in their

axils. The blooms themselves are little separately, yet the delicacy of their shading and the

thick bunches in which they develop, give a significance altogether, as ring in the wake of

ring of the blooms frame in general an obvious head. The blooming season keeps going all

through August and September.

Chemical Constituents:- (+)- unpredictable oil, carvone, limonene, 1,8-cineole, trans-

carveol, linarin, pulegone, menthol, methane, menthenone.

Uses:- The whole plant is antibacterial, antifebrile. It yields a fundamental oil and menthol

which apply, through their quick vanishing, marginally soporific, and anodyne nearby

impact. It is powerful in migraine, rhinitis, hack sore throat, colic, and prurigo and retching.

Menthol acquired from this is utilized as a part of emollients. It is likewise utilized as

seasoning operator in culinary arrangements. It is notable as a heart tonic in pharmaceutical

arrangements. It is a decent blood chemical. Because of it is clean and hostile to bacterial

propert, it can be utilized as a part of swollen gums, mouthwash or mouth ulcers and

toothache.

CAMPHOR[17]

Synonyms:-camphor tree, camphor laurel, shiu leaf, gum camphor, laurel camphor.

Family:- Lauraceae.

Description:- The camphor tree is a thick broadleaved evergreen that is fit for growing 50-

150 ft (15.2-45.7 m) tall and spreading twice that wide with a trunk up to 15 ft (4.6 m) in

breadth, however the biggest U.S. examples are just a large portion of that size and those in

the Caribbean are considerably littler. The gleaming foliage is comprised of substitute 1-4 in

(2.5-10.2 cm) oval leaves dangling from long petioles. Each leaf has three particular

yellowish veins. The external edges of the leaves have a tendency to be to some degree wavy

and rotate toward the sky. The new foliage begins corroded burgundy shading, yet the leaves

soon turn dim green on the upper sides and paler green underneath. New branches rising up

out of the shallowly fissured grayish darker trunk are smooth and green. Twigs are generally


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green, yet might be tinged with red when youthful. The unnoticeable little cream shaded

blooms are borne in the spring on expanding 3 in (7.6 cm) blossom stalks. They are trailed by

huge products of organic product, included round pea estimated berries connected to the

branch lets by cuplike minimal green cones. The berries first turn ruddy and after that mature

to dark. Camphor tree can be promptly recognized by the particular scent of a smashed leaf.

Chemical Constituents:- The fundamental substance segments are a-pinene, camphene, b-

pinene, sabinene, phellandrene, limonene, 1,8-cineole, y-terpinene, p-cymene, terpinolene,

furfural, camphor, linalool, bornyl acetic acid derivation, terpinen-4-ol, caryophyllene,

borneol, piperitone, geraniol, safrole, cinnamaldehyde, methyl cinnamate and eugenol. The

dark colored and yellow camphor oil has a high safrole content, with yellow having between

10 - 20 % and the darker having 80%. These two oils are viewed as poisonous, and in

addition cancer-causing.

Uses:- Camphor oil can be utilized as a part of the treatment of anxious misery, skin break

out, aggravation, joint inflammation, strong a throbbing painfulness, sprains, ailment,

bronchitis, hacks, colds, fever, influenza and irresistible maladies. Since this oil can be

dangerous, it should not be utilized as a part of fragrance based treatment knead, however

could be utilized as a part of vapor treatment to ease respiratory issues. Now and again it can

likewise be utilized as a part of packs.

TEJOVATI[10,18]

Synonyms:- Tejphal(Hindi), Tejowati(Sanskrit), Mukthrubi (manipuri), Timur (Nepal).

Biological source:- It is obtained from the seeds of plant Zanthoxylum alatum.

Family: - Rutacea.

Description: - Various phytochemical constituents like alkaloids, Sterols, phenolic, lignins,

coumarins, terpenoids, flavonoids and their glycosides and benzenoids, unsaturated fats,

alkenic acids, amino acids have been confined from this plant. Unstable constituent's linalool,

limonene and methyl cinnamate are likewise found from seed.

Chemical constituents: -The bark, products of the soil of Z. armatum are widely utilized as a

part of indigenous arrangement of medication as a carminative, stomachic and anthelmintic.

The products of the soil are utilized as a sweet-smelling tonic in fever and dyspepsia. A


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concentrate of the natural products is accounted for to be viable in removing round worms.

As a result of their antiperspirant, disinfectant and germ-free properties, the organic products

are utilized as a part of dental inconveniences, and their salve for scabies.

Uses:- The bark, fruits and seeds of Z. armatum are extensively used in indigenous system of

medicine as a carminative, stomachic and anthelmintic. The fruit and seeds are employed as

an aromatic tonic in fever and dyspepsia. An extract of the fruits is reported to be effective in

expelling round worms. Because of their deodorant, disinfectant and antiseptic properties, the

fruits are used in dental troubles, and their lotion for scabies.

CONCLUSIONS

The outcome got would be utilized to set out an arrangement of new pharmacopoeial

guidelines for the readiness of hostile to diabetic churna to get ideal adequacy of the

prescription. In the present examination it was reasoned that the physicochemical parameters,

for example, the water-solvent, liquor dissolvable, and, dampness content, mass thickness,

tapped thickness, Carr's file, Hausner's proportion, pH, water-dissolvable powder, corrosive

insoluble fiery debris, and organoleptic qualities can be proficiently utilized for

institutionalization of poly-home grown definition. The outcomes acquired from the

investigation could be used as a source of perspective for setting limits for the reference

principles for the quality control and quality confirmation of these medications.

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3. Indian Pharmacopoeia, Ed, 2007; 3: 425.

4. Zack Sakhi Lorraine, The basic principal of Ayurveda, www.kimayaayurveda.com, 3, 5,

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6. Cown, Robin.”High Technology and the Economics of Standardization.”

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ACTIVITY AND ESSENTIAL USES OF HERBAL DRUG IN LAL DANT