Dominic Job, David Rodriguez, Elizabeth McDowell, Joanna Wardlaw

Centre for Clinical Brain Sciences – Neuroimaging Sciences

The University of Edinburgh, October 2014

Data Management in Human Imaging

Requirements for Research Data Management & BRIC, CRIC and WTCRF

•Significant risks to data longevity– Ever changing nature of research– Reliance on ‘Human infrastructure’

For data linking, provenance, support and documentation

(Whyte A. et al., 2008 – Digital Curation Centre)

Data & risks• ImagingImaging:

• MR scanners, PET, Ultrasound, Optical (retinal)–5+ Scanners in the University, up to 500k 2D images/hour (Mostly DICOMDICOM format)?

• Clinical/other dataClinical/other data:• Formal interviews by professionals:

Psychiatrist, Neonatologist, Psychologist, Researcher

• AnonymisationAnonymisation & securitysecurity • Processing pipelines Processing pipelines && Analysis Analysis • Publication Publication && Archiving/ Archiving/Preservation?Preservation?

Data Preservation and Reuse

– Data is of high value as it is expensive to collect(BRIC, CRIC) Current imaging assets > £100 million > 100TBMuch of this data is very ‘rare’Collected and Analysed over past 20 yearsMultiple P.I’s/groups/sites/universities/hospitals/IT teamsWTCRF: 30,000 + documents

– Cost of curation vs. reuse value–Old data often reused

» Huge cost savings £200 - £5,000 per subject–Enables future discoveries in basic and clinical neuroscience–Reused as new methods and theories develop

Data sharing & security

• Medical data is highly sensitive– DPA1988, NHS R&D, Caldicott, MHRA, GCP

• Must be held securely Catalogued & Anonymised• DICOM Confidential, (Rodríguez González D. et al., 2010);• Scan Manager, CRF Manager® ( UoE, WTCRF software)

• Secure, auditable access control and sharing– 2 factor verification under deployment (CMVM)

Solutions

– CRF Imaging Core application & CRF Manager ®– Data management Planning - Online– Scan Manager & DICOM Confidential– Standard Provenance templates

(to capture research -> Electronic lab note books)

– BRAINS database– Research Data Management Service (UoE)• MANTRA, Data Vault, Data Store, Data Share, w3

Alzheimer's disease (AD) vs normal control group