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PSYCHOENDOCRINOLOGY
Dr. James M. Alo, RN,MAN,MAP.PHD
ENDOCRINE GLANDSENDOCRINEGLAND
HORMONES FUNCTIONS
PITUITARYANTERIOR
TSH Thyroid to releasehormones
LOBE ACTH Adrenal cortex to releasehormones
FSH,LH Growth, maturation &function of sex organs
GH/SOMATOTROPIN
Growth of body tissues &bones
PROLACTIN/LTH
Development ofmammary glands &lactation
ENDOCRINE GLANDSENDOCRINEGLAND
HORMONE FUNCTION
PITUITARYPOSTERIORLOBE
ADH Regulates water metabolism
OXYTOCIN Stimulate uterine contractionsrelease of milk
INTERME-DIATE LOBE
MSH Affects skin pigmentation
ENDOCRINE GLANDSENDOCRINEGLAND
HORMONES FUNCTION
ADRENALCORTEX
ALDOSTERONE Fluid & electrolyte balance;Na reabsorption;K excretion
CORTISOL Glycogenolysis;GluconeogenesisNa & water reabsorptionAntiinflammatoryStress hormone
SEXHORMONES
Slightly significant
ENDOCRINE GLANDS
ENDOCRINEGLAND
HORMONE FUNCTION
ADRENALMEDULLA
EPINEPHRINENOR-EPINEPHRINE
Increase heart rate & BPBronchodilation,GlycogenolysisStress hormone
ENDOCRINE GLANDSENDOCRINEGLAND
HORMONE FUNCTION
THYROID T3 & T4’ Regulate metabolic rateP,C,F metabolismRegulate physical & mental
growth & development
THYRO-CALCITONIN
Decrease serum Ca byincreasing bone deposition
PARA-THYROID
PTH Increase serum calcium bypromoting bone decalcification
ENDOCRINE GLANDSENDOCRINEGLAND
HORMONE FUNCTION
PANCREASBETACELLS
INSULIN Decrease blood glucose by:Glucose diffusion across cell
membrane;Converts glucose to
glycogen
ALPHACELLS
GLUCAGON Increase blood glucose by:GluconeogenesisGlycogenolysis
ENDOCRINE GLANDSENDOCRINEGLAND
HORMONES FUNCTION
OVARIES ESTROGEN &PROGES-
TERONE
Development of secondary sexcharac in female
Maturation of sex organsSexual functioningMaintenance of pregnancy
TESTES TESTOS-TERONE
Development of secondary sexcharac in male
Maturation of sex organsSexual functioning
HORMONE REGULATIONNEGATIVE FEEDBACK MECHANISM
CHANGING OF BLOOD LEVELS OFCERTAIN SUBSTANCES (e..g CALCIUM & GLUCOSE)
RHYTHMIC PATTERNS OF SECRETION(e.g. CORTISOL, FEMALE REPRODUCTIVE HORMONES)
AUTONOMIC & C.N.S. CONTROL(PITUITARY-HYPOTHALAMIC AXIS,
ADRENAL MEDULLA HORMONES)
NEGATIVE FEEDBACKMECHANISM
DECREASED HORMONE CONCENTRATIONIN THE BLOOD (e.g. Thyroxine)
PITUITARY GLANDRELEASE OF STIMULATING HORMONE (e.g. TSH)
STIMULATION OF TARGET ORGANS TOPRODUCE & RELEASE HORMONE
(e.g. Thyroid gland release of Thyroxine)
RETURN OF THE NORMALCONCENTRATION OF HORMONE
NEGATIVE FEEDBACKMECHANISM
INCREASED HORMONE CONCENTRATIONIN THE BLOOD (e.g. Thyroxine)
PITUITARY GLAND IS INHIBITED TORELEASE STIMULATING HORMONE (e.g. TSH)
DECREASED PRODUCTION & SECRETIONOF TARGET ORGAN OF THE HORMONE(e.g. Thyroid gland release of Thyroxine)
RETURN OF THE NORMALCONCENTRATION OF HORMONE
CASE STUDYKatie, an elderly, came in because ofpalpitations.
VS revealed: 37.9o , 120, 25, 140/ 90
She expressed hyperactivty, sweating,increased appetite & weight loss
CASE STUDY
She claimed history of goiter since her30’s but no follow-up was done.
What are your nursing plans?
PLANNINGHEALTH PROMOTIONl IODIZED SALTl CONTROLLING WEIGHT
HEALTH MAINTENANCE &RESTORATIONl STEROID THERAPY
STEROID THERAPY
STEROID LEVELS
PITUITARY GLAND IS INHIBITED TOREALEASE ACTH
ENDOGENOUS CORTISOLPRODUCTION &
RELEASE BY ADRENAL MEDULLAADRENAL ATROPHY
STEROID THERAPYPHARMACOLOGIC CONSIDERATIONS:
PEPTIC ULCER IN SHORT TERM, HIGHDOSE STEROID TX
ADMINISTER DRUG: HIGHER DOSE INTHE MORNING, TAPERING TO LOWER ONES INTHE AFTERNOON
LAST DOSE @ MEAL TIME TO AVOIDINSOMNIA
PALLIATIVE EFFECT
STEROID THERAPYASSESSMENT:
BASELINE STEROID LEVEL ISASSESSED BEFORE PROLONGED THERAPY ISSTARTED TO DETERMINE THE DOSE REQUIRED
STEROID WITHDRAWAL (LOW STRESSTOLERANCE)l EXHAUSTIONl WEAKNESSl LETHARGY
STEROID THERAPYASSESSMENT:
ACUTE ADRENAL CRISISl RESTLESSNESSl WEAKNESSl HEADACHEl DHNl N/Vl FALLING BP TO SHOCK
PSYCHOLOGICAL CXSl MOOD ELEVATION,l FRANK EUPHORIAl THEN, DEPRESSION
STEROID THERAPYIMPORTANT FACTS:
MAJOR UNTOWARD EFFECTS:l MASKS INFECTIONl DEFENSE AGAINST INFECTION FROM
LYMPHOPENIAl SLOW WOUND HEALING FROM ITS
ANTIINFLAMMATORY EFFECTl P.U.D. ACTIVATION/ REACTIVATIONl SERUM SODIUMl SERUM POTASSIUM
STEROID THERAPYIMPORTANT FACTS:
MINOR UNTOWARD EFFECTS:l PIGMENTATIONl ACNEl FACIAL HAIRl MOON-FACIE
STEROID THERAPYIMPORTANT FACTS:
PROBLEMS OF LONG TERM THERAPY:l GROWTH RETARDATIONl OBESITYl GASTRITIS TO P.U.D.l OSTEOPOROSISl HPNl RENAL CALCULIl ADRENAL ATROPHY
STEROID THERAPY
STEROID LEVELS
PITUITARY GLAND IS INHIBITED TOREALEASE ACTH
ENDOGENOUS CORTISOLPRODUCTION &
RELEASE BY ADRENAL MEDULLAADRENAL ATROPHY
STEROID THERAPYIMPLEMENTATION
DECREASE Na IN THE DIETCALORIC RESTRICTIONFOODS HIGH IN POTASSIUMGIVE MEDS WITH ANTACIDS OR WITHFOODTEST STOOLS OR EMESIS FOR BLOODREPORT ANY EVIDENCE OF GI BLEEDINGLYMPHOPENIC PRECAUTION
ANTERIOR PITUITARYDISTURBANCES
HYPOPITUITARISM
HYPERPITUITARISM
HYPOPITUITARISMANTERIOR LOBE
PANHYPOPITUITARISM(SIMMOND’S DSE)
l DECREASED SECRETION OF ALLANTERIOR LOBE HORMONES
HYPERPITUITARISMANTERIOR LOBE
EOSINOPHILIC TUMORl INCREASED GROWTH HORMONE AND
PROLACTINBASOPHILIC TUMORl INCREASED TSH, FSH, LH, MSH,l INCREASED ACTH (CUSHING’S DSE)
CHROMOPHOBE TUMORl INCREASED ACTH & GROWTH
HORMONE
PITUITARY ANTERIOR LOBEHORMONE HYPO FXN HYPER FXN
GH Dwarfism – youngCachexia - adult
Gigantism – youngAcromegaly - adult
ACTH Atrophy of adrenalcortex
Cushing’s dse
TSH Atrophy &depressed thyroid fxn
Grave’s dse
FSH Atrophy & infertility Exaggerated fxn ofsex organs
PROLACTIN Underdevelopmentof mammary glands
Decreased milkproduction
MANAGEMENTHYPOPITUITARISMl SURGICAL REMOVAL / IRRADIATIONl REPLACEMENT THERAPY
l THYROID HORMONESl STEROIDSl SEX HORMONESl GONADOTROPINS (restore fertility)
HYPERPITUITARISMl SURGICAL REMOVAL / IRRADIATIONl MONITOR FOR HYPERGLYCEMIA &
CARDIOVASCULAR PROBLEMS
POSTERIOR PITUITARYDISTURBANCES
DIABETES INSIPIDUS
SYNDROME OF INAPPROPRIATEANTIDIURETIC HORMONE
DIABETES INSIPIDUSABSOLUTE / PARTIAL DEFICIENCY OF VASOPRESSIN
CAUSE:TUMORTRAUMAVASCULAR DSEINFLAMMATIONPITUITARYSURGERY
S/SX:POLYURIA15-29L/ DAYPOLYDIPSIASG OF URINE IS<1.010S/SX OF DHNSHOCK
DIABETES INSIPIDUSABSOLUTE / PARTIAL DEFICIENCY OF VASOPRESSIN
MANAGEMENTHORMONAL REPLACEMENT – FOR LIFEl VASOPRESSIN (PITRESSIN TANNATE IN OIL) – IM OR
NASAL SPRAY
NON-HORMONAL THERAPYl CHLORPROPRAMIDE – INCREASE RESPONSE OF THE
BODY TO DECREASED VASOPRESSIN
SALT & P RESTRICTED DIET, INCREASEFLUIDSMONITOR I&OMAINTAIN FLUID & ELECTROLYTEBALANCE
SYNDROME OFINAPPROPRIATE ADHELEVATED ADH
CAUSES:BRONCHOGENIC CANONENDOCRINE TUMORS
S/SX:DECREASED SERUM SODIUMl CX IN LOC TO UNCONSCIOUSNESSl SEIZURES
WATER INTOXICATIONl N/Vl MENTAL CONFUSION
SYNDROME OFINAPPROPRIATE ADH
MANAGEMENT:WATER INTAKE RESTRICTIONADMINISTER AS ORDERED:l NaCll Diureticsl Demeclocycline (declamycin) – a
tetracycline analogue that interferes withthe action of ADH on the collecting tubules
Mission possible
THYROID GLAND
STIMULATED BY THYROID STIMULATINGHORMONE (TSH)NEEDS IODINE TO SYNTHESIZE HORMONE
SECRETES:l THYROXINE (T4)l TRIIODOTHYRONINE (T3)
THYROID DISTURBANCESDIAGNOSTIC TESTS:
B.M.R.- AMT OF O2 USED BY A PERSON @ A GIVENTIME
PBI – MEASURE IODINE LIBERATED IN THE BLOOD WITHTHYROID DAMAGE
SERUM THYROXINE (T4), SERUMTRIIODOTHYRONINE (T3), SERUM TSHBLOOD SERUM CHOLESTEROLRADIOACTIVE IODINE TESTS:l T3 RED CELL UPTAKEl RADIOACTIVE IODINE UPTAKE (I131l THYROID SCAN
THYROID DISTURBANCESHYPOTHYROIDISM HYPERTHYROIDISM
CRETINISM- infants,young children
HYPOTHYROIDISMWITHOUT MYXEDEMA-atrophy/ destruction ofthyroid gland
MYXEDEMA –adults
GRAVE’S DSE orExophthalmic goiter
EFFECTSHYPOTHYROIDISM HYPERTHYROIDISM
Reduction in HEATPRODUCTION
Failure of MENTAL &PHYSICAL GROWTH
increased storage ofC, P & F
Abnormal collectionof WATER
Increase heat
Deranged Cmetabolism, glycosuria
Increase use of F &P as fuel
HYPOTHYROIDISM HYPERTHYROIDISM
SERUMCHOLESTEROL:INCREASED
BMR:DECREASED
SKIN:THICK, PUFFY, DRY
HAIR:DRY, BRITTLE
DECREASED
INCREASED
WARM, MOIST, FLUSHED
SOFT, SILKY
HYPOTHYROIDISM HYPERTHYROIDISM
NERVOUS SYSTEM:APATHETICLETHARGICMAYBE
HYPERIRRITABLESLOW CEREBRATION
WEIGHT:INCREASED
APPETITE:DECREASED
HYPERACTIVELABILE MOODHYPERSENSITIVETENSED
DECREASED
INCREASED
MANAGEMENTHYPOTHYROIDISM HYPERTHYROIDISMMEDICAL:HORMONEREPLACEMENT
DESSICATED THYROIDTHYROGLOBULINNa LEVOTHYROXINENa LYOTHYRONINE
MEDICAL:RESTANTITHYROID
DRUGS:LUGOL’S SOLUTIONTHIOUREA DERIVATIVESRADIOACTIVE IODINEBETA-BLOCKERS
SURGICAL:SUBTOTAL
THYROIDECTOMY
ANTITHYROID MEDICATIONSLUGOL’S SOLUTION
(POTASSIUM IODIDE)l DECREASE THYROID VASCULARITYl INHIBIT IODINE RELEASEl DILUTED IN MILK / JUICEl STAINS THE TEETH- USE STRAW
THIOUREA & DERIVATIVES(PTU,METHIMAZOLE)l BLOCK THYROID HORMONE RELEASEl TOXIC SIGNS: FEVER, SORETHROAT, LEUKOPENIA
RADIOACTIVE IODINEl PATIENT IS ISOLATED FOR 3 DAYS
BETA BLOCKERSl PROPANOLOL
SUBTOTAL THYROIDECTOMYREMAINING TISSUE PROVIDES ENOUGH HORMONES FOR
NORMAL FXN
PRE OP NURSING CARE:PATIENT EDUCATION ON POST OP:l LITTLE HOARSENESSl DIFFICULTY OF SWALLOWING
POST OP NURSING CARE:SEMIFOWLER’SAVOID HYPEREXTENSION OF THE NECKBE ASKED TO SPEAK @ 40 MIN INTERVAL –ASSESS RECURRENT NERVE INJURYWATCH OUT FOR COMPLICATIONS.
SUBTOTAL THYROIDECTOMYCOMPLICATIONS:
RECURRENT LARYNGEAL NERVE INJURYl HOARSENESS
HEMORRHAGEl 12-24 HRS POST OPl OBSERVE FOR IRREGULAR BREATHING, CHOKING
SIGNSl TRACHEOSTOMY SET @ BEDSIDE
TETANYRESPIRATORY OBSTRUCTIONTHYROID STORM
TETANYDEPENDS UPON THE NUMBER OF PARATHYROID GLANDS
REMOVED
S/SX:1ST – TINGLING TOES & FINGERS2ND – CHEVOSTEK’S SIGN (TAPPING THE FACIALMUSCLES)
3RD – TROUSSEAU’S SIGN (CARPO-PEDAL SPASMWITH OCCLUSION OF CIRCULATION WITH A BP CUFF)
MANAGEMENT:CALCIUM REPLACEMENT: CaGluconate IV
THYROID STORM / CRISISS/SX:
HYPERTHERMIA> 41C
TACHYCARDIAAPPREHENSIONRESTLESSNESSIRRITABILITYDELIRIUMCOMA
MANAGEMENT:DECREASE TEMPANTITHYROIDDRUGSGLUCOSEDIGITALISSTEROIDS TODECREASE ACTH
THYROID STORM / CRISISINCREASED AMOUNT OF THYROID HORMONES
POST OPAFTER RADIOACTIVE IODINEADMINISTRATIONTOO SHORT PERIOD OF PRE OP TX
CAUSES:EMOTIONAL STRESSPHYSICAL STRESS
VARIANTS OFHYPERTHYROIDISM
GRAVE’S DSE
THYROIDITIS
GOITER
GRAVE’S DISEASE
CAUSE:UNKNOWNAUTOIMMUNE WITH LONG-ACTINGTHYROID STIMULATOR
S/SX: TRIAD OF SYMPTOMS:HYPERTHYROIDISMOPHTHALMOPATHYDERMOPATHY
OPHTHALMOPATHY
EXOPHTHALMOS – ACCUMULATION OFFLUID IN THE FAT PADS BEHIND HE EYEBAL
LID LAG – PROMINENT PALPEBRAL FISSUREWHEN THE PATIENT LOOKS DOWN
THYROID STARE(DARYMPLE’S SIGN) – INFREQUENT EYEBLINKING
DERMOPATHYPRETIBIAL MYXEDEMA
@ THE DORSUM OF THE LEG
RAISED, THICKENED, PRURITIC,HYPERPIGMENTED SKIN
CLUBBING OF FINGERS & TOES
OSTEOARTHROPATHY
THYROIDITISCLASSIFICATION:
SUBACUTE, NONSUPPURATIVEl UNKNOWN CAUSEl ASSOC. WITH VIRAL URT INFECTIONS
CHRONIC, HASHIMOTO’Sl IMMUNOLOGICAL FACTORSl PRESENCE OF IMMUNOGLOBULINS &
ANTIBODIES DIRECTED AGAINST THETHYROID
GOITER
ENLARGEMENT OF THE THYROID GLAND.
TYPES:TOXIC NODULAR
NONTOXIC
TOXIC NODULARGOITER
COMMON IN ELDERLYFROM LONG STANDING SIMPLEGOITERNODULESl FUNCTIONING TISSUEl SECRETES THYROXINE
AUTONOMOUSLY FROM TSH
NON-TOXIC GOITER(SIMPLE/ COLLOID/ EUTHYROID)
CAUSE :IODINE DEFICIENCYINTAKE OF GOITROGENIC SUBSTANCES/DRUGS:l CASSAVA,l CABBAGE,l CAULIFLOWER,l CARROTSl RADDISHl TURNIPSl RED SKIN OF PEANUTSl IODINEl COBALTl LITHIUM
NON-TOXIC GOITER
IMPAIRED THYROID HORMONE SYNTHESIS
SERUM THYROXINE
PITUITARY SECRETE TSH
THYROID GLAND ENLARGESTO COMPENSATE FOR THE REDUCED LEVEL OF THYROXINE
IODINE DEFICIENCY ORINTAKE OF GOITROGENIC SUBSTANCES
NON-TOXIC GOITER
COMMON INWOMEN:ADOLESCENTPREGNANTLACTATINGMENOPAUSE
TREATMENT:IODIZED OIL IMIODINE TABLETSSALTFORTIFICATIONWITH IODINEEDUCATE ABOUTINTAKE OF:l SEAWEEDSl SHELLFISHl FISH- TAMBAN, HITO,
DALAG
MYXEDEMA COMA
MEDICAL EMERGENCYOCCURS IN SEVERE & UNTREATEDMYXEDEMAHIGH MORTALTY RATE
S/SX:INTENSIFIED HYPOTHYROIDISMNEUROLOGIC IMPAIRMENT COMA
MYXEDEMA COMA
PRECIPITATING FACTORS:
FAILURE TO TAKE MEDSINFECTIONTRAUMAEXPOSURE TO COLDUSE OF SEDATIVES, NARCOTICS,ANESTHETICS
MYXEDEMA COMA
MANAGEMENT:
IV THYROID HORMONESCORRECTION OF HYPOTHERMIAMAINTAIN VITAL FXNSTREAT PRECIPITATING CAUSES
PARATHYROID GLAND4 GLANDSSECRETES PARATHORMONE (PTH) INRESPONSE TO SERUM Ca & Ph LEVELSREGULATE CALCIUM & PHOSPHORUSMETABOLISM
ORGANS AFFECTED:BONES - RESORPTIONKIDNEYSl Ca REABSORPTIONl Ph EXCRETION
GIT – ENHANCES Ca ABSORPTION
PARATHYROID DISORDERSDIAGNOSTIC TESTS:
HEMATOLOGICALl SERUM CALCIUMl SERUM PHOSPHORUSl SERUM ALKALINE PHOSPHATASE
URINARY STUDIESl URINARY CALCIUMl URINARY PHOSPHATE - TUBULAR
REABSORPTION OF PHOSPHATE
HYPOPARATHYROIDISMDECREASED PTH PRODUCTIONHYPOCALCEMIACALCIUM IS:l DEPOSITED IN THE BONEl EXCRETED
CAUSE:HEREDITARYIDIOPATHICSURGICAL
HYPOPARATHYROIDISMS/SX:
ACUTE HYPOCALCEMIAl TINGLING OF THE FINGERSl CHEVOSTEK’S, TROUSSEAU’S
CHRONIC HYPOCALCEMIAl FATIGUE, WEAKNESSl PERSONALITY CHANGESl LOSS OF TOOTH ENAMEL, DRY SCALY SKINl CARDIAC ARRHYTHMIAl CATARACT
HYPOPARATHYROIDISMXRAY: INCREASED BONE DENSITYMANAGEMENT:
Ca SUPPLEMENTVIT D SUPPLEMENT – LIQ FORM: WITH WATER,JUICE OR MILK, pc
SEIZURE precLISTEN FOR STRIDOR OR HOARSENESSTRACHEOSTOMY SET @ BEDSIDE
CaGLUCONATE @ BEDSIDE
HYPERPARATHYROIDISMINCREASED PTH PRODUCTIONHYPERCALCEMIAHYPOPHOSPHATEMIAPRIMARY – TUMOR OR HYPERPLASIA OF THEPARATHYROID GLAND
SECONDARY – COMPENSATORY OVERSECRETIONOF PTH IN RESPONSE TO HYPOCALCEMIA FROM:l CHRONIC RENAL DSEl RICKETSl MALABSORPTION SYNDROMEl OSTEOMALACIA
HYPERPARATHYROIDISMS/SX:
BONE PAIN : ESP @ THE BACK, PATHOLOGICFRUCTURESTUBULAR CALCIUM DEPOSITS - KIDNEYSTONES, RENAL COLIC, POLYURIA, POLYDIPSIAMUSCLE WEAKNESSPERSONALITY CX, DEPRESSIONCARDIAC ARRHYTHMIAS, HPN
XRAY: BONE DEMINERALIZATION
HYPERPARATHYROIDISMMANAGEMENT:
TX OF CHOICE : SURGICAL REMOVAL OFHYERPLASTIC TISSUEIV PNSS 5L/ DAY WITH DIURETICSCRANBERRY JUICE (ACID-ASH)LOW Ca, HIGH Ph DIETNO MILK, CAULIFLOWER & MOLASSESSTRAIN URINE FOR STONESCARE FOR PARATHYROIDECTOMY
ADRENAL GLANDSTIMULATED BY ACTH
HORMONE PRECURSOR:l CHOLESTEROL
SECRETES:l CORTISOLl ALDOSTERONEl SEX HORMONES : ANDROGEN, ESTROGEN
ADRENAL GLANDHORMONE FUNCTION
ALDOSTERONE Renal : Na & Cl reabsorption; Kexcretion
GI : Na absorptionGLUCO-
CORTICOIDSincrease serum glucose by
gluconeogenesis & glycogenolysis espduring STRESS
Blocks inflammationCounteracts effect of histamine
SEX HORMONE Physiologically insignificantBecomes useful during menopause in
women
SYMPTOMATOLOGY
ALDOSTERONE DEFICIENCY
DECREASE IN PLASMA VOLUME LEADING TODEHYDRATONHYPOTENSION TO SHOCKINCREASED K
METABOLIC ACIDOSIS
SYMPTOMATOLOGY
CORTISOL DEFICIENCY
ANOREXIA, N/V, ABDOMINAL PAIN, WT LOSS,LETHARGYHYPOGLYCEMIAHYPOTENSIONINCREASED K, WEAK PULSEPIGMENTATIONIMPAIRED STRESS TOLERANCE
SYMPTOMATOLOGY
SEX HORMONE DEFICIENCY
LOSS OF BODY HAIRLOSS OF LIBIDO OR IMPOTENCEMENSTRUAL & FERTILITY DISORDER
ADRENAL CORTEXDISORERS
ADRENAL INSUFFICIENCY
ADRENAL CRISIS
CUSHING’S SYNDROME
ALDOSTERONISM
ADRENAL INSUFFICIENCYADDISON’S DISEASE
INCAPABILITY OF THE ADRENALCORTEX TO PRODUCEGLUCOCORTICOIDS IN RESPONSETO STRESS
ADRENAL CRISIS
ACUTE EPISODES FROM STRESSTHAT TAXES THE ADRENALCORTICAL FUNCTION BEYOND ITSCAPABILITIES
POSSIBLE COMPLICATION OFADDISON’S DISEASE
ADRENAL CRISIS
PRECIPITATING CAUSES:ABDOMINAL DISCOMFORTINFECTIONTRAUMAHIGH TEMPEMOTIONAL UPSETANTICOAGULANT DRUGS
ADRENAL CRISIS
S/SX:
HYPOTENSIONFLUID LOSSHYPONATREMIA
ADRENAL CRISISLAB:
SERUM ELEC: DECREASED NaINCREASED K
S. BUN :S. GLUCOSE:ADRENAL HORMONE ASSAY :HYDROXYCORTICOID & 17 KETOSTEROID IN 24-HR URINE DET.
ADRENAL CRISIS
GOALS OF CARE:TO REVERSE SHOCK
RESTORE BLOOD CIRCULATION
REPLENISH NEEDED STEROID
ADRENAL CRISIS
TREATMENT:D5NSSADRENAL CORTICAL HORMONEREPLACEMENT: INJECTABLENEOSYNEPHRINE - SHOCKHIGH SALT DIETANTIBIOTICS
CUSHING’S SYNDROME
CAUSE:SUSTAINED OVER-PRODUCTION OFGLUCOCORTICOIDS BY ADRENAL GLAND FROM
ACTH BY PITUITARY TUMOR
EXCESSIVE GLUCORTICOIDADMINISTRATION
CUSHING’S SYNDROME
S/SX:TRUNCAL OBESITYBUFFALO HUMPMOON-FACIEWT GAINSODIUM RETENTIONTHINNING OF EXTREMITIES – FROMLOSS OF MUSCLE TISSUE DUE TO PROTEIN CATABOLISM
CUSHING’S SYNDROME
PURPLE STRIAE – FROM THINNINGOF SKINECHYMOSIS FROM SLIGHT TRAUMAANDROGENIC EFFECTS:
OLIGOMENORRHEAHIRSUTISMGYNECOMASTIA
HYPERTENSION FROM S. Na
CUSHING’S SYNDROME
TREATMENT & NURSING CARE:
PSYCHOLOGICAL SUPPORTPREVENT INFECTION – INFLAM &IMMUNE RESPONSE ARE SUPPRESSED
PROMOTE SAFETYSURGERY – SUB/TOTAL ADRENALECTOMY
ALDOSTERONISMHYPERSECRETION OF ALDOSTERONE
PRIMARY – CONN’S SYNDROME
SECONDARY
CONN’S SYNDROMEPRIMARY ALDOSTERONISM
CAUSE:ADRENAL ADENOMA
S/SX:HYPOKALEMIAFATIGUEHYPERNATREMIA, HPN, TETANY
MANAGEMENT:SURGERYALDACTONE – ALDOSTERONE ANTAGONIST
SECONDARYALDOSTERONISM
THE PROBLEM IS OUTSIDE THEADRENAL GLAND:
e.g. RENIN – ANGIOTENSIN SYSTEM
ADRENAL MEDULLA
HORMONES : EPINEPHRINENOREPINEPHRINE
EFFECTS
PHEOCHROMOCYTOMATUMOR OF ADRENAL MEDULLASECRETES INCREASED AMOUNT OF CATECHOLAMINES
S/SX:HPNHYPERGLYCEMIACARDIAC ARRHYTHMIA & CHF
DIAGNOSTIC TEST :VMA IN 24H URINE
VMA IN 24H URINE
END PRODUCT OF CATECHOLAMINEMETABOLISMDRUGS & FOOD TO BE WITHHELD24H B4 THE TEST:l COFFEE & TEAl BANANAl VANILLAl CHOCOLATES
PHEOCHROMOCYTOMA
MANAGEMENT:SURGERYMEDICAL : ADRENERGIC BLOCKINGAGENTS: PHENTOLAMINE
NURSING CARE:MONITOR BP IN SUPINE & STANDINGMONITOR URINE FOR GLUC & ACETONE
PANCREAS
HORMONES:
INSULIN BY BETA CELLS
GLUCAGON BY ALPHA CELLS
DIABETES MILLETUS
CAUSE:INSUFFICIENCY OF INSULINLACK OF INSULIN
EFFECT:HYPERGLYCEMIA
DIABETES MILLETUSPATHOPHYSIOLOGY
REDUCED /NO INSULINREDUCED /NO INSULIN
HYPERGLYCEMIAHYPERGLYCEMIA
GLUCOSURIAGLUCOSURIA
WEIGHT LOSS
OSMOTICDIURESISOSMOTICDIURESIS
POLYURIAPOLYURIA
CELLULARCELLULARHUNGER
POLYPHAGIA
POLYDIPSIAPOLYDIPSIA
LIPOLYSIS
OSMOTICDEHYDRATION
DIABETES MILLETUS
S/SX:3 – P’sWEIGHT LOSS
STAGES:PREDIABETESSUSPECTEDCHEMICALCLINICAL / OVERT
DIABETES MILLETUS
PREDIABETES / POTENTIAL:
CONCEPTION
EVIDENCE OF GLUCOSE METABOLISMALTERATION
DIABETES MILLETUS
SUSPECTED/ SUBCLINICAL/ LATENT:
PREDIABETES
NO STRESS STRESS
NORMAL GLUCOSEMETABOLISM
OVERT DIABETES
DIABETES MILLETUSCHEMEICAL:
SUBCLINICAL
GTT IS ABNORMAL
NO STRESS STRESS
ASYMPTOMATIC SYMPTOMATIC
DIABETES MILLETUSCLINICAL / OVERT:
CHEMICAL
PERSISTENT INCREASED FBS
WITH OR WITHOUT STRESS
SYMPTOMATIC
DIABETES MILLETUSTYPES:
TYPE Il JUVENILE ONSETl BEFORE 15 YOl LEAN/ NORMAL
WEIGHTl ABSOLUTE INSULIN
DEFICIENCYl INSULIN -DEPENDENTl PRONE TO DKA
TYPE II –l MATURITY ONSETl AFTER AGE 40l OBESEl REDUCED INSULIN
RECEPTORl NONINSULIN
DEPENDENTl PRONE TO HHONK
DIABETES MILLETUS
DIAGNOSTICEXAMS:FBS2 HR-POSTPRANDIALOGTTGLYCOSYLATEDHGB
DEXTROSTRIPURINE TESTS:l BENEDICT’Sl CLINITEST TABl ACETONE TEST
2 HR POSTPRANDIALBLOOD SUGAR
INTAKE OF 100GM GLUCOSE, 2 HRSBEFORE THE TEST
TEST FOR ABILITY TO DISPOSEGLUCOSE LOAD
OGTTCONFIRMATORY, WHEN OTHER BLOOD TESTSARE BORDERLINE
3 DAYS OF NORMAL ACITIVITY & 150MGOF CARB DIETNPO 10-12HRS BEFORE THE TEST
BASELINE BLOOD SUGAR TAKENGLUCOSE LOAD IS GIVEN, P.O. OR IV
BLOOD & URINE SPECS TAKEN 30 MIN, 1HR,2HRS, 3 HRS, AFTER GLUCOSE LOADING
GLYCOSYLATEDHEMOGLOBIN
MEASURES GLUCOSE METABOLISMFOR THE PAST 3 MONTHS
USEFUL TO CHECK:l COMPLIANCE WITH THERAPYl HISTORY OF SUBCLINICAL OR
CHEMICAL DIABETES
DIABETES MILLETUSPLANNING & IMPLEMENTATION:
CLIENT’S ACTIVITYDIET : C,F,P – 50, 30, 20 LOW SATURATED FATS,HIGH FIBERDRUGS:l ORAL HYPOGLYCEMICS
l BIGUANIDEl SULFONYLUREASl CONTRAINDICATED - PREGNANCY
l INSULIN
DIABETES MILLETUS
INSULIN THERAPYDISPENSED IN “U”/ml : eg 100, 80REFRIGERATEGIVEN @ ROOM TEMPGENTLY ROTATED, NOT SHAKENROUTE : SQ (MTC); IM OR IVSYRINGE: 5/8 INCH ; SAME BRAND
DIABETES MILLETUS
INSULIN THERAPY:SITE OF INJECTION:l ABDOMENl ANTERIOR THIGHl ARMl UPPER BACKl BUTTOCKS
DIABETES MILLETUS
INSULIN THERAPYREACTIONS:LOCAL:l STNGINGl INDURATIONl ITCHING
LIPODYSTROPHY
GENERALIZED:l HIVESl URTICARIAl ANTIHISTAMINES
30 MIN B4l DESENSITIZATION
LIPODYSTROPHY
CAUSE:FAULTY TECHNIQUETRAUMAINJECTION OF REFRIGERATEDINSULIN
MANAGEMENT:ROTATING SITES: 1 AREA IS NOT USEDMORE THAN ONCE EVERY 3 WKS
INSULIN THERAPY &HORMONAL ACTIVITYGLUCORTICOIDS & EPINEPHRINECAUSES HYPERGLYCEMIA DURING:l PHYSICAL TRAUMAl STRESSl INFECTIONl ANXIETYl ANGERl FEARl CHANGE IN LIFESTYLE
INCREASE IN INSULIN DOSE IS NEEDED
SURPRISE!!!
ACUTE COMPLICATIONSOF DIABETES MILLETUS
DIABETIC KETO-ACIDOSIS (DKA)
INSULIN SHOCK
HYPERGLYCEMIC, HYPEROSMOLAR,NONKETOTIC (HHONK) COMA
SOMOGYI EFFECT
D.K.A.PATHOPHYSIOLOGY
NO INSULINNO INSULIN
MARKED HYPERGLYCEMIA
GLUCOSURIAGLUCOSURIA
WEIGHTLOSS
OSMOTICDIURESISOSMOTICDIURESIS
POLYURIAPOLYURIA
CELLULARCELLULARHUNGER
POLYPHAGIAPOLYPHAGIA
POLYDIPSIA
LIPOLYSISLIPOLYSIS
OSMOTICDEHYDRATION
KETOACIDOSISKETOACIDOSIS
D.K.A.S/SX:
S/SX OF DM +KETONURIAMETABOLIC ACIDOSISKUSSMAUL’S RESPIRATIONACETONE BREATHDHNFLUSHED FACETACHYCARDIACIRCULATORY COLLAPSE COMA DEATH
D.K.A.
MANAGEMENT:
ADEQUATE VENTILATIONFLUID REPLACEMENTINSULIN – RAPID ACTINGECG – ELEC IMB
INSULIN SHOCKLOW BLOOD SUGAR
CAUSE:OVERDOSE OF EXOGENOUS INSULIN
EATING LESS
OVEREXERTION WITHOUT ADDITIONALCALORIE INTAKE
INSULIN SHOCKS/SX:
PARASYMPATHETICl HUNGERl NAUSEAl HYPORTENSIONl BRADYCARDIA
CEREBRALl LETHARGY,l YAWNINGl SENSORIUM CX
SYMPATHETICl IRRITABILITYl SWEATINGl TREMBLINGl TACHYCARDIAl PALLOR
INSULIN SHOCK
CLINICAL FINDING :BLOOD GLUCOSE BELOW 55-60 mg%
TREATMENT:GLUCOSE PO ( SUGAR, ORANGE JUICEOR CANDY) or IVADMINISTRATION OF GLUCAGON IM, IVOR SQ
HHONKPATHOPHYSIOLOGY
Very insufficient INSULIN
MARKED HYPERGLYCEMIA
GLUCOSURIAGLUCOSURIA
WEIGHTLOSS
WEIGHTLOSS
OSMOTICDIURESISOSMOTICDIURESIS
POLYURIAPOLYURIA
CELLULARHUNGER
POLYPHAGIAPOLYPHAGIA
POLYDIPSIAPOLYDIPSIA
LIPOLYSISWithout
KETOSIS
SEVEREOSMOTIC
DEHYDRATION
HHONK
S/SX:S/SX OF DKA WITHOUT:l KAUSMAUL’S BREATHINGl ACETONE BREATHl METABOLIC ACIDOSISl KETONURIA
LACTIC ACIDOSIS
SEVERE TISSUE ANOXIA
LACTIC ACID PRODUCTION
AGGRAVATION OF EXISTINGMETABOLIC ACIDOSIS
SOMOGYI EFFECTTOO MUCH INSULIN
HYPOGLYCEMIA
GLUCAGON IS RELEASED
LIPOLYSISGLUCONEOGENESISGLYCOGENOLYSIS
REBOUNDHYPERGLYCEMIA
+KETOSIS
CHRONIC COMPLICATIONSOF DIABETES MILLETUS
DEGENERATIVE CHANGES IN THEVASCULAR SYSTEMl UNDERNOURISHMENTl ATHEROSCLEROSIS
NEUROPATHY FROM:l VASCULAR INSUFFICIENCYl VIT B DEFICIENCYl HYPERGLYCEMIA
EYE COMPLICATIONS FROM ANOXIAl CATARACTl DIABETIC RETINOPATHYl RETINAL DETACHMENT
CHRONIC COMPLICATIONSOF DIABETES MILLETUSNEPHROPATHYl DAMAGE & OBLITERATION OF CAPILLARIES
SUPPLYING THE KIDNEY
HEART DISEASEl MI FROM ATHEROSCLEROSIS
SKIN CHANGESl DIABETIC DERMOPATHY – HYPERPIGMENTED &
SCALY PRETIBIAL AREAS
LIVER CHANGESl ENLARGEMENT & FATTY INFILTRATION
Ms A, 45 y.o., has a simple goiter. She’sbeing seen by the community health nursefor teaching & follow-up regarding nutritionaldeficiencies related to her goiter. Ms A’sproblem is almost associated with whatnutritional deficiency?
a. Calciumb. Iodinec. Irond. Sodium
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