2006

Other bioactive productsU 1300 A Stereoselective Synthesis of (4E,7S)-(—)-7-Methoxydodec-4-enoic Acid. — The

synthesis of title compound (X), which belongs to the fatty acid portion of malyng-amides, is accomplished in 8 steps from hexanal (I) in 24% overall yield. The key steps involve the catalytic asymmetric allylation of (I) and the coupling reaction of chiral alkyne (VI) and the protected bromide (VII) in the presence of tBuLi. — (LI, Y.; CHEN, J.; CAO*, X.-P.; Synthesis 2006, 2, 320-324; State Key Lab. Appl. Org. Chem., Inst. Org. Chem., Lanzhou Univ., Lanzhou 730000, Gansu, Peop. Rep. China; Eng.) — M. Paetzel

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