Lincoln Memorial University MEDT 340: Immunohematology Component Summary Sheet Component Indications For Use Compositio n Volume (mls) EXP Storag e Temp Notes: Whole Blood To replace the loss of both RBC mass and plasma volume 40% HCT with platelets 450-570 35 d in CPDA-1 1-6°C Rarely transfused today; MUST BE ABO IDENTICAL Major Risk : Volume overload can trigger CHF: Congestive Heart Failure, complication of renal impairments, pulmonary edema, etc PRBC To increase the oxygen- carrying capacity in anemic patients HCT: 55-75% 330 35 d in CPDA-1 1-6°C Each unit will raise HgB 1.0 - 1.5 g/dL Leukocyte Reduced PRBCs Same as PRBC but without the risks of febrile reaction HCT: 55-75% 330 35 d in CPDA-1 1-6°C WBC: <5.0 x 10 6 WBC/uL (average PRBC unit: 2 x 10 9 WBC/uL) Washed RBCs Patient history of anaphylactic or febrile reactions HCT: 75% 180 24 hrs 1-6°C Washed RBCs are especially useful for rare IgA deficient patients who develop an anti-IgA antibody that reacts with IgA in donor blood. Frozen RBCs Long-term storage of rare or autologous units HCT: 75% 180 24 hrs after thaw 1-6°C after thaw Frozen Storage : High glycerol (40): -80C; Low glycerol (20%): -120C Three Aspects Must Be Monitored : RBC Recovery (80%) RBC Viability (70% at 24 hours post transfusion) Maximum allowable osmolarity is 500 mOsm. (420 mOsm is the target.) Irradiated PRBC FIRM HCT: 55-75% 330 Origina l outdate or 28 days from 1-6°C Used to prevent Graft vs. Host Disease

340 Summary Sheet Blood Components Sp 10

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Page 1: 340 Summary Sheet Blood Components Sp 10

Lincoln Memorial UniversityMEDT 340: Immunohematology

Component Summary Sheet

Component Indications For Use

Composition Volume (mls)

EXP Storage Temp

Notes:

Whole Blood To replace the loss of both RBC mass and plasma volume

40% HCT with platelets

450-570 35 d in CPDA-1

1-6°C Rarely transfused today; MUST BE ABO IDENTICAL Major Risk: Volume overload can trigger CHF: Congestive Heart Failure, complication of renal impairments, pulmonary edema, etc

PRBC To increase the oxygen-carrying capacity in anemic patients

HCT: 55-75% 330 35 d in CPDA-1

1-6°C Each unit will raise HgB 1.0 - 1.5 g/dL

Leukocyte Reduced PRBCs

Same as PRBC but without the risks of febrile reaction

HCT: 55-75% 330 35 d in CPDA-1

1-6°C WBC: <5.0 x 106 WBC/uL (average PRBC unit: 2 x 109 WBC/uL)

Washed RBCs Patient history of anaphylactic or febrile reactions

HCT: 75% 180 24 hrs 1-6°C Washed RBCs are especially useful for rare IgA deficient patients who develop an anti-IgA antibody that reacts with IgA in donor blood.

Frozen RBCs Long-term storage of rare or autologous units

HCT: 75% 180 24 hrs after thaw

1-6°C after thaw

Frozen Storage: High glycerol (40): -80C; Low glycerol (20%): -120CThree Aspects Must Be Monitored:RBC Recovery (80%)RBC Viability (70% at 24 hours post transfusion)Maximum allowable osmolarity is 500 mOsm. (420 mOsm is the target.)

Irradiated PRBC FIRM HCT: 55-75% 330 Original outdate or 28 days from irradiation

1-6°C Used to prevent Graft vs. Host Disease

Platelet-S Severe Thromobcytopenia (<50,000 plts/uL)

>5.5 x 1010 plts 60 5 days 20–24 °C pH: 6.21 Plt-P or 6 Plt-S should increase the platelet count by 5,000 – 10,000 plts/uL in a typical 70-kg human

Platelet-P Severe Thromobcytopenia (<50,000 plts/uL)

>3.0 x 1011 plts 300 5 days 20–24 °C pH: 6.21 Plt-P or 6 Plt-S should increase the platelet count by 5,000 – 10,000 plts/uL in a typical 70-kg human

FFP Multiple coag deficiencies

Coagulation factors

220 24 hrs after thaw

1-6°C after thaw

Frozen Storage: <= -18°C for up to 1 year or <= -65°C for up to 7 years

Cryoprecipitate Hypofibrinogenemia, dysfibrinogenemia