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Mahrous Article Summary - 2 - Iron Treatment after Upper Gastrointestinal Bleeding - 2013 Nov.
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Mahrous Article SummaryIron Treatment after Upper Gastrointestinal Bleeding - 2013 Nov.
2
Waleed Mahrous
Dr Waleed Kh. Mahrous http://www.ncbi.nlm.nih.gov/pubmed/24251969
OBJECTIVES
BACKGROUND: Nonvariceal acute upper gastrointestinal
bleeding (AUGIB) is often accompanied by post-discharge anemia.
AIM: To investigate whether iron treatment can effectively treat anemia and to compare a 3-month regimen of oral iron treatment with a single administration of intravenous iron prior to discharge.
Dr Waleed Kh. Mahrous
Dr Waleed Kh. Mahrous
http://www.nature.com/ajg/journal/v108/n12/full/ajg2013249a.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/24251969
METHODS
Dr Waleed Kh. Mahrous
Dr Waleed Kh. Mahrous
97 patients with nonvariceal AUGIB and anemia were enrolled in a double-blind, placebo-controlled, randomised study.
The patients were allocated to one of three groups, receiving a single intravenous administration of 1000 mg of iron; oral iron treatment, 200 mg daily for 3 months; or placebo, respectively. The patients were followed up for 3 months.
http://www.nature.com/ajg/journal/v108/n12/full/ajg2013249a.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/24251969
RESULTS
From week 4 onwards, patients receiving treatment had significantly higher haemoglobin levels compared with patients who received placebo only.
At the end of treatment, the proportion of patients with anemia was significantly higher in the placebo group (P < 0.01) than in the treatment groups.
Intravenous iron appeared to be more effective than oral iron in ensuring sufficient iron stores.
http://www.nature.com/ajg/journal/v108/n12/full/ajg2013249a.htmlDr Waleed Kh. Mahrous http://www.ncbi.nlm.nih.gov/pubmed/24251969
CONCLUSIONS
Iron treatment is effective and essential for treating anemia after nonvariceal acute upper gastrointestinal bleeding.
The route of iron supplementation is less important in terms of the increase in haemoglobin levels.
Iron stores are filled most effectively if intravenous iron supplementation is administered .
Dr Waleed Kh. Mahrous http://www.ncbi.nlm.nih.gov/pubmed/24251969
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