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2013 RIGGTEKDissolution Test Systems
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2
Content
2
Media Preparation – Regulatory Demands
Media Preparation – User Demands
DissoPrep X8/15 – features, advantages, options
Sampilio X8 – features, advantages, options
easyDISS TX6 / TX8 – features, advantages, options
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 33
Media PreparationRegulatory Demands – why?
The correct and repeatable media preparation has significant influence on the reproducibilty of the dissolution test results
Following parameters are important:
1. precise and repeatable mixing of the media
2. precise dispensing of the media into the vessels
3. timesaving warming of the media
4. degassing of the media
5. documentation of the media preparation.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 44
Media PreparationRegulatory Demands – mixing, heating, dispensing
USP:
„Place the stated volume of the dissolution medium with an ...... accuracy of 1% in the vessels ...... and equilibrate it to 37 +/- 0,5 °C...“
„Standard Conditions“ for filling the vessels:
• reference temperature according USP is 25°C:1 Litre of Water weighs 998,3g
• Standard Conditions according EP is 20°C and 1bar:1 Litre of Water weighs 997,1g
Conclusion:
• The „Stated Volumes“ – when mixing of all components of the media - must be filled cold at „Standard Conditions“ into the vessels and then heated up.
• In accordance with the USP e.g. 900ml dispensed into a vessel weigh 897,4g. Only the weight of a liquid is not changing when warming it! Density and volume are changing!
• It would be wrong to measure warm media in a volumetric flask or device calibrated at 20°C.
• It would be wrong to use the specific weight (density) for gravimetric volume measuring of the media at e.g. 37°C.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 55
Media PreparationRegulatory Demands – degassing
USP:
„The USP recognizes that dissolved gases in the dissolution media may affect dissolution test results and ...... recommends that gases be removed by filtering, warming and stirring under vacuum before the test is performed*.“
*Dissoution Technologies, May 1996
FDA:
The FDA targeted the degassing more than ever as an area of concern. The recommended method* refers to parameters of the USP recommendation „filtering, warming, stirring, vacuum and process time“. Stirring is realized by feeding air bubbles in the media bin. Additionally feeding air bubbles causes an Avalanche-Effect .
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 66
Media PreparationRegulatory Demands – degassing
Experiences:
• there were not published many and clear experience reports on the consequences of various degassing methods till now *. Usually, internal company experiences are not pubished.
• a high theoretical degassing efficiency of an arbitrary degasing method is reduced by fast resaturation of dissolved air in the media. The re-aeration takes place during intermediate storage, during filling, during waiting periods and in the initial phase of the dissolution test.
• under dissolution test conditions with degased media at least the dissolved air in the media may not be oversaturated, i.e. no formation of bubbles may arise.
• In case of water with a temperature of 20°C and an ambient air pressure of 1bar, there are 9,08ppm oxygen and air components dissolved. In case of 37°C there are 6,72ppm. If the temperature is increased to 100°C and / or the air pressure is reduced against 0 bar (full vacuum), no more air can be solved.
Conclusion:
• The degassing is necessary at least to avoid oversaturation.
• The media can be dagassed either with the parameter „temperature“ or „vacuum“.
• The results of different degassing methods must be compared after dosage into the vessel or at the start of the dissolution test.
*Dissoution Technologies, May 1996 / Dissoution Technologies, Feb 2004 / Dissoution Technologies, Aug 2008
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 77
Media PreparationRegulatory Demands – documentation
GLP / GMP:
The GLP / GMP rules demand a prescribed handling method SOP for the production of the media and ...
... the documentation of all working steps has to be done (traceability).
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 88
Media PreparationUser Demands – easy handling, space saving
easy handling:
The handling must be simple and convenient. Efficiency is increased only in connection with the...... full acceptance of the equipment by the laboratory staff.
space saving:
Nowhere in the labs is enough space available... ... such a unit must be compact.
time and cost saving:
Media filtering, heating, mixing, and degassing must be performed without user intervention in a reasonable time... ... for increasing throughput, avoiding manual media handling and waiting for warming the media before the start of the dissolution test. The compliance of the regulations and standards saves a lot of operational and administrative work.
USP, EP, FDA, GLP/GMP comformity:
There are many different requirements from regulations and standards, generating a lot of additional work... ... such a unit has to comply all requirements and has to save all associated operational and administrative work.
1. xx2. yy3. ww4. ...
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 99
DissoPrep X8 / X15features (1)
The Dissoprep X8 / X15 is the original media preparation system which is working according the gravimetrical principle for more than 14 years and so fulfills the USP, FDA, EP, GLP / GMP.
GRAVIMETRICAL PRINCIPLE (lockout spec) NO FLUDIC PUMP (lockout spec) mixing of acid or buffer high dispensing accuracy complete printout / documentation high degassing efficiency 8 or 15 liter tank fast economic amortisation
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1010
DissoPrep X8 / X15features (2)
The Dissoprep X8 / X15 is filtering, mixing, warming, degassing and dispensing the media according the USP, FDA, EP, GLP / GMP.
filtering:
by an easily exchangeable Filter Cartridge, the remaining filter capacity is checked automatically, when necessary the system prompts the user to change the filter. The Flow Through Principle prevents bacterial growth.
warming:
A special continous-flow heater warms the media before degassing. This generates an enhanced degassing and saves considerable time when heating in the dissolution tester.
Mixing:
For the precise addition of concentrated hydrochloric acid, buffer or surfactant (SLS) a second inlet channel is provided.
The composition of additive and water is controlled gravimetricly by a Precision Load Cell.
An electronic stirrer mixes the components in the storage tank and ensures a homogenous mixture concentration (functionally monitored).
The precision of the composition is very high (deviation lower than 0,2% typ.).
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1111
DissoPrep X8 / X15features (3)
degassing:
The media is exposed to a high vacuum during sucking in the raw media.
The interaction of heating, mixing and degassing generates an effective de-aeration of the medium e.g. for water with typically 3-5ppm O2 (after filling into the vessel).
The USP does not specify degassing in figures because the dissolved oxygen measurement is not robust and no traceable standards for the calibration of oxygen meters are available.Only the physical effect paramaters temperature, vacuum and duration of media exposure can be measured reliably.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1212
DissoPrep X8 / X15features (4)
Degassing Efficiency Investigation with DissoPrep X8© 2010www.riggtek.comDipl.- Ing. Hansjuergen Riggenmann
Oxymeter from WTW OXI 330DissoPrep X8 with Firmware 7.108
Method Parameter Test No. 1 2 3 4 5 6 (7)Temperature °C 36 45,2 22,1 36,7 45,5 36,9 37,1Temperature eff. °C/10 360 452 221 367 455 369 371min. Pressure (vacuum) mbar 450 450 90 90 90 90 90Volume mL 1x 5000 1x 5000 1x 5000 1x 5000 1x 5000 6x 1000 6x 1000add. Degas Time sec 120 120 120 120 240 120 120
start Oxygen ppm O2 8,54 8,47 8,36 8,24 8,55 8,1 8,55
end Oxygen ppm O2 6,26 5,64 5,62 3,59 3,09 3,66 3,18DPX8 routine application(time saving method without add. Degas Time)
YES YES YES
0
1
2
3
4
5
6
7
0
50
100
150
200
250
300
350
400
450
500
1 2 3 4 5 6 (7)
end
Oxy
gen
(pp
m)
Pre
ssu
re (m
bar
) /
Tem
p. (
°C)
Test no.
Temperature
Pressure
end Oxygen
degassing:
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1313
DissoPrep X8 / X15features (5)
1313
Not degassed Degassed degassing:
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1414
DissoPrep X8 / X15features (6)
dispensing:
The vessels in the dissolution tester are filled directly with a Dispense Tube.
The highly precise dosage (<1% at 500 - 8.000g / 15.000g, typ. 2g) of 900mL needs approximately 25 seconds and is controlled by the Precision Load Cell.
The target volume can be selected between 150g and 8.000g / 15.000g (weight equivalents of mL).
documentation:
All internal dosage processes are accurately controlled and monitored by a Precision Load Cell. The individual dosage processes are documented and can be printed on an external printer or administrated with PC (Option: RC Software).After each DISPENSE cycle the DissoPrep provides a DISPENSE Protocol containing the weights, the mixing ratio, the vacuum and the temperature.Also a CALIBRATION Protocol is provided. The DissoPrep can be calibrated trough a software guided procedure easily.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1515
DissoPrep X8 /X15features (7)
DISPENSE PROTOCOLNo: 14for the media dosagewith DosaPrep X8Serial Number : 22020999Firmware Version: 6.000General Data:Nominal filter capacity [l]: 5000Remaining filter capacity [l]: 4827Volume throughput up to now : 173Method: 0Standard Media 0,1N HCLResult of the dosages [g]: MEDIUM ADDTV RATIO DEV%Fill Nominal: 5400 0.0 0.000Fill Actual : 5504 0.0 0.000 +0.0 MEDIUM DEV% ADDTV DEV%Vessel No. 6: 899 -0.1 0.0 +0.0Vessel No. 5: 901 +0.1 0.0 +0.0Vessel No. 4: 900 +0.1 0.0 +0.0Vessel No. 3: 900 -0.0 0.0 +0.0Vessel No. 2: 900 +0.0 0.0 +0.0Vessel No. 1: 900 -0.0 0.0 +0.0Temperature (average): 37.1 CMAX.VACUUM at 144 mbar absolute pressure *Date, Time: ............................Name: ............................Signature: ............................
documentation:
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1616
DissoPrep X8 / X15features (8)
MANUAL CALIBRATION PROTOCOLNo: 7for the media dosagewith DOSAPREP X8Serial Number : 20100056Firmware Version: 4.25General Data:Nominal filter capacity [l]: 5000Remaining filter capacity [l]: 4950Volume throughput up to now : 50Result of the quantity measurings [g] INTERN EXTERN DEV% No. 8: 1003 1005 -0.2 No. 7: 1004 1004 +0.0 No. 6: 1004 1005 -0.1 No. 5: 1004 1003 +0.1 No. 4: 1003 1003 +0.0 No. 3: 1004 1003 +0.1 No. 2: 1004 1005 -0.1 No. 1: 1003 1002 +0.1Result (average): 1004 1004 -0.0Result of the temperature measurings[C] INTERN EXTERN DEV No. 8: 36.2 36.2 +0.0 No. 7: 36.3 36.3 +0.0 No. 6: 36.2 36.2 +0.0 No. 5: 36.2 36.2 +0.0 No. 4: 36.3 36.3 +0.0 No. 3: 36.3 36.3 +0.0 No. 2: 36.3 36.3 +0.0 No. 1: 36.3 36.3 +0.0Result (average): 36.2 36.2 +0.0Date, Time: ............................Name: ............................Signature: ............................ 2000-10-03 21:21:21 (UTC)
documentation:
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1717
DissoPrep X8 / X15features (9)
documentation:
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1818
DissoPrep X8 / X15advantages (1)
easy handling:
The user-interface of the DissoPrep is quite simple with only a few buttons.The Remote Control Nozzle simplify the dispensing into the vessels.
space saving:
The dimensions of the DissoPrep X8 / X15 are W 30cm x H 66cm x D 59cm quite compact to fit in every lab.
USP, EP, FDA, GLP/GMP comformity:
DissoPrep fulfills all requirements of the media preparation according to the demanded rules of the USP and EP, as well as according to the recommendations of the FDA and of the GLP/GMP.
Safety in the Laboratory:
By automating the process - particularly the acid preparation and media dispensing - the risk to laboratory personnel is minimized.
Reproducibility of the results:
Reproducibility of the test results is independently of the operators(a result of the automation of the media preparation).
Simplification of administrative documentation:
With the optional available Remote Control Software all methods can be administrated and all protocols which are generated with the DissoPrep can be transmitted in a PC network “21CFR Part 11 compliant”.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 1919
DissoPrep X8 / X15advantages (2)
time and cost saving:
The saving of time is considerable. E.g. the DissoPrep X8 prepares up to 8L of dissolution media automated in less than 15 minutes (12 minutes with prepared media). The fast and precise dosage by a tube into the individual vessels (~25 seconds for 900ml) saves time-consuming handling steps. The preheated media saves up to 45 minutes for media heating with a conventional water bath dissolution tester.
If you calculate with:
• 180€ full costs of a manual test and• 30€ costs of a test with the DissoPrep X8,
the ROI will already be reached after 90 tests
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2020
Media PreparationRegulatory Demands – why?
The correct and always repeatable media preparation has significant influence on the reproducibilty of the dissolution test results
Following parameters are important:
1. precise and repeatable mixing of the media
2. precise dispensing of the media into the vessels
3. timesaving warming of the media
4. degassing of the media
5. documentation of the media preparation
with DissoPrep:
to remember...
1. xx2. yy3. ww4. ...
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2121
DissoPrep X8 / X15options / accessories (1)
DissoPrep X8 or X15
X8 with 8 liter tank X15 with 15l tank (gross) same housing dimensions same working principle
RC-Nozzle
comfortable remote-controled dispensing with buttons at handle bar at tubing´s end
especially if 3m distance (tubings length) is used
RC-Software
Remote-Control-Software for easy method configuration and
easy protocol and certification administration
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2222
DissoPrep X8 / X15options / accessories (2)
Water-Interface
for continous, pressureless contection to DI-water tap
installation has to be done from house technicans of customer
shut-off valve should be installed
LabCart
comfortable use of DissoPrep at different places
place for different reservoirs (available at RIGGTEK), printer and vessel-rack
has to be connected to power-supply during whole media preparation and dispensing
UPS (uninterruptable power supply) not available at the moment (in work)
Vessel-Rack
safe transportation of vessels to dissolution tester
isolation keeps vessels warm available for 6 or 8 vessels
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2323
DissoPrep X8 / X15options / accessories (3)
printers
for immediate protocol / certification printout
suitable parallel-printers in DINA4- or bon-paper-size
measuring equipment
all necessary measuring equipment for qualification of the DissoPrep is available at RIGGTEK
special balance with automatic communication to DissoPrep for easy and comfortable qualification
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2424
Autosampler „Sampilio X8“The result of your requests
easy to operate
first-in, first-out
reproducable
prepared for future tasks
reliable
expansible
easy to upgrade
easy to service
fast
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2525
Autosampler „Sampilio X8“We heard the problems with autosampling
Do your customers have the following problems with their existing Autosamplers?
• The pumps are not reliable• The samples taken with your autosampler are not comparable with the manual sampling• The cross-contamination between samples is too big• The possible intervals are not short enough for your desired sampling times• The autosampler is not easily to connect to different types of dissolution baths• The overall handling with the autosampler is complex, the operating is complicated• The cleaning and maintenance of the autosampler is time-consuming• Your autosampler is not equipped for future tasks such as cooling / heating and direct
offline / online transfer to UV / HPLC .
We have solved these problems with the Sampilio X8
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2626
Sampilio X8features (1)
The Sampilio X8 is the new generation of dissolution autosamplers
reliable with SMALL VOLUME DIAPHRAGM PUMPS (lockout spec) compareable to manual sampling – FIFO delivery principle lowest cross contamination extremly short interval times easy conntection to other dissolution testers easy handling and operation easy cleaning and maintenance flexible for the future (Connectivity (in development), Cooling-Option
(in development), Transfer-Module-Option (to be customized).
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2727
Sampilio X8features and advantages (2)
Reliable with small diaphragm pumps
The small volume bidirectional diaphragm pumps (unique feature) for each line allow a simple functional principle without the need of additional valves, fittings etc.
and so guarantee less components which could be getting defect
The diaphragm pumps do not produce wrapped-off parts such as syringe pumps do, so you will not find any particle of seals, etc. in your samples.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2828
Sampilio X8features and advantages(3)
Compareable results as manual sampling
The small volume diaphragm pumps (unique feature) for each line allow with their lowest dead volume FIFO delivery principle
together with the lowest tubing volume – because of the working principle – the sampling is compareable with the manual sampling with syringe
The diaphragm pumps do not produce wrapped-off parts such as syringe pumps do, so you will not find any particle of seals, etc. in your samples.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 2929
Sampilio X8features and advantages (4)
Lowest cross contamination
The functional principle of the Sampilio X8 with small tubing length and small dead volume of the diaphragm pumps allow
together with the test tubes in the first row of the racks lowest cross contamination. Additional a cleaning of an „waste bin“ is not necessary.
200cm 40cm
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3030
Sampilio X8features and advantages (5)
Extremly short interval times
The functional principle of the Sampilio X8 with small tubing length, small dead volume of the pumps and so total small total dead volume allow fast flushing, sampling and recycling.
This results in the possiblility of extremly short interval times between the sampling steps (typ. < 2min).
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3131
Sampilio X8features and advantages (6)
Easy connection to dissolution baths
Easy connection: For each line there is a 3m long tubing coming out of the Sampilio X8. The UNF ¼” -28 screw head fittings used at the tubings end are a standard for easy connection to sample probes, syringe filters or luer adapters.
There are different sample probes and stoppers available to fit all kinds of dissolution baths (DISTEK, Erweka, Sotax, etc.).
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3232
Sampilio X8features and advantages (7)
Easy operation and handling
Easy operation: Turn on the Sampilio X8. With only 5 keys and a easy menu structure you operate the Sampilio quickly and intuitively.
Easy handling: With only 6 tubes (one for each vessel) there are no unnecessary tubings between pumps and collectors, etc. . Open the door of the Sampilio X8 and insert rack filled with HPLC-Vials or Test Tubes on the rack carriage and close the door again - the Sampilio is ready for your sampling method.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3333
Sampilio X8features and advantages (8)
Easy cleaning and maintenance
The housing of the Sampilio X8 is completely closed and therefore easy to clean
For the flush volume so called "Waste tubes" are used. These are commercially available "Test Tubes / sample tubes“, that are placed in the first row of the rack and after a sample method they can be easily replaced / thrown away. A cleaning of any tank is not necessary.
Since the tubings and diaphragm pumps are installed in series without any valves in between, they can be cleaned with an automatic cleaning program easily and efficiently.
The mechanism is kept simple and robust and does not require expensive maintenance.
row for „Waste Tubes“
serial configruration
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3434
Sampilio X8features and advantages (9)
Flexible for the future - Connectivity (in development)
The Sampilio X8 has different interfaces to communicate with different units and softwares (Media Preparation Systems, dissolution baths, UV´s, HPLC´s, Data-Software)
A software will collect and summarize all datas for a complete dissolution test.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3535
Sampilio X8features and advantages (6)
Flexible for the future - Cooling option (in development)
A Peltier Element will allow together with the closed housing a cooling of the collected samples and so reduces additional effort to take each collected sample to a refrigerator
For drying the inside of the Sampilio X8, a heating will be possible as well.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3636
Sampilio X8features and advantages (7)
Flexible for the future – Transfer Module-Option (to be customized)
The Transfer Module-Option will allow in combination with one pump for each line a flexible configuration of the Sampilio X8
So the transfer of a single sample, a sample row as well as media replacement or transfer to UV (or HPLC) in online- or offline-configuration will be possible
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3737
Sampilio X8options / accessories (1)
DUAL
as DUAL-configuration two Sampilio´s are connected via USB (max. 2m distance) to allow an autosampling at a simultanoues dual dissolution test with max. 16 positions
special price for the DUAL-configuration
The Slave-Unit does not work independently
Additional Lines
as standard, the Sampilio X8 has 6 sample lines
up to two additional lines can be added
Racks
as standard the Sampilio X8 is delivered with one Test-Tube-Rack and one HPLC-Rack
for a possible rack-change additional racks are available
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3838
Sampilio X8options / accessories (2)
Cooling-Option(in work)
will allow cooling to safe taking collected samples to a refrigerator after each sampling step
heating will possilbe for drying the inside of the Sampilio X8
Transfer-Module-Option(in work)
the Transfer-Modul will allow single offline transfer of samples to an UV
or will allow replacement of media
RC-Software(in work)
as standard the Sampilio X8 is delivered with one Test-Tube-Rack and one HPLC-Rack
for a possible rack-change additional racks are available
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 3939
Sampilio X8options / accessories (3)
Sample Probes
diffrent sample probes are available for a correct connection to a dissolution tester (e.g. Sotax, Distek)
Filters
different filters – disc, canuales, syringe -are available
luer adapters
diffrent kinds of luer adapters are available for optimal connection of the tubings
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4040
easyDISS TX6 / TX8features and advantages (1)
The easyDISS TX6 / TX8 is all you really need at a dissolution tester
Rugged, compact and easy-to-use Conforms to all current Ph.Eur. And USP specifications Available with 6 (TX6) and 8 positions (TX8) Screw-in baskets/paddles allow method changes in seconds Individual clutches allow each shaft to be raised, lowered and
engeged independent of the drive head Uncluttered design allows maximum access to working area 316 stainless steel teflon coated vessel support plate „Easy-Centre“ vessel centring system One piece PETG water bath with built- in drain tap: no leaks;
easy to remove and clean Independent digital heater/circulator with over-temperature cut-
out and indicator. Full printed test report on completion of the run RS232 bi-directional interface and USB/parallel printer port Menu guided calibration procedure (with print-out) Various options and accessories available.
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4141
Interchangeable Baskets/Paddles
for method changes in seconds
„Easy-Centre“Vessel Location
ensures that the vessels are perfectly centred very time
vessel easy to remove and locate
one piece wather bath
easy to remove and clean with: built in drain drop round edges no leaks
easyDISS TX6 / TX8features and advantages (2)
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4242
Laser numbering and certification
for shafts, paddles, baskets, vessles, etc.
Teflon coated baskets and paddles
for aggressive media
rotating cylinders
for transdermal patches
easyDISS TX6 / TX8options and accessories (1)
diffrent vessels and vessel covers
vessels with clear glass or amber
EMC Ultra Precision Vessels low evaporation covers
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4343
Intrinsic Kit
easy to remove and clean with: built in drain drop round edges no leaks
easyDISS TX6 / TX8options and accessories (2)
Automatic Tablet Drop for simultanous drop of
dosage forms at all vessels
paddle over disk vessels with clear glass or
amber low evaporation covers
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4444
Immersion Cell
for testing semisolids
easyDISS TX6 / TX8options and accessories (3)
Small Volume Conversion Kit
for special dosage forms with lower concentrations
sampling accessories
for all kinds of automatic or manual sampling
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4545
calibration equipment
for calibration issues
accessories
we support you finding the correct dissolution accessories
easyDISS TX6 / TX8options and accessories (4)
RIGGTEK – Dissolution Test Systems 11/2013Company Presentation 4646
Demo, Questions and Discussionplease feel free to ask all questions
Thank you for your attention
Any questions?