132 PATENT ABSTRACTS

monoclonal antibodies gives a uniform level of protection against all strains of infectious bursal disease tested. The monoclonal antibodies were effective in inducing priming for an active anti- viral response in a heterologous host.

4956479

2 3 - D E O X Y - 2 7 - C H L O R O D E R I V A T I V E S O F LL-F28249

C O M P O U N D S

Susan Y Tamura, Goro Asato, Hamilton Sq, N J, United Statee assigned to American Cyanamid Company

The present invention relates to novel derivatives of LL-F28249 compounds. These LL-F28249 compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subspecies non- cyanogenus having deposit accession number NRRL 15773. The 23-deoxy-27-halo(chloro) derivatives have the 23-hydroxy group of the LL-F28249 compounds replaced by hydrogen and a halogen such as chlorine in the 27-position with the double bond shifted to the 26,26'- position. The novel derivatives of the present in- vention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents and are useful in areas of human and animal health and in agricultural crops. Compositions containing the present compounds also are presented herein.

4957599

A L K A L I N E E X T R A C T I O N , P E R O X I D E B L E A C H I N G O F

N O N W O O D Y L I G N O C E L L U L O S I C

S U B S T R A T E S

Yu-Chia T Chou, David Garrison, William Lewis assigned to E I du Pont de Nemours and Company

An improved process for delignifying and bleaching nonwoody, lignocellulosic material into products digestible by ruminants and in- gestible by humans. The process comprises treating the substrate in an alkaline solution for a period of time, separating the wetted substrate from the slurry and then treating the wetted sub- strate with an alkaline peroxide solution at an in- itial pH of 8.5 to 11.0 for a period of time, and separating, washing and drying the product.

4957739

P H A R M A C E U T I C A L C O M P O S I T I O N S O F A 105 K D P.

H A E M O L Y T I C A D E R I V E D A N T I G E N U S E F U L F O R

T R E A T M E N T O F S H I P P I N G F E V E R

Peter Berget, Michael Engler, Sarah Highlander, George Weinstock assigned to Board of Regents The University of Texas System

Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell- free Pasteurella haemolytica supernatants are employed to provide individual antigen com- positions, identified through reaction with sera from naturally-infected or convalescent cattle. In particular, at least seven individual P. hameolytica antigen groups were recognized in cell-free culture supernatants. Purified P. haemolytica supernatant, formulated in a suitable pharmaceutical vaccine composition is shown to elicit a specific immune response, in both cows and rabbits, directed against the in- dividual immunoreactive P. haemolytica poly- peptides identified. Also disclosed are novel recombinant cells, plasmids and bacteriophage which include transcriptionally active P. haemolytica antigen genes. Recombinant clones are similarly selected to be reactive with naturally-infected antisera. Examples, and fur- ther disclosure, are also provided which demons- trate the utility of a presently disclosed antibody and antigen compositions in immunodetection of both antigens and antibodies in various bio- logical samples.

4957743

M E T H O D F O R T R E A T I N G H E R P E S

Helmu Keller, D 8646 Nordhalben, Federal Republic Of Germany

This application relates to a composition and method for treating herpes and chronic in- flammatory intestinal tract diseases. According to the invention, herpes, Morbus Crohn and Colitis ulcerosa are treated with a medication prepared from the juice or watery extract of meat-eating plants, preferably the Venus Fly Trap (Dionaea muscipula).