05-03-10

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NewsMonday, May 3, 2010 • Volume 12, Issue 18

New Departmental Research Grant Award

Joern Karhausen, MD from the Division of Cardiothoracic Anesthesia and Critical Care Medicine received the Roizen Anesthesia Research Foundation New Investigator Grant - $100,000 ($50,000 per year for a maximum of two years) for the project entitled: “The intestinal injury in a rat model of deep hypothermic circulatory arrest: critical role of mucosal mast cells for barrier function and inflammation.” The announcement came at the 32nd Annual Meeting of the Society of Cardiovascular Anesthesiologists held in New Orleans, LA.

The proposal has evolved from a newly established collaborative effort between Dr. Karhausen and his scientific mentor in the Cardiothoracic Anesthesia Division, Dr. G. Burkhard Mackensen as well as Drs. Soman N. Abraham, PhD, Professor of Pathology, Molecular Genetics and Microbiology and Immunology at Duke and Adam J. Moeser, DVM, PhD, Assistant Professor, North Carolina State University College of Veterinary Medicine.

In this proposal the team aims to define morphological and functional changes of the intestinal barrier in a rat model of deep hypothermic circulatory arrest (DHCA) and elucidate the interaction between intestinal epithelial and mucosal mast cells as a potentially crucial relationship that determines mucosal inflammation and barrier performance.

Patients undergoing cardiopulmonary bypass with DHCA display a more pronounced intestinal injury, impaired renal function and poorer neurological outcome and often develop a systemic inflammatory response syndrome (SIRS) that itself can lead to a decline in function of various organ systems. The pathogenesis of SIRS remains unclear but ongoing interest has focused on the contributing role of the intestinal barrier which provides a crucial natural interface between the gut associated lymphoid tissue as the body’s biggest immune organ and approximately 1014 bacteria within the lumen.

The intestinal barrier is a complex multi-cellular and even multi-organism system. A seamless interaction of all constituents is essential to maintain a selective barrier against luminal antigens, toxins, inflammatory activators and bacteria. While epithelial cells provide the backbone to the mechanical barrier, mucosal mast cells (MMC) are uniquely located within the lamina propria to negotiate incoming signals of epithelial injury and bacterial translocation with the innate and adaptive immune system. Simultaneously, MMC can respond to various stimuli through their unique ability to secrete preformed mediators and enzymes. Resultant effector functions have implications for intestinal performance in a number of pathophysiologies including the systemic inflammatory response associated with extracorporeal circulation during CPB and DHCA.

Duke Blue Devils Wins Again!

The Duke team of Drs. Jonathan Mark, Burkhard Mackensen and Madhav Swaminathan once again won bragging rights at the Echo Jeopardy game at the Society of Cardiovascular Anesthesiologists annual meeting in New Orleans on April 27. They comfortably beat the other two teams - a UPenn team comprising Drs. Steve Konstadt (SCA President), Albert Cheung and Stuart Weiss and a young Stanford team. This marks back-to-back titles for the Blue Devil team, which also won last year.

Department of Anesthesiology Research Conference

Monday, June 14, 20105-6 pm in 5685-HAFS

ThIs MoNTh IN The DepARTMeNT of ANesThesIoloGy

May 2010MoNDAy TUesDAy WeDNesDAy ThURsDAy fRIDAy3 4 5 6 7

7:15-8:00 a.m., RM203-Pain ClinicMRC Pain Conference

2:30-3:30 p.m., VAMCVA EchocardiographyConference

5-6 p.m., 5685-HAFSFaculty Meeting

5-6 p.m., 5685-HAFSCT Conference: “Saphenous Vein Aortocoronary Bypass Graft”- Susan Eagle, MD

5-6 p.m. 6686-HAFSGVTCCM Conference: “Journal Club” - Elliott Bennett-Guerrero, MD

IRB Deadline: Submit 1 originaland 3 copies to Dr. Gan’s office by 5 p.m.

6:15-7:15 a.m., 5685-HAFSCT Anesthesia Fellow/Faculty Pre-ceptor Seminar: “Three Dimensional TEE” - G. Burkhard Mackensen, MD

6:30 a.m., 2001DNResident Conference Lecture: “Esophagectomy, Why is it so hard?” - Katherine Grichnik, MD

7:15 a.m., 2001DNGrand Rounds: “Clinical Case Con-ference” - Stuart Grant, MB

5-6 p.m., 5685-HAFSDepartment Fellow/Faculty Fellow/Faculty Preceptor Seminar: “Industry, Academics, Money, and Ethics” - Joseph Mathew, MD

7:15-8:00 a.m., RM203-Pain ClinicMRC Pain Journal Club

12:00-12:45 p.m., 2003DNCritical Care Grand Rounds: CAN-CELLED

4-5 p.m., 5680A-HAFSPediatric Conference: M&M Confer-ence & Faculty Meeting

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5:30-6:30 p.m., 5680A-HAFSPerioperative Leadership Group Meeting

5-6 p.m., 5685-HAFSCT Conference

5-6 p.m. 6686-HAFSGVTCCM Conference: “Journal Club” - Elliott Bennett-Guerrero, MD


6:15-7:15 a.m., 5685-HAFSCT Anesthesia Fellow/Faculty Pre-ceptor Seminar

6:30 a.m., 2001DNResident Conference Lecture: “The Perils of Pericardial Windows” - G.Burkhard Mackensen, MD

7:15 a.m., 2001DNGrand Rounds: “Perioperative Glucose Management” - Juliann Hobbs, MD


12:00-12:45 p.m., 2003DNCritical Care Conference: “NICU Fel-low Talk - Statins in Traumatic Brain Injury” - Dr. Elissa Wible

4-5 p.m., 5680A-HAFSPediatric Conference

5-6 p.m., 7683A-HAFSResident Education Session: Merel Harmel, MD

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4-6 p.m., 5685-HAFSExecutive Team Meeting

5-6 p.m., 5685-HAFSCT Conference: CANCELLED

5-6 p.m. 6686-HAFSGVTCCM Conference: CANCELLED

5:45 p.m. Millennium hotelAcademic evening


6:30 a.m., 2001DNResident Conference Lecture: “Danger! It’s a Thoracic Emergency” - Steven Hill, MD

7:15 a.m., 2001DNGrand Rounds: “Toward Evidence Based Mentoring” - Ann Brown, MD


12:00-12:45 p.m., 2003DNCritical Care Grand Rounds


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5-6 p.m., 5685-HAFSCT Conference

5-6 p.m. 6686-HAFSGVTCCM Conference: “Echo Talk”- Dr. Roth



6:30 a.m., 2001DNResident Conference Lecture: “Not so easy: Lung Isolation & One Lung Ventilation” - Andrew Shaw, MB

7:15 a.m., 2001DNGrand Rounds: “Duty Hours, Fatigue & Performance” - Steven H. Rose, MD

5 p.m., Chen Conference RoomNeuroradiology Conference


12:00-12:45 p.m., 2003DNCritical Care Conference


5-6 p.m., 7683A-HAFSResident Journal Club

Upcoming:Resident Graduation Banquet: Saturday, June 12, 2010 | Hope Valley Country Club | Durham, NCAsA Annual Meeting: October 16-20, 2010 | San Diego, CAAnnual Alumni Reception: Sunday, October 17, 2010 | San Diego, CA | More information TBA!Annual Departmental holiday party: Saturday, December 11, 2010 | 7 p.m. to 11 p.m. More details to come.



DUKe ANesThesIoloGy NeWs

schroeder Wins AhA/Npsf patient safety leadership fellowshipDana Wiener, MD

Congratulations to Dr. Becky Schroeder, loyal member of the VA Division! Dr. Schroeder recently won a AHA/NPSF Patient Safety Leadership Fellowship (American Hospital Association/National Patient Safety Foundation). This is a nationally renowned 1 year transformative learning opportunity for health care leaders who desire to become patient safety champions. Becky will use her skills to complete a major improvement project during the program. This fellowship will reinforce her organization-wide commitment to patient

safety at the VA and Duke. Way to go Becky!

Resident leadership for 2010-2011 AnnouncedCatherine Kuhn, MD

I am very pleased to announce the selection of the following rising CA-3 residents who will serve in the indicated leadership positions for the next academic year.

Chief Residents: Ryan Fink and Chris MerrittTeaching Scholars: Erin Chaney and Aaron SandlerAcademic Chief Resident: Russell Roberson

Please join me in congratulating these residents!

AAMC QI Meeting – June 3-4, 2010The second meeting of the AAMC Integrating Quality Initiative will be held June 3-4, 2010 in Chicago, and will showcase innovative and integrative approaches to education in QI and patient safety in UME, GME, CME and faculty development, linking learning and clinical care in academic medical centers. This highly interactive meeting will feature presentations from leaders in the field, including Dr. Darrell Kirch, President and CEO, AAMC; Dr. David Nash, Dean, Jefferson School of Population Health; and Dr. Kevin Weiss, President and CEO, American Board of Medical Specialties; as well as panel presentations, poster sessions, and workshops. For complete program details and registration, please visit: www.aamc.org/meetings/opiquality/2010.

Comings and Goings in the DepartmentPlease welcome Marisa Gray to the Department. Marisa is a new Intern hired by the department today, May 3, 2010.

May 1 - 9 Birthday Wishes

Linda Bullock Elizabeth PerezBarbara Decker Dr. Nam-Kha PhamDr. Nicole Guinn Dr. Aaron SandlerDr. John Keifer Prometheus Solon

Note: If you do not want your name listed here, please send a removal notice to [email protected].

Upcoming CMe Activities

Carolina Cadaver CourseMay 22-23, 2010 | The Duke school of Nursing, Durham, NCfor more information, contact Kate shaw: [email protected].

This activity is designed to educate or refresh the knowledge of practicing anesthesiologists, critical care specialists, and certified registered nurse anes-thetists (CRNAs) in the anatomical requirements, techniques, and side effects of ultrasound-guided regional anesthesia and peripheral nerve blockade.

3rd Annual emerging Technologies in the oRJune 6-9, 2010 | Disney’s yacht and Beach Club Resort, lake Buena Vista, flfor more information, contact Katherine siler: [email protected].

13th Annual Duke Cardiothoracic Update and Tee Review CourseAugust 5-8, 2010 | sea pines Resort, hilton head Island, sCfor more information, contact Jaime Cooke: [email protected].

Mark your calendars for another year of cutting-edge research and updated information designed for medical personnel of all skill levels. NEW FOR THIS YEAR! Critical Care Track!

Ultrasound Guided Regional Anesthesia preceptorship Course2010 Dates Available | Duke University Medical Center, Durham, NCfor more information, contact Katherine siler: [email protected].

Participants in the Duke Preceptorship will spend three days in the regional block area, operating rooms and on the floor with post surgery patients observ-ing ultrasound guided single shot nerve blocks and catheter techniques in a wide variety of clinical scenarios. They will learn how to set up the block area for maximum efficiency in the OR environment, improve their decision making ability and make choices in the performance of regional anesthesia. A one-on-one discussion with the Duke Faculty member reviewing cases, scanning techniques and the image library as well as covering handout materials will augment the preceptorship experience.

Visiting preceptorship in Intraoperative Transesophageal echocardiography2010 Dates Available | Duke University Medical Center, Durham, NCfor more information, contact Jaime C. Cooke: [email protected].

Participants in the Duke Intraoperative TEE Preceptorship spend one three-day session in the cardiac operating suites, observing techniques of intraop-erative TEE and interpretation of images. Preceptors will participate in active discussions with cardiothoracic anesthesia faculty and fellows, and learn the basic TEE exam. They will also learn how to troubleshoot difficult cases and enhance their decision-making skills in the operating room. Cases will be reviewed with fellows and faculty and images from pathology libraries will be used to augment the preceptorship experience.


The BACK pAGe

ClassifiedsRentals

Department-member owned 3 floor luxury townhouse in Kure Beach NC available for rent. Six bedroom, four bath townhouse with private elevator, granite kitchen, stainless appliances, fully-stocked chef’s kitchen (All-Clad pots and Kitchen Aid appliances). Master has private balcony, King bed, walk-in closet with ocean views, spa -like bathroom with jetted tub, glassed-in shower, other bedrooms have two twins, one queen, one queen, one queen and two twin

sleeper chairs. flat panel HD TVs and wireless internet. 2 blocks to the Kure beach pier and restaurants, beach access diagonally across the street. Ocean views from living room and master bedroom. May 1 to October 31 $2300/week November 1 to April 30 $1800/week. Visit http://web.mac.com/bford71/Brad_and_Neil/the_Sand-piper/the_Sandpiper.html for more info.

Wanted

small load of firewood wanted: I’d like to purchase a car trunkload of seasoned firewood for our backyard fire pit. I don’t have room for a cord or half-cord of fire-wood, so would appreciate a purchase of some of a smaller amount if you can part with some. Thanks. E-mail: [email protected]. Call: 681-3811 or 638-9069.

Renatal wanted: Please let me know if anyone has a room, studio, small house or apartment that they would like to rent. I am asking for a very responsible young lady (early 20s) that teaches young children at the Duke School, and needs a place by June 1. Please contact Deb Clements, CRNA at [email protected] or page at 970-3815.

May 1 – May 31Duke Discounts at LocalRestaurantsSpecial offers for Duke employeesthroughout May.

April 30, May 1 – 2Duke Baseball at DurhamBulls Athletic Park $5 tickets with valid DukeCard.Game times vary.

May 2 @ 11 a.m.Duke Chapel ServiceHonoring Employees

May 7, 14, 21, & 28MARKET-GRAM at theFarmers Market

Purchase a small giftfor a colleague andpick up a freepersonalized gift tagbookmark with amessage ofappreciation from theLIVE FOR LIFE table.

May 20 Night of Duke StarsDuke pays special tribute to staffand faculty celebrating significantcareer service milestones.(Invitation only)

May 22 @ 7:05 p.m.Duke Family Night at DurhamBulls Athletic ParkEach $10 discount ticket includes aTerrace Reserved Seat and aNational Champions Cap.

May 27 @ 11:30 a.m. – 2 p.m.(Rain Date May 28)Music, Art & Ice Cream on the Quad Bring lunch and enjoy ice cream,employee art exhibits and livemusic by Sensory Expressions.

May 30 @ 11 a.m. – 2 p.m. (Rain Date June 6)Sarah P. Duke GardensFamily Fun Day Featuringgarden-themedactivities for allages, and afestival-endingparticipatoryparade led bythe acclaimedPaperhandPuppetIntervention.Free.

Duke Appreciation2010Calendar of Events

Compliment a ColleaguePost a compliment about a colleague on the “Making a

Difference” Duke Appreciation blog. Tell the Duke community how

a co-worker makes a difference. Post your note at

hr.duke.edu/appreciation.

GO ONLINE: For everything Duke Appreciation 2010, visit hr.duke.edu/appreciation

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05-03-10