February 25, 2013 Farzana 1

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Farzana Z Ali

HBY 554 TA

LECTURE OUTLINE FOR MARCH 14, 2013

Part I: Touch (1st subsystem) and Proprioception (2

nd subsystem)

1. Peripheral receptors: Somatic Sensory Afferents

a. Mechanism of sensory transduction

b. Dermatomes

c. Functional properties:

axon diameter, receptive field (size, density), temporal dynamics, channels

expressed/filter properties

d. Mechanoreceptors

i. Cutaneous mechanoreception- body surface

fine touch, vibration and pressure

ii. Proprioception- within body

muscles, tendons and joints

2. Central pathways

a. Tactile information from the body: Dorsal Column-Medial Lemniscal System

b. Tactile information from the face: Trigeminothalamic System

c. Proprioceptive information from the body: collateral branches, cerebellar function

d. Proprioceptive information from the face: mesencephalic trigeminal nucleus

e. Somatosensory components of the thalamus

3. Cortical maps

4. Cortical circuit plasticity in adults

Part II: Pain: 3rd

subsystem (painful stimuli, changes in temperature, coarse touch)

1. Nociceptors: Aδ mechanosensitive, Aδ mechanothermal, and polymodal C fibers

2. Nociceptive signal transduction

3. Central pathways:

a. Anterolateral system

b. Parallel pain pathways: Body and Face

VPL/ VPM: sensory discriminative

location, intensity and quality

Midline thalamic nuclei: affective-motivational

unpleasant feeling, fear and anxiety, autonomic activation

c. Descending pathways

4. Visceral pain

a. Referred pain

b. Dorsal Column pathway

5. Sensitization:

a. Peripheral

b. Central

6. Phantom pain

7. Placebo effect

8. Pain modulation