Upload
luqman-al-bashir-fauzi
View
218
Download
0
Embed Size (px)
Citation preview
8/7/2019 8. Superficial Mycosis
1/8
SUPERFICIAL MYCOSES
= DERMATOMYCOSES
= SUPERFICIAL MYCOSES
= CUTANEOUS MYCOSES
MYCOLOGY
Dermatophytes (literally: Skin plants)
Separated primarily by morphology of their MACROCONIDIA and MICROCONIDIA
Sexual forms for many Microsporum & Trichophyton spp
Identified and assigned to genera ASCOMYCETE (Arthroderma, Nannizzia)
Most grow best at 25 C on Sabourauds agar.
Hyphae are spetate
Conidia either directly on hyphae or on conidiophores
Small microconidia may or may not be formed
Larger & more distinct MACROCONIDIA identification
Genus Epidermaphyton
- Macroconidia: smooth-walled, singlt or in clusters- Micr: nil
Genus Microsporum
Mac: rough-walled, fusiform or culindrical
Mic: few, pear-shaped, alone, along hyphae
Genus Trichophyton
Mac: smooth-walled, cylindrical
Mic: numerous, spherical/pear shaped, appear in clusters along hyphae
DERMATOPHYTES (Disease dermatophytosis)
Moulds/fungi which infect KERATINIZED TISSUES (i.e superficial areas of the body) which include the
SKIN, HAIR and NAILS
Current number of fungal species ~ 50,000
Those that are known to cause disease in man ~ 100-150
8/7/2019 8. Superficial Mycosis
2/8
At least 40 species of dermatophytes infect humans
Only about 15 common causes of superficial mycosis
Classified as DEUTEROMYCETES (FUNGI IMPERFECTI)
Family: MONOLIACEAE and 3 (THREE) GENERA
y MICROSPORUM/ARTHRODERMA -> Infection: MICROSPOROSIS(NOT microspora! protozoa -> MICROSPORIDIOSIS)
y Trichophyton ->INFECTION: trichophytosis(not Trichomoonas! flagellated protozoa -> TRICHOMONIASIS
y Epidermophyton -> infection: EpidermophytosisAll the 3 fungi/GENERA have rather similar MORPHOLOGY, INFECTIVITY and PATHOGENICITY.
Therefore usually categorized according to the CLINICAL SYNDROME and PREFERRED ANATOMIC
SITE with which they are associated. And these superficial mycoses often manifest as serpenginous
skin markings thereby often referred to as:
TINEA (Latin) = grub/moth larva/worm = ringworm
TINEA (RINGWORM) : examples
Examples:
Tinea Capitis Ringworm of the scalp
Tinea Corporis Ringworm of the body
Tinea Pedis Ringworm of the athletes foot
Tinea Unguium Ringworm of the nails (Onychomycosis)
Tinea Imbricata (Tokelau/Oriental ringworm) island in NZ
Etc, etc + at least 15 others refer to big medical dictionary or dermatology textbook!
+Tinea versicolor strictly not a dermatophytosis but included as it affects the superficial skin layers.
EPIDEMIOLOGY
DERMATOPHYES specially adapted to 3 sites/niches: on/in
Humans
Animals
Soil Geophilic
8/7/2019 8. Superficial Mycosis
3/8
y Occur worldwidey Vary in presentation according to site of infectiony High living standards
= Lowered incidence of T. capitis
= Increased incidence of T.Pedis (athletes foot. Shoes & stockings -> warmth & moisture)
y Increased Dermatomycosis due to Trichophyton rubrum (an anthropophilic dermatophytethe most common dermatophyte pathogen worldwide)y Transmission of zoophilic dermatophytes
Direct contact
Fomites
y Geophilic dermatophytesFarmers
Greenhouse workers
y The most common of the 3 anthropophilic dermatophytesPATHOGENESIS OF DERMATOPHYTOSES
HOST FACTORS which favour disease
Abraded skin
Occlusive clothing, footwear, dressings
Presence of other cutaneous diseases like atopic dermatitis
Dermatophyte invade keratinized layer of skin -> produce keratinases that digest keratin
Most lesions contained within this anatomic boundary
May be self-limiting
Widespread infection seen in patients:
- With HIV/AIDS- On immunosuppressive drug regimes- Have endocrinopathies like Cushings disease
Superficial Mycosis II
Pathogenic features refer diagram
a. Normal continual shedding of stratum corneum protects from dermatophytesb. Inflammatory reactions following dermatophytoses
1. Penetration of stratum corneum CMI response2. Vesiculation occurs in severe cases3. Stratum corneum contains nucleated cells!
- Inflammatory reaction increases epidermal cell division rates pass more rapidlythrough epidermis
- Full differentiation of cells of different strate does not take place
8/7/2019 8. Superficial Mycosis
4/8
4. Loss of normal translucency causing- stratum corneum to appear white- And dermal vessels to dilate
5. Mononuclear inflammatory cells infiltrate the dermisNOTE: A crude extract called TRICHOPHYTON from certain dermatophyres produces a tuberculin-like
response in most adults
This contains 2 moieties ofgalactomannan
- Carbohydrate immediate response- Peptide Delayed Type Hypersensitivity and probably immunity, too.
CLINICAL FINDINGS
y Superficial mycoses named according to site of infection.y These usually correspond to site of local inoculation.y Degree of inflammation often dictated by the nature of the environment from which fungus
originates.
y Anthrophilic dermatophytes milder IR in humansy e.g: microsporum dermii
TINEA CAPITIS (SCALP RINGWORM)
y Mainly affects prepubertal children ages 4-14y Often seen in- Crowded living conditions- Areas of povertyy Infection of hair shaft:y Ectothrix fungi that produces arthrospores ON hair shaft. Present with gray or
scaling patches of alopecia with or without inflammation.y Black dot appeatance seen.y Kerions and prominent inflammatory lesion +.y Kerions = nodular, circumscribed exudative tumefaction (swelling) covered with
pustules (usually M. canis, rarelt y T. verruocosum or T. mentagrophytes)
y Endothrix Fungus that grows INSIDE the hair shaft.y Cuticle not destroyedy Clinically appears as simple scaling of scalp
8/7/2019 8. Superficial Mycosis
5/8
y May resemble seborrheic dermatitis dandruff
y There may be gray patches of alopecia with or without inflammation or black dotalopecia in which hair breaks off at roots
yFavus infection leads to crusting and matter hair on the scalp with such severeinvasion that permanent alopecia often results.
y Usually seen in Eastern Europe and Africa.TINEA BARBAE
y Like tinea capitis, but affects the hair follicles and shafts of the facial area. Maydevelop into tumourlike abscess
y Usual aetiologies: T. mentagrophytes, T. verrucosumTINEA CORPORIS
y Affects non-hairy, glabrous (smooth & bare) skin.y Can be the extensions of scalp or groin infections.y Range from mild to highly inflamed lesions with pustules.y Central areas may become brown / hypoigmented and less scaly.
TINEA CRURIS (JOCK ITCH)
8/7/2019 8. Superficial Mycosis
6/8
y Commonly in men. May involve perineum, perianal and thighs.y Rarely affects srotum (cf Candida typically involves scrotum)y Typically presents with bilateral erythematous plaques with central healing. Erythematous
border active.
y May have vesicles and papules.y Pruritus and burning sensations most common complaints.y Infection usually transmitted from foot to groin.y Predisposing factors sweating, wet/many layered clothing
TINEA PEDIS (ATHLETES FOOT)
y Most common dermatophytosisy Usual cause T. rubrumy Occlusive footwear warmth and wet for fungal growthy Presents in 4 general fashions:1. Interdigital infection with erythema, maceration and scalin.2. Moccasin foot erythema and thick hyperkeratotic scales3. Inflammatory infections with vesicles, usually on the medial foot
8/7/2019 8. Superficial Mycosis
7/8
4. Less common ulcerative infection affecting the web spaces of the toesy If tinea unguium (of the nails) + tinea pedis may persist due to reinfections.
TINEA UNGUIUM (ONYCHOMYCOSIS)
y Infection causes nails to become opaque, chalky or yellowish.y May become thickened and brittle.y Toenails more frequently unvolved.y Incidence increases with age.
DERMATOPHYTID or ID REACTION
y Allergic response to tinea processes that cause sterile dermatitis at distant sites.y Most common Tinea pedis itching and burning near the creases.y Vesicles and bullae may form.y Lesions may persist until primary process resolves.
TINEA VERSICOLOR
Aetiology:
y Genus: Malasseziay Species: Malassezia furfur (formerly Pityrosporum orbiculare/ovale)y Organisms: Lipophilic and makes use of medium-chain length fatty acidsy Excess heat, humidity, pregnancy, oral contraceptives, malnutrition, burns and
corticosteroids promote their proliferation.
Clinically:
y Begins as small circular macules of various colours (versicolor) white, pink or browndepending on hosts response reddish; hyperaemic inflammation
yHypopigmented/hyperpigmented depends on melanosome formation in individual
y Upper trunk most commonly affected. Highes numbers in areas of increases sebaceousactivity. Usuall asuymptomatic. Itch when inflamed.
DERMATOPHYTOSIS DIAGNOSIS
y Clinical manifestationsy UV (Woods) light examination in darkened roomy M. audouinii, M. canis & T. schoenleinii all give off a blue-green colour.
8/7/2019 8. Superficial Mycosis
8/8
y Tinea versicolor: whitish-yellow fluorescence.y Skin/nail scrapings (keratinized/flaking material)/cutting:
- +10-20% KOH direct microspopy hyphae- Cellophane tape Tinea versicolor.- spaghetti and meatballs appearance.
yCulture Sabourauds agar 1-3 weeks.
- Identified by colony colour, texturey Light microscopy morphologic patterns
TREATMENT
y Most tinea infections: Topical agent imidaole b.d x 2-3/52y Severe cases: oral- Itraconazole- Fluconazole- Terbinafine
yTinea versicolor:
- 2.5% selenium sulphide suspension (Selsun shampoo) entire body 10 minutes x 7.7- Single dose oral keto/itra/flunazole
PREVENTION & CONTROL
- Keep clean- Dry body surfaces all the time