Journal of Automatic Chemistry Vol. 11, No. 4 (July-August 1989), pp. 179-190

New products

Amino-acid analyserThe System 6300 Amino-AcidAnalyser from Beckman Instrumentsis now available with the SystemGold Data System. This systemallows nutritionists and biochemiststo simultaneously collect data frominstruments while reanalysing pre-viously collected data. Applicationsinclude the diagnosis ofinborn errorsof metabolism, monitoring of dietaryand follow-up treatment, the nutri-tional assessment of pre-surgery andtrauma patients, and follow-up treat-ment of these patients.

The 6300 offers performance equal todedicated systems. Amino-acids arederivatized with ninhydrin in a mi-crovolume tubular reactor set at anideal 135C. This patented 100 V1reactor is packed with diamond dustto optimize the reaction, and thesmall volume ensures greater quanti-tative accuracy than can be achievedwith larger capacity reactors inwhich diffusion and consequent lossof resolution may occur.

An in-line conductivity sensorensures complete filling of the meter-ing loop through which sample flows,and allows reliable and precise sam-ple delivery to the column.

The stainless-steel analytical col-umns are prepacked with sphericalion-exchange resin--a lithium bufferform for physiological analyses, and asodium buffer form for hydrolyzateanalyses. High-pressure operationup to 3000 p.s.i, permits fast, accur-ate analyses.

The manufacturer offers buffers, re-agents and standards specially for-mulated for the system. In addition,Beckman provides extensive after-sales support with user training pro-grammes and applications assistancefrom the company’s research scien-tists and technical library.

For more information contact BeckmanInstruments, Inc., 2500 Harbor Blvd.,Fullerton, California 92634-3100, USA.Fax: 714 870 8083.

Robotic sampler senses liquidlevel

Several advanced features have beenadded to Beckman’s Biomek roboticlaboratory workstation for the auto-mation of microtitre plate work.

An interchangeable pipetting tool-the P200L- is a syringe device whichpipettes liquids with a volume range10-20 microlitres with microlitreincrements. The P200L’s liquid levelsensing system, which uses dispos-able plastic tips to eliminate carry-over, finds the meniscus of sampleliquids, avoiding tip over-immersionand therefore eliminating contami-nation. The sensing system functionswith aqueous and non-aqueousliquids and verifies tip pick-up by thetool. The P200L can cope with arange of depths, from those of micro-titre plate wells to test-tubes.

The Biomek 1000 PC-based controlsoftware has also been upgraded foruse with the new Biomek Sideloader(SL) which automatically loads lab-ware onto the workstation. The SLprovides several hours of totallyunattended operation for manyapplications, including dilution workand routine assays such as ELISAand receptor binding. An additionalsoftware enhancement means thatthe normal operation of Biomek canbe interrupted to run an externalprogram to organize files, transferdata, perform calculations andswitch external devices.

Further information from Beckman,Progress Road, Sands Industrial Estate,High Wycombe, Buckinghamshire, UK.Tel.: 0494 441181.

Gas analysisThe Bioquad gas analysis systemfrom Spectramass, which is designedfor the monitoring of fermentationand other biological processes, hasbeen attracting a good deal ofinterestsince its introduction last year.

New options include a more flexible,spread-sheet-compatible software

0309-1902/89 $3.00 ( 1989 Taylor & Francis Ltd.

package for data logging and datamanipulation, making the gas analy-sis data more readily available forcombination with other processmeasurements.

Improvements to membrane probetechnology now permit the easyanalysis of dissolved gases and vola-tile components present within afermentation broth, and the newdesign now permits the multiplexingof probes so that any combination ofmembrane probes, inlet and exhaustgas streams can be handled by oneBioquad control unit.

For more information contact SpectramassLtd, Radnor Park Industrial Estate,Congleton, Cheshire CW12 4XR, UK.Tel.: 0260 279531.

Particle size analysisLabcon are now offering a quicksolution to particle size analysis.Their Epson Pine system, which ismounted in a splash proof case, ispre-programmed to control both thesieve shaker and electronic balanceand to produce a rapid print out ofanalysed data. Key features of thepackage include simple screen-prompted operation; onscreengraphic display; memorized sievesizes and weights; results storage;remote or inbuilt printer options;compatibility with all sieve shakersand many commonly used balanceswith a bidirectional RS232 interface;additional software options to cus-tomers’ own specifications.

Further detailsfrom Labcon, 24 NorthfieldWay, Aycliffe Industrial Estate, NewtonAycliffe, County Durham DL5 63J, UK.Tel.: 0325 313379; fax: 0325 311044.

Gas-detection instrumentation inresponse to COSHH

In response to new COSHH legisla-tion, Bruel & Kjaer have announceda multi-gas monitor which providesquantitative analysis of up to fivecomponents and water vapour in anair sample.

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Bruel & Kjaer’s gas-monitoring equipment, which has been designed to help employers inthe UK to comply with recent government safety legislation. The instrumentation canmeasure virtually any gas which absorbs infra-red light.

In October 1989 UK employersbecome subject to legislation, basedon EEC directives, related to thecontrol ofhazardous substances. Thelegislation is aimed at improving airquality, and creates a need for precisemeasurement of gases and vapoursby both employers and thegovernment.

instrument designed to perform themeasurement tasks required by thelegislation. The measurement princi-ple is based on photoacoustic infra-red detection, a technique whichoffers advantages over existingmethods in terms ofspeed ofresponse,sensitivity, calibration interval, andimmunity to interferents.

The Type 1302 Multi-gas Monitor,which is the first product on themarket from the company’sManchester-based Gas AnalysisDivision, is a portable, easy-to-use

The Type 1302 can be used tomeasure virtually any gas whichabsorbs infra-red light, and can beequipped with the appropriateoptical filters to enable measurement

of the concentrations in an air sampleof up to five component gases andwater vapour. The detection thresh-old is gas dependent and of the orderof 10.3 parts per million. Addition ofthe Type 1303 Multipoint Samplerand Doser enables air sampling at sixlocations within 50 metres of theinstrument, with delivery of tracergases if required.

A special feature of the analyser iscompensation for water vapour, andany other known interferent, by theaddition of optical filters. Once thefilters are installed, the instrument iszero-point and span calibrated andholds its calibration for around threemonths this is significantly longerthan chromatographic and spectro-scopic alternatives. Re-calibration isa simple procedure directed by on-screen prompts; and comprehensiveself-testing aids performancereliability.

The 1302 can be set up and used bypersonnel with no technical expertiseand any sequence of measurementfunctions can be programmed to beautomatic. Results are stored inmemory, and a number of stastisticalfunctions are built in. RS232C andIEEE488 interfaces are provided forremote control and output of resultsto any standard text printer.

Applications will include engineer-ing, chemical, pharmaceutical, min-ing, oil and gas, water, building,transport and waste disposal indus-tries, medical environments, and fire-fighting authorities.

For further information contact Bruel &Kjaer (UK) Ltd, 86 East Road,Longsight, Manchester M12 5GY, UK.Tel.: 061 224 7590; fax: 061 248 6140.

Gas analysis brochure

Spectramass have recently publisheda short brochure giving details oftheir complete range of products forvacuum elucidation, leak detectionand gas analysis. The colour leafletcovers RGA, environmental moni-toring, process control, QC andresearch applications.

Copiesfrom Spectramass Ltd, Rednor ParkIndustrial Estate, Congleton, CheshireCW12 4XR, UK. Tel.: 0260 279531.

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GC-TALK

GC-TALK links the Model 8600 and8700 has chromatographs to anEpson or IBM (or compatible PC)for transfer ofmethods, reports, chro-matographic data and automationcontrol parameters. Data can bestored in the PC for later reprocess-ing and review. It is based on GEMsoftware, with mouse control andpull-down menus for ease of use.Automation control allows complete-ly unattended operation of the gaschromatograph for fully automatedanalyses and data storage. In addi-tion, instrument can be remotelystarted by the PC during automationqueues. Hard copy can be producedon the PC’s printer, or the GCprinter/plotter; and chromato-graphic data and reports may beexported to commercial software,such as word processors orspreadsheets.

For further information contactPerkin-Elmer Ltd, Maxwell Road,Beacons,field, Buckinghamshire HP91QA,UK. Tel.: 0494 676161; fax: 0494678324.

Quality control

Software for Beckman’s Real TimeQuality Control (RTQC) systemallows users instant access to monthsof quality, control data. The packagedeals with laboratory QC data fromall instruments within the clinicalfacility and can monitor quality onany manufacturer’s instrumentationor control materials.

RealTime software is an intra-laboratory IBM MS-DOS basedquality assurance system which eli-minates hours of paperwork andcalculations, and maintains perma-nent records of out-of-control situa-tions with historical correctiveactions.

Further details from Be&man, ProgressRoad, Sands Industrial Estate, HighWycombe, Buckinghamshire, UK. Tel.:0494 441181.

Titration

Radiometer Analytical A/S haveannounced a series of enhancementsto the software in the VIT90 Video

Users of the TitraLab High Performance Titration Laboratory requested a number ofenhancements ofthe system. Radiometer Analytical A/S have recently improved the softwarein the VIT90 Video Titrator- the ’brain’ of the system.

Titrator. With an increasing numberof samples, identification is crucial.VIT90’s new sample stack includesfull information on up to 60 individ-ual samples: numeric and/or alpha-numeric ID, weight or volume, plus asample-specific factor, for example tocorrect for drying loss. An easy-to-use ’spelling’ display enables theoperator to enter alphanumeric sam-ple data rapidly.

Analysis of water often includes pH,conductivity, titration, and measure-ment with Ion-Selective Electrodes.With TitraLab, combinations ofthese can be performed automati-cally. The new VIT90 has directserial communication with he auto-ranging CDM83 ConductivityMeter; consequently, it works withinseven decades without operatorinteraction.

Calculation facilities have also beenexpanded. In addition to a built-informula library with all standardformulas, the user can specify andstore eight further formulas for eachmethod. Normal operators as well as’Log’ and ’Exp’ functions, can beused.

Global variables can be used fortransferring results from one titration

to another. With this facility, theresult of a titre determination can beincorporated in all methods usingthis titrant concentration for calcula-tion of results. Statistics with meanvalue and standard deviation areavailable and can be reset automati-cally. Thus, requested means ofduplicates or triplicates are easilyobtained.

Also titration curves can now bereprocessed electronically. This facil-ity is especially useful during generalmethods development. Results canbe reviewed and alterations made: soall curve inflections are detected.Even the weakest equivalence pointsare never lost.

Reaction kinetics measurement oftenincludes calculation of reaction rate.With the new TitraLab, a user-selectable calculation window can beused to determine maximum andmeans reaction rates for the desiredparts of the curve. Correlation co-

efficent statistics, and user-programmable formulas areavailable.

For more information contact RadiometerAnalytical A/S, Krogshojvej 49, DK 2880Bagsvaerd, Denmark. Tel.: 45 31 696311;fax: 45 44 490011.

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Electric shock treatment openscells to genetic manipulationProbably the most significant recentadvance in biotechnology instrumen-tation has been the development tothe twin techniques of electro cellfusion and electroporation. Theseprovide an alternative to tissue cul-ture for creating hybrid cells orinserting genetic material. A range oftop-quality instruments for thesetechniques is now available in theUK from Biotech Instruments ofLuton.

By exposing animal, plant or bacter-ial cells to carefully applied, highvoltage, pulsed electric fields, poresare opened up in cell membranesthrough which cells can be fusedtogether (electro cell fusion) or gen-etic material inserted (electropor-ation). This provides a simple, clean,and easily controlled means of per-forming cell manipulations, and isespecially useful when dealing withcells which resist the insertion ofgenetic material in tissue culture (forexample wheat, corn and other graincells).

The equipment developed andmanufactured by Biotechnologiesand Experimental Research Inc(BTX) of San Diego, California iswidely recognized as the mostadvanced and effective for this type ofwork. The BTX range is now avail-able in the UK exclusively fromBiotech Instruments, who canprovide detailed advice, based on anextensive data-base of publishedwork, on the optimum way of hand-ling many different cell types.

The Electro Cell Manipulator 200, a

sophisticated system for cell fusionand electroporation of human, ani-mal and plant cells, features a MHzradiofrequency generator for rapidand consistent cell alignment. Its lowimpedance design provides maxi-mum voltage transmission, and pre-cise, high voltage, square wave pulsesare selectable in xsec pulse widthincrements, with automatic multiplepulsing capability. Hybridoma yieldsof mouse and human cells have beenshown to be 10 times those obtainedby conventional methods, and therapid fusion of plant protoplasts isalso performed at much higherefficiencies.

Electroporation of micro-organismsrequires very high electrical fieldstrengths, and for this theTransfector 100 is ideal. High voltageelectric pulses enhance the transfor-mation frequencies of intactmicrobial cells, providing a highlyefficient means of transforming most

popular strains of E. coli, Streptococcuslactis and many other micro-organisms, including Gram-positives.

A wider range of capacitance set-

tings, ranging from 50 to 3150 F in50 xF increments, is available withthe Transfector 300. This gives theeresearcher the ability to fine-tunepulse lengths to optimize transforma-tion efficiencies.

The main feature ofthese systems is agraphic pulse analyser, theOptimizor, which monitors chamberconditions during electro cell fusionand electroporation to a very highlevel of accuracy. A liquid crystaldisplay shows a graphic trace of thepulse going into the chamber,together with measurements andparameters. In this way the exactchamber field strengths are indicatedinstantaneously, so that optimalexperimental conditions may beestablished.

Safety has been a prime consider-ation in the design of BTX systems.Safety features include full protectionagainst operator shock and shortcircuit, which is an essential safe-guard as very high voltages are used.An isolator guards against accidentalexposure to the electrodes duringoperation.

A choice of nine different chambers,both disposable and re-usable, areoffered, in 14 sizes ranging from a20 tl microslide to a 75 ml produc-tion chamber.

More information from BiotechInstruments Ltd, 183 Camford Way,Luton, Bedfordshire LU3 3AN, UK.Tel.: 0582 502388; fax: 0582 597091.

High-performance, high-reso-lution capillary GC

Since its launch in 1983, the HP5890A has proved a highly successfulgas chromatograph. Hewlett-Packard have launched a new series

II version, which represents the stateof the art in analytical GCtechnology.

Chromatographic performance isincreased by the facility for on-column capillary injection. The on-column capillary inlet option is com-patible with the HP 7673A automaticinjector and sampler and allowsautomated methodologies using on-column capillary injection to be de-veloped, without compromising onflexibility or ease of use.

Electronic pressure control of the on-column inlet means that columnhead pressure, as well as inlet tem-

perature, may be defined from thekeyboard. This gives increased reten-tion time reproducibility and theability to separate complex mixtures.

Pressure programming of the columnhead provides more accurate results,as compounds are analysed at lowertemperatures and therefore with lessthermal degradation. Analyses are

faster, and cryogenic cooling reduces.the time between sample runs.

The oven temperature range on theSeries II has been extended to 450C.With the on-column inlet, this allowshigh boiling-point compounds to beanalysed with ease. Such appli-cations as the analysis of C-120 inwaxes, and of steroids and triglycer-ides in biosamples, may be per-formed automatically, as may petro-leum applications wht,,’e highertemperatures are required for accur-ate characterization of heavyfractions.

The capacity ofthe HP 5890 Series IIis doubled by the use of two valve-driver channels, which reduce thecost of valve configurations.Additional heated zones provideincreased flexibility.

Automatic control is furtherenhanced by an events monitorwithin the GC which allows time-programming of thermal conduc-tivity detector sensitivity, detectorsignal switching and multiple valveevents. Storage ofGC setpoint makesthe unit easier to use as a stand-alonedevice.

Current users of the HP 5890A mayupgrade their systems to full Series II

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specifications, to incorporate the newfeatures and options while retainingexisting methods and processes.

Details from Analytical Products Group,Hewlett-Packard Ltd, King Street Lane,Winnersh, Wokingham, Berkshire RGll5AR, UK. Tel.: 0734 784774.

Wallac sale to Bio-Orbit

The luminescence product line mar-keted by Wallac OY (a member ofthe Pharmacia group) has beenacquired by Bio-Orbit OY, a com-pany specifically formed for thispurpose. A wholly owned subsidiary,Bio-Orbit (UK) Ltd, has also beenestablished.

The new companies intend to makerapid bacterial cell counting aswidespread in routine quality controlin production areas as it is in quality-assurance laboratories, which istimely in view of the current publicinterest in bacterial infection. A rapidassay of microbiological conditions isan almost essential requirement foranyone with a responsibility forstandards of any ingestible productor service, where the mere hint ofcontamination leads to the mediademanding instant confirmation ordenial. With Bio-Orbit’s lumines-cence method of counting bacteria,the results can be verified withinminutes (as opposed to hours or daysrequired with incubation on cultureplates) which means that process orproduct contamination may be deter-mined at an early stage of produc-tion, avoiding subsequent wastageand possible damaging speculation ofa bacterial outbreak incident.

Detailsfrom Bio-Orbit 0 Y, Mustionkatu2, SF 20750 Turku, Finland. Tel.: 358 21363 666; fax: 358 21 363 150.

Centrilab

A new company has been formed inRingwood, UK, to manufacture anddistribute bench-top centrifuges.’Centrilab’ is run by Simon Ellis andDavid Prevett, who have taken overthe production and sales of low-cost,compact centrifuges from EllisendCentrifuge Services.

The company was formed to fill a gapin the market for simple, high-

performance units across manyindustries. Small centrifuges arerequired by pathology laboratories,general practitioners, veterinarypractices, food processing businesses,petro-chemical and chemical works,marine and electronic industries.Centrilab offer a range ofUK-manufactured centrifuges whichare ideal for industrial use as a simplelaboratory tool.

An agreement has been reached withJS Pathology PLC who offer a leasingservice on Centrilab centrifuges aspart of their drug-testing service.

Covering such a wide range of indus-tries, Centrilab’s first design has beendeveloped with customizing in mindso that, for example, special headscan be readily supplied to suit manysizes and types of sample tube.

More information from Centrilab atKingsbury House, Friday Cross Mews,Christchurch Road, Ringwood, HampshireBH24 1DG, UK. Tel.: 0425 480455.

Process monitoring of industrialeffluent

By monitoring sewage and wasteeffluents for chemical oxygendemand, COD, potentially danger-ous levels of contaminants can bedetected and diverted in time tomaintain effluent concentrationswithin safe limits. A new processCOD analyser by Ionics Ltd, desig-nated the Model 304, is intended forindustrial and municipal sewage andwaste real-time monitoring to ensurecompliance with water authorityrequirements. Whereas many labor-atory met.hods on grab samples cantake hours and miss possible spill-ages, the COD analyser is designedto operate continuously and providereliable on-line monitoring.

The Model 304 COD Analyseremploys the acid dichromate openreflux method. Chosen for its highfficiency in oxidizing a variety oforganics in water, the acid dichro-mate open reflux method involvesrefluxing at 150C for a fixed periodof time (normally 2 hours, but this isuser programmable). The CODmeasurement is then measured color-imetrically, providing a rapid andsensitive determination of dichro-mate concentration. The amount of

dichromate consumed is directly pro.portional to the sample CODAutomatic calibration and zero-check are standard.

Forfurther information contact Ionics UILtd, Carrington Business Park.Carrington, Urmston, Manchester M34DD, UK. Tel.: 061 776 4550;fax: 06777 9630.

Yokogawa introduces integratedfactory-wide control system fosmall processing operationsA new cost-effective distributedcontrol system, designed to offersmaller industry manufacturers thesame processing benefits previouslyavailable only to larger plants, is nowavailable from Yokogawa Electric,international supplier of controlsystems.

The MXL (Micro Excel) DistributedControl System is a completely inte-grated, factory-wide control systembased on micro-level computing, butproviding the same processing bene-fits normally associated with systemsserved by midrange or mainframecomputers.

The MXL is designed for the real-time production process control of a

plant’s batch, discrete and con-tinuous processing operations. Thebasic system consists of an operatorstation, a field control unit and acommunication bus that can manageeverything from raw materials,advanced batch-sequence andproduction-process control to

shipping.

As orders come in to a plant, theMXL determines how many prod-ucts or activities must be initiated. Ittracks inventory to ensure thatenough resources are available andindicates when supplies are low. TheMXL is capable of memorizing anumber of pre-set recipes or produc-tion processes and will aid in deter-mining when maintenance checks or

clean-up procedures should start.Finally, when the product is com-pleted, the MXL will track packing(where each package should beshipped, and which shipment willcontain which packages).

Ready-to-use application packagesand ’fill-in-the-forms’ engineering, as

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The MXL Distributed Control System from Yokogawa Electric Corporation. Ready forshipping, the system costs from $40 000.

well as BASIC and graphic buildersoftware, mean low engineeringcosts, flexibility and use-configurability. Expandability isanother important feature of thesystem- its fibre optic data link canspan the largest factories.

The basic MXL system consists oftwo PC-like control units, one centraland one for field use anda communi-cations arm. Expansion is achievedby adding more control units.

Based on the same technology thatYokogawa developed for its Centumsystem, the MXL incorporates vari-ous feedback and sequence control

functions, including simple PIDcontrol, dead time compensation,feedforward control and scheduledstart-up.

In addition, the system contains a

real-time BASIC programmingenvironment which can handle suchsophisticated management tasks asreal-time management reporting,logging, system interfacing, recipemanagement and data analysis.

Forfurther information contact YokogawaElectrofact B. V. HeadquartersRadiumweg 30, 3812 RA Amersfoort, TheNetherlands. Tel.: 31 33 641611;fax: 3133 631202.

Chromatography software onVAXBeckman’s PeakPro chromatographysoftware is now available to run onVAX computers. Proven in use since1986, when it was first introduced onHewlett-Packard computers, Peak-Pro greatly simplifies the work of thechromatographer. Easy-to-under-stand full colour menus and ’userfriendly’ conversational prompts,guide the operator through a range offunctions.

Data reduction and reporting rou-tines include internal and externalstandards and normalized per cent

with multi-level calibration.Real-time plotting is possible whiledata are being acquired. The pack-age also contains many options forexpanding and comparing storedchromatograms; and results sum-maries for multiple analyses may beproduced for comparing and identi-fying trends.

PeakPro also offers full compliancewith GLP/GMP guidelines. All dataare protected from being changed or

purged except by authorized users,and any such activity creates anautomatic entry in the system log.Furthermore, full documentation ofall analyses is provided. Test results,summary reports, system suitabilityand audit trail reports are easilycalled on screen or printed on

command.

Although the basic PeakPro packageis an economical solution for smallerlaboratories, the modular design ofits hardware and software means thatthe system can grow with the needs ofthe laboratory- the basic system canreadily be expanded into a full-scaleCALS Lab Manager LIMS system.

For further information contact BeckmanInstruments (UK) Ltd, Progress Road,Sands Industrial Estate, High Wycombe,Buckinghamshire HP12 4JL, UK. Tel.:0494 441181; fax: 0494 461935.

Chemical analyses documentedfor metal plating industries

A series of 15 chemical analysesespecially documented for use inmetal plating and coating processlaboratories is now available, free ofcharge, from the Radiometer UK.

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Close monitoring of the concen-tration of metals and impurity levelsin plating solutions is essential toachieve and maintain optimum pro-cess efficiency, cost-effectiveness andend-product quality. All 15 analysesemploy potentiometric titration, afield in which Radiometer has longoffered a wide range of instrumentsand ancillary equipment.

The procedures determine cadmium,chromium, copper, gold, lead, nickel,silver, tin and zinc in plating solu-tions and also sulphuric acid andaluminium together in anodizingsolutions. Other analyses within the15 are aimed at controlling boricacid, chloride and cyanide levels inthe plating baths.

The metal plating analyses are available asthe ’Plating Solutions Package’from TheAnalytical Division, Radiometer Ltd, TheManor, Manor Royal, Crawley, WestSussex RHIO 2PY, UK. Tel.: 0293517599.

Autosampler for ICAP spec-trometers

Thermo Jarrell Ash’s TJA-300 auto-sampler, which has 300 sample tubepositions, allows large sample work-loads to be run without constantattention. The TJA-300 incorporatesdecision-making logic for true un-attended operation. The TJA-300

accommodates automatic profiling,automatic standardization, limitchecking of samples, and quality-control checking with the option ofreprofiling and/or restandardizingupon failure. All rinse and samplingtimes are computer controlledthrough menus selections in theThermoSPEC software.

When coupled to the TJA PrepStation and sample mixing vessel, theTJA-300 can be used to automati-cally dilute and mix samples accord-ing to a user-generated method. Afterdilution, the samples are automati-cally delivered to the plasma.

The TJA-300, with its optional over-flow sampling station and externalwarning system, can be used toautomatically sample a stream pipedto the autosampler with its sipperprobe. The sampled stream passes toa flow-through mixing vessel for dilu-tion, followed by delivery to thesample introduction system of thespectrometer. The quality-controlroutines of ThermoSPEC softwarecan be used to monitor control levelsin the stream. Any out-of-controlresults can trigger automatic recali-bration of the spectrometer andreanalysis of the controls.

More information from Thermo JarrellAsh Corporation, 8E Forge Parkway,Franklin, Massachusetts 02038, USA.Tel.: 508 520 1880.

Factory management’FIP’ is a new digital communica-tions system for factory management.Factory Instrumentation Protocol isan industrial network, or bus,intended to replace point-to-pointwiring, connecting sensors, actuatorsand regulators. It is also an opensystem, so it provides a means ofconnecting the components of themodern automated factory- process-ing units, programmable controllersand robots.

In operation, FIP improves thegeneral behaviour of control systems,ensuring that all components receivecoherent information. Onceinstalled, the system needs littlemaintenance, and it is easilyupgraded to adapt to changingconditions.

The system acts as a real-time distri-buted data-base, providing data to

management and maintenanceservices. FIP uses a ’broadcasting’topology, in which each device con-nected is a potential consumer ofinformation broadcast on the bus. Itcan be up to 2000 m in length andcan support as many as 256 stations.FIP was developed by a non profit-making consortiuum of French com-panies, and has been tested in siteswhich include hydro-electric powerstations, oil refineries and manufac-turing plants.

Details from Jean-Pierre Bardinet, ClubFIP, Ensem, BP 850, F 54011 NancyCgdex, France. Tel.: 83 32 3901.

The TJA-3OO’autosampler for ICAP spectrometers.

Multi-channel pipettesA range of multi-channel pipettesthat take the ’hit-and-miss’ out ofvolume setting was recently launchedby Flow Laboratories. The pipettesfeature a preset volume control anddigital display, which make incorrectsetting virtually impossible. Thepipettes have a colour-coded thumbbutton which is used to dial-in therequired dispense volume- thevolume is then displayed in an

integral window.

The pipettes are available with four-,eight- and 12-channels. All models inthe range are lightweight, reducingoperator fatigue and feature indi-vidually replaceable tip cones, keep-

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and service readily available. Anadditional advantage was consideredto be the simplicity of maintenanceon the Array.

Further information about the ArrayfromBeckman, Progress Road, Sands IndustrialEstate, High Wycombe, Buckinghamshire,UK. Tel.: 0494 441181.

Flow Laboratories’ multichannel pipettes which offer preset volume control and digitaldisplay. The pipettes are pricedfrom 198.

ing service costs to a minimum andensuring accurate dispensing everytime. The pipettes are available intwo colour coded volume ranges:yellow for the 5-50 btl (0.5 btl incre-mental steps) and green for the50-300 btl range (5 btl incrementalsteps).

More information from Woodcock Hill,HareJield Road, Rickmansworth,Hertfordshire WD31PQ UK. Tel.: 0923774666; fax: 0923 777005.

Transparent ’Aerosolve’ cannisters forBeckman TJ-6 and GP centrifuges provideincreased protection by minimizing thechance of contamination from aerosolsshould a tube break during centrifugation.The accessory holds tubes of3 ml capacity,and the cannister can be used as a 500 mlwide-mouth bottle. Details from Beckmanat 2500 Harbor Boulevard, Fullerton,California 92634-3100, USA.

Array protein chemistryBeckman’s Array Protein ChemistrySystem has been tested in theImmunology Department of theRoyal United Hospital in Bath, UK,where it has freed the staff of a

laboratory where the workloadcontinues to increase steadily formore technical duties, and hasallowed samples from many differentsources to be managed efficiently andat optimum speed. At Bath the Arraywas used largely for immuno-globulins and complement, RhFactor, C-Reactive protein andAlpha antitrypsin studies. Thelaboratory is a reference unit for theRoyal Hospital for RheumaticDiseases; samples are also receivedfrom two busy clinics each month,and, often in emergency situationswhere a ’STAT’ method is demandedof the Array, the laboratory copeswith regular C-Reactive protein esti-mations on leukaemic patients andthose undergoing marrow transplantoperations.

As the Royal United is a districtgeneral hospital covering a wide areaand providing a service for no lessthan 28 outlying hospitals and about500 local GPs, the workload is sub-stantial for the 4.5 staff working inthe only Immunology Department inthe district. The laboratory foundBeckman’s support on Array veryeffective, with back-up information

LIMS interfacingBeckman’s IDAS (Instrument DataAcquisition System) was designed forthe Beckman CALS Lab Manager,but it is fully compatible with othersystems and permits the interfacingof a laboratory computer to practi-cally every laboratory instrumentwith RS-232 output. Complete two-day communication between instru-ment and host is achieved throughthe use of a special LaboratoryInterface Language (LIL) andDigimetry MK5 instrument coupler.

The microprocessor-controlledinstrument coupler provides anumber ofvital interactive communi-cation functions. An operator can usethe keypad and function keys on theMK5 to select instruments, selecttests and enter sample identification,or, as data is collected to review,accept and process it before transmit-ting it to the host computer forstorage and processing.

An advantage of the IDAS systemover custom software packages is itsflexibility: IDAS applications arereadily moved between supportedcomputer systems so it shouldcontinue to perform effectivelydespite operating system changes.

Further information from Beckman,Progress Road, Sands Industrial Estate,High Wycombe, Buckinghamshire, UK.Tel.: 0494 441181.

PSA’s TouchStone softwareexpandedThe PSA TouchStone software wasdeveloped to provide automaticcontrol data capture and manipula-tion for the PSA Merlin PlusSystems. It is an IBM compatiblesoftware system which utilizes aU-Micro DIO card to set up theequipment included in any system.

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The instruments involved typicallyinclude an autosampler, PSA vapourgenerator and a fluorescence detec-tor. The menu-driven software sets

up and controls these instrumentsand continually checks their perfor-mance. The output derived from thefluorescence detector is on a conti-nuous flow basis and the measure-ments are collected as peak height orpeak areas or even time sliced integ-ration on the peak plateau.

For many techniques in analyticalchemistry, such as flow-injectionanalysis and electrothermal vapori-zation, a transient signal is producedin contrast to the continuous level.The PSA TouchStone software hasbeen extended to handle these signalsand to control the PSA 40.630 12-Port Teflon rotary valve assembly.With this unit, which is plug-compatible with the PSA hydridegenerator, the user is able to switchfrom hydride generation sampleintroduction to flow-injection princi-ples. This is accomplished in a simplefashion by setting up the methodtemplate. The sample is withdrawnfrom the autosampler into the loop ofthe Teflon valve, after a predefinedtime the sample is fed into the sampleinput stream, the transient signalmonitored, and after a set period thevalve is returned for the next sample.

The full facilities include sample Tagnumber, reporting facilities or exten-sion to ’hands off’ analysis using theFPSA 20.080 Autosampler.

Forfurther details contact P S AnalyticalLtd, Arthur House, B4 Chaucer BusinessPark, Watery Lane, Kemsing, Sevenoaks,Kent TN15 6QY, UK. Tel.: 0732 63416;fax: 0732 61340.

Peptide synthesizerThe BT 7600 peptide synthesizerincorporates a device that detectsand monitors coupling reaction ratesby responding to conductivitychanges in the sample solution. Thisconductivity sensor tracks andcontrols the coupling reaction anddeprotection steps of the synthesis,providing a simple, accurate, non-destructive means of monitoring theprogress of synthesis reactions anddetermining when they are complete.

The sensor is economical, offeringsignificant savings both in time andreagent use, and gives high couplingefficiencies. It predicts the timerequired for the coupling reaction,and suspends the synthesis if it is notcompleted within this time so thatthe operator can take appropriateaction. It provides unrivalled accur-acy on the reaction rate ofany scale ofsynthesis from 0.05 to mole ofpeptide.

The BT 7600 is controlled by a built-in computer under MS-DOS.Menu-driven software makes oper-ation simple, and methodologies maybe set up and stored on disc. Undercomputer control, all reagents aredelivered to the reaction chamber

under positive inert gas pressurefrom sealed, airtight bottles. Theprogress of the synthesis is shown inreal time on a full-colour display.

The system allows up to eight amino-acids to be coupled automaticallywithout operator intervention. TheBT 7600 and its conductivity sensorare optimized for FMOC opfp esters,and can handle modified andunusual amino-acids. Peptides mayalso be synthesized using otherFMOC and BOC methodologies..

Further information from BiotechInstruments Ltd, 183 Camford Way,Luton, Bedfordshire LU3 3AN. Tel."0582 502388.

Teledyne has recently announced a continuous on-line carbon monoxide analyser. The Model826features measuring ranges ofO-5OO/0.1OOparts-per-million (ppm). Optional ranges aslow as 0-100 ppm and as high as 0-2.5% are available. The analyser uses Teledyne’sF-series elecrolyte andfeatures +2%full-scale accuracy with 90% response in less than 30seconds. A data-sheet is available from Teledyne Analytical Instruments, The HarlequinCentre, Southall Lane, Southall, Middlesex UB2 5NH, UK.

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Electronic thermometer

Hanna have announced a new elec-tronic thermometer called ’Ercole’which will be suitable for tempera-ture monitoring in offices, computerrooms, factories, and hospitals andfor laboratory and process appli-cations. The light-weight Ercole hasa built-in sensor for ambient tem-

perature measurement over the range10 to +60C. The Ercole also has a

permanently connected remoteprobe with a metre cable whichmeasures from -20 to + 70C and issuitable for air and liquid tempera-ture measurement. The Ercole allowsan upper and lower temperaturelimit to be pre-set and if the tempera-ture is exceeded an audible alarm istriggered. A digital clock is anotherstandard feature of the thermometer.

The Ercole is priced at 22.00 and isavailablefrom Hanna UK, Happy ValleyIndustrial Park, Primrose Hill, KingsLangley, Hertfordshire WD4 8HZ, UK.Tel.: 09277 60655.

Oxygen alarm

Teledyne’s Model 335 OxygenMonitor quickly and accuratelymeasures the oxygen concentrationin control rooms, closed atmos-

pheres, critical breathing circuits andother situations that require the fail-safe continuous monitoring ofambient air. This AC-poweredinstrument is provided with a power-failure back-up consisting of twoNiCad battery packs maintained on a’trickle’ charge. Primary power inter-ruption and subsequent battery ope-ration is signalled by illumination ofthe LO AC panel light.

Two oxygen alarm levels are avail-able: caution (19% 02) and danger (171/2% 02). Both alarm setpoints arecustomer specified and factory set to

prevent tampering or resetting byunauthorized personnel. When aninsufficient oxygen concentrationtriggers either alarm, both a redpanel light and audible annunciatorare energized. The alarms remainnergized until the oxygen concen-tration has been elevated above thetrigger point.

Details from Teledyne AnalyticalInstruments, The Harlequin Centre,Southall Lane, Southall, Middlesex UB2

5NH, UK. Tel.: O1 571 9596; fax: O1571 9439.

Titrator

Up to four burettes can be mountedon Mettler’s new DLT0 Titrator.Automation can thus be extendedwith several burettes without theneed for more space. As a multitask-ing system, the titrator controlsburettes and electrodes automati-cally. Parallel to this, new sampledata can be entered, a new methoddeveloped, or modifications made toa method currently in progress.

Each method is composed of a seriesof functions, such as sample prep-aration, content determination,evaluation and result recording. Thefunctions can be freely defined by theuser, allowing a practically unlimitedfield of applications.

The DL70 handles most commontitration methods, such as acid/base,redox, complexation and precipi-tation titrations to equivalence or

end-point. Special applications suchas pH-stating or titrations accordingto standards (DIN, ASTM) can alsobe performed.

Operation is via an alphanumerickeypad which is used to identify thesample, configure methods and enterinstructions. The multiline displaywith graphics capability providescontinuous information during thetitration, including online titrationcurves and curve of the first deriva-tive. These titration data and addi-tional information can be displayedon a terminal if desired.

Various peripherals such as the ST20Sample Changer and computers canbe attached to the DL70. An RS232Cinterface for a dot matrix printer anda current loop interface for theattachment of a Mettler balance, aswell as three outputs for auxiliaryinstruments such as pumps andvalves, are built in a standard.

Details from Mettler Instrumente A G,CH-8606 Greifensee, Switzerland.

Reverse osmosis systemAn American automobile manufac-turer has discovered a cost-effectivesolution to high deionized (DI) water

costs in a chromate rinse for automo-bile parts- the OSMO(R)-43B reverseosmosis (RO) system by Osmonics.

Automobile parts are dipped in treat-ment solutions ofphosphate and thenchromate to clean and prepare themetal surfaces prior to an electro-deposition paint bath. After the chro-mate treatment, the parts are sub-merged in two rinse baths, followedby two DI spray rinses. The DI waterused in this spray rinse is often sent todrain.

However, at this location anOSMO-43B machine takes the waterfrom the first DI spray rinse, lowersits conductivity level, and returns theDI water to a second spray rinse. Akey benefit to the system is that thevolume of wastewater sent to drainfrom the second spray rinse is greatlyreduced by as much as 90%.

A typical chromate spray rinse usesnearly 100 000 gallons of DI water

per day at a cost of roughly $500 perday ($5.00/1000 gallons) or $125 000per year (250 working days). TheOSMO-43B RO system can saveover $100 000 per year by reclaimingvaluable DI rinse water sent to drain.

Osmonics can help manufacturers usingED paint processes to face the challenge ofhigh DI water costs. For further infor-mation on OSMO reverse osmosis systemscontact OSMO Engineered Products andSystems, Osmonics, Inc., 5951 ClearwaterDrive, Minnetonka, Minnesota 55343,USA. Tel.: 612 933 2277; fax: 612 9330141

Electro-hydraulic mountingpressBuehler have introduced a mountingpress for sample preparation appli-cations. The Simplimet 3 is an auto-matic electro-hydraulic mountingpress that brings fast production ofquality mounted samples to the mi-crostructural analysis laboratory. AllSimplimet 3 presses incorporate anumber of state-of-the-art features,including corrosion and impactresistant reaction-injection-mouldedcabinetry, a reliable electro-hydraulic system for applying andmaintaining selected pressure, elec-tronic touch-pad switches for selec-tion and automatic control of allmoulding cycle parameters, includ-

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New products

ing temperature, pressure and time,and digital LED parameter read-outsand bar graphs. In addition, theSimplimet 3 mounting pressaccoim.,todates a range ofmould sizesfrom 25mm to 1-1/2in and incorpor-ates a water-cooled mould-coolingunit to produce cool mounts in sevento nine minutes.

Further information from Buehler UKLtd, PO Box 150, Binns Close, CoventryCV4 9XJ, UK. Tel.: 0203 471411.

Solvector

As a further step in increasingCavendish’s expertise and range ofproducts available in the field ofsolvent vapour detection, a newversion of the Solvector has recentlybeen launched. This can operate as a

continuous-reading instrument orwith the GC attachment to give aspecific response to one solvent. This

is an advance over the other photo-ionization detection systems avail-able and is priced competively.

Details from Cavendish ApflliedTechnolog7 Ltd, Unit 24, Clifton Road,Cambridge CB1 4ZD, UK.

PC-based chromatography work-station

Compatible with gas or liquid chro-matographs from any manufacturer,the new HP 3365 ChemStation is apersonal computer functioning as afully featured chromatographyworkstation. The MS-DOS basedanalytical software, which includesdata reduction algorithms for precisequantitative results, will run on theHP Vectra PC or any other PC/ATcompatible. Used with the HPVectra, it is the only single-vendorsystem of its kind.

The software uses Microsoft(R)

Windows Presentation Manager toprovide a mouse-driven, graphicalenvironment with multitasking capa-bilities and multiple windows.Pull-down menus, dialogue boxesand icons simplify operation, and asthe software runs under MS-DOS,results may be ported to word-processors, spreadsheets and otherstandard office packages.

Many such tasks can be performedsimultaneously through the use ofMS-Windows, which also allowseveral chromatograms to be dis-played and compared on screen.Windows may be enlarged, reduced,overlapped or moved.

The HP 3365 ChemStation may beconnected directly to the HP 5890Series II GC for full instrumentcontrol and data acquisition. It isfully multitasking, and can operate

The HP 3365 chromatographic ChemStationfrom Hewlett-Packard. The workstation runs on the HP Vectra PC and can control single or

multiple chromatographic instruments. With it is the HP 5890 Series H gas chromatograph.

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New products

several GCs simultaneously. It mayalso be connected, via the HP35900C dual-channel interface, toany other manufacturer’s liquid orgas chromatograph for single or mul-tiple instrument data acquisition.

As a PC-based system, the HP 3365is compatible with all standard inter-

faces. It may be linked to other PCsand can share such peripherals asprinters and data storage devices,saving both space and cost.

The ChemStation can be networkedto laboratory data systems. It is fullycompatible with HP 1000 and HP3000 minicomputers, as well as IBM

and DEC systems. It may also belinked into HP LABSAM and othercommercially available LIMSsystems.

Enquiries to Analytical Products Group,Hewlett-Packard Ltd, King Street Lane,Winnersh, Wokingham, Berkshire RGll5AR, UK. Tel.: 0734 784774.

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