View
29
Download
0
Category
Preview:
Citation preview
TrypanosomaTrypanosomiasis
Prepared by:
NOE P. MENDEZCENTRAL MINDANAO UNIVERSITY (CMU)
npolomendez@gmail.com
Reference Beaver, P.C., R.C. Jung and E. . Cup, 1984.
Clinical Parasitology. Lea and febiger Publishers. Philadelphia
Neva, F.A and H.W. Brown. 1994. basic Clinical parasitology. Appleton and Lange
Publishers. Norwalk, Connecticut Despommier, Gwadz, Hotez and Knirsch,
1990. Parasitc Diseases. Apple Trees productions L.L.C., New York
Trypanosoma Kingdom: ProtistaPhylum: ProtozoaClass: Zoomastogophora Order: KinetoplastidaFamily: Trypanosomatidae
General Characteristics single nucleus a single flagellum, and a leaf-like or
rounded body Members are all
parasitic
Morphology
Reproduction
Stages Amastigote- spherical- very short
flagellum
Leishmania amastigote
Promastigote
- has elongated body form
- kinetoplast and kinetosome at the anterior end, in front of nucleus
Trypomastigote- characteristic of
blood stream forms - metacyclic forms in
the invertebrate vector
- undulating membrane- kinetoplast and
kinetosome
Trypanosoma lewisi
Trypanosoma equiperdum
Trypanosoma brucei gambiense
Trypanosoma cruzi
Diagnosis:Chronic cases severe headache, mental
apathy, slow speech, deep sleep, coma & death
Trypanosoma chancre (at the site of bite)
Via lymphatics: enlarged lymph nodes especially
posterior cervical region.Via blood stream: headache, fever(fluctuating),
muscle & joint pain, irregular erythematous rash.
Invasion of bone marrow
Enlarged liver & spleen, generalized weakness.
Invasion of CNS: In East African Trypanosomiasis: Disease runs more rapid & fatal courseRomana’s sign (Unilateral
conjunctivitis appear suddenly) together with edema of upper & lower eye lids & cheek
Recommended