2015 LanzaTech. All rights reserved.

12 Years On the Road to Awesome! 2016 LanzaTech. All rights reserved.

“The best way to predict the future is to invent it.”

Alan Kay

What I CAN predict

linear circular

Confidential

Innovation, Strong Will and Regulation!

1950s 2013

5 Business Confidential

Los Angeles

London

Cuyahoga River

New Delhi

Lima

1969 2016

4.3

Trillion tons lost 2003-2010

0.5inches

Added to global sea level

A Carbon Smart World

Gas Feed Stream

Gas Reception Compression Fermentation Recovery Product Tank

Recycling Carbon

Gas fermentation

technology converts C-

rich gases (CO, CO2) to

fuels and chemicals

Proprietary

Microbe

Performance milestones achieved and exceeded for >1000 hours at 0.3kMTA Potential Feedstocks

Recycling Carbon Around the World

Caofeidian, China

16M

gallons/year

Gent, Belgium

21M

gallons/year

From Mill to Wing

Ethanol

Chemical

Conversion Diesel

&

Jet Fuel

4,000 gallons of on-spec jet and 600 gallons of diesel produced Excellent analytical and Fit for Purpose results

Phase 1 Research Report Submitted $4M DOE Award to Build Demo

Recycle Make

CCU

“CCS”

Enables the Circular Economy

Building a Technology Platform

Gas Feed Stream

Gas Reception Compression Fermentation Recovery Product Tank

Hydrocarbon Fuels

Ethanol

Butanediol

Acrylonitrile Butadiene Styrene (ABS)

Nylon 6,6 (from Adiponitrile/HDMA)

Propanol Butanol

LanzaTech’s Integrated Multi-Scale Platform

Industrial proven

host strain

Intellectual Property >200 granted patents on all aspects of process

Efficient genetic toolbox

Scalable reactor designs

Process optimization and scale up

Integrated models and algorithms

Synthetic Biology to Improve Selectivity

Ethanol 2,3-BDO

Biomass

Acetate

Ethanol

Biomass Acetate

From Lab to Pilot in 1st Attempt!

Inokuma et al., 2010, Improvement of isopropanol production by metabolically engineered Escherichia coli using gas stripping. J Biosci Bioeng, 110: 696-701.

Bes

t N

ati

ve P

rod

uce

r: C

. bei

jeri

nck

ii • Native Promoter

• Genome Expression

• Batch fed

• Pure Glucose

• Minimal medium

Bes

t En

gin

eere

d s

tra

in:

E. c

oli • High-cost

promoter

• Plasmid expression

• Batch fed

• Pure Glucose

• Complex medium

C. a

uto

eth

an

og

enu

m

• Low cost promoter

• Plasmid expression

• Continuous

• Waste steel mill gas

• Minimal medium

<0.1 g/L/h Stable < 3 days

0.67 g/L/h Stable <10

days

>2.5 g/L/h Stable >3 weeks

Isopropanol Production

Synthetic Biology to Develop New Products

Fluctuations in price Predict 5-10 years down line

Disrupting Market Cycles

DISRUPTION = 1) Rapid Reaction to Market Fluctuations 2) Feedstock ≠ Commodity

Same reactor Same operating

conditions

Same feedstock

“hardware”

“software”

improved efficiency, tolerance, ethanol only

new product molecule

Microbe 1.0

Microbe 1.1

Microbe 2.0

Ethanol

1 Organism, over 20 Products…

Pyruvate

CO/CO2/H2

Acetyl-CoA

Fatty Acids,

Terpenoids

Aromatics

Ethanol

Succinate

Lactate

2,3-Butanediol

Biodiesel

3-Hydroxypropionate

Isopropanol

Acetone

3-Hydroxybutyrate

1,3-Butanediol

Joint development

Isobutene

1,3-Butadiene

2-Hydroxyisobutyrate

Branched-chain Amino Acids

Methyl Ethyl Ketone

2-Butanol

Acetoin

1,2-Propanediol

1-Propanol

Jet

Isoprene

Aromatics

Acetate

(R), (S), mixed isomers

(R), (S), mixed isomers

1-Butanol

Butyrate

(R,R), meso, mixed isomers

Valine, leucine, Isoleucine

(R), (S), mixed isomers

Benzoate (p-hydroxyl, 2-amino, dihydroxy),

salicylate

Farnesene

Mevalonate

FAEE, FABE

Citramalate

Long chain alcohols

Acetone

100% 1% Selectivity

Demonstrated over 30 new products directly from gas

PHB

Jump to the Next Curve

We are the Next Curve

Diffusion

Adapt and adopt from others

Continuous improvement

at scale

Crossing the Valley of Death

Technology Evolution

Ease

of

fun

din

g

Pilot and Demonstration

First Commercial

Applied R&D

Engineering Development

Discovery

Sustainable enterprise

“There is only one way to avoid criticism: do

nothing, say nothing, and be nothing.”

Aristotle (384 - 322 BC)

We all Need to be Superheros!