© ANZOD Registry

Figure 94 Australia and New Zealand

Number of All Transplants * By Year 1984 - 2007

(Total of all Transplants = 3393)

Year Heart Heart/Lung

Single Lung

Bilateral Lung

1984 14 0 0 0

1985 22 0 0 0

1986 34 1 0 0

1987 30 1 0 0

1988 56 2 0 0

1989 93 14 0 0

1990 103 12 5 0

1991 103 19 18 0

1992 115 18 27 3

1993 114 13 24 33

1994 104 13 26 44

1995 108 13 28 43

1996 103 7 32 42

1997 105 4 43 43

1998 82 4 38 50

1999 76 2 27 47

2000 70 2 28 73

2001 82 1 29 55

2002 82 9 29 70

2003 89 5 20 68

2004 78 6 13 91 2005 89 6 10 79

2006 80 6 17 88 2007 68 6 8 78

Total 1900 164 422 907

* I ncludes domino, hetero and retransplants

© ANZOD Registry

Figure 95 Australia and New Zealand

Recipient Age at Heart Transplant

By Year 1984 - 2007

Year Number Patients

Mean Std Dev +-

Median Minimum- Maximum

1984 14 33 15 39 11-51

1985 19 39 13 38 10-54

1986 32 40 13 43 11-57

1987 30 41 12 46 13-56

1988 56 41 14 45 4-63

1989 93 42 14 46 1-65

1990 103 43 15 47 6-65

1991 103 47 14 52 1-64

1992 115 45 15 51 4-66

1993 114 46 14 51 6-65

1994 104 47 13 50 1-66

1995 108 46 16 50 2-68

1996 103 48 13 53 10-64

1997 105 46 14 50 9-66

1998 82 46 15 51 1-64

1999 75 47 15 53 2-67

2000 70 49 13 53 12-66

2001 80 45 15 49 2-64

2002 82 45 18 52 7-70

2003 88 45 15 47 1-67

2004 76 47 15 52 9-66

2005 89 48 14 52 5-65

2006 79 43 17 49 3-67

2007 66 46 16 49 5-71

Number of patients excludes re transplants

© ANZOD Registry

Figure 96 Australia and New Zealand

Mean Heart Ischaemic Time

Minutes 1984 - 2007

Year Number Patients

Mean Std Dev +-

Median Minimum- Maximum

1984 14 74 16 70 54-108

1985 19 114 41 95 53-183

1986 32 136 47 133 80-235

1987 30 151 45 155 60-260

1988 56 152 44 158 78-240

1989 93 150 57 147 39-311

1990 103 165 74 144 54-441

1991 103 178 80 163 55-390

1992 115 183 76 164 52-420

1993 114 207 82 198 41-446

1994 104 193 75 190 75-445

1995 108 208 98 186 42-465

1996 103 201 79 177 60-405

1997 105 211 90 194 60-454

1998 82 240 103 213 74-612

1999 75 236 101 244 43-447

2000 70 247 89 242 102-516

2001 80 265 102 253 186-338

2002 82 237 79 224 107-443

2003 88 258 90 268 176-323

2004 76 244 87 239 88-427

2005 89 239 91 239 59-491

2006 79 246 84 238 109-413

2007 66 244 91 248 73-510

Number of patients excludes re transplants

© ANZOD Registry

Figure 97 Australia and New Zealand

Cause of Death

Hearts 1984 -2007

Transplant Coronary Artery Disease (T x CAD) 139

I nfection 109

Acute Rejection 92

Non PTLD Malignancy 104

Non-specific Graft Failure (NSGF) 72

PTLD 34

CVA 20

Haemorrhage 11

Other (including unspecified) 185

Total all Deaths = 766

Renal failure (34), sudden death (22), cardiac arrest (16), heart failure (10), TxCAD + rejection (11), pulmonary failure (7), motor vehicle accident (6), suicide (6), non-compliance (5), pancreatitis (4), liver failure (3), pulmonary hypertension (3), pulmonary embolism (3), bowel ischaemia (3), (R) ventricular failure (2), respiratory failure (2), aortic dissection (Marfan’s) (2), drug overdose (2), congenital bronchomalacia (1), pericarditis (1), peripheral vascular disease (2), acute abdomen (1), anoxic brain/head injury (3), myelodysplasia (1), oesophageal perforation (1), oesophageal diverticulum (1), drug induced lung damage (2), COPD (2), died on table (1), hepatic encephalopathy (1), general deterioration (2), amyloidosis (1), Parkinson’s (1) mesenteric ischaemia (1), aortic aneurysm (1), unspecified (no data) (2).

© ANZOD Registry

Figure 98 Australia and New Zealand

Cause of Death All Hearts < 5 Years

After Transplant 1984 - 2007

Number %

I nfection 85 21

Miscellaneous 62 15

Rejection 74 18

Non Specific Graft Failure 58 14

Graft Atherosclerosis (T x CAD) 52 13

Non Lymphoid Malignancy 28 7

Lymphoproliferative Disease 12 3

CVA 9 2

Haemorrhage 9 2

Graft Atherosclerosis and Rejection 8 2

Pulmonary Failure 5 1

Pulmonary Hypertension 2 1

Totals 404 100%

Figure 99 Australia and New Zealand

Cause of Death All Hearts ≥ 5 Years

After Transplant 1984 - 2007

Number %

Miscellaneous (including 2 no data) 105 28

Graft Atherosclerosis (T x CAD 86 24

Non Lymphoid Malignancy 76 21

I nfection 23 6

Lymphoproliferative Disease 22 6

Rejection 17 5

CVA 11 3

Non Specific Graft Failure 14 4

Haemorrhage 2 0.5

Pulmonary Failure 2 0.5

Graft Atherosclerosis and Rejection 3 0.5

Pulmonary Hypertension 1 0.5

Totals 362 100%

© ANZOD Registry

0

10

20

30

40

50

60

70

80

90

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23

ISHLT ANZCOTR

%

Years

ISHLT n=70,702 Time Period=1/82-6/05 Kaplan-Meier method

ANZCOTR n=1,889 Time Period=2/84-12/07 Cutler-Ederer method

81.4

86.9

77.1

68.361

50.1

17.5

37.4

32.7

48

International vs Australasia All Heart Actuarial Survival

ANZCOTR 2007

© ANZOD Registry

Year

ANZCOTR 2007

mm1 v mm2 p<0.05

0

20

40

60

80

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

MM0 MM1 MM2Years ANZCOTR 2007

Australia and New Zealand

%

Actuarial Survival HLA DR Locus Mismatch Hearts 1984 - 2007

© ANZOD Registry

Actuarial Survival According to Pre-transplant Status Hearts

1984 - 2007

0

20

40

60

80

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23

NYHA III NYHA IV INOTROPES IABP All VAD

Years ANZCOTR 2007

Australia and New Zealand

%

© ANZOD Registry

Reason for Heart Transplant 1984 -2007

Australia and New Zealand

Ischaemic Heart Disease 37%

Idiopathic Dilated Cardiomyopathy

40%

Viral CM / Myocarditis 3%

Congenital HD 5%

Other 12%

Familial CM 2%

Peripartum CM 1%

ANZCOTR 2007

Retransplants not included

© ANZOD Registry

0

20

40

60

80

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

Positive Negative

Actuarial Survival Crossmatch Hearts 1984 - 2007%

p < 0.01

Years ANZCOTR 2007

Australia and New Zealand

© ANZOD Registry

2 of the 11 cases in the greater than 59 years category are heterotopic heart transplants

0

20

40

60

80

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

0 - 16 17 - 39 40 - 49 50 -59 >59

Australia and New Zealand

Years ANZCOTR 2007

Actuarial Survival Donor Age Hearts 1984 - 2007

0-16 v 40-49 p=.0050-16 v 60+ p=.00517-39 v 40-49 p=.00517-39 v 50-59 p=.00517-39 v 60+ p=.00540-49 v 50-59 p=.00550-59 v 60+ p=.005

%

© ANZOD Registry

Figure 106 Australia and New Zealand

Mean Recipient Age at Lung Transplant 1989 - 2007

Heart/ Lung Single Lung Bilateral Sequential Lung

Year No. Pts

Mean Std

Dev +- Minimum- Maximum

No. Pts

Mean Std

Dev +- Minimum- Maximum

No. Pts

Mean Std

Dev +- Minimum- Maximum

1989 14 32 12 11-46 - - - - - - - -

1990 12 37 10 20-51 5 48 5 42-55 - - - -

1991 19 34 11 19-46 18 46 8 32-57 - - - -

1992 18 31 12 15-49 27 46 7 26-57 3 34 17 19-52

1993 13 31 13 12-48 24 51 3 46-57 33 34 13 19-56

1994 13 32 10 14-46 26 49 6 30-57 44 36 10 19-54

1995 13 38 11 24-52 28 51 7 22-59 43 35 13 16-60

1996 7 26 6 18-37 32 54 6 30-60 42 39 14 13-60

1997 4 36 9 23-42 43 51 6 35-62 43 37 14 14-61

1998 4 26 14 13-43 38 51 9 30-65 50 38 14 14-60

1999 2 38 n/a 22-53 27 55 7 37-64 47 36 13 15-62

2000 2 34 n/a 22-46 28 55 6 39-65 73 40 13 14-63

2001 1 40 n/a 40 29 56 9 32-69 55 38 14 13-60

2002 9 35 10 22-49 29 57 5 43-66 70 39 14 14-65

2003 5 36 18 13-55 21 57 7 42-66 65 41 15 17-64 2004 6 36 10 21-47 13 56 6 48-64 90 44 14 15-65

2005 5 37 8 25-46 10 61 3 57-66 77 44 14 16-64

2006 6 25 14 9-45 17 54 7 34-60 85 45 16 15-66

2007 6 38 12 15-48 8 57 5 50-64 73 45 15 9-63

© ANZOD Registry

Figure 107 Australia and New Zealand

Cause of Death All Lungs < 5 Years After Transplant 1984 - 2007

Number %

Bronchiolitis Obliterans 193 32.9

I nfection 137 23.3

Miscellaneous 88 15.0

Pulmonary Failure 44 7.5

Non Specific Graft Failure 38 6.5

Rejection 21 3.6

Haemorrhage 18 3.1

PTLD 16 2.7

Non Lymphoid Malignancy 14 2.4

CVA 13 2.2

Graft Atherosclerosis (T xCAD) 4 0.7

No data 1 0.2

Totals 587 100%

© ANZOD Registry

Figure 108 Australia and New Zealand

Cause of Death All Lungs ≥ 5 Years After Transplant 1984 - 2007

Number %

Bronchiolitis Obliterans 80 41.7

Miscellaneous 35 18.2

I nfection 33 17.2

Non Lymphoid Malignancy 19 9.9

Pulmonary Failure 14 7.3

PTLD 3 1.6

No data 3 1.6

Rejection 2 1.0

Haemorrhage 2 1.0

CVA 1 0.5

Totals 192 100%

© ANZOD Registry

%

SL v HL p<0.005

SL v BL p<0.005

0

20

40

60

80

100%

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

HLTx SLTx BSLTx

Actuarial Survival All Lung Transplants 1986 - 2007

Years ANZCOTR 2007

Australia and New Zealand

© ANZOD Registry

0

20

40

60

80

100%

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

R-ve/D-ve R-ve/D+ve R+ve ANZCOTR 2007Years

R-D+ vs R+ p<0.05

R+ve = R+ve/D+ve or R+ve/D-ve

Actuarial Survival CMV Status Lungs 1986 - 2007

Australia and New Zealand

© ANZOD Registry

0102030405060708090

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20

ISHLT ANZCOTR

%

81.4

62.9

50.8

42.4

40

28.1

28.5

19.8

Years ANZCOTR 2007

International vs Australasia Heart/Lung Actuarial Survival

ISHLT n=3,184 Time Period=1/82-6/05 Kaplan-Meier method

ANZCOTR n=163 Time Period=11/86-12/07 Cutler-Ederer method

© ANZOD Registry

Reason for Transplant Heart Lung 1986 - 2007

PPH 26%

Eisenmenger’s 21%

Other PH 3%

AAT Deficiency 9%

Emphysema 3%

Congenital Heart Disease

13%

Cystic Fibrosis 14%

CFA 3%Bronchiectasis 3%

Misc 5%

ANZCOTR 2007

Australia and New Zealand

© ANZOD Registry

%

YEARS

0102030405060708090

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

ISHLT ANZCOTR

80.5

76.6

47.9

46.2 23.7

20.2

International vs Australasia Single Lung Actuarial Survival

Years ANZCOTR 2007

%

ISHLT n=8,369 Time Period=1/94-6/05 Kaplan-Meier method

ANZCOTR n=423 Time Period=10/90-12/07 Cutler-Ederer method

© ANZOD Registry

Reason for Transplant Single Lung 1990 - 2007

AAT 17%

Emphysema 53%

CFA 14%

Misc 14%

Bronchiectasis 1%

Other PH / Eisenmengers / CF 1%

ANZCOTR 2007

Australia and New Zealand

© ANZOD Registry

YEARS

0102030405060708090

100

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

ANZCOTR ISHLT

86.7

60.1

39.7

33.9

53.8

78.6

International vs Australasia Bilateral Lung Actuarial Survival

Years ANZCOTR 2007

%

ISHLT n=8,658 Time Period=1/94-6/05 Kaplan-Meier method

ANZCOTR n=895 Time Period=8/92-12/07 Cutler-Ederer method

© ANZOD Registry

Reason For TransplantBilateral Lung 1992 - 2007

Cystic Fibrosis 38%

Emphysema 21%

CFA 5%

Bronchiectasis 11%

Misc 10%

AAT 8%

Other PH 1%PPH 5%

ANZCOTR 2007

Eisenmengers 1%

Australia and New Zealand