Abstractbook_Reims2015

ABSTRACTBOOKReims, France 13 - 14 April 2015

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1st European Conference on Pharmaceutics Drug DeliveryReims, France 13 - 14 April 2015 3

Chairs and Committees

Chair of the ConferenceProf. Jrgen Siepmann, Lille, France

Co-Chairs of the Conference Prof. Franco Alhaique, Rome, ItalyProf. Jrg Breitkreutz, Dsseldorf, Germany

Programme Committee ChairProf. Jrg Breitkreutz, Dsseldorf, Germany

Programme CommitteeProf. Franco Alhaique, Rome, ItalyProf. Johannes Bartholomaeus, Aachen, GermanyProf. Jrg Breitkreutz, Dsseldorf, GermanyProf. Anna Maria Fadda, Cagliari, ItalyDr. Alexandre Gil, Montpellier, France

International Support PannelDr. Eva Roblegg, Graz, AustriaProf. Chris Vervaet, Ghent, BelgiumProf. Thomas Rades, Copenhagen, DenmarkProf. Leena Peltonen, Helsinki, FinlandProf. Marie-Christine Andry, Reims, FranceProf. Sandra Klein, Greifswald, GermanyDr. Gza Regdon Jr, Szeged, HungaryProf. Elka Touitou, Jerusalem, IsraelProf. Gaetano Giammona, Palermo, ItalyProf. Vitalis Briedis, Kaunas, LithuaniaProf. Malgorzata Sznitowska, Gdansk, PolandProf. Joao Pinto, Lisbon, PortugalProf. Julijana Kristl, Ljubljana, SloveniaProf. Maria Jos Alonso, Santiago de Compostela, SpainProf. Anette Larsson, Gothenburg, SwedenDr. Rainer Alex, Basel, SwitzerlandProf. Wim Hennik, Utrecht, The NetherlandsProf. Sema alis, Ankara, TurkeyProf. Yvonne Perrie, Birmingham, United Kingdom

1st European Conference on Pharmaceutics Drug Delivery4 Reims, France 13 - 14 April 2015

Social programme

Monday, 13 April 2015

17:00 Welcome reception at the Centre des Congrs Reims The Welcome Reception will be held in the exhibition halls of Centre des Congrs Reims (La Nef). Enjoy a glass of champagne while networking with old and new friends.

Opening hours: business office and registration desk

Monday 13 April 2015 07:00 to 20:00

Tuesday 14 April 2015 08:00 to 17:00

RECEPTION DESKHandicappedpersonsaccess

RECEPTION SPACE

MAIN ENTRANCE

PARC DE LAPATTE D'OIE

LUGGAGE ROOMSTORAGE

Access to undergroundcar park by lift

Access to undergroundcar park

Badge checkpoint& accessto building

Access to undergroundcar park by stairs

Acce

ss by lift

for h

andica

pped

persons

BOULEVARD MAURICE NOIROT

RIA

Coffeemachine

Lobby

Level 0 : R E C E P T I O N

0 1m 5m 10m 15m 20m12.10 - Centre des congrs de Reims



Amphithtre Royal

09:00 Opening Ceremony and APGI Student Award Jrg Breitkreutz, President of APV Franco Alhaique, President of A.D.R.I.T.E.L.F. Jrgen Siepmann, President of APGI Arnaud Robinet, Mayor of Reims

09:15 Plenary lecture Chair: F. Alhaique

Drug Targeting - Where are we? Patrick Couvreur, Chtenay-Malabry (Paris), France

10:15 Coffee break (La Nef) Poster session and industrial exhibition 10:45 Invited talks: Transdermal Drug Delivery Chairs: A. M. Fadda/H. Franke 10:45 Transdermal drug delivery: A Mature and Evolving Technology Richard Guy, University of Bath, Bath, United Kingdom 11:25 Transdermal Drug Delivery: An Industrial Viewpoint Michel Sournac, Pierre Fabre, Toulouse, France 12:05 The new Guideline on Quality of Transdermal Patches: New Requirements in Development Sean Jones, Medicine and Healthcare Products Regulatory Agency, London, United Kingdom 12:45 Lunch break (La Nef) Poster session and industrial exhibition

15:00 Invited talks: Oral Drug Delivery Chairs: D. Craig/S. Page 15:00 Recent Challenges in Oral Controlled-Release Drug Delivery Martin Lueck, Gruenenthal, Aachen, Germany 15:40 Therapeutic Index Issues around Oral Peptide Permeation Enhancers David Brayden, University of Dublin, Dublin, Ireland 16:20 Orodispersible Dosage Forms Dejan Djuric, Bayer, Berlin, Germany 17:00 End of session

17:00 Welcome Reception with Champagne Tasting in the exhibition area (La Nef)


Amphithtre Clovis 10:15 Coffee break (La Nef) Poster session and industrial exhibition 10:45 Short talks: Oral Controlled Drug Delivery Chairs: C. Caramella/P. Lefevre 10:45 How does the drinking volume affect gastric dissolution in infants? New in vitro approaches for preclinical screening E. Kersten and S. Klein 11:05 In-vitro dissolution testing of oral thin films (OTFs): theory and experiments A. Adrover, M. Casadei, S. Pacelli, P. Paolicelli, S. Petralito and R. Spera 11:25 Proposal for a new dissolution method for soft chewable delivery systems C. Stomberg, E. Melzer, J. Radtke and P. Kleinebudde 11:45 Assessing Softgel Disintegration in the Gastric Compartment: Correlating the Dynamic Gastric Model with In Vivo Visualization by Camera-Capsules H. Teles, K. van den Dries, S. Chessa, D. Bar-Shalom, H. Huatan, P. Sassene and A. Mllertz 12:05 Mucoadhesive polymeric nanocomposites for oral delivery of S-nitrosoglutathione W. Wu, C. Gaucher, I. Fries, X. Hu, Y. Xiao, p. Maincent and A. Sapin-Minet 12:25 Amphiphilic Nucleic Acid Conjugates for Local Treatment of Intestinal Diseases E. Moroz, S. Lee, H. Jahns, J. Hall, K. Yamada, M. Damha, B. Castagner and J. Leroux 12:45 Lunch break (La Nef) Poster session and industrial exhibition

15:00 Short talks: Nanoparticles & Vesicles Chairs: N. Dragicevic-Curic/C. Lemarchand 15:00 The effect of using different nebulisers on the delivery of Amphotericin B and Cisplatin Non-Ionic Surfactant Vesicles M. Puig, C. Carter and A. Mullen 15:20 Ex vivo and in vivo siRNA delivery to activated T cells as novel anti-inflammatory asthma therapy Y. Xie, N. Kim, A. Thakur, L. Lum, D. Bassett and O. Merkel 15:40 Chitosan-iron-based nanogels for the cellular delivery of polyphosphate drugs G. Giacalone, H. Hillaireau, A. Bochot and E. Fattal 16:00 Anti-E6/E7/MCL1 pegylated lipoplexes for a vaginal treatment of cervical cancer A. Lechanteur, T. Furst, B. Evrard, P. Delvenne, G. Piel and P. Hubert 16:20 Delivery of Andrographolide to the brain by human serum albumin nanoparticles M. Bergonzi, C. Guccione, V. Piazzini, A. Torracchi, C. Grossi, F. Casamenti and A. Bilia 16:40 Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: a comparative study E. Gilbert, L. Roussel and F. Pirot 17:00 End of session 17:00 Welcome Reception with Champagne Tasting in the exhibition area (La Nef)


Tuesday, 14 April 2015

Amphithtre Royal 09:00 Invited talks: Smart Drug Delivery Systems Chairs: T. Rades/J. Voorspoels 09:00 Progresses in Anticancer Drug Delivery by Polymer Conjugation Gianfranco Pasut, University of Padova, Padova, Italy 09:40 3D Printing Clive Roberts, University of Nottingham, Nottingham, United Kingdom 10:20 Smart Drug Delivery from an industrial perspective Paul Gellert, AstraZeneca, Macclesfield, United Kingdom 11:00 Coffee break (La Nef) Poster session and industrial exhibition 11:30 Plenary lecture Chair: J. Breitkreutz Advances in Pulmonary Drug Delivery Hartmut Derendorf, Gainesville, Florida, United States 12:30 Lunch break (La Nef) Poster session and industrial exhibition

15:00 Invited talks: Peptide and Protein Delivery Chairs: P. Matricardi/M. Lueck 15:00 Protein and Peptide Delivery: Current State of the Art Wim Hennink, University of Utrecht, Utrecht, The Netherlands 15:40 Challenges and advances in vaccine delivery Derek O Hagan, Novartis Vaccines and Diagnostics Inc., Cambridge, United States 16:20 Novel Application Systems for Transdermal Vaccine Delivery Heiko Spilgies, LTS Lohmann Therapie-System AG, Andernach, Germany 17:00 End of session

Amphithtre Clovis 09:00 Short talks: Advanced Drug Delivery Chairs: K. Andrieux/G. Verreck

09:00 Modifications of the stratum corneum barrier structure and function introduced by freezing: consequences for drug permeation studies L. Roussel, R. Abdayem, N. Zaman, E. Gilbert, F. Pirot and M. Haftek


09:20 IN VITRO PHAGE DISPLAY AS A STRATEGY TO ENHANCE THE SKIN PENETRATION OF HEPARINS S. Franz, C. Gennari, S. Pellegrino, F. Cilurzo and P. Minghetti 09:40 Hyaluronic acid gels containing liposomes for the sustained delivery of a corticoid to the inner ear N. El Kechai, F. Agnely, E. Mamelle, V. NIcolas, N. Huang, Y. Nguyen, E. Ferrary and A. Bochot 10:00 MESOPOROUS PHOSPHOLIPID PARTICLE AS A NOVEL DRUG DELIVERY PLATFORM K. Kawakami, S. Zhang, G. Jayakumar, M. Fukushima, J. Hill and K. Ariga 10:20 THALIDOMIDE NASAL POWDERS FOR LOCAL TREATMENT OF NOSE BLEEDING IN HEREDITARY HEMORRHAGIC TELANGECTASIA V. Chiapponi, A. Rossi, G. Colombo and P. Colombo 10:40 In vitro estimation of drug delivery to stenosed coronary blood vessels via drug-coated balloon catheters A. Seidlitz, W. Kempin, T. Reske, S. Kaule, N. Grabow, S. Petersen, S. Nagel and W. Weitschies 11:00 Coffee break (La Nef) Poster session and industrial exhibition 11:30 Plenary lecture (Amphithtre Royal) Chair: J. Breitkreutz Advances in Pulmonary Drug Delivery Hartmut Derendorf, Gainesville, Florida, United States 12:30 Lunch break (La Nef) Poster session and industrial exhibition

15:00 Short talks: Development & Manufacturing of Solid Dosage Forms Chairs: M. Repka/P. Gellert 15:00 Thermodynamics of API/Polymer Amorphous Formulations G. Sadowski 15:20 Hot-melt extrusion of polyvinyl alcohol and plasticizer for oral immediate release applications W. De Jaeghere, T. Monteyne, T. De Beer, J. Remon and C. Vervaet 15:40 Melt blowing and electrospinning for dissolution enhancement A. Balogh, B. Farkas, Z. Nagy, G. Marosi, I. Assche and G. Verreck 16:00 Exploring the Use of Pressurised Gyration for Large Scale Manufacture of Pharmaceutical Nanofibres B. Raimi-Abraham, S. Mahalingam, M. Edirisinghe and D. Craig 16:20 PAT tools for the control of the manufacturing processes of co-extruded implants, tablets and capsules F. Krier, A. Pestieau, G. Thoorens, T. Justine, D. Anas, T. Marion, M. Jrme, E. Ziemons, P. Hubert and B. Evrard 16:40 The Application of Novel nano-Thermal and Imaging Techniques for Monitoring the Drug Distribution within PLGA Microspheres M. Zhao, F. Yang, D. Chen, Z. Guo, Y. Zhang and D. Craig 17:00 End of session


Posters


PostersExhibited continuously from 9:00 to 20:00, with special sessions from 12:45 to 15:00. The number indicates the number displayed on the poster panel.

Advanced Drug Delivery Systems

1 Lipid-based formulations as a way to improve the solubilization of cinnarizineS. Siqueira, G. Kasten, T. Rades, H. Mu and A. Mllertz

2 A new RNA delivery platform for tumor immunotherapyH. Haas, K. Buch, I. Esparza, D. Fritz, M. Meng, L. Kranz, K. Reuter, M. Diken, S. Kreiter and U. Sahin

3 Anti-inflammatory properties of synbiotic loaded chitosan-Ca-alginate microparticles in animal model of colitisT. Petreska Ivanovska, Z. Zhivikj, M. Jurhar Pavlova, M. Glavas Dodov, T. Ristoski, I. Gjurovski, L. Petrushevska-Tozi and K. Mladenovska

4 Cationic lipid-free cationic nanoemulsions - a novel approach for the treatment of ophthalmic infectionsX. Li, N. A. Bou-Chacra, R. H. Mller and C. M. Keck

5 Charge reversal inulin-doxorubicin conjugate as tailor-made tool for cancer targeted therapyN. Mauro, C. Scialabba, M. Licciardi, G. Giammona, G. Adamo, S. Campora and G. Ghersi

6 Development and characterization of SEDDS containing babassu oil associated with copaiba oil for treatment of benign prostatic hyperplasiaL. Abreu, F. Carmo and L. Cabral

7 DEVELOPMENT AND CHARACTERIZATION OF SELF NANOEMULSIFYING SYSTEM (SNEDDs) FOR ROSUVASTATINH. Y. KARASULU, E. GUNDOGDU, T. TURGAY, S. APAYDIN, U. O. TURK, I. YILDIRIM SIMSIR, C. YILMAZ and E. KARASULU

8 Development of internally self-assembled lipid-based systems for vaccine deliveryL. Pires Rodrigues, K. Kyriakos, C. Papadakis, G. Winter and M. Hubert

9 Development of microsponges as drug delivery carriers using multivariate analysesM. Simonoska-Crcarevska, E. Mitanovksa-Janeva, N. Sibinovska, V. Komoni, N. Geskovski, S. Dimcevska, K. Mladenovska, R. Slaveska-Raicki, S. Trajkovic-Jolevska and M. Glavas-Dodov


10 Development of mucoadhesive drug delivery systems by precipitation of chitosan on drug-loaded microparticlesD. Preisig, M. Weingartner, F. J. Varum, R. Bravo, R. Alles, M. Puchkov and J. Huwyler

11 Does cinnarizine form amorphous complexes with lipids during digestion of lipid-based drug delivery systems?P. Sassene, M. Mosgaard, K. Lbmann, H. Mu, F. Larsen, T. Rades and A. Mllertz

12 Drug delivery in UTI treatment new perspectives by mimicking uropathogenic Escherichia coli cytoinvasionC. M. Pichl, C. Apfelthaler, B. Dunkl, B. Brauner, F. Gabor, M. Wirth and L. Neutsch

13 Drug-Loaded Silica for Oral FormulationsD. Lubda, R. Ognibene, G. Birk, M. Wagner, S. Kucera, F. Bauer and M. Zheng

14 Dry Coating for Taste-Masking of Bitter Drugs with Hydroxypropyl Cellulose PowdersH. Ichikawa, T. Andoh, Y. Fukumori, B. Ehlig, S. Kodama, S. Tsue and K. Sugisawa

15 Embedding of a poorly water-soluble drug in silica particle systems for the application in orodispersible filmsJ. H. Finke, S. Melzig and A. Kwade

16 FUSED DEPOSITION MODELING (FDM) FOR 3D PRINTING OF DRUG DELIVERY CAPSULESA. Melocchi, F. Parietti, G. Loreti, A. Maroni, L. Zema and A. Gazzaniga

17 Generation and characterization of small single domain antibodies inhibiting human TNF receptor 1.S. Steeland, L. Puimge, R. Vandenbroucke, F. Van Hauwermeiren, J. Haustraete, N. Devoogdt, D. Laukens, P. Meuleman, M. Devos and C. Libert

18 How to Easily Provide Zero Order Release of Freely Soluble Drugs from Coated PelletsB. Dekyndt, J. Verin, C. Neut, F. Siepmann and J. Siepmann

19 Improving the delivery of vaginal dosage formsH. STRAUB and D. CADE

20 In situ Gel Formulation for Intravesical Gemcitabine Hydrochloride InstallationS. Y. Karavana, Z. Ay Senyigit, . aliskan and E. Baloglu

21 In situ liposomes from novel pre-liposome tablets for vaginal drug deliveryZ. Vanic, N. Skalko-Basnet and I. Tho

22 Influence of size and protein concentration on the cross-linking degree of serum albumin microcapsulesF. Deshayes, E. Charpentier, E. Bourguet and F. Edwards-Lvy

23 Influence of the Ester Group Structure of Modified Alginates on the Preparation of Microparticles by Transacylation with Serum AlbuminI. HADEF, M. OMRI, C. BLIARD, B. ROGE and F. EDWARDS-LEVY

24 Interaction studies of Memantine loaded biodegradable polymeric nanoparticlesM. A. Egea, E. Snchez, M. Espina, N. Carmona, G. Ramos, A. C. Calpena and M. L. Garca

25 Lipid self-assembled structures as carriers for antimicrobial peptidesL. Boge, H. Bysell, L. Ringstad and M. Andersson


26 Lyophilized microemulsions: the influence of heating on the droplet size and phase transitionA. Rochelle do Vale Morais

27 Microcontainers improve oral bioavailability of furosemideL. Hagner Nielsen, A. Melero, S. Sylvest Keller, A. Mllertz and A. Boisen

28 Mucoadhesion of thiolated poly(aspartic acid) polymers for ophthalmic useG. Horvt, B. Gyarmati, B. Szilgyi, T. Csihi, G. Sandri, M. C. Bonferoni, C. Caramella, A. Szilgyi, E. Csnyi and M. Budai-Szucs

29 Nanotubes-in-Microgel Oral System (NiMOS) by prilling for Protein DeliveryJ. K. de Kruif, G. Ledergerber, C. Garofalo and M. Kuentz

30 New Two Piece Enteric Drug Delivery Capsules: Human gamma-scintigraphy and pharmacokinetic evaluationA. Sivert, P. Dfossez, M. Clauzel, D. Nombret, D. Cad and H. Benameur

31 Phosphorous dendrimers siRNA complexes for treatment of chronic inflammationA. Bohr, N. Tsapis, A. Chamarat, J.-P. Majoral, C. Foged and E. Fattal

32 PLATELET LYSATE EMBEDDED SCAFFOLD FOR WOUND HEALING: IN VITRO AND PRELIMINARY IN VIVO CHARACTERIZATIONG. Sandri, F. Saporito, M. C. Bonferoni, S. Rossi, F. Ferrari, M. Mori, I. Liakos, C. Boselli, A. Invernizzi and C. Caramella

33 PREPARATION OF MODIFIED RELEASE DRUG LOADED HPMC-AS MATRIX MICROPARTICLES SUITABLE FOR PRECLINICAL DELIVERYS. Sood, C. Freire and M. Saunders

34 Redox-responsive mesoporous silica as carriers for controlled drug deliveryY. Wang, Q. Zhao, Y. Gao, B. Hou, J. Zhang and S. Wang

35 Serum Albumin-Alginate Microparticles Prepared by Transacylation: Effect of Polymer Interfacial InteractionsI. HADEF, B. ROGE and F. EDWARDS-LEVY

36 Serum Albumin-Alginate Microparticles Prepared by Transacylation: Physicochemical and Structural PropertiesI. HADEF, B. ROGE and F. EDWARDS-LEVY

37 Smart ruthenium nanodrugs for tumor targeted delivery: a new approach to fight cancerA. Valente, M. H. Garcia, F. Marques, A. Matos and P. Zinck

38 SmartCrystals - stability in dermal hydrogels and creamsX. Li, X. Zhai, R. H. Mller and C. M. Keck

39 SOLVENT FREE APPROACH FOR ENHANCEMENT OF DRUG SOLUBILITY USING MESOPOROUS SILICAF. Monsuur, Y. Choudhari and W. McCarthy

40 Synthesis and Characterization of Poly(-Caprolactone)- vitamin E TPGS Copolymers for Potential Applications in Drug DeliveryZ. Binkhathlan


41 Targeted Poly-(L)-glutamic acid drug delivery systems for intravesical therapy of non-muscle invasive bladder cancerC. Apfelthaler, C. M. Pichl, P. Gassenbauer, F. Gabor and M. Wirth

42 The drug-initiated method: a convenient approach for the synthesis of efficient polymer prodrug nanoparticlesD. T. Bui, S. Harrisson, A. Maksimenko, P. Couvreur and J. Nicolas

Controlled Drug Delivery

43 A Mechanistic Model for Drug Release Using Spherical Particles Made of PLGAK. SEVIM and J. PAN

44 CHARACTERIZATION OF SUPRAMOLECULAR SYSTEMS CONTAINING FENBUFEN, PLURONIC AND CYCLODEXTRINSA. Figueiras, S. Nunes, S. Simes, A. Pais and F. Veiga

45 Controlled release from drug/Eudragits delivery systemsY. Ji, M. Lemberg, A. Prudic and R. Paus

46 Controlled Release Implants prepared by compression of spray-dried PLGA/water-soluble polymer microparticlesM. Hamoudi, R. Pattacholi, C. Debraize and J. Siepmann

47 Controlled release of quercetin encapsulated in biopolymer films modulated by electron beam irradiationN. Benbettaieb, T. Karbowiak, A. Assifaoui, F. Debeaufort and O. Chambin

48 Core shell coated chitosan microspheres at low pH durability for controlled drug releaseM. nal

49 Development of novel formulations for organoboron drugs by association to anionic claysS. Sn, S. Bgu, C. Gervais and D. Laurencin

50 Drug release from PEO-hot melt extrudates: impact of the drug loadingO. Cantin, F. Siepmann, F. Dande, Y. Karrout and J. Siepmann

51 Factors Shaping the Release Profile from Film Coated Pellets Controlling Drug Release Through CracksS. Muschert, F. Siepmann, Y. Rosiaux, A. Axelsson and J. Siepmann

52 Hot Melt Extrusion can Provide More Robust Drug Release from PEO Matrices than Direct CompressionO. Cantin, F. Siepmann, Y. Karrout and J. Siepmann

53 Importance of Diffusion and Limited Drug Solubility in Silicone Matrices for Cochlear ImplantsM. Gehrke, J. Sircoglou, C. Vincent, J. Siepmann and F. Siepmann

54 In vitro accelerated drug release from parenteral levonorgestrel butanoate suspensionsK. Tietz, D. Friend and S. Klein


55 Influence of controlling agent and fillers on acetylsalicylic acid release kinetics from matrix tabletsJ. Conceio, S. Fernandes, P. Costa and J. M. Sousa Lobo

56 INFLUENCE OF POLYMERIC COMPOSITION IN BENZNIDAZOLE RELEASE FROM MODULAR ASSEMBLED FLOATING DELIVERY SYSTEMA. C. Melo-Miranda, M. A. Segatto-Silva, P. Colombo and A. Rossi

57 Novel polymeric carriers for the sustained release of an antipsychotic drugD. Bikiaris, P. Siafaka, M. Lazaridou, C. Koulouktsi, G. Papageorgiou, E. Koutris and E. Karavas

58 Release Study and Anti-inflammatory Activity of Pentacyclic TriterpenesH. L. Alvarado Bonilla, G. Abrego Escobar, A. Parra Coca, L. E. Sosa Diaz, M. L. Garduo Ramirez, B. Clares Naveros, A. C. Calpena Campmany and M. L. Garcia Lopez

59 Slow-release drug-loaded mini-tablets for ocular use: effect of polymer particle size on formulation behaviourA. S. Mohmad Sabere, S. Barker and D. Craig

60 Sustained Release Formulations for a New Broad-Spectrum Antibacterial Agent against ColitisM. S. Nieto Bobadilla, F. Siepmann, M. Djouina, L. Dubuquoy, J. Siepmann, L. Dubreuil and C. Neut

61 Synthesis and characterization of S-nitrosoglutathione-alginate as an NO donorS. U. SHAH, M. SOCHA and S. GIBAUD

62 Why increasing drug loadings might lead to faster drug release from Kollicoat SR coated pelletsJ. Fahier, C. Velghe, S. Muschert, G. Byrne, F. Siepmann and J. Siepmann

63 Why sugar cores might lead to slower drug release from coated pellets compared to MCC coresJ. Fahier, C. Velghe, S. Muschert, G. Byrne, F. Siepmann and J. Siepmann

Oral Delivery

64 An investigation of interaction between ibuprofen and modified diatomite: potential drug carrierJ. Janicijevic, D. Krajinik, B. ?alija, V. Dobricic and J. Milic

65 Development of a Bioequivalent Montelukast 5mg Zydis Dosage FormA. Cusack and L. Grother

66 Development of a coated ODT nutraceutical formulationJ. CAMARGO, G. WEISS, G. LE BIHAN and P. LEFEVRE

67 Effect of curcumin encapsulation in whey protein-pectin beads upon their properties with intestinal mediumB. Fernandez, T. A. Nguyen, Y. Wach, M. Subirade, I. Fliss and O. Chambin

68 Effect of digestion on absorption of halofantrine from SNEDDS and super-SNEDDSin a rat modelM. H. Michaelsen, K. Wasan, T. Rades and A. Mllertz


69 Encapsulation of anthocyanins from purple corn cob by spray drying and release studies of encapsulated powderN. Kapcum, J. Uriyapongson, M. Meenune, G. Roudaut and O. Chambin

70 Evaluating different manufacturing options to formulate loperamide HCl as orally disintegrating tabletT. Agnese and T. Cech

71 Evaluating poly(vinyl acetate) as taste masking agent for paracetamol formulated in chewable tabletsF. Bang, T. Cech and M. Mistry

72 Evaluating various disintegrants regarding their performance in orally disintegrating tablet formulationsT. Agnese, F. Bang, T. Cech and M. Mistry

73 Evaluating various wet binders to gain lactose based agglomerates applicable for orally disintegrating tablet formulationsT. Agnese, T. Cech and M. Mistry

74 Examination of the behaviour of hydroxypropyl cellulose free films with lidocaine base for oral use with thermal analysis methodG. Regdon, jr., M. Gottnek and K. Pintye-Hdi

75 Experimental design of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholineT. T. Tran, T. Rades and A. Mllertz

76 HOT MELT EXTRUSION TECHNOLOGY (HME): DISSOLUTION RATE ENHANCEMENT OF RITONAVIR IN GASTRIC pH WITH EUDRAGIT EPOD. Jaiswar, P. Amin, M. Seervi, D. Sarvaiya, H. Kundaikar and A. Gangurde

77 Hydroxypropyl methyl cellulose based Efavirenz Solid Dispersions by Hot Melt Extrusion and Spray drying Technique: Physical Characterization and Insilico studyS. Javeer, H. Kundaikar, A. Gangurde, J. Pawar, M. Degani and P. Amin

78 Ibuprofen self-emulsifying pellets prepared with colloidal silicon dioxide/microcrystalline cellulose and triglyceridesA. PANAGOPOULOU, K. MAVRIDOU, T. AVGERINOS and I. NIKOLAKAKIS

79 Influence of Artificial Saliva on Taste Masking StudiesM. Khaydukova, L. I. Immohr, D. Kirsanov, A. Legin and M. Pein

80 Influence of pore former and sintering temperature on the mechanical properties of hydroxyapatite tabletsK. Kachrimanis, N. Kantiranis, C. Grammenos and I. Nikolakakis

81 Low density floating matrix tablets prepared by hot melt extrusionW. Kriangkrai, S. Puttipipatkhachorn, P. Sriamornsak, F. Siepmann, J. Siepmann and S. Sungthongjeen

82 MESOPOROUS SILICA GEL AS FORMULATION AID FOR MOISTURE SENSITIVE DRUG/EXCIPIENTF. Monsuur, Y. Choudhari and W. McCarthy


83 Milk protein-pectin beads a novel means for curcumin encapsulationT. A. Nguyen, T. U. Huynh, P. Winckler, Y. Wach, M. Subirade and O. Chambin

84 Mucoadhesive films for treatment of oral infections containing vermiculite/chlorhexidine nanocompositesJ. Gajdziok, H. Landov, P. Doleel and D. Vetch

85 New Enteric Coating Method with AQOAT (HPMCAS)V. Henner, A. Sauer and S. Kikuchi

86 Novel fenofibrate-gelatin microcapsules with improved solubility and excellent flow property: preparation, physicochemical characterization and pharmacokinetic evaluationA. Yousaf, D. W. Kim, T. Ramasamy, O. Mustapha, F. Din, J. O. Kim, C. S. Yong and H.-G. Choi

87 Overcome the Color Stability Issue Exhibited by Indigo Carmine: AquariusTM Preferred HSP Film Coating SystemT. Tuglu, N. Ekmekciyan, E. Stoyanov and S. Porter

88 Overcoming Disintegration Challenges in an Oral Biologic Tablet FormulationA. Balasundaram, J. Sutch and K. Van den Dries

89 Preparation of Fast Dissolving Drug-Loaded Sucrose Fibers using a Cotton-Candy Floss MachineS. Marano, D. Craig, S. Barker, B. T. Raimi-Abraham, S. Missaghi and A. Rajabi-Siahboomi

90 Preparation of lysozyme enzyme containing orally disintegrating tabletsI. Olh, J. Lasher, G. Baki, A. Kenneth, T. Sovny, K. Pintye-Hdi and G. Regdon Jr

91 Process integration for the improved production of nanoparticle-loaded orodispersible filmsD. Steiner, J. H. Finke and A. Kwade

92 Protein distribution in solid lipid microparticles visualized using coherent anti-Stokes Raman scatteringP. C. Christophersen, D. Birch, J. Saarinen, A. Isomki, H. M. Nielsen, M. Yang, C. J. Strachan and H. Mu

93 Quality by Design (QbD) approach to optimize the disintegration time of enteric coated capsulesT. Dassinger, N. Hauschildt and T. Kuntz

94 QUATERNARY POLYMETHACRYLATE - ALGINATE COATED TABLETS: EFFECT OF ALGINATE BLOCK STRUCTURE ANG CURING ON DRUG RELEASET. Pongjanyakul, R. Khlibsuwan and N. Khuathan

95 Simple Process Changes to Overcome Reduced Dissolution of Agglomerating Micronized APIJ. Sutch, A. Balasundaram and K. van den Dries

96 SPRAY-DRIED CHITOSAN-MAGNESIUM ALUMINUM SILICATE COMPOSITE TABLETS: EFFECT OF CHITOSAN MOLECULAR WEIGHTR. Khlibsuwan and T. Pongjanyakul


97 STUDIES ON DISSOLUTION RATE ENHANCEMENT, PHYSICOCHEMICAL CHARACTERIZATION, AND IN-SILICO MOLECULAR MODELLING OF ARTEMETHER USING HYDROPHILIC CARRIERS.J. PAWAR, R. SHETE, H. KUNDAIKAR, S. JAVEER, A. GANGURDE, M. DEGANI and P. AMIN

98 Study of the relationships among mechanical and texture properties of mucoadhesive oral films using multivariate data analysisD. Vetch, J. Gajdziok, P. Doleel and H. Landov

99 The influence of polysaccharide carrier on solid SMEDDS characteristics and on dissolution profile of naproxenM. Gaperlin, K. Cerpnjak, F. Vrecer and A. Zvonar

100 The role of different salts in drug release from -carrageenan matricesS. De Robertis, L. Elviri and R. Bettini

101 Type III lipid-based formulations design for oral delivery of acyclovirJ. Jankovic, L. Djekic and M. Primorac

102 Type III lipid-based formulations for oral delivery of high-dosage drugs: design and in vitro evaluationL. Djekic, J. Jankovic and M. Primorac

103 Understanding the formation of co-amorphous drug-amino acid formulationsK. Tarp Jensen, K. Lbmann, H. Grohganz and T. Rades

104 D/A Model to Evaluate Absorption Effects from a Transient Supersaturated StateR. Berthelsen, A. L. Slot and A. Mllertz

Pulmonary Delivery

105 A framework for a Biopharmaceutical Classification of Antibiotics for Pulmonary DeliveryS. M. Marchand, J. Brillault, N. Grgoire, I. Lamarche, P. Gobin and W. Couet

106 Aerodynamic and structural evaluation of microcomposites containing meloxicam potassiumR. Ambrus, A. Chvatal, A. Pomzi and P. Szab-Rvsz

107 Ciprofloxacin-loaded mineral calcium-hyaluronan composite microparticles to treat chronic bacterial lung infectionF. Tewes, J. Brillault, B. Lamy, P. OConnell, J.-C. Olivier, W. Couet and A. M. Healy

108 Compared toxicity of lung delivered nanoparticles, biodegradable or not: in vitro and in vivo studiesH. Hillaireau, N. Grabowski, L. A. Santiago and E. Fattal

109 Construction of amikacin dry powders for inhalation by a Central Composite DesignS. Belotti, A. Rossi, P. Colombo, R. Bettini, D. Rekkas, S. Politis, G. Colombo, A. G. Balducci and F. Buttini

110 CYCLODEXTRINS INHALATION PREVENTS ALLERGEN-INDUCED INFLAMMATION AND AIRWAY HYPERRESPONSIVENESS ASSOCIATED WITH ASTHMAG. Dufour, N. Rocks, S. Ormenese, C. Leonard, M.-P. Mingeot-Leclercq, D. Cataldo and B. Evrard


111 Development of dry powder carrier systems for pulmonary applicationR. Ambrus, B. Szab and P. Szab-Rvsz

112 Development of Theophylline Effervescent Powder for Pulmonary Drug DeliveryJ. Napaporn, T. Seetawun, P. Tarnsuwan and W. Junkheiw

113 Effect of polymeric nanoparticles on the stability of biomimetic models of the lungs surfactantW. Daear, P. Lai, M. Anikovskiy and E. J. Prenner

114 FORMULATION AND CHARACTERIZATION OF ANTIBIOTIC AND MUCOLYTIC CONTAINING DRY POWDER INHALER FORMULATIONSY. Akdag Cayli, S. Sahin, I. Vural and L. Oner

115 Formulation of levofloxacin-loaded chitosan microspheres for pulmonary deliveryM. Da Costa Gaspar, A. Pais, J. Sousa, F. Tewes and J.-C. Olivier

116 Inhaled SLM for anti-TB therapy by DPI device: process parameters affecting freeze-drying and breathabilityE. Maretti, E. Porcheddu, E. Imbuluzqueta, A. G. Balducci, F. Buttini, F. Sacchetti, M. Romagnoli, E. Leo and V. Iannuccelli

117 Lecithin/TPGS-based spray-dried SMEDDS for lung cancer: in vitro pulmonary deposition and cytotoxicityR. Ishak and R. Osman

118 Microencapsulated rifabutin-loaded lipid nanoparticles for inhaled therapyD. Gaspar, P. Taboada, A. Almeida and C. Remun-Lpez

119 Nanomicelle-based dry powders for inhalation for targeted delivery to lung cancer cells: in vitro evaluation and in vivo local pulmonary tolerance on healthy miceR. Rosire, M. Van Woensel, I. Langer, V. Mathieu, K. Amighi and N. Wauthoz

120 Nebulization characteristics of surface modified liposomes optimized for pulmonary drug deliveryB. Lehofer, P. P. Jain, F. Bloder, R. Leber, L. M. Marsh, H. Olschewski, A. Olschewski and R. Prassl

121 Polyaspartamide based microparticles for Tobramycin delivery to the lung in FC therapyC. Sardo, M. Licciardi, E. G. Di Domenico, D. De Rocco, P. Del Porto, F. Ascenzioni, G. Giammona and G. Cavallaro

122 Polymeric micelles based on a polyaspartamide copolymer for pulmonary delivery of beclomethasone dipropionateD. Triolo, C. Sardo, E. F. Craparo, G. Giammona and G. Cavallaro

123 Rifabutin-loaded solid lipid nanoparticles for pulmonary deliveryD. Gaspar, V. Faria, L. Gonalves, C. Remun-Lpez and A. Almeida

Dermal preparations

124 Application of factorial design methodology in transdermal absorption: optimization of skin absorption from cosmetic/pharmaceutical formulationsF. Laredj and M. Salmon


125 Azithromycin smartCrystals for prevention of infections by tick bitesN. Jin, S. Staufenbiel, C. M. Keck and R. H. Mller

126 Characterization and Ex-Vivo Permeation Studies of Melatonin-Incorporated Elastic NiosomesG. Arslan Azizoglu, S. Tuncay Tanriverdi and . zer

127 Confocal Raman Microscopic (CRM) methodology for the analysis of the penetration of pharmaceutical actives into the skinD. Lunter

128 Development of sulphur-salicylic gel systems as new bioactive formulations for the topical treatment of acne vulgarisR. Langasco, G. Spada, S. T. Tanriverdi, O. Ozer, P. Giunchedi and E. Gavini

129 Development, Characterization and Skin Delivery Studies of Related Ultradeformable Vesicles: Transfersomes, Ethosomes and TransethosomesA. Ascenco, S. Raposo, C. Baptista, P. Cardoso, T. Mendes, F. Praa, M. Bentley and S. Simes

130 Employing Pickering emulsions as carrier system for retinol palmitate and -tocopherol acetateJ. Schfer, T. Agnese, T. Cech and T. Schmeller

131 Enhanced Delivery of Actives to Skin with Silicone TechnologiesM. EEMAN, H. ALIYAR, M. LE MEUR and X. THOMAS

132 Glycolic acid in alkyl polyglucosed based vehicleM. Lukic, T. Isailovic, I. Pantelic, R. Daniels and S. Savic

133 Improved Treatment of Atopic Dermatitis with Corticosteroid Loaded LiposomesI. Eroglu, E. Azizoglu, M. zyazici, M. Nenni, H. Grer Orhan, S. zbal, I. Tekmen, I. Ertam, I. nal and . zer

134 In-vitro study of imiquimod skin retentionS. Nicoli, I. Tel, C. Padula and P. Santi

135 Investigating the impact of phosphate buffer on the gelF. Bang, T. Cech and F. Soergel

136 Investigation of physico-chemical characteristics of W/O liquid emulsion with high hydrating effectB. Vucelic, J. Bjeletic, N. Dragicevic-Curic and M. Bajcic

137 Microencapsulated haiir dyes: safety and efficacyM. Centini, E. Hanno, F. Francescon and C. Anselmi

138 Nanoemulsion with clotrimazole - design and optimalization the mean droplet size using high pressure homogenizerK. Sosnowska, E. Szymanska and K. Winnicka

139 Nanosuspensions improve diclofenac dermal deliveryR. Pireddu, F. Lai, C. Sinico, F. Marongiu, G. Ennas and A. M. Fadda


140 PLATELET LYSATE AND MANUKA HONEY COMPONENTS LOADED IN PECTIN PARTICLES FOR THE TREATMENT OF CHRONIC SKIN ULCERSM. Tenci, S. Rossi, F. Ferrari, M. Daglia, A. Di Lorenzo, M. C. Bonferoni, G. Sandri, M. Mori, C. Boselli and C. Caramella

141 Pluronic F127 micellar carriers for topical acne treatmentS. Gngr

142 Preparation and characterization of topical hydrogel containing nanonized papaverine hydrochlorideS. Berk, R. Ambrus, G. Dek, P. Szab-Rvsz, L. Pajor and E. Csnyi

143 PREPARATION AND EVALUATION OF COLLAGEN-LAMININ DERMAL MATRIX IMPREGNATED WTH RESVERATROL MICROPARTICLESE. H. GOKCE, I. EROGLU, N. TSAPIS, S. TUNCAY-TANRIVERDI, G. GOKCE, E. FATTAL and O. OZER

144 Preparation, characterization and long-term stability evaluation of O/W cream containing coenzyme Q10-loaded nanoemulsion in galenical laboratory conditionsN. Dragicevic-Curic, J. Bjeletic, B. Vucelic and M. Bajcic

145 Quercetin smartCrystals: production, antioxidant activity, and physical stability in nonionic gelsT. Hatahet, M. Morille, A. Hommoss, R. Muller and S. Bgu

146 Release profile and antioxidant activity evaluation of a topical gel enriched with bioactive extract from grape pomaceM. Allegro, J. Marto, C. Montoya, N. Oliveira, S. Gonalves, A. Paiva, S. Barreiros, P. Simes, L. Gonalves and H. Ribeiro

147 Silicone Pressure Sensitive Adhesive as a topical creamM. Le Meur, L. Marteaux, F. Galeone, X. Thomas, H. Aliyar, L. Maes and M. Eeman

148 SKIN ADAPTED AGAR DIFFUSION ANTIBIOGRAM AS IN-VITRO PHARMACODYNAMIC EQUIVALENCE MODELM. Sacha, A. Fargier and E. Haltner

149 smartPearls/SYLOID 3D - superior generation of dermal delivery systems based on amorphous actives/drugsR. H. Mller, F. Monsuur, H. H. Hfer and C. M. Keck

150 Starch nanocapsules as potential carriers for topical delivery of hydrophobic drugsJ. Marto, L. Gouveia, L. Gonalves, E. Oliveira, H. Ribeiro and A. Almeida

151 Starch-based Pickering emulsions containing a hydrophilic drug for topical application: a quality by design approachJ. Marto, L. Gouveia, I. Jorge, L. Gonalves, E. Oliveira, A. Almeida and H. Ribeiro

152 STUDY OF HUMAN SKIN BIOMECHANICAL PROPERTIES AFTER TOPICAL APPLICATION OF AN ANTIFUNGAL NANOSTRUCTURED EMULSIONC. Caadas, J. Suer, M. Mallandrich, L. Halbaut, A. M. del Pozo and A. C. Calpena

153 Sucrose esters and polysorbate 80 as co-emulsifiers in development of nanoemulsions for improved aceclofenac skin deliveryT. Isailovic, S. Dordevic, M. Lukic, I. Pantelic, D. Randelovic, B. Markovic and S. Savic


154 The effect of PAMAM-NH2 G2 and G3 on physicochemical properties of hydrogels with erythromycinK. Winnicka, M. Wroblewska and K. Sosnowska

Physical Pharmacy

155 Amorphous Recrystallisation to the Hydrated State: Correlation between Predictive Thermodynamic Approaches and Real-Time Stability StudiesM. d. F. Pina, J. Pinto, J. Sousa, D. Craig and M. Zhao

156 Cerebroprotection of S-nitrosoglutathione-loaded in situ forming microparticles against thromboembolic strokeM. Parent, F. Dupuis, J. Perrin, C. Vigneron, N. Violle, J.-F. Bisson, I. Lartaud and A. Boudier

157 Processing induced lactose polymorphismA. Della Bella, M. Muller, L. Soldati and R. Bettini

158 Sustained-release formulations of monoclonal antibody for subcutaneous delivery: pK study in ratsS. Marquette, A. Yates, L. Denis, I. Langer, K. Amighi and J. Goole

159 The use of a low glass transition temperature polymer allows in situ formation of solid dispersionsM. Doreth, K. Lbmann, H. Grohganz, R. Holm, H. Lopez de Diego, A. Mllertz, T. Rades and P. Priemel

160 Tobramycin solid-state investigationD. Frascio, E. Salomi, F. Martinelli, M. Di Cuia, A. G. Balducci, P. Colombo, F. Buttini and R. Bettini

161 Towards the fabrication of electrospun fibers for controlled drug release: controlling the release kinetics by overcoming drug crystal formationS. Seif and M. Windbergs

Preformulation

162 Influence of excipients on solvent-mediated hydrate formation of piroxicam studied by dynamic imagingW. Kirchmeyer, N. Wyttenbach, J. Alsenz and M. Kuentz

163 Adjusting the particle sizes of solid lipid microparticle dispersions for various drug delivery applicationsA. Lauterbach and C. C. Mller-Goymann

164 Assessment of drug-stabilizer interactions by contact angle and surface plasmon resonance measurementsT. Viitala, S. Langeraert, A. Kartal.Hodzic, C. Vervaet, J. Hirvonen and L. Peltonen

165 Benefits of hypromellose capsules Vs. hard gelatin capsules to improve stability hydroxy-acids based formulation: ascorbic acid case studyF. Maron

166 DEVELOPMENT AND CHARACTERIZATION OF A NEW RECTAL FORMJ. BOUYSSOU, L. GRISLAIN, P. GUEROULT, D. LARROUTURE, G. LEMAGNEN and E. VIOLET


167 Dissolution behavior of crystalline and quench cooled carbamazepine in biorelevant gastric and intestinal mediaL. Jensen, P. Priemel, F. Skautrup, A. Mllertz and T. Rades

168 DSC studies on water effusion as a complementary tool for drug release investigationsB. Bellich, M. Borgogna and A. Cesro

169 Effect of polymers on the stability of anhydrous olanzapine during processingM. Paisana, M. A. Wahl and J. F. Pinto

170 Alkylamine Template Based Hexagonal Mesoporous Silica (HMS) For Dissolution Enhancement Of fenofibrateN. Jadhav and P. Vavia

171 Is thermodynamic solubility of tadalafil in Kollidon VA 64 the key parameter affecting physical stability of the amorphous solid dispersion?K. Wlodarski, W. Sawicki, L. Tajber and M. Paluch

172 Moisture sorption of granulated pyridostigmine bromideT. Avgerinos, K. Kachrimanis, A. Avgerinos and I. Nikolakakis

173 Molecular water interaction in lipid-based formulations regarding capsule compatibilityA. Machado, T. Kokubo, R. Bravo, B. Jones, C. Scialdone, G. Dujovny and M. Kuentz

174 Pharmacokinetics evaluation of tramadol in thermoreversibles gelsG. Tofoli, J. Pedrazzoli Junior, S. A. Calafatti, D. R. de Araujo and J. Z. B. Papini

175 Production and Stabilization of Olanzapine Nanoparticles with Rapid Expansion of Supercritical Solutions (RESS)M. Paisana, K. Mllers, J. F. Pinto and M. A. Wahl

176 Supersaturation of zafirlukast in fasted and fed intestinal media with and without precipitation inhibitorsC. M. Madsen, A. Mllertz and T. Rades

177 SURFACE ACTIVITY OF NOVEL SURFACE ACTIVE COMPOUNDS, PRODUCTS OF CATALYTIC OXYETHYLATION OF CHOLIC ACID AND THEIR MICELLAR ADDUCTS WITH SELECTED LIPOPHILIC THERAPEUTIC AGENTSM. Kolodziejczyk, M. Nachajski, M. Lukosek and M. Zgoda

178 TABLETS WITH THE CONTENT OF CORNELIAN CHERRY (CORNUS MAS L.) PREPARED BY DIRECT COMPRESSIONA. Franc, S. Krahujec, P. Doleel, D. Sabadkov and J. Muselk

Protein Formulation & Aggregation

179 In vivo evaluation of rh-insulin loaded microemulsion as oral delivery systemG. Erel, M. Kotmaki, S. Szer Karadagli and A. G. Kantarci

180 Novel in vitro instrument for estimating formulation performance of subcutaneously administered therapeuticsH. Kinnunen, K. Box and R. Mrsny

181 The Use of SAXS for Screening the Dissolution Behavior of Lyophilized ProteinV. Wahl, E.-M. Saurugger, J. Khinast and P. Laggner


Gene Delivery

182 Cationic Polyaspartamide as siRNA delivery systems for down regulation of a proinflammatory cytokineS. Di Gioia, C. Sardo, D. Triolo, G. Belgiovine, S. Castellani, M. Conese, G. Giammona and G. Cavallaro

183 Development of non-toxic, cationic lipid coated, magnetic nanoparticles (MNPs) for gene delivery with a novel methodH. Akbaba, U. Karagz, Y. Selamet and A. G. Kantarci

184 IN VIVO ELECTROPORATION: A VERSATILE AND MULTITASK TECHNOLOGY TO FIGHT CANCERE. Marra

185 Lipid Nanoparticles Formulated with HM-Chitosan for siRNA DeliveryO. Tezgel, A. Szarpak-Jankowska, R. Auzly-Velty, F. Navarro and I. Texier-Nogues

186 Mucoadhesive hydroxyethyl-cellulose sponges as lipoplexes delivery system for vaginal applicationT. Furst, A. Lechanteur, B. Evrard and G. Piel

187 Polyplex based on polycarbonate polymers for an efficient delivery of HDAC5 and HDAC7 siRNAA. Frre, S. Tempelaar, B. Evrard, O. Peulen, L. Mespouille, D. Mottet and G. Piel

Miscellaneous

188 Development of hydrogel-formulations containing local anesthetics in poly(-caprolactone) nanocapsules for topical oral application.M. Franz-Montan, C. B. da Silva, S. d. C. Santos, B. V. Muniz, C. M. G. da Silva, E. de Paul, M. C. Volpato, F. C. Groppo and L. F. Fraceto

189 Influence of Papp values on prediction of plasma levels by in silico modeling of inhalation productsS. Salar-Behzadi, C. Meindl, S. Stranzinger, N. Dzidic, S. Mohr, S. Wu, A. Mercuri and E. Frhlich

190 Jet coating for the development of drug eluting stentsN. Scoutaris, F. Chai, B. Maurel, J. Sobocinski, M. Zhao, J. Moffat, D. Craig, N. Blanchemain and D. Douroumis

191 Clinical analysis of Paclitaxel Eluting Stent compared with Simvastatin Eluting Stent, coated by means of inkjet printing technologyN. Scoutaris, F. Chai, B. Maurel, J. Sobocinski, M. Zhao, J. Moffat, D. Craig, N. Blanchemain and D. Douroumis

192 ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CURCUMIN BY EUDRAGIT EPO-BASED SOLID DISPERSIONS PREPARED BY HOT MELT EXTRUSION AND SPRAY DRYING TECHNOLOGYA. Gangurde, S. Javeer, J. Pawae, D. Jaiswar and P. Amin

193 Formulation of magnetic siRNA nanovectors (MSN) as a promising theranostic tool for (breast) cancerS. David, H. Marchais, D. Bedin and I. Chourpa



PostersExhibited continuously from 9:00 to 17:00, with special sessions from 12:30 to 15:00. The number indicates the number displayed on the poster panel.

Bioavailability & Absorption Enhancement

1 Biphasic dissolution studies: Impact of concentration and particle size on partition rateJ. Comer, K. Box and R. Taylor

2 Co-Crystals and Their Advantages for Life Cycle Management of APIs with Difficult PropertiesM. Viertelhaus, A. Hafner, T. Chiodo, T. Hintermann and M. Vossen

3 Effect of organic solvents on the recrystallization behavior of amorphous solid dispersions prepared by spray dryingC. Marschall, R. Maurer and S. Page

4 Lipid Based Capsule Products to Increase Bioavailability and Reduce Food Effect for a Poorly Soluble CompoundA. IGONIN, J. MENSCH, S. INGHELBRECHT, J. CEULEMANS, H. VERMEERSCH, H. BENAMEUR and J. VERTOMMEN

5 Optimization of a PGSS manufacturing process of lipid-based solid dispersion containing fenofibrateA. Pestieau, F. Krier, P. Lebrun and B. Evrard

6 Pharmacokinetics of pro-pheroid formulated amodiaquineA. Grobler, L. Gibhard, C. Masimirembwa and R. Thelingwani

7 Preparation and Characterization of Nano Suspension of Poorly Soluble Drugs using Hydroxypropyl Cellulose (HPC)S. Kodama, K. Sugisawa, B. Ehlig, R. Fukuda, T. Andoh and H. Ichikawa

8 Production of amorphous nano-solid dispersions using a solvent controlled precipitation process. Duarte, R. Pereira, J. Vicente, J. F. Pinto and M. Temtem

9 Scale-up Transition from Spray Drying to HME with AFFINISOL HPMC HMEW. Porter III, O. Kevin, S. Wes and S. Uma

10 Study of the synergic effect of naringenin and quercetin in their permeability and metabolic fateN. Orrego-Lagarn, M. Martnez-Huelamo, M. R. Lamuela-Ravents and E. Escribano

11 Supersaturation, phase separation and the measurement of drug precipitation ratesJ. Comer, K. Box and R. Taylor

12 Transbuccal delivery of semi-solid formulations containing doxepin: ex vivo and in vivo evaluationR. Sanz, B. Clares, M. Mallandrich and A. C. Calpena


Buccal & Nasal Delivery

13 Chitosan particulate delivery system for intranasal influenza DNA vaccineC. Sawaengsak, Y. Mori, K. Yamanishi, W. Chaicumpa and N. Sinchaipanid

14 Composite hydroxylpropylmethylcellulose based films and wafers for buccal drug deliveryO. Okeke and J. Boateng

15 CORRELATION BETWEEN DISSOLUTION AND BUCCAL PERMEATION OF KETOPROFEN ORODISPERSIBLE FILMSM. Sacha, A. Fargier, R. Krampe, D. Sieber, P. Kleinbudde, J. Breitkreutz and E. Haltner

16 Fillet: A New Dosage Form Combining Orodispersible Films and Orodispersible Tablets- Influence of Different Films and Tablets -R. Krampe, D. Sieber, C. Stolze, V. Lenhart, M. Preis and J. Breitkreutz

17 Fillet: A New Dosage Form Combining Orodispersible Films and Orodispersible Tablets- Preparation concepts -D. Sieber, R. Krampe, C. Stolze, V. Lenhart, M. Preis and J. Breitkreutz

18 In vitro permeability study of betahistine dihydrochloride delivered by bioadhesive microspheres intended for nasal drug deliveryB. Pilicheva, M. Draganova-Filipova, P. Zagorchev and M. Kassarova

19 In-Vitro Models Simulating Buccal Tissue in the Oral CavityC. Schimpel, B. Teubl, E. Frhlich and E. Roblegg

20 Intranasal delivery of anti-Galectin-1 formulation to increase the efficiency of chemo- and immunotherapy for glioblastomaM. Van Woensel, N. Wauthoz, R. Rosiere, K. Amighi, V. Mathieu, F. Lefranc, S. Van Gool,T. Mathivet and S. De Vleeschouwer

21 Oromucosal film preparations for peptides - Points to considerS. Lindert, M. Pein, F. K. Hansen and J. Breitkreutz

22 Whey proteins: a promising excipient to promote oral drug delivery and permeabilityH. Hsein, V. Hoffart, G. Garrait, E. Dat-Lain and E. Beyssac

Nanoparticles & Vesicles

23 A Novel Oxalipatin Derivative Showed Enhanced Efficacy in an Orthotopic Model of Ovarian CancerA. Abu Ammar, T. Nassar, D. Gibson and S. Benita

24 A PROCESS FOR PREPARATION OF ULTRASMALL CURCUMIN NANOPARTICLESR. Kalhapure, S. Sonawane and T. Govender

25 Aminodextran-coated magnetic nanoparticles as a new hyperthermia approachM. K. Lima Tenrio, E. Alfonso Gmez Pineda, H. Fessi and A. Elaissari


26 Ammonium glycyrrhizinate-loaded niosomes as potential nanotherapeutics for inflammation: a comparative studyC. Marianecci, F. Rinaldi, C. Ingallina, P. N. Hanieh, D. Paolino, C. Celia, F. Cilurzo, S. Pieretti and M. Carafa

27 Amorphous Flubendazole Dispersed in Electrospun Nanofibers: Bioavailability in the Rat and Tablet FormationG. Verreck, I. Van Assche, C. Mackie, P. Boeykens, M. E. Brewster, Z. K. Nagy, T. Vigh, A. Balogh and G. Marosi

28 Antibiofilm activity of Melaleuca alternifolia nanoparticlesM. Ebling de Souza, R. de Almeida Vaucher, L. Quintana Lopes, R. Raffin, D. Martinez Stefani, R. Christ Vianna Santos and P. Gomes

29 Antidepressant-like activity of liposomal formulation containing nimodipine treatment in the tail suspension and forced swim test in miceL. C. G. e A. I. Moreno, J. M. Irache, R. M. Freitas and N. S. Santos Magalhes

30 Arsenic loaded anti-GD2 immunoliposomes: Design and in vitro targeting to neuroblastoma cellsH. Deibel and R. Schubert

31 Aspherical Nanoparticles for Drug Delivery ApplicationA. Castoldi, P. Dersch, S. Gordon and C.-M. Lehr

32 Biocompatibilization of micelles by hyaluronanT. Pilgrov and M. Peka r

33 Biocompatible nanoparticles and gadolinium chelates: towards new hypersensitive MRI contrast agentsM. Callewaert, V. G. Roullin, Y. Belabassi, C. Cadiou, C. Portefaix, S. Laurent, L. Vander Elst, M. Molinari, F. Chuburu and M.-C. Andry

34 Biological evaluation of liposomes containing 6BrCaQ, a C-terminal Hsp90 inhibitor, for prostate cancer treatmentF. Sauvage, S. Franze, S. Messaoudi, M. Alami, S. Lesieur, F.-X. Legrand, E. Fattal, G. Barratt and J. Vergnaud-Gauduchon

35 Carbohydrate Ligand Anchored Nanoparticles with Improved Efficacy in the Fibrosarcoma Tumor ModelS. Pranatharthiharan and P. Devarajan

36 Cardiovascular risk potential of PLGA-PEG nanoparticles used in drug delivery and targetingR. Bakhaidar, S. O'Neill and Z. Ramtoola

37 Cationic nanoparticles. An analytical approach to biological relevanceR. Gossmann, M. Hummel, D. Mulac, J. Brockmeyer and K. Langer

38 Cholesterol Free Pegylated Liposomes: A Potential for Brain TargetingP. Wavikar and P. Vavia

39 Co-encapsulating lipid nanoparticles for transdermal and oral deliveryM. Mendes, C. Vitorino, J. Sousa and A. Pais

40 Comparison of different nanonization approaches for -caroteneP. Scholz, S. Lohan, M. C. Meinke, R. H. Mller and C. M. Keck

41 Comparison of m-PEG-PCL polymersomes size measurements by 3 optical techniques: DLS, NTA and two-photon microscopyM. Inkichari, C.-H. Brachais, C. Bouvier, A. Assifaoui, P. Winckler, R. Seigneuric, S. Auguste and O. Chambin

42 Cyclosporin smartPearls for improved topical deliveryS. Staufenbiel, G. B. Romero, N. Jin, C. M. Keck and R. H. Mller

43 Design of new nanoparticles as tools for CNS disease diagnosisE. Teston, Y. Hamdous, C. Chuon, J. Seguin, C. Marie, T. Maldiney, B. T. Doan, N. Mignet, C. Richard and K. Andrieux

44 DESIGN OF POLYMERIC NANOFIBER DIAMETER, DRUG LOADING AND RELEASEJ. Kristl, . Zupansis, P. Kocbek and S. Baumgartner

45 Development and characterization of piroxicam loaded nanospheres to enhance the solubility and bioavailability adopting electrospraying techniqueO. Mustapha, F.-U.-. Din, A. Yousaf, D. W. Kim, R. Rashid, J. H. Park, T. Ramasay, J. O. Kim, C. S. Yong and H.-G. Choi

46 Electrospun cyclodextrin-based formulation of aripiprazole and its in vitro dissolution-absorption testing using micro-FluxTMG. Marosi, E. Borbas, Z. Nagy, A. Balogh and B. Sinko

47 Development of novel solid lipid nanoparticles-loaded dual-reverse thermosensitive nanomicelle with improved bioavailability and reduced toxicityF. Din, O. Mustapha, A. Yousaf, D. W. Kim, R. Rashid, J. H. Park, T. Ramasamy, J. O. Kim, C. S. Yong and H.-G. Choi

48 Development, evaluation and mathematical modeling of insulin release from chitosan and chitosan derivatives nanoparticlesJ. Hecq, F. Siepmann, J. Siepmann, K. Amighi and J. Goole

49 Dexamethasone nanocrystals for improved ocular deliveryG. Bahu Romero, C. M. Keck, N. Bou-Chacra and R. H. Mller

50 Effect of ionic strength on the formation of fluoride loaded pectin nanoparticles for dental deliveryS. Nguyen, S. Pistone, C. Claudio, G. Smistad and M. Hiorth

51 Effects of suberin fatty acids on the formation and physical stability of medicated nanofibers intended for wound healingI. Tamm, L. Rammo, I. Laidme, U. Paaver, K. Kirsime, N. Skalko-Basnet, A. Halenius, J. Yliruusi, J. Heinmki and K. Kogermann

52 Encapsulation efficiency of a drug into a nanosize carrier & amp; assessment of nanoparticle stability in a complex liquid matrix: Two working examples of NTA characterizationP. PEOTTA, P. HOLE, B. CARR and P. VINCENT

53 Encapsulation of dexamethasone palmitate into PLGA-PEG nanoparticlesR. Simn-Vzquez, N. Tsapis and E. Fattal



54 Enhancing Vancomycin Delivery via Lipid-Polymer Hybrid NanoparticlesN. Seedat, R. Kalhapure, C. Mocktar and T. Govender

55 Evaluation of biodegradability of novel polymeric nanoparticles based on amphiphilic polylactide-polyaspartamide derivativesB. Porsio, E. F. Craparo, D. Triolo, G. Giammona and G. Cavallaro

56 Evaluation of Chitosan Nanoparticles for Intravesical Administration of Gemcitabine HCl for the Treatment of Superficial Bladder CancerZ. Ay Senyigit, D. Ilem zdemir, S. Y. Karavana, . aliskan, S. Sen and E. Baloglu

57 Evaluation of cytotoxicity of Geranium oil-loaded nanoemulsionsJ. Giongo, R. Vaucher, A. Ourique, M. Steffler, M. Sagrillo, P. Gomes and M. Steppe

58 Exploring drug release from magnetic nanocarriers by low-level magnetic stimulationR. Spera, F. Apollonio, M. Liberti, M. A. Casadei, C. Merla, R. Pinto and S. Petralito

59 Factorial design-aided development of salicylic acid loaded-nanostructured lipid carriersB. Sto, N. Ungvri, E. Csnyi, P. Szab Rvsz and S. Berk

60 Feasibility of encapsulation dihydromyricetin in cationic nanocapsulesA. J. Figueir Dalcin, A. Ferreira Ourique, R. Platcheck Raffin, R. Christ Vianna Santos and P. Gomes

61 Flavanones: Cytotoxic activity and release study of nanoestructured emulsionB. Andrade, C. Caadas, M. Mallandrich, V. No, B. Clares, A. Calpena, M. L. Garca and M. L. Garduo

62 Formation and stability of curcumin nanoemulsions prepared by phase inversion temperature methodA. Jintapattanakit, R. Leam-or, S. Maneejansook and V. Junyaprasert

63 FORMULATING LINOLEIC ACID AS A NANOEMULSION ENHANCES ITS ANTIMICROBIAL ACTIVITYS. Sonawane, C. Mocktar, R. Kalhapure and T. Govender

64 Formulation and In Vitro Evaluation of Furosemide NanosuspensionsT. Glsn Inal, S. Ebadi Borna, I. Vural and S. Sahin

65 Formulation and stability evaluation of novel antimicrobial nanofibrous wound dressingsU. Paaver, I. Tamm, A. Toom, I. Laidme, A. Meos, K. Kirsime, N. Skalko-Basnet, J. Heinmki and K. Kogermann

66 Gemcitabine-squalene nanoparticles: involvement of plasma lipoproteins in the therapeutic responseD. Sobot, S. Mura, L. Dalbin, S. Lepetre and P. Couvreur

67 Human Serum Albumin (HSA) nanoparticles stabilized by polymer coating for the delivery of suraminI. Luis de Redin, M. Ageros, J. M. Llabot, C. Boiero and J. M. Irache

68 PHB based microparticles for ivermectin sustained releaseE. Engasheva, S. Yakovlev, A. Zernov, A. Bonartsev, G. Bonartseva, E. Daugalieva, K. Shaitan and S. Engashev


69 In vitro behaviour of hybrid lipid/chitosan nanoparticles for the oral delivery of heparinF. Sacchetti, R. Aracri, E. Maretti, V. Iannuccelli, M. Montanari, B. Pavan, A. Dalpiaz and E. Leo

70 In Vitro Release and In Vivo Tolerance of Pranoprofen-Loaded Nanoparticles HydrogelB. Guevara Granados, G. Abrego Escobar, M. L. Garca Lopez and A. C. Calpena Campmany

71 Influence of colloidal lipid carrier matrix on fenofibrate loading capacity a passive loading approachK. Gke and H. Bunjes

72 Influence of polymer end-chemistry on the morphology of perfluorohexane polymeric microcapsules intended as ultrasound contrast agentsL. Mousnier, N. Huang, E. Morvan, E. Fattal and N. Tsapis

73 Investigating the influence of glass transition temperature on the release behaviour of flurbiprofen- and mTHPP-loaded poly(D,L-lactic-co-glycolic acid) nanoparticlesS. Lappe and K. Langer

74 Investigation of titanate nanotube-API composites as promising drug delivery systemsB. Sipos, T. Sovny, A. Spi, Z. Knya, K. Pintye-Hdi and G. Regdon jr.

75 LABELING EFFICIENCY AND CELL BINDING of 99mTc LABELED CHITOSAN NANOPARTICLESE. Gundogdu, D. Ilem Ozdemir, M. Ekinci, E. Ozgenc and M. Asikoglu

76 Layer-by-layer nanoencapsulation of paclitaxelA. Polomska, H. Merten, A. Plckthun, M.-A. Gauthier and J.-C. Leroux

77 LIPOSOME CONTAINING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASESIN PREMATURE BABIESC. Palazzo, R. Karim, M. Mawet, C. Maillard, J.-M. Foidart, B. Evrard and G. Piel

78 LIPOSOMES AS CARRIERS OF LIPID SOLUBLE ANTIOXIDANTS- RESVERATROL IN PRESENCE OF VITAMIN EV. KENCHAPPA, M. WAHL, L. BUKARICA, J. CEVIC and H. HEINLE

79 Loading of Aloe-Emodin in gemini based cationic liposomes by the acetate gradient methodC. Bombelli, C. Giuliani, B. Altieri, G. Mancini, L. Galantini, A. Stringaro and M. Colone

80 Manufacture of Perfluorocarbon-Nanoemulsions for site specific targeting of activated platelets via a single-chain variable fragment binding to glycoprotein IIb/IIIaC. Grapentin and R. Schubert

81 MIL100 nanoparticles as a Busulfan delivery systemT. Simon-Yarza, L. L. Lesuer, A. Seck, T. Baati, M. Chiper, A. Paci, P. Couvreur, C. Serre, R. Gref and P. Horcajada

82 NLC and nanocrystal combination for effective treatment of couperosisS. M. Pyo, G. B. Romero, M. Meinke, A. Klein, T. C. Fischer, C. M. Keck and R. H. Mller

83 Novel Approaches for Gelatin Nanoparticle PreparationK. Geh, M. Hubert and G. Winter


84 Novel formulations for mitochondrial delivery based on alkylphosphoniumbolaamphiphilesF. Ceccacci, C. Bombelli, S. Sennato, E. Rossi, S. Gallina, B. Altieri, V. Moresi, E. Pignaand M. Diociaiuti

85 OLEIC ACID DERIVED HETEROLIPID BASED SMEDDS ENHANCE THE AQUEOUS SOLUBILITY OF CURCUMINR. Kalhapure, D. Sikwal and T. Govender

86 Optimization of the production of curcumin liposomes by ultrasonication based on Pharmaceutical Quality by Design approachA. R. Bilia, F. Mazzacuva, C. Guccione and M. C. Bergonzi

87 PEGylated liposomes containing apigenin for the treatment of glioblastomaR. Karim, C. Palazzo, N. Dubois, V. Bours, C. Passirani and G. Piel

88 Peptide-functionalized Nanoparticles for Selective Targeting of Pancreatic TumorS. MURA, S. VALETTI, F. MAIONE, D. DESMAELE, M. NOIRAY, J. VERGNAUD, C. VAUTHIER, L. CATTEL, E. GIRAUDO and P. COUVREUR

89 pH sensitive PEGylated Liposomes delivering active hydrophilic peptide with anticancer activity: in vitro study on cDDP-resistant ovarian cell lineF. Sacchetti, C. Marraccini, D. D'Arca, D. Pinetti, F. Genovese, E. Maretti, V. Iannuccelli, M. P. Costi and E. Leo

90 Physicochemical Stability and Corneal Permeation of Pranoprofen-Loaded Nanoparticles Based HydrogelG. Abrego Escobar, H. Alvarado Bonilla, B. Guevara Granados, A. C. Calpena Campmanyand M. L. Garcia Lopez

91 Pigs scleral permeation by freeze drying carprofen nanoparticlesA. Parra, M. Mallandrich, H. L. Alvarado, B. Clares, M. L. Garca and A. C. Calpena

92 Poly(ethylene glycol)-cholesterol molecules for liposomal surface modification via the sterol-based post-insertion technique (SPIT) and their behavior towards acceptor mediaD. Molnar

93 Poly-L-Lysine-coated liposomes as potential delivery systems for treatment of diabetic vascular diseases.M. L. Manca, D. Valenti, F. Marongiu, M. Manconi, G. Brotzu and A. M. Fadda

94 Polysaccharide-based nanohydrogel systems for drug delivery applicationsP. Matricardi, C. Di Meo, E. Montanari, C. Cencetti, S. Laserra, G. Manzi, T. Covielloand F. Alhaique

95 Preformulation study of liposomes as nanosized drug delivery systems In vitro drug transport.K. Dr, J. Malth, P. Hegyi, P. Szab-Rvsz and P. Sipos

96 Preparation and Pharmaceutical Evaluation of Nano-fiber Matrix Supported Drug Delivery System using the Solvent-Based Electrospinning MethodM. Hamori, K. Yoshida, K. Nagano, S. Kakimoto, A. Nishimura, K. Naruhashi and N. Shibata

97 Preparation of liposomes with asymmetric bilayers produced from nanoemulsions in a centrifugal fieldJ.-H. Sommerling, M. de Matos, E. Hildebrandt, G. Leneweit and H. Nirschl


98 Preparation of New Nanovectors from Biomass: Chemo-Enzymatic Synthesis ofGlycerolipidyl-Cyclodextrins and study of drug encapsulationV. Bonnet, Y. Miao, A. Furlan and C. Sarazin

99 Preparation of submicron magnetic latex particles for biomedical applications:Morphology controlE. Taveira Tenrio-Neto, T. Jamshaid, N. Zine, A. Errachid El-Salhi, M. Hiroiuqui Kunita, H. Fessi and A. Elaissari

100 Production of chitosan nanoparticles as matrix to sustain drug release across orally disintegrating tablets with the aid of design of experiment to optimize conditionsA. Matoug-Elwerfalli and A. El-shaer

101 Protective effect of curcumin-loaded new polymer-glycerosome systems onpulmonary diseases.M. L. Manca, I. Castangia, C. Caddeo, M. C. Cardia, M. Manconi, C. Sinico and A. M. Fadda

102 Remote loading of Voacamine in cationic liposomes for the treatment of osteosarcoma resistant cell linesL. Giansanti, B. Altieri, M. Condello, E. Pellegrini, G. Mancini and S. Meschini

103 smartCrystals for functional foods: BIOSMARTS

G. Bahu Romero, C. M. Keck, E. Brysch, W. Brysch and R. H. Mller

104 smartLipids the smarter Nanostructured Lipid Carriers (NLC)R. H. Mller, R. Ruick and C. M. Keck

105 The Use of Excited-State Proton Transfer in Observation of The Interaction of Potential Hyaluronan-Surfactant Drug NanocarriersJ. Mondek and M. Pekar

106 Thermoresponsive mesoporous silica nanoparticles as a topical delivery system for antioxidantsS. Sapino, E. Ugazio, L. Gastaldi, S. A. Jadhav, V. Brunella, D. Scalarone, I. Miletto and G. Berlier

107 Transcorneal delivery of PLGA-based nanoparticles of KetorolacM. Mallandrich, A. Calpena, A. Parra, M. L. Garcia and F. Fernndez-Campos

108 Use of Lipid Nanocapsules for air bubbles stabilizationC. R. A. MOUZOUVI, P. SAULNIER and A. BIGOT

109 Verbascoside loaded in liposomes: increased stability and prolonged antineuropathic and antiinflammatory activitiesA. R. Bilia, B. Isacchi, M. C. Bergonzi, C. Ghelardini and N. Galeotti

110 ZnO-based Quantum Dots for biological applicationsE. Berbel Manaia, B. Caetano, V. Briois, R. Kiatkoski Kaminski, L. Chiavacci and C. Bourgaux

Transdermal Delivery

111 Aceclofenac loaded bicontinuous microemulsions: in vitro release, tape strippingand pharmacokinetic studyM. Todosijevic, V. Savic, M. Savic, D. Randelovic, M. Gaperlin, B. Batinic, T. Isailovic, B. Markovic and S. Savic


112 Captisol as Dermal Penetration Enhancer for Lipophilic DrugsA. Juluri and N. Murthy

113 Early preclinical evaluation of transdermal druglikeness - a case study with selective androgen receptor modulatorsT. Ullrich, H. Keller, S. Weiler and P. G. Santos

114 Hydrogels of carboxymethyl scleroglucan: a smart biocompatible system fortopical formulationsP. Paolicelli, S. Pacelli, S. Petralito, A. Adrover and M. A. Casadei

115 In vitro and ex vivo evaluation of a ready to use transdermal vehicle for the permeation of ondansetronF. BOURDON, M. LECOEUR, P. ODOU, C. VACCHER and C. FOULON

116 Influence of formulation polarity on transdermal delivery by implementation of the delivery gap principleM. Gerber, C. Burger, J. Du Preez and J. Du Plessis

117 Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acidD. Mahrhauser, H. Khlig, E. Partyka Jankowska, K. Kwizda and C. Valenta

118 Macromolecules penetration in irritant contact dermatitisM. Abdel-Mottaleb, A. Bduneau, Y. Pellequer and A. Lamprecht

119 Microrheological study of hyaluronan based system for dermal delivery applicationsZ. Hnyluchov and M. Pekar

120 Modified Chitosan sponges as antibacterial agentsP. Siafaka and D. BIkiaris

121 Non-invasive in vivo comparison of penetration enhancers containing hydrogel formulationsB. Balzs, M. Bakonyi, S. Berk, M. Budai-Szucs and E. Csnyi

122 Optimization of microemulsion composition applying experimental planningV. Jukait, M. ilius, K. Ramanauskien and V. Briedis

123 PDT(Photo Dynamic Therapy) using LPC (Lysophosphatidylcholines) and the photo-sensitizer chlorine- derivatives useful for Trichophyton rubrumY. Woo, Y. Park, H. Ji, J. Kim, S. Jo and H. Yu

124 Physical characterization and release of a silver sulfadizine-chitosan hydrogel for wound treatmentR. d. O. Batista, G. d. S. Nascimento, L. M. Verssimo, P. S. H. Picciani, K. G. d. H. Silvaand F. Reynaud

125 Preparation and characterization of alcohol-free, grapefruit oil base microemulsionsN. Jaipakdee and E. Limpongsa

126 smartPearls - stability and performance in topical gelsN. Jin, S. Staufenbiel, C. Keck and R. Mller

127 The impact of low molecular weight polysiloxanes on the skin barrierK. Mojsiewicz-Pienkowska, K. Szymkowska, D. Glamowska, K. Cal and Z. Jankowski


128 Thermal Analysis of Stratum Corneum using Modulated Temperature Differential Scanning Calorimetry (MTDSC)C. F. Goh, D. Craig, J. Hadgraft and M. Lane

129 Topical delivery of lidocaine and prilocaine with the use of Pheroid technologyJ. Du Plessis, D. Nell, J. Du Preez and M. Gerber

130 Transdermal iontophoretic delivery of propofol (CAPTISOL-enabled Complex); plasma and brain pharmacokinetic studyA. Juluri, N. Murthy and P. Manda

Parenteral Delivery

131 Development of an Ex-Vivo Pig Skin Model to Determine Mechanistic Effects of Antibody Formulations Following Subcutaneous InjectionS. Eichling, C. Jahn, A. Popp, W. Frie and G. Fricker

132 Indocyanine green-loaded chitosan/alginate microparticles for transcatheter arterial embolization (TAE) in hepatocellular carcinoma (HCC)E. P. Porcu, A. Salis, G. Rassu, E. Gavini, P. Dionigi, M. Maestri and P. Giunchedi

133 Investigation of a flow through cell adapter for dissolution testing of an intramuscular applied aqueous solution and an oily suspensionM. Probst, M. Schmidt, E. Noll, A. Seidlitz and W. Weitschies

134 Is poloxamer 188 desorbed from the trimyristin nanoparticle interface upon dilution? A DSC studyE. Roese and H. Bunjes

135 Monitoring of size changes of single PLGA-microparticles and comparison with drug releaseH. Gasmi, J. Siepmann and F. Siepmann

136 Nanostructured Lipid Carriers (NLC) of Artemether-Lumefantrine combination for intravenous malaria therapyP. Prabhu, M. Joshi, S. Pathak, S. Sharma and V. Patravale

137 Parenteral nanoemulsions for risperidone brain delivery: design, characterization and in vivo evaluationS. Dordevic, T. Isailovic, N. Cekic, M. Savic, S. Savic, D. Randelovic and S. Savic

138 Progress in Complex Parenteral Formulations for the Delivery of Biopharmaceuticals and Small Molecules Microencapsulation Scale Up and Product EnhancementsT. Tice, K. Burton, J. Atkinson, P. Markland and G. Winchester

Pediatric & Geriatric Drug Delivery

139 A novel versatile gastro-resistant paediatric formulation based on Omeprazole/SBA-15 loaded in alginate beads by prillingP. Del Gaudio, F. De Cicco, S. Giovagnoli, M. Ricci and R. P. Aquino


140 An in vivo taste assessment method for the optimisation of taste-masking formulations: the rat brief-access taste aversion (BATA) modelJ. Soto, R. Turner, S. Desset-Brthes, G. Winzenburg, M. Orlu Gul and C. Tuleu

141 Anti-CD19-Targeting of Doxorubicin Liposomes for an Improved Treatment of Pediatric Acute Lymphoblastic LeukemiaK. Zfle and R. Schubert

142 Development and Characterization of Orodispersible Mini-tablets Manufactured by Direct CompressionM. Mnster, C. Pfeifer and J. Breitkreutz

143 Development of aged cell culture model to assess the in vitro fate of drug delivery systems for older patientsI. Espadas Garcia, S. Hanning, M. Bunc, J. M. Prieto-Garcia and M. Orlu-Gul

144 Development of casein micellar pediatric formulationsM. Brachkova, J. T. Pinto, A. I. Fernandes and J. F. Pinto

145 Development of extended release Compritol 888 mini matrix tablets for geriatric administrationR. Grybos, L. Freerks, Y. Rosiaux, D. Marchaud and S. Klein

146 Evaluation of the ability of powdered milk to produce mini-tablets containing paracetamolJ. T. Pinto, M. Brachkova, A. I. Fernandes and J. F. Pinto

147 Formulation of orodispersible films for childrenZ. Senta-Loys, S. Bourgeois, S. Brianon and H. Fessi

148 Hot melt coating - taste-masked multiparticulate drug delivery systems with immediate drug releaseA. Zimmer, K. Becker and S. Salar-Behzadi

149 In situ preparation of microcapsules with ethylcellulose and polyacrylate shells incorporated in a lyophilized matrixK. Hoppe and M. Sznitowska

150 Multiparticulate extended release dosage form for pediatric use development and characterizationM. E. Martinez Teran, S. Mangalaboyi and M.-P. Flament

151 Orally Disintegrating Tablet Preparation by Dry Granulation Method Using Super Fine Powder, Special Low Viscosity Hydroxypropyl CelluloseK. Sugisawa, S. Kodama, S. Tsue, B. Ehlig, Y. Takeuchi and H. Takeuchi

152 Patient centric and age appropriate drug product design: Theory biased and evidence basedS. Stegemann, R. Becker, R. Messina and D. van Riet-Nales

Pharmaceutical Manufacturing & Engineering

153 Comparison of a novel aerodynamic dry granulation method and conventional slugging method in preparation of granules and tabletsA. Penkina, T. Saarinen, O. Antikainen, A. Lust, K. Kogermann, J. Yliruusi and J. Heinmki


154 Continuous manufacturing of delta mannitol via spray dryingV. Vanhoorne, P.-J. Van Bockstal, B. Van Snick, P. Gomes, T. De Beer, J.-P. Remon and C. Vervaet

155 Evaluating the validity of the Unified Theory of Compaction using sodium chloride and ammonium sulphate tabletsM. Gamlen, T. Uddin and L. Martini

156 Evaluating Youngs Modulus from diametral compression dataM. Gamlen, H. Dhaliwal and L. Martini

157 Evaluation of binders for dry granulationM. Kirsolak, H. Mangal and P. Kleinebudde

158 Co-Extrusion as innovative method for PharmaceuticsK. Paulsen, I. Ruff and D. Leister

159 Improved Spray Drying Capability with AFFINISOL HPMCAS and HPMC High Productivity PolymersW. Porter III, K. ODonnell, B. Schmitt, M. Brackhagen, M. Sprehe, M. Knarr and W. Spaulding

160 Influence of different drying conditions on mono- and double-layer orodispersible films during continuous manufacturingY. Thabet and J. Breitkreutz

161 Interaction of emulsifier and membrane material during the preparation of nanoemulsions by premix membrane emulsificationS. Gehrmann and H. Bunjes

162 NANEX: Process design with potential matrix materialsR. Baumgartner, J. G. Khinast and E. Roblegg

163 Production of Dexpanthenol Loaded Polyethylene Oxide Nanofiber Mats for Wound HealingE. Azizoglu, C. elik, S. Tuncay Tanriverdi and . zer

164 Production, stability and downstream processing of high speed electrospun amorphous solid dispersion of itraconazoleZ. K. Nagy, B. Dmuth, A. Balogh, H. Pataki, E. Borbs, G. Marosi, I. V. Assche and G. Verreck

165 Small Scale Twin-Screw Extrusion - Evaluation of Continuous Split Feeding in Wet Extrusion/SpheronizationC. Mhlenfeld, D. Ghanam, J. Schwarz and M. Thommes

166 Tablet strength related to adhesion forces of tablet components measured at the nanoscaleM. Badal Tejedor, N. Nordgren, M. Schuleit, M. W. Rutland and A. Millqvist-Fureby

167 Taguchi method used for optimization of coating process for minitabletsM. Czajkowska and M. Sznitowska

168 The Impact of Crospovidone as a Superdisintegrant for Hard Gelatin Capsule FormulationsC. Muehlenfeld, G. Warnke, M. Opitz and S. Stegemann


Solving the Insoluble with DowOur AFFINISOL polymers are uniquely tailored to address the solubilization performance requirements of your APIs, whether you have chosen to formulate via Spray-Dried Dispersion or Hot Melt Extrusion.

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La Nef Amphithtre Royal Amphithtre Clovis

Poster Sessions and Exhibition Invited talks: Transdermal Drug Delivery Short talks: Oral Controlled Drug Delivery



Oral Delivery

Pulmonary Delivery

Dermal preparations

Physical Pharmacy

Preformulation


Gene Delivery

09:00 20:00; all day

Transdermal drug delivery: A Mature and Evolving TechnologyR. Guy

Transdermal Drug Delivery: An Industrial ViewpointM. Sournac

The new Guideline on Quality of Transdermal Patches: NewRequirements in DevelopmentS. Jones

How does the drinking volume affect gastric dissolution in infants? New in vitro approaches for preclinical screeningE.Kersten

In-vitro dissolution testing of oral thin films (OTFs): theory and experimentsA. Adrover

Proposal for a new dissolution method for soft chewable delivery systemsC. Stomberg

Assessing Softgel Disintegration in the Gastric Compartment:Correlating the Dynamic Gastric Model with In Vivo Visualization by Camera-CapsulesH. Teles

Mucoadhesive polymeric nanocomposites for oral delivery ofS-nitrosogluta-thioneW. Wu

Amphiphilic Nucleic Acid Conjugates for Local Treatment ofIntestinal DiseasesE. Moroz

Poster Sessions and Exhibition Invited talks: Oral Drug Delivery Short talks: Nanoparticles & Vesicles



Oral Delivery

Pulmonary Delivery

Dermal preparations

Physical Pharmacy

Preformulation


Gene Delivery

09:00 20:00; all day

Recent Challenges in Oral Controlled-Release Drug DeliveryM. Lueck

Therapeutic Index Issues around Oral Peptide PermeationEnhancersD. Brayden

Orodispersible Dosage FormsD. Djuric

The effect of using different nebulisers on the delivery ofAmphotericin B and Cisplatin Non-Ionic Surfactant VesiclesM. Puig

Ex vivo and in vivo siRNA delivery to activated T cells as novelanti-inflammatory asthma therapyY. Xie

Chitosan-iron-based nanogels for the cellular delivery of poly-phosphate drugsG. Giacalone

Anti-E6/E7/MCL1 pegylated lipoplexes for a vaginal treatmentof cervical cancerA. Lechanteur

Delivery of Andrographolide to the brain by human serum albumin nanoparticlesM. Bergonzi

Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: a comparativestudyE. Gilbert


10:45 11:05 11:25 11:4512:05 12:25

15:00 15:20 15:40 16:00 16:20 16:40

09:00 Amphithtre Royal Opening Ceremony and APGI Student Award

09:15 Amphithtre Royal Plenary lecture: Drug Targeting - Where are we?, Patrick Couvreur

La Nef Amphithtre Royal Amphithtre Clovis

Poster Sessions and Exhibition Invited talks: Smart Drug Delivery Systems Short talks: Advanced Drug Delivery





Parenteral Delivery



Quality Assurance

Quality Control & PAT

Stability Testing

Technical Innovations

Green & Sustainable Pharma

In-vitro/In-vivo Correlations

09:00 17:00; all day

Progresses in Anticancer Drug Delivery by Polymer Conjuga-tionG. Pasut

3D PrintingC. Roberts

Smart Drug Delivery from an industrial perspectiveP. Gellert

Modifications of the stratum corneum barrier structure andfunction introduced by freezing: consequences for drugpermeation studiesL. Roussel

In vitro phage display as a strategy to enhance the skin penetration of heparinsS. Franz

Hyaluronic acid gels containing liposomes for the sustaineddelivery of a corticoid to the inner earN. El Kechai

Mesoporous phospholipid particle as a novel drug deliveryplatformK. Kawakami

Thalidomide nasal powders for local treatment of nose bleeding in hereditary hemorrhagic telangectasiaV. Chiapponi

In vitro estimation of drug delivery to stenosed coronaryblood vessels via drug-coated balloon cathetersA. Seidlitz

11:30 Amphithtre Royal Plenary lecture: Advances in Pulmonary Drug Delivery, Hartmut Derendorf

Poster Sessions and Exhibition Invited talks: Peptide and Protein Delivery Short talks: Development & Manufacturing of Solid Dosage Forms





Parenteral Delivery



Quality Assurance

Quality Control & PAT

Stability Testing




09:00 17:00; all day

Protein and Peptide Delivery: Current State of the ArtW. Hennink

Challenges and advances in vaccine deliveryD. O Hagan

Novel Application Systems for Transdermal Vaccine DeliveryH. Spilgies

Thermodynamics of API/Polymer Amorphous FormulationsG. Sadowski

Hot-melt extrusion of polyvinyl alcohol and plasticizer fororal immediate release applicationsW. De Jaeghere

Melt blowing and electrospinning for dissolution enhance-mentA. Balogh

Exploring the Use of Pressurised Gyration for Large ScaleManufacture of Pharmaceutical NanofibresB. Raimi-Abraham

PAT tools for the control of the manufacturing processes ofco-extruded implants, tablets and capsulesF. Krier

The Application of Novel nano-Thermal and Imaging Techniques for Monitoring the Drug Distribution withinPLGA MicrospheresM. Zhao


09:0009:20 09:40 10:00 10:20 10:40

15:00 15:20 15:40 16:00 16:20 16:40

Technological Lac tose ExcipientsgolonhceT ipicx Eseotac Llaci sten


Quality Assurance/Quality Control & PAT

169 In vitro dissolution behavior of extended release theophylline tablets in ethanolic mediaK. Knop and P. Kleinebudde

170 BIORELEVANT DISSOLUTION METHOD IN QUALITY CONTROL OF DRUGS CONTAINING API IN THE FORM OF SALTS OF WEAK ACIDSJ. Muselk, A. Franc, R. Gonc, D. Vetch, D. Majerckov and V. Durovcov

171 Improvement of pharmacists service in Pharmacy BelgradeJ. Bjeletic

Stability Testing

172 Evaluation of stability of bupivacaine hydrochloride 0.5% solution for injection under non-temperature controlled conditionsA. Zygler, B. Kubiak, R. Lunio, A. Kot-Wasik, W. Sawicki and K. Wlodarski

173 Interaction and stability of biomoleculesA. Audfray and M. Terray

174 Investigation into a Potential Stabilizer for Moisture Induced Amorphous-Amorphous Phase Separation of Solid DispersionsC. Orive and M. Zhao


175 Analysis of Nano-sized Particles for the Precise Engineering of Drug Delivery Systems for Nanomedicine ApplicationsC. Roesch, M. Broom and R. Vogel

176 Explicit Identification of Sub-Visible Particulates in Solution-Phase BioFormulations: A Hybrid ApproachM. Terray and K. Dahl

177 Is Ion Mobility Mass Spectrometry the Missing Tool in Polymer Drug Delivery Development?J. R. N. Haler, D. Morsa, J. Far, P. Lecomte, C. Jrme and E. De Pauw

178 New perspectives for fabrication and analysis of biomimetic electrospun scaffolds for skin tissue engineering applicationsV. Planz, S. Seif and M. Windbergs

179 Stability and Structure of Therapeutic ProteinsS. Kenyon and M. Terray



180 Particle engineering of cocrystals using a solvent-free approach by spray congealing. Duarte, M. Pereira, L. Padrela, J. F. Pinto and M. Temtem

181 Release profile and antioxidant activity evaluation of two topical gels enriched with bioactive extracts from agro-industrial coffee wastesM. Allegro, J. Marto, C. Montoya, N. Oliveira, S. Gonalves, A. Paiva, S. Barreiros, P. Simes, L. Gonalves and H. Ribeiro


182 Selection of a Discriminant Dissolution Test for Extrudates Containing ItraconazoleJ. Thiry, F. Krier, A. Pestieau and B. Evrard


Acknowledgements

We thank our sponsors:

Main sponsor

Platinum Sponsor

Silver sponsor

Bronze sponsor


World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

4th 7th April 2016SECC, Glasgow, Scotland

Find out moreSEE YOU IN GLASGOW IN 2016

10th


SPONSORSReims, France 13 - 14 April 2015

We thank our sponsors


Sirius Analytical Main sponsor

BOOTH 18

Sirius Analytical is the market leader in instrumentation and CRO ser-vices for measurement of pKa, logP/logD, Solubility and Dissolutionin aqueous, solvent, biorelevant media and in the presence of formu-lation additives.

Our unique solutions for automated supersaturation measurementreveal new insights about the pH-dependent supersaturation a com-pound can exhibit and how supersaturation may be enhanced orsuppressed via the use of formulation additives and excipients.

With facilities in the US and UK Sirius offers global coverage with detailed and reliable analysis, expertstaff and rapid turnaround.

ContactPaul Whittles Phone: +44 1 34 28 20 72 0

Fax: +44 1 34 28 20 72 5Forest Row Business Park E-mail: [email protected] Road, Forest RowEast Sussex, RH18 5DWUnited Kingdom www.sirius-analytical.com

Advantest Platinum sponsor

BOOTH 17

A world-class technology company, Advantest is the leading producer ofautomatic test equipment (ATE) for the semiconductor industry and apremier manufacturer of measuring instruments. The companys leading-edge systems and products are integrated into the most advanced semi-conductor production lines in the world.

The company also focuses on R&D for emerging markets that benefitfrom advancements in nanotech and terahertz technologies, and has re-cently introduced critical multi-vision metrology scanning electron mi-croscopes and 3D imaging analysis tools for pharmaceutical and industrial applications. Founded in Tokyoin 1954 has subsidiaries worldwide.

ContactAnthony Petrolonis Phone: +1 6 09-89 77 32 6Director TAS Sales + E-mail: [email protected] Development

508 Carnegie Ctr. # 102NJ 08540 PrincetonUSA www.advantest.com


armor pharma Platinum sponsor

BOOTH 13

ARMOR PHARMA manufactures and markets 3 ranges of pharmaceuticalgrade lactose for all your applications:

- ARMOR PHARMA lactose monohydrate: sieved & milled lactose- EXCIPRESS: lactose for Direct Compression- EXCIPURE: lactose for Dry powder InhalationIts state of the art industrial facility, located in Brittany, FRANCE, is in fullcompliance with pharmaceutical standards (cGMP, GDP, PAT) and enablesthe production of lactose in line with pharmaceutical regulati

Documents

Abstractbook_Reims2015